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UNILATERAL MACULAR HOLE IN A PATIENT WITH RETINITIS PIGMENTOSA TREATED WITH COVER FLAP TECHNIQUE WITH THE USE OF PLATELET-RICH PLASMA UNDER AIR TAMPONADE. 一例色素性视网膜炎患者的单侧黄斑孔,采用皮瓣技术,在空气填塞下使用富含血小板的血浆进行治疗:病例报告。
Q3 Medicine Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1097/ICB.0000000000001491
Gregorio Lo Giudice, Amedeo Alessandria, Aurelio Imburgia, Marco Anastasi, Viviana Randazzo, Filippo Masaniello, Antonino Pioppo

Purpose: The purpose of the study is to show the excellent anatomical result of the inverted flap-assisted technique with platelet-rich plasma under air for retinitis pigmentosa complicated with macular hole.

Methods: A 32-year-old woman, previously diagnosed with retinitis pigmentosa, was referred to our department complaining of decreased central vision in her left eye for 4 weeks. At the time of presentation, the optical coherence tomography and fundoscopy examination showed the presence of a macular hole of 620 μ m in diameter. The closure of the macular hole was observed after the surgical procedure, but endophthalmitis occurred 5 days, postoperatively.

Results: In our presented case, the cover flap-assisted technique with platelet-rich plasma under air for retinitis pigmentosa complicated with macular hole resulted in excellent anatomical outcomes with unremarkable visual recovery.

Conclusion: The physiopathology of full-thickness macular holes in retinitis pigmentosa patients remains still not fully elucidated. Pars plana vitrectomy with the adjunct of highly concentrated pure platelet-rich plasma have shown successful results.

目的:本研究的目的是展示倒置皮瓣辅助空气下PRP技术治疗视网膜色素变性并发黄斑裂孔的良好解剖效果。方法:一名32岁的女性,先前被诊断为视网膜色素变性,被转诊到我们的科室,抱怨她的左眼中心视力下降了4周。在报告时,光学相干断层扫描和眼底镜检查显示存在直径620微米的黄斑孔。手术后黄斑孔闭合,但术后5天出现眼内炎。结果:在我们提出的病例中,空气下PRP覆盖皮瓣辅助技术治疗视网膜色素变性并发黄斑裂孔,取得了良好的解剖结果,视觉恢复不明显。结论:RP患者全层黄斑裂孔的病理生理学尚未完全阐明。高度浓缩P-PRP辅助的平坦部玻璃体切除术已显示出成功的结果。
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引用次数: 0
IRIS NODULES SECONDARY TO RETAINED PERFLUORO-N-OCTANE IN THE ANTERIOR CHAMBER AFTER MACULA-OFF RHEGMATOGENOUS RETINAL DETACHMENT REPAIR. 黄斑脱离孔源性视网膜脱离修复术后前房内残留PFO继发虹膜结节。
Q3 Medicine Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1097/ICB.0000000000001487
Jessica J Waninger, Bernadete Ayres, Kanishka Jayasundera, Hakan Demirci

Purpose: To describe a case of perfluoro-n-octane (PFO) retention, migration into the anterior chamber, and the subsequent formation of iris nodules after the repair of a giant retinal tear.

Methods: Patient data were collected by a manual chart review. All patient information was deidentified.

Results: Slit-lamp photographs demonstrate nodules on the iris surface and retained PFO in the anterior chamber. Ultrasound biomicroscopy shows multifocal hyperreflective signals on the iris surface, corresponding to the retained PFO within the iris.

Conclusion: Retention and migration of PFO to the anterior chamber after retinal detachment repair can lead to formation of nodules on the surface of the iris.

