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BILATERAL MULTIFOCAL INNER RETINITIS AFTER A VIRAL ILLNESS, LIKELY COVID-19. 病毒性疾病引起的双侧多灶性内层视网膜炎,很可能是 Covid-19。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001697
Aaron J Chidgey, Carlos Pavesio

Purpose: To describe a young female patient who presented with unilateral vision loss with multiple bilateral inner retinal lesions after a nonspecific viral illness, likely COVID-19.

Methods: Case Report: We reviewed the medical record, examined the retina, optical coherence tomography images, and fundus fluorescein angiogram of the patient along with the relevant medical literature.

Results: The patient presented to our emergency department at Moorfields Eye Hospital with a 2-week history of new onset floaters and blurred vision in her right eye. On examination she was found to have a low-grade bilateral vitritis, mild right optic nerve head swelling, and multiple white inner retinal lesions in both eyes.

Conclusion: Retinitis can be due to multiple infectious and noninfectious etiologies. In this case report, we discuss a case of rare multifocal inner retinitis from a nonspecific viral illness-likely COVID-19.

目的:描述一名年轻女性患者在非特异性病毒性疾病(可能是 Covid -19)后出现单侧视力下降并伴有多发性双侧视网膜内层病变:方法:病例报告:我们回顾了病历,检查了患者的视网膜、OCT 图像和眼底荧光素血管造影,并查阅了相关医学文献:患者因右眼新发浮游物和视力模糊两周后到 Moorfields 眼科医院急诊科就诊。经检查发现,她患有低度双侧玻璃体炎,右眼视神经头轻度肿胀,双眼视网膜内侧有多处白色病变:结论:视网膜炎可由多种感染性和非感染性病因引起。在本病例报告中,我们讨论了一例由非特异性病毒性疾病(可能是 COVID -19)引起的罕见多灶性内视网膜炎。
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引用次数: 0
CASE REPORT: A UNIQUE CASE OF BRAINSTEM ANESTHESIA AND CONTRALATERAL AMAUROSIS AFTER A SUBTENON BLOCK. 病例报告:腱下阻滞术后脑干麻醉和对侧失神的独特病例。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001687
Melissa Lu, Mohammed Al Kaabi, Cynthia Xin-Ya Qian

Purpose: To report and discuss a case of brainstem anesthesia and contralateral amaurosis after a sub-Tenon block.

Methods: Single surgical case report of a patient who underwent an uncomplicated pars plana vitrectomy for an epiretinal membrane peel in the left eye after a sub-Tenon anesthesia technique.

Results: Postoperatively, the patient experienced symptoms of brainstem anesthesia as well as akinesia, a nonreactive pupil, and reduced visual acuity in the contralateral eye that gradually resolved within 24 hours. Imaging was within normal limits and did not reveal any anatomic abnormalities.

Conclusion: Despite the use of a blunt-ended cannula in a sub-Tenon block, there is a non-negligible risk of it penetrating surrounding structures such as the optic nerve sheath. This case emphasizes the importance of monitoring for brainstem anesthesia and contralateral eye involvement in patients both intra- and postoperatively.

目的:报告并讨论一例腱膜下阻滞术后脑干麻醉和对侧失明的病例:单例手术病例报告:一名患者因左眼视网膜外膜剥离接受了不复杂的平面旁玻璃体切除术,术中使用了腱膜下麻醉技术:术后,患者出现脑干麻醉症状、运动障碍、瞳孔无反应、对侧眼视力下降,这些症状在 24 小时内逐渐缓解。影像学检查在正常范围内,未发现任何解剖学异常:结论:尽管在腱膜下阻滞术中使用了钝头插管,但其穿透视神经鞘等周围结构的风险不容忽视。本病例强调了术中和术后监测患者脑干麻醉和对侧眼影响的重要性。
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引用次数: 0
PLASMA MEMBRANE RICH IN GROWTH FACTORS FOR THE TREATMENT OF MACULAR HOLES ASSOCIATED WITH MACULAR TELANGIECTASIA TYPE 2. 富含生长因子膜的血浆在治疗与麦克尔 2 型相关的黄斑孔中的应用。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001693
Juan D Arias, Carlos M Córdoba-Ortega, Dayron F Martinez-Pulgarín, Eduardo J Viteri, Maria M Parra, Carlos M Rangel

Purpose: The aim of the study is to demonstrate the regenerative effects of plasma membrane rich in growth factors as an adjuvant in the surgical treatment of full-thickness macular holes associated with macular telangiectasia Type 2.

Methods: Observational study of a consecutive case series involving Type 2 macular telangiectasia patients with full-thickness macular holes. Best-corrected visual acuity, optical coherence tomography data, anatomical closure rates, and duration of follow-up were documented.

Results: Three patients who met the inclusion criteria were enrolled: two were naive and one was already operated with silicon oil in situ. Median follow-up was 6 months (range 6-18 months), anatomical closure rate was 100%, and median visual acuity change was 20/60 (range 20/40-20/100). No complications related to plasma membrane rich in growth factors were found.

Conclusion: Plasma membrane rich in growth factors is a valuable option for the treatment of full-thickness macular holes associated with macular telangiectasia Type 2. Its application promotes tissue regeneration and facilitates anatomical closure. The technique is reproducible and does not require manipulation of the internal limiting membrane.

目的:证明富含生长因子的等离子体膜(PRGFm)作为手术治疗与 MacTel 2 型(MacTel)相关的全厚黄斑孔(FTMH)的辅助药物的再生效果:连续病例系列观察研究。方法:对连续病例系列进行观察研究。记录最佳矫正视力、光学相干断层扫描(OCT)数据、解剖闭合率和随访时间:3名符合纳入标准的患者入选,其中2名是新手,1名已经进行了原位硅油手术。随访时间中位数为 6 个月(6-18 个月),解剖闭合率为 100%,视力变化中位数为 20/60(20/40 - 20/100)。没有发现与 PRGFm 相关的并发症:结论:PRGFm 是治疗与 MacTel 2 型相关的 FTMH 的重要选择。结论:PRGFm 是治疗与 MacTel 2 型相关的 FTMH 的重要选择,其应用可促进组织再生,有利于解剖闭合。该技术具有可重复性,且无需操作内缘膜。
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引用次数: 0
MODIFIED PRO RE NATA REGIMEN OF BROLUCIZUMAB IN TREATMENT-NAIVE NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. 改良的勃卢珠单抗治疗新生血管性年龄相关性黄斑变性的初始方案。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001692
Myrta Lippera, Alessandro Feo, Claudia Del Turco, Francesco Santoru, Giovanni Fossati, Piero Zollet, Edoardo Panico, Mario R Romano, Giuseppe Querques, Claudio Panico, Carlo La Spina

Purpose: To study the efficacy and safety of pro re nata regimen of brolucizumab, without loading dose, in treatment-naive patients with neovascular age-related macular degeneration.

Methods: Retrospective, observational study. We included all consecutive patients diagnosed with treatment-naive neovascular age-related macular degeneration undergoing brolucizumab treatment in the Humanitas eye clinic, Turin, Italy between April 2022 and May 2023. Treatment was performed following pro re nata regimen without loading phase. Injection intervals (time between two injections), adverse events, changes in best corrected visual acuity, central macular thickness, maximal retinal thickness, and intraretinal and subretinal fluid were evaluated descriptively up to 1 year after the first injection.

Results: Twenty-one eyes of 21 patients were included in the study. The mean number of injections was 2.4 ± 0.7 at 3 months, 3.0 ± 2.0 at 6 months, 3.1 ± 2.4 at 9 months, and 3.8 ± 2.8 at 12 months, respectively. Best corrected visual acuity significantly improved from 20/80 Snellen (0.6 ± 0.3 LogMAR) to 20/50 Snellen (0.4 ± 0.3 LogMAR) at month 12 ( P = 0.044). Central macular thickness and maximal retinal thickness significantly reduced from 426 µm and 606 µm at baseline to 248 µm and 356 µm at 1-year follow-up ( P = 0.00067 and P = 0.02, respectively). Subretinal fluid and intraretinal fluid also progressively resolved. In contrast, intraocular inflammation events occurred in 9.5% of patients during follow-up. Intraocular inflammation resolved in all patients with prompt treatment without visual sequelae.