目的:描述一例PFO滞留、迁移到前房,并在巨大视网膜撕裂修复后形成虹膜结节的病例。方法:通过手动图表审查收集患者数据。所有患者信息都被取消标识。结果:裂隙灯照片显示虹膜表面有结节,前房内有PFO残留。超声生物显微镜显示虹膜表面有多焦高反射信号,对应于虹膜内保留的PFO。结论:视网膜脱离修复后PFO的保留和迁移可导致虹膜表面结节的形成。
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引用次数: 0
IATROGENIC MACULAR HOLE BECAUSE OF NEODYMIUM:YTTRIUM-ALUMINUM-GARNET-SELECTIVE LASER TRABECULOPLASTY LASER: CASE REPORT AND MANAGEMENT. Nd:YAG-SLT激光致医源性黄斑孔1例报告及处理:Nd:YAG-SLT激光医源性黄斑孔。
Q3 Medicine Pub Date : 2025-01-01 DOI: 10.1097/ICB.0000000000001517
Zara Saleem, Drew Scoles, Antonio Capone, Tamer H Mahmoud

Purpose: To report a case of a patient who suffered a full-thickness macular hole because of the accidental utilization of the selective laser trabeculoplasty mode of a dual mode laser.

Method: Case report.

Results: A 69-year-old woman experienced vision loss in her left eye immediately after undergoing attempted neodymium:yttrium-aluminum-garnet capsulotomy using a neodymium:yttrium-aluminum-garnet-selective laser trabeculoplasty laser system. Postinjury visual acuity was 20/25 and 20/800 in the right and left eyes, respectively. Ophthalmic examination and multimodal imaging revealed multiple macular hemorrhages and an irregular full-thickness macular hole. The patient required multiple surgeries including an autologous retinal transplant to achieve hole closure.

Conclusion: Macular hole formation is a devastating consequence of inadvertent use of the selective laser trabeculoplasty mode when performing a neodymium:yttrium-aluminum-garnet laser capsulotomy with a neodymium:yttrium-aluminum-garnet-selective laser trabeculoplasty laser system. The authors emphasize the importance of ensuring the correct mode is selected for treatment to minimize the risk of retinal damage and permanent vision loss.

目的:报告一例因意外使用双模激光选择性小梁成形术(SLT)模式而造成全层黄斑孔(FTMH)的病例。方法:病例报告。结果:一名69岁的女性在尝试使用Nd:YAG- slt激光系统进行钕钇铝石榴石(Nd:YAG)囊切开术后立即出现左眼视力丧失。伤后右眼视力为20/25,左眼视力为20/800。眼科检查及多模态影像显示多发黄斑出血及不规则FTMH。该患者需要进行多次手术,包括自体视网膜移植以关闭孔洞。结论:在使用Nd:YAG-SLT激光系统进行Nd:YAG激光囊切开术时,无意中使用SLT模式造成了黄斑孔的形成。我们强调确保选择正确的治疗模式的重要性,以尽量减少视网膜损伤和永久性视力丧失的风险。
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引用次数: 0
A NOVEL FINDING IN THE DIAGNOSIS OF PRIMARY VITREORETINAL LYMPHOMA: A CASE REPORT. 诊断原发性玻璃体视网膜淋巴瘤的新发现:一例报告。
Q3 Medicine Pub Date : 2025-01-01 Epub Date: 2023-10-09 DOI: 10.1097/ICB.0000000000001489
Arash Maleki

Purpose: Introduce a unique case of primary vitreoretinal lymphoma with a new optical coherence tomography finding.

Methods: A case report. A 67-year-old healthy man with complaints of blurry vision in his right eye.

Results: The patient's visual acuity was 20/60 and 20/20 in the right and left eyes, respectively. Anterior segment examination of the right eye demonstrated mild inflammation. Dilated fundoscopy revealed 2+ vitreous haze and 4+ disk edema. Optical coherence tomography of the macula in the right eye revealed optic nerve head swelling and thickening of the retina. Fluorescein angiography demonstrated mild leakage and staining of vessels along the inferotemporal arcade in the right eye. Labs were within normal limits except positive Herpes simplex virus 1 IgG. Initially, the patient was treated for herpetic panuveitis for 3 weeks with a favorable response. However, the clinical condition deteriorated as a new abnormality was identified in the macular region of the right eye through optical coherence tomography. Considering intraocular lymphoma as a potential diagnosis, the patient underwent a diagnostic vitrectomy. The vitreous sample analysis confirmed primary vitreoretinal lymphoma through immunohistochemistry and flow cytometry. The patient exhibited a rapid response after the initiation of intravenous and intravitreal methotrexate treatment.