Conclusion: In our study, pro re nata regimen of brolucizumab without loading phase seems to be an effective treatment option in treatment-naive neovascular age-related macular degeneration patients, with intraocular inflammation rate similar to the one reported in trials and lower number of injections.

目的:研究无负荷剂量的勃卢珠单抗自然治疗方案在新生血管性年龄相关性黄斑变性(nAMD)患者中的疗效和安全性。病例系列:回顾性观察性研究。我们纳入了2022年4月至2023年5月期间在意大利都灵Humanitas眼科诊所接受Brolucizumab治疗的所有连续患者naïve nAMD。治疗按照自然方案进行,无负荷期。对注射间隔(两次注射之间的时间)、不良事件、最佳矫正视力(BCVA)、黄斑中心厚度(CMT)、最大视网膜厚度(MRT)、视网膜内液和视网膜下液(IRF, SRF)进行描述性评估,直至第一次注射后一年。21例患者的21只眼睛被纳入研究。平均注射次数3个月为2.4±0.7次,6个月为3.0±2.0次,9个月为3.1±2.4次,12个月为3.8±2.8次。第12个月时,BCVA从20/80 Snellen(0.6±0.3 LogMar)显著改善至20/50 Snellen(0.4±0.3 LogMar) (p = 0.044)。CMT和MRT从基线时的426 μm和606 μm显著降低到1年随访时的248 μm和356 μm (p=0.00067和p=0.02)。SRF和IRF也逐渐得到解决。另一方面,随访期间9.5%的病例发生眼内炎症(IOI)事件。所有病例经及时治疗后均痊愈,无视觉后遗症。结论:在我们的研究中,无负荷期的单抗治疗方案似乎是治疗初治nAMD患者的有效治疗选择,其IOI率与试验中报道的相似,并且注射次数更少。
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引用次数: 0
MULTIMODAL IMAGING OF VITELLIFORM LESION IN MACULAR TELANGIECTASIA TYPE 2. 黄斑毛细血管扩张2型黄斑卵泡样病变的多模态成像。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001701
Amrita Pradhan, Mukesh Jain, Ankeeta Baliarsingh, Ruchira Chowdhury, Soumava Mandal, Md Imran Ansari, Ahana Sen, Bristi Majumdar, Surabhi Chattree, Kumar Saurabh, Rupak Roy

Purpose: To evaluate multimodal imaging of vitelliform lesions in macular telangiectasia type 2.

Method: Color fundus photograph, optical coherence tomography angiography, fundus autofluorescence, and fundus fluorescein angiography.

Result: Vitelliform lesions were found in two cases of macular telangiectasia type 2.

Conclusion: Vitelliform deposits can be present in eyes with macular telangiectasia type 2. Fundus autofluorescence imaging is a highly sensitive modality for detecting vitelliform lesions.

目的:探讨黄斑毛细血管扩张2型患者卵泡样病变的多模态影像学表现。方法:眼底彩色摄影、光学相干断层血管造影、眼底自体荧光、眼底荧光素血管造影。结果:黄斑2型毛细血管扩张2例可见卵黄样病变。结论:黄斑毛细血管扩张2型眼可出现卵黄样沉积。眼底自体荧光成像是一种高度敏感的检测卵泡状病变的方法。
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引用次数: 0
STERILE HYPOPYON FOLLOWING PARS PLANA VITRECTOMY AND SILICONE OIL INJECTION. "玻璃体旁切除术和硅酮油注射后的无菌下腔"。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001672
Konstantinos Stamoulas, Haider Manzar, Vasant Raman, Aman Chandra

Purpose: To report five cases of postoperative sterile endophthalmitis in patients who underwent pars plana vitrectomy with silicone oil injection for retinal detachment.

Methods: Review of the medical records of five patients who underwent pars plana vitrectomy with silicone oil injection at Southend University Hospital and the Royal Eye Infirmary, Derriford Hospital, University Plymouth Hospitals NHS Trust, for rhegmatogenous or tractional retinal detachment.

Results: All five patients presented with signs of anterior chamber inflammation exhibiting flare, fibrin, and hypopyon in the early or late postoperative period following vitrectomy with silicone oil injection. Treatment with topical antibiotics and steroids was began, with rapid resolution of the anterior chamber inflammatory reaction and no further intervention required.

Conclusion: The use of silicone oil as a tamponade agent for retinal detachment can rarely induce sterile anterior chamber inflammation with signs resembling infectious endophthalmitis. Onset of symptoms, absence of pain, and good response to topical steroids can help differentiate between the two entities.

目的:报告五例因视网膜脱离而接受玻璃体旁切除术并注射硅油的患者术后发生无菌眼内炎的病例:回顾五例因流变性或牵引性视网膜脱离而在索森德大学医院和皇家眼科医院、Derriford 医院接受玻璃体旁切除术并注射硅油的患者的病历:结果:所有五名患者在硅油注射玻璃体切割术后早期或晚期都出现了前房炎症症状,表现为发炎、纤维蛋白和黄斑水肿。开始局部使用抗生素和类固醇治疗后,前房炎症反应迅速缓解,无需进一步干预:结论:使用硅酮油作为视网膜脱离的填塞剂,在极少数情况下会诱发无菌性前房炎症,并出现类似感染性眼内炎的症状。症状的出现、无痛苦以及对局部类固醇的良好反应有助于区分这两种病症。
{"title":"STERILE HYPOPYON FOLLOWING PARS PLANA VITRECTOMY AND SILICONE OIL INJECTION.","authors":"Konstantinos Stamoulas, Haider Manzar, Vasant Raman, Aman Chandra","doi":"10.1097/ICB.0000000000001672","DOIUrl":"10.1097/ICB.0000000000001672","url":null,"abstract":"<p><strong>Purpose: </strong>To report five cases of postoperative sterile endophthalmitis in patients who underwent pars plana vitrectomy with silicone oil injection for retinal detachment.</p><p><strong>Methods: </strong>Review of the medical records of five patients who underwent pars plana vitrectomy with silicone oil injection at Southend University Hospital and the Royal Eye Infirmary, Derriford Hospital, University Plymouth Hospitals NHS Trust, for rhegmatogenous or tractional retinal detachment.</p><p><strong>Results: </strong>All five patients presented with signs of anterior chamber inflammation exhibiting flare, fibrin, and hypopyon in the early or late postoperative period following vitrectomy with silicone oil injection. Treatment with topical antibiotics and steroids was began, with rapid resolution of the anterior chamber inflammatory reaction and no further intervention required.</p><p><strong>Conclusion: </strong>The use of silicone oil as a tamponade agent for retinal detachment can rarely induce sterile anterior chamber inflammation with signs resembling infectious endophthalmitis. Onset of symptoms, absence of pain, and good response to topical steroids can help differentiate between the two entities.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHOROIDAL INFILTRATION IN ERDHEIM-CHESTER DISEASE: A CASE SERIES. 厄德海姆-切斯特病的脉络膜浸润:一个病例系列。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001676
Fatam El Fakih, Stéphane Abramowicz, Adélaïde Toutée, Valérie Touitou, Bahram Bodaghi

Purpose: We describe two cases of choroidal involvement in patients with Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis.

Methods: Short case series.