Conclusion: The presence of subretinal fluid accompanied by suspended hyperreflective lesions originating from the roof of the subretinal fluid pocket on the optical coherence tomography of macula "stalactite sign" may serve as a characteristic sign indicative of primary vitreoretinal lymphoma; however, further investigation using robust studies is necessary to examine this hypothesis.

目的:介绍一例独特的原发性玻璃体视网膜淋巴瘤,并用一种新的光学相干断层扫描发现。方法:病例报告。一名67岁的健康男子抱怨右眼视力模糊。结果:患者的右眼视力为20/60,左眼视力为20/20。右眼前段检查显示有轻度炎症。扩张性眼底镜检查显示2+玻璃体混浊和4+椎间盘水肿。右眼黄斑的光学相干断层扫描显示视神经头肿胀和视网膜增厚。荧光素血管造影术显示右眼颞下拱廊有轻度渗漏和血管染色。除单纯疱疹病毒1型IgG阳性外,实验室均在正常范围内。最初,患者接受了为期三周的疱疹性全葡萄膜炎治疗,反应良好。然而,由于通过光学相干断层扫描在右眼黄斑区发现了新的异常,临床情况恶化。考虑到眼内淋巴瘤是一种潜在的诊断,患者接受了诊断性玻璃体切除术。玻璃体样本分析通过免疫组织化学和流式细胞术证实了PVRL。患者在开始静脉和玻璃体内甲氨蝶呤治疗后表现出快速反应。结论:黄斑“钟乳石征”OCT上存在视网膜下液并伴有源自视网膜下液袋顶部的悬浮性高反射性病变,可能是原发性玻璃体视网膜淋巴瘤的特征性征象;然而,有必要使用稳健研究进行进一步的调查来检验这一假设。
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引用次数: 0
UNVEILING THE HIDDEN: EARLY MANIFESTATIONS OF EXTENSIVE MACULAR ATROPHY WITH PSEUDODRUSEN-LIKE APPEARANCE. 揭开隐藏:广泛性黄斑萎缩的早期表现,具有假核果样外观。
Q3 Medicine Pub Date : 2025-01-01 DOI: 10.1097/ICB.0000000000001513
Francesco Romano, Mariano Cozzi, Stefano Casati, Francesca Bosello, Chiara Zaffalon, Andrea Trinco, Marco Pellegrini, Alessandro Invernizzi, Giovanni Staurenghi, Anna Paola Salvetti

Purpose: To describe novel microperimetry and imaging findings in two patients affected by extensive macular atrophy with pseudodrusen-like appearance without signs of retinal pigment epithelium atrophy.

Methods: Case series. Both patients underwent mesopic and dark-adapted two-color scotopic microperimetry, followed by multimodal imaging assessment including ultra-widefield photography, fundus autofluorescence, high-resolution optical coherence tomography, optical coherence tomography angiography, and high-magnification module.

Results: Albeit normal visual acuity, both patients had a significant reduction of retinal sensitivity-especially under scotopic cyan conditions. One patient had macular pigment abnormalities, whereas the combination of blue and near-infrared autofluorescence modalities highlighted different patterns of pseudodrusen-like lesions.Of notice, high-resolution optical coherence tomography revealed a marked separation between the retinal pigment epithelium and Bruch membrane, containing a hyperreflective material with two different reflectivities. Optical coherence tomography angiography excluded the presence of macular neovascularization and documented several choriocapillaris flow voids. High-magnification module images showed severe alteration of photoreceptors' mosaic in the perifovea.