Results: The first patient was a 25-year-old man with asymptomatic ECD at the level of bones, lung, and central nervous system. Fundus examination revealed bilateral yellowish choroidal infiltration in the superior macula and nasal midperiphery. After initial mild enlargement of the choroidal lesions, treatment with weekly subcutaneous pegylated interferon α2a was started inducing partial regression of the lesions. The second patient was a 45-year-old man with ECD involving the left orbit, maxillary sinus, heart, blood vessels, kidney, retroperitoneum, bones, and testes. Fundus examination of the left eye showed choroidal folds. Macular spectral-domain optical coherence tomography confirmed the folds and revealed underlying choroidal infiltration. Final ocular diagnosis was left choroidal, scleral, and orbital involvement. The patient was initially treated with pegylated interferon α2a, and later with cobimetinib, a Mitogen-activated protein kinase kinase inhibitor, with favorable results. Neither patient developed choroidal neovascularization during the follow-up.

Conclusion: Erdheim-Chester disease is a rare multisystem disorder that can present with ocular involvement, including orbital masses, xanthelasma-like lesions, and, occasionally, choroidal infiltrates. Early recognition and prompt treatment can lead to improvement of ophthalmic and systemic symptoms and prevent further complications. We recommend treating patients with choroidal ECD, regardless of the presence of symptoms, considering these patients are at increased risk of developing choroidal neovascularization.

目的:我们描述了两个病例脉络膜累及患者的埃尔德海姆-切斯特病(ECD),罕见的非朗格汉斯细胞组织细胞增多症。方法:短病例系列。结果:第一位患者是一名25岁的男性,在骨骼,肺和中枢神经系统水平无症状ECD。眼底检查显示双侧黄斑上部及鼻中周黄斑黄脉络膜浸润。在脉络膜病变最初轻度扩大后,开始每周皮下注射聚乙二醇化干扰素α2a治疗,诱导病变部分消退。第二例患者为45岁男性,ECD累及左眼眶、上颌窦、心脏、血管、肾脏、腹膜后、骨骼和睾丸。左眼眼底检查发现脉络膜皱褶。黄斑光谱域光学相干断层扫描证实了褶皱,并显示了潜在的脉络膜浸润。最后的眼部诊断是左脉络膜、巩膜和眼眶受累。患者最初使用聚乙二醇化干扰素α2a治疗,随后使用cobimetinib(一种丝裂原活化蛋白激酶抑制剂)治疗,效果良好。随访期间,两例患者均未出现脉络膜新生血管。结论:Erdheim-Chester病是一种罕见的多系统疾病,可累及眼部,包括眼眶肿块、黄斑样病变,偶尔也有脉络膜浸润。早期识别和及时治疗可以改善眼部和全身症状,防止进一步的并发症。考虑到这些患者发生脉络膜新生血管的风险增加,我们建议治疗脉络膜ECD患者,无论是否存在症状。
{"title":"CHOROIDAL INFILTRATION IN ERDHEIM-CHESTER DISEASE: A CASE SERIES.","authors":"Fatam El Fakih, Stéphane Abramowicz, Adélaïde Toutée, Valérie Touitou, Bahram Bodaghi","doi":"10.1097/ICB.0000000000001676","DOIUrl":"10.1097/ICB.0000000000001676","url":null,"abstract":"<p><strong>Purpose: </strong>We describe two cases of choroidal involvement in patients with Erdheim-Chester disease (ECD), a rare non-Langerhans cell histiocytosis.</p><p><strong>Methods: </strong>Short case series.</p><p><strong>Results: </strong>The first patient was a 25-year-old man with asymptomatic ECD at the level of bones, lung, and central nervous system. Fundus examination revealed bilateral yellowish choroidal infiltration in the superior macula and nasal midperiphery. After initial mild enlargement of the choroidal lesions, treatment with weekly subcutaneous pegylated interferon α2a was started inducing partial regression of the lesions. The second patient was a 45-year-old man with ECD involving the left orbit, maxillary sinus, heart, blood vessels, kidney, retroperitoneum, bones, and testes. Fundus examination of the left eye showed choroidal folds. Macular spectral-domain optical coherence tomography confirmed the folds and revealed underlying choroidal infiltration. Final ocular diagnosis was left choroidal, scleral, and orbital involvement. The patient was initially treated with pegylated interferon α2a, and later with cobimetinib, a Mitogen-activated protein kinase kinase inhibitor, with favorable results. Neither patient developed choroidal neovascularization during the follow-up.</p><p><strong>Conclusion: </strong>Erdheim-Chester disease is a rare multisystem disorder that can present with ocular involvement, including orbital masses, xanthelasma-like lesions, and, occasionally, choroidal infiltrates. Early recognition and prompt treatment can lead to improvement of ophthalmic and systemic symptoms and prevent further complications. We recommend treating patients with choroidal ECD, regardless of the presence of symptoms, considering these patients are at increased risk of developing choroidal neovascularization.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":"20 1","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEMPORARY AMNIOTIC MEMBRANE GRAFT PLACEMENT FOR TREATMENT OF REFRACTORY MACULAR HOLES. 暂时性羊膜移植治疗难治性黄斑孔。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001671
Vichar Trivedi, Qisheng You, Rao Me, Patrick S Y Lee, Kim Le, David Tran, Xihui Lin

Purpose: To report two patient cases demonstrating the management of refractory macular holes through the application of temporary thin amniotic membrane grafts, followed by subsequent graft removal on achieving hole closure.

Methods: Comprehensive chart and literature review was conducted using the PubMed database.

Results: We describe two patients who underwent repeat pars plana vitrectomy for treatment of refractory macular holes. In both patients, the epiretinal placement of a thin amniotic membrane graft was done to achieve hole closure. After a period of retinal stabilization, the amniotic membranes were removed because of the healthy appearance of the outer retinal layers and the ellipsoid zone, ultimately resulting in an improved final visual acuity in both patients.

Conclusion: This case series demonstrates a new approach of using a temporary amniotic membrane graft to close refractory macular holes. After graft removal, both patients reported enhanced visual acuity and subjective visual improvement, accompanied by the stable closure of macular holes on serial optical coherence tomography scans.

目的:报告两例通过应用临时薄羊膜移植物治疗难治性黄斑孔,并在孔闭合后移除移植物的病例:方法:利用 PubMed 数据库进行全面的病历和文献回顾:结果:我们描述了两名为治疗难治性黄斑孔而再次接受玻璃体旁切除术的患者。在这两个病例中,都在视网膜外放置了薄羊膜移植片(AMG),以达到封闭孔洞的目的。视网膜稳定一段时间后,由于视网膜外层和椭圆体区外观健康,羊膜被移除,最终两名患者的最终视力都得到了改善:本系列病例展示了一种使用临时 AMG 封闭难治性黄斑孔的新方法。移植物移除后,两名患者的视力均有所提高,主观视力也有所改善,同时在连续的 OCT 扫描中,黄斑孔也稳定闭合。
{"title":"TEMPORARY AMNIOTIC MEMBRANE GRAFT PLACEMENT FOR TREATMENT OF REFRACTORY MACULAR HOLES.","authors":"Vichar Trivedi, Qisheng You, Rao Me, Patrick S Y Lee, Kim Le, David Tran, Xihui Lin","doi":"10.1097/ICB.0000000000001671","DOIUrl":"10.1097/ICB.0000000000001671","url":null,"abstract":"<p><strong>Purpose: </strong>To report two patient cases demonstrating the management of refractory macular holes through the application of temporary thin amniotic membrane grafts, followed by subsequent graft removal on achieving hole closure.</p><p><strong>Methods: </strong>Comprehensive chart and literature review was conducted using the PubMed database.</p><p><strong>Results: </strong>We describe two patients who underwent repeat pars plana vitrectomy for treatment of refractory macular holes. In both patients, the epiretinal placement of a thin amniotic membrane graft was done to achieve hole closure. After a period of retinal stabilization, the amniotic membranes were removed because of the healthy appearance of the outer retinal layers and the ellipsoid zone, ultimately resulting in an improved final visual acuity in both patients.</p><p><strong>Conclusion: </strong>This case series demonstrates a new approach of using a temporary amniotic membrane graft to close refractory macular holes. After graft removal, both patients reported enhanced visual acuity and subjective visual improvement, accompanied by the stable closure of macular holes on serial optical coherence tomography scans.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETINAL VASCULAR ABNORMALITY OF NONPERFUSION AND NEOVASCULARIZATION IN A TODDLER WITH NEUROFIBROMATOSIS TYPE 1. 一名患有神经纤维瘤病 1 型的幼儿视网膜血管出现非灌注和新生血管异常。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001673
Qiaozhu Zeng, Yusheng Zhong, Tong Qian, Yong Cheng