Conclusion: Our comprehensive assessment of two stage 1 extensive macular atrophy with pseudodrusen-like appearance patients revealed a predominant damage of perifoveal rods over areas of retinal pigment epithelium-Bruch membrane separation. These findings underscore the importance of basal laminar deposits in the initial stages of extensive macular atrophy with pseudodrusen-like appearance, contributing to a deeper understanding of its underlying mechanisms.

目的:描述两名无视网膜色素上皮(RPE)萎缩迹象的广泛性黄斑萎缩伴假核糖核酸酶样外观(EMAP)患者的新显微检查和成像结果。方法:病例系列。两名患者都接受了中视野和暗适应双色暗视野显微检查,然后进行了多模式成像评估,包括超宽视野摄影、眼底自发荧光(AF)、高分辨率光学相干断层扫描(Hi-Res OCT)、OCT血管造影术和高放大率模块(HMM)。结果:尽管视力正常,两名患者的视网膜敏感性均显著降低,尤其是在暗青色条件下。一名患者有黄斑色素异常,而蓝色和近红外AF模式的结合突出了不同模式的假核膜样病变。值得注意的是,高分辨率光学相干断层扫描显示RPE和Bruch膜之间有明显的分离,包含具有两种不同反射率的高反射材料。OCT血管造影术排除了黄斑新生血管的存在,并记录了几个绒毛膜毛细血管流动空隙。HMM图像显示中央凹周围光感受器的马赛克严重改变。结论:我们对两名1期EMAP患者的综合评估显示,RPE-Bruch膜分离区域的中央凹周围杆主要受损。这些发现强调了基底层流沉积在EMAP初始阶段的重要性,有助于更深入地了解其潜在机制。
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引用次数: 0
BELZUTIFAN FOR TREATMENT OF GIANT RETINAL HEMANGIOBLASTOMA WITH EXTRASCLERAL EXTENSION ASSOCIATED WITH VON HIPPEL-LINDAU SYNDROME. 贝尔祖替芬治疗伴希佩尔-林道综合征的巨大视网膜血管母细胞瘤。
Q3 Medicine Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1097/ICB.0000000000001516
Caroline C Cotton, Anirudha S Chandrabhatla, Patrick H Andrews, Benjamin W Purrow, Yevgeniy Eugene Shildkrot

Purpose: To describe the clinical response and safety profile of the novel HIF-2ɑ inhibitor belzutifan in treating a giant retinal hemangioblastoma with extrascleral extension associated with von Hippel-Lindau syndrome.

Methods: A 71-year-old woman with Von Hippel-Lindau syndrome presented with a giant retinal hemangioblastoma with extrascleral extension in her only remaining eye. She had no light perception in the right eye and intraocular pressure was 48. She requested enucleation because of chronic pain, but because of concern for significant bleeding given the size of the neoplasm, a trial of belzutifan was initiated.

Results: Within 3 months of treatment initiation, the patient reported an 80% reduction in pain. Magnetic resonance imaging showed 30% reduction in longest tumor diameter. Dose adjustments were guided by serum hemoglobin levels, allowing the patient to remain on the medication for over a year with continued tumor regression on MRI and avoid enucleation.

Conclusion: Retinal hemangioblastoma with extrascleral extension is exceedingly rare and its treatment is complex, often requiring enucleation or external beam radiotherapy. This report demonstrates the use of belzutifan to safely and successfully reduce ocular tumor burden of complicated retinal hemangioblastoma with extrascleral extension, ultimately decreasing the need for enucleation.

目的:描述新型HIF-2抑制剂贝尔祖替芬治疗血管瘤母细胞瘤(RHB)的临床疗效和安全性,RHB伴有神经束外延伸,并伴有von Hippel-Lindau综合征(VHL)。方法:1例71岁女性VHL患者仅剩一只眼出现巨大RHB伴巩膜外延伸。无光感,眼压48。由于慢性疼痛,她要求去核,但是,考虑到肿瘤的大小,考虑到大量出血,开始了贝尔祖替芬的试验。结果:在治疗开始的三个月内,患者报告疼痛减轻了80%。MRI显示最长肿瘤直径缩小30%。剂量调整以血清血红蛋白水平为指导,允许患者在MRI上持续肿瘤消退并避免去核的情况下继续用药一年多。结论:RHB伴巩膜外展极为罕见,治疗复杂,常需去核或外束放疗。本报告证明了使用贝祖替芬可以安全、成功地减轻伴有巩膜外扩张的复杂RHB的眼部肿瘤负担,最终减少了去核的需要。
{"title":"BELZUTIFAN FOR TREATMENT OF GIANT RETINAL HEMANGIOBLASTOMA WITH EXTRASCLERAL EXTENSION ASSOCIATED WITH VON HIPPEL-LINDAU SYNDROME.","authors":"Caroline C Cotton, Anirudha S Chandrabhatla, Patrick H Andrews, Benjamin W Purrow, Yevgeniy Eugene Shildkrot","doi":"10.1097/ICB.0000000000001516","DOIUrl":"10.1097/ICB.0000000000001516","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical response and safety profile of the novel HIF-2ɑ inhibitor belzutifan in treating a giant retinal hemangioblastoma with extrascleral extension associated with von Hippel-Lindau syndrome.</p><p><strong>Methods: </strong>A 71-year-old woman with Von Hippel-Lindau syndrome presented with a giant retinal hemangioblastoma with extrascleral extension in her only remaining eye. She had no light perception in the right eye and intraocular pressure was 48. She requested enucleation because of chronic pain, but because of concern for significant bleeding given the size of the neoplasm, a trial of belzutifan was initiated.</p><p><strong>Results: </strong>Within 3 months of treatment initiation, the patient reported an 80% reduction in pain. Magnetic resonance imaging showed 30% reduction in longest tumor diameter. Dose adjustments were guided by serum hemoglobin levels, allowing the patient to remain on the medication for over a year with continued tumor regression on MRI and avoid enucleation.</p><p><strong>Conclusion: </strong>Retinal hemangioblastoma with extrascleral extension is exceedingly rare and its treatment is complex, often requiring enucleation or external beam radiotherapy. This report demonstrates the use of belzutifan to safely and successfully reduce ocular tumor burden of complicated retinal hemangioblastoma with extrascleral extension, ultimately decreasing the need for enucleation.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FAMILIAL EXUDATIVE VITREORETINOPATHY WITH NASAL RETINAL INVOLVEMENT: A RARE PRESENTATION. 家族性渗出性玻璃体视网膜病变(FEVR)伴鼻视网膜受累:罕见表现。
Q3 Medicine Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1097/ICB.0000000000001511
Amelia Cooper, Henry Stevens, Ivan Batlle

Purpose: To present a case of familial exudative vitreoretinopathy with nasal retinal involvement and aim to describe the clinical presentation, diagnostic findings, management strategies, and genetic testing.

Methods: An evaluation of a 31-year-old female patient with familial exudative vitreoretinopathy presenting with predominate nasal retinal involvement. Diagnostic tests-including fundus examination, optical coherence tomography, fluorescein angiography, and genetic testing-were performed. The patient's management involved intravitreal injection of 1.25 mg/0.05 mL of bevacizumab in the left eye and sectoral panretinal photocoagulation in both eyes.

Results: The patient exhibited discrete neovascularization and tortuosity predominantly localized to the nasal retinal blood vessels. Optical coherence tomography imaging showed macular schisis and vitreomacular traction without retinal detachment. Genetic testing identified a likely pathogenic variant associated with autosomal dominant and recessive exudative vitreoretinopathy. Treatment with bevacizumab and panretinal photocoagulation resulted in regression of neovascularization and improvement in macular schisis. Conclusion: This case report highlights an atypical presentation of familial exudative vitreoretinopathy with nasal retinal involvement. Early recognition and genetic testing aids in diagnosis and management.