Purpose: This report describes the case of a 13-month-old boy diagnosed with neurofibromatosis type 1, who presented with retinal vascular abnormalities including extensive nonperfusion and neovascularization. We also discuss the observed changes after photocoagulation treatment.

Methods: A 13-month-old boy presented to the Department of Ophthalmology at Peking University People's Hospital with a reduction in the width of the left palpebral fissure for the past 6 months.

Results: The boy exhibited more than six café-au-lait spots larger than 5 mm in diameter on his trunk and legs. Fundus examination of the left eye revealed significant neovascularization in the temporal periphery of the retina, with late leakage and nonperfusion also noted temporally in fluorescein angiography. Magnetic resonance imaging of the brain and orbits showed an enlarged left sphenoid body, a widened left cavernous sinus, and a large plexiform neurofibroma. Laser treatment was performed on the left eye. Five months later, the neovascularization was controlled.

Conclusion: Careful fundus examinations and systemic reviews, especially fluorescein angiography, are essential. Timely laser treatment is crucial for controlling disease progression and preventing retinal detachment.

目的:本报告描述了一名 13 个月大的男孩的病例,他被诊断为神经纤维瘤病 1 型,出现视网膜血管异常,包括广泛的非灌注和新生血管。我们还讨论了光凝治疗后观察到的变化:方法:一名 13 个月大的男孩因左侧睑裂宽度在过去 6 个月中缩小而到北京大学人民医院眼科就诊:结果:男孩的躯干和腿部出现了六个以上直径大于 5 毫米的咖啡斑。左眼眼底检查发现视网膜颞部周边有明显的新生血管,荧光素血管造影(FA)也发现了晚期渗漏和无灌注。脑部和眼眶的磁共振成像显示,左侧蝶骨体增大,左侧海绵窦增宽,还有一个巨大的丛状神经纤维瘤。对左眼进行了激光治疗。五个月后,新生血管得到控制:结论:仔细的眼底检查和系统复查,尤其是 FA,至关重要。结论:仔细的眼底检查和全身复查,尤其是视网膜纤维化检查是必不可少的,及时的激光治疗对于控制病情发展和预防视网膜脱离至关重要。
{"title":"RETINAL VASCULAR ABNORMALITY OF NONPERFUSION AND NEOVASCULARIZATION IN A TODDLER WITH NEUROFIBROMATOSIS TYPE 1.","authors":"Qiaozhu Zeng, Yusheng Zhong, Tong Qian, Yong Cheng","doi":"10.1097/ICB.0000000000001673","DOIUrl":"10.1097/ICB.0000000000001673","url":null,"abstract":"<p><strong>Purpose: </strong>This report describes the case of a 13-month-old boy diagnosed with neurofibromatosis type 1, who presented with retinal vascular abnormalities including extensive nonperfusion and neovascularization. We also discuss the observed changes after photocoagulation treatment.</p><p><strong>Methods: </strong>A 13-month-old boy presented to the Department of Ophthalmology at Peking University People's Hospital with a reduction in the width of the left palpebral fissure for the past 6 months.</p><p><strong>Results: </strong>The boy exhibited more than six café-au-lait spots larger than 5 mm in diameter on his trunk and legs. Fundus examination of the left eye revealed significant neovascularization in the temporal periphery of the retina, with late leakage and nonperfusion also noted temporally in fluorescein angiography. Magnetic resonance imaging of the brain and orbits showed an enlarged left sphenoid body, a widened left cavernous sinus, and a large plexiform neurofibroma. Laser treatment was performed on the left eye. Five months later, the neovascularization was controlled.</p><p><strong>Conclusion: </strong>Careful fundus examinations and systemic reviews, especially fluorescein angiography, are essential. Timely laser treatment is crucial for controlling disease progression and preventing retinal detachment.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SYMMETRIC BILATERAL MACULAR ATROPHY IN MUCOLIPIDOSIS TYPE 3: A RARE MANIFESTATION. 粘脂病 3 型的对称性双侧黄斑萎缩:一种罕见的表现。
Q3 Medicine Pub Date : 2026-01-01 DOI: 10.1097/ICB.0000000000001679
Fernanda Galante Dourado, Daniel Queiroz Omote, Paula Dandara Correia de Pinho, Sergio Luis Gianotti Pimentel

Purpose: Describe a case of symmetric bilateral macular atrophy as an ophthalmologic manifestation of Mucolipidosis type 3.

Methods: Multimodal retinal imaging evaluation was performed, with color fundus photograph, fundus autofluorescence, fluorescein angiography, and optical coherence tomography. Genetic testing confirmed the systemic diagnosis.

Results: Genetic testing confirmed the diagnosis of Mucolipidosis type 3, and macular bilateral atrophy was considered a rare manifestation of the systemic disease.

Discussion: Ophthalmologic manifestations in mucolipidosis are rare, with corneal opacities being most reported. Our patient presented bilateral macular atrophy, which had not been previously described in association with the disease, and is important to consider different diagnosis.

Conclusion: It is important to consider different diagnosis, such as retinal dystrophies and conditions causing macular atrophy, and this case highlights the importance of considering rare ophthalmologic manifestations in syndromic diseases.

目的:描述一例双侧对称性黄斑萎缩的病例,这是黏脂病 3 型的一种眼科表现:方法:进行多模式视网膜成像评估,包括彩色眼底照片、眼底自动荧光、荧光素血管造影和光学相干断层扫描。基因检测证实了系统诊断:结果:基因检测证实了黏脂病 3 型的诊断,双侧黄斑萎缩被认为是全身性疾病的罕见表现:讨论:粘脂病的眼科表现非常罕见,其中以角膜混浊报道最多。我们的患者出现了双侧黄斑萎缩,这在以前的病例中从未出现过,因此考虑不同的诊断非常重要:结论:考虑不同的诊断非常重要,如视网膜营养不良和导致黄斑萎缩的疾病,本病例强调了在综合征疾病中考虑罕见眼科表现的重要性。
{"title":"SYMMETRIC BILATERAL MACULAR ATROPHY IN MUCOLIPIDOSIS TYPE 3: A RARE MANIFESTATION.","authors":"Fernanda Galante Dourado, Daniel Queiroz Omote, Paula Dandara Correia de Pinho, Sergio Luis Gianotti Pimentel","doi":"10.1097/ICB.0000000000001679","DOIUrl":"10.1097/ICB.0000000000001679","url":null,"abstract":"<p><strong>Purpose: </strong>Describe a case of symmetric bilateral macular atrophy as an ophthalmologic manifestation of Mucolipidosis type 3.</p><p><strong>Methods: </strong>Multimodal retinal imaging evaluation was performed, with color fundus photograph, fundus autofluorescence, fluorescein angiography, and optical coherence tomography. Genetic testing confirmed the systemic diagnosis.</p><p><strong>Results: </strong>Genetic testing confirmed the diagnosis of Mucolipidosis type 3, and macular bilateral atrophy was considered a rare manifestation of the systemic disease.</p><p><strong>Discussion: </strong>Ophthalmologic manifestations in mucolipidosis are rare, with corneal opacities being most reported. Our patient presented bilateral macular atrophy, which had not been previously described in association with the disease, and is important to consider different diagnosis.</p><p><strong>Conclusion: </strong>It is important to consider different diagnosis, such as retinal dystrophies and conditions causing macular atrophy, and this case highlights the importance of considering rare ophthalmologic manifestations in syndromic diseases.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"80-83"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Retinal Cases and Brief Reports
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