目的:介绍一例鼻视网膜受累的FEVR病例,目的描述其临床表现、诊断结果、治疗策略和基因检测。方法:对一名31岁女性FEVR患者进行评估,该患者主要表现为鼻视网膜受累。进行了诊断性检查,包括眼底检查、OCT、荧光素血管造影术和基因检测。患者的治疗包括在左眼玻璃体内注射1.25 mg/0.05 mL贝伐单抗,在双眼进行全视网膜光凝。结果:患者表现出离散的新生血管和主要局限于鼻视网膜血管的扭曲。OCT成像显示黄斑裂和玻璃体黄斑牵引,无视网膜脱离。基因检测发现了一种可能与常染色体显性和隐性渗出性玻璃体视网膜病变相关的致病性变体。贝伐单抗和全视网膜光凝治疗导致新生血管消退和黄斑裂的改善。结论:本病例报告强调了鼻视网膜受累的FEVR的非典型表现。早期识别和基因检测有助于诊断和管理。
{"title":"FAMILIAL EXUDATIVE VITREORETINOPATHY WITH NASAL RETINAL INVOLVEMENT: A RARE PRESENTATION.","authors":"Amelia Cooper, Henry Stevens, Ivan Batlle","doi":"10.1097/ICB.0000000000001511","DOIUrl":"10.1097/ICB.0000000000001511","url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of familial exudative vitreoretinopathy with nasal retinal involvement and aim to describe the clinical presentation, diagnostic findings, management strategies, and genetic testing.</p><p><strong>Methods: </strong>An evaluation of a 31-year-old female patient with familial exudative vitreoretinopathy presenting with predominate nasal retinal involvement. Diagnostic tests-including fundus examination, optical coherence tomography, fluorescein angiography, and genetic testing-were performed. The patient's management involved intravitreal injection of 1.25 mg/0.05 mL of bevacizumab in the left eye and sectoral panretinal photocoagulation in both eyes.</p><p><strong>Results: </strong>The patient exhibited discrete neovascularization and tortuosity predominantly localized to the nasal retinal blood vessels. Optical coherence tomography imaging showed macular schisis and vitreomacular traction without retinal detachment. Genetic testing identified a likely pathogenic variant associated with autosomal dominant and recessive exudative vitreoretinopathy. Treatment with bevacizumab and panretinal photocoagulation resulted in regression of neovascularization and improvement in macular schisis. Conclusion: This case report highlights an atypical presentation of familial exudative vitreoretinopathy with nasal retinal involvement. Early recognition and genetic testing aids in diagnosis and management.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SCLEROMYXEDEMA ASSOCIATED WITH MACULAR EDEMA AND RETINAL HEMORRHAGE. 与黄斑水肿和视网膜出血相关的硬化性水肿。
Q3 Medicine Pub Date : 2025-01-01 DOI: 10.1097/ICB.0000000000001510
Keirnan L Willett, Nneka Comfere, Sophie J Bakri

Purpose: We discuss a case of macular edema and retinal hemorrhage associated with scleromyxedema.

Methods: A case report is presented.

Results: A 64-year-old man with history of deep vein thrombosis and pulmonary embolism presented with new-onset rash in the setting of switching anticoagulation treatments. He developed blurred vision, was found to have macular edema and dot blot retinal hemorrhages that improved with systemic and topical corticosteroids.

Conclusion: Systemic autoimmune conditions including scleromyxedema should be considered in the workup of occult cystoid macular edema.

目的:我们讨论一例黄斑水肿和视网膜出血合并硬化性粘液水肿。方法:病例报告。结果:一名64岁男性,有深静脉血栓形成和肺栓塞病史,在转换抗凝治疗的情况下出现新发皮疹。他出现视力模糊,发现有黄斑水肿和斑点视网膜出血,全身和局部皮质类固醇治疗后情况有所改善。结论:在隐匿性黄斑囊样水肿的检查中,应考虑包括硬化性粘液水肿在内的全身性自身免疫性疾病。
{"title":"SCLEROMYXEDEMA ASSOCIATED WITH MACULAR EDEMA AND RETINAL HEMORRHAGE.","authors":"Keirnan L Willett, Nneka Comfere, Sophie J Bakri","doi":"10.1097/ICB.0000000000001510","DOIUrl":"10.1097/ICB.0000000000001510","url":null,"abstract":"<p><strong>Purpose: </strong>We discuss a case of macular edema and retinal hemorrhage associated with scleromyxedema.</p><p><strong>Methods: </strong>A case report is presented.</p><p><strong>Results: </strong>A 64-year-old man with history of deep vein thrombosis and pulmonary embolism presented with new-onset rash in the setting of switching anticoagulation treatments. He developed blurred vision, was found to have macular edema and dot blot retinal hemorrhages that improved with systemic and topical corticosteroids.</p><p><strong>Conclusion: </strong>Systemic autoimmune conditions including scleromyxedema should be considered in the workup of occult cystoid macular edema.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"104-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PROGRESSION OF CHOROIDAL THICKNESS ON ENHANCED DEPTH IMAGING-OPTICAL COHERENCE TOMOGRAPHY AS THE FIRST SIGN OF ORBITAL LYMPHOMA. 眼眶淋巴瘤的第一个征象是EDI-OCT上脉络膜厚度的进展。
Q3 Medicine Pub Date : 2025-01-01 DOI: 10.1097/ICB.0000000000001497
José Ignacio Vela, Marta Giró-Rosa, Marta García-Vilaró, Irene Loscos-Giménez, Daniela Rego-Lorca, Philipp Schwember

Purpose: To present an orbital extranodal marginal zone B-cell lymphoma (mucosa-associated lymphoid tissue lymphoma) with increased choroidal thickness as the first diagnostic sign.

Methods: A patient presented with mild blurred vision in the left eye. Progressively increased choroidal thickness was demonstrated by enhanced depth imaging-optical coherence tomography and ocular ultrasound-confirmed diffuse choroidal effusion. Orbital MRI revealed a well-circumscribed intraconal orbital mass surrounding the optic nerve and molding around the globe. An orbital biopsy of the lesion with subsequent histologic and immunohistochemical analyses demonstrated mucosa-associated lymphoid tissue lymphoma.

Results: After initial treatment with rituximab without improvement, the patient received orbital radiotherapy (36 Gy in 20 sessions). A reduction in choroidal thickness was observed during follow-up visits. Congestion of the choroidal vasculature and choroidal infiltration by the lymphoma are discussed as possible causative mechanisms.

Conclusion: Enhanced depth imaging-optical coherence tomography can be a helpful tool to detect the presence of orbital lymphoid tumors in contact with the globe and to monitor response to therapy.

目的:提出一种以脉络膜厚度增加为第一诊断标志的眼眶结外边缘区B细胞淋巴瘤(MALT淋巴瘤)。EDI-OCT显示脉络膜厚度逐渐增加,眼部超声证实弥漫性脉络膜积液。眼眶MRI显示,视神经周围有一个边界清晰的眶内肿块,并在全球范围内形成。病变的眼眶活检及随后的组织学和免疫组织化学分析显示为MALT淋巴瘤。结果:在用利妥昔单抗进行初步治疗后,患者接受了眼眶放射治疗(20次36 Gy)。随访期间观察到脉络膜厚度减少。脉络膜血管系统充血和淋巴瘤的脉络膜浸润被讨论为可能的病因机制。结论:EDI-OCT可用于检测与眼球接触的眼眶淋巴肿瘤的存在,并监测对治疗的反应。
{"title":"PROGRESSION OF CHOROIDAL THICKNESS ON ENHANCED DEPTH IMAGING-OPTICAL COHERENCE TOMOGRAPHY AS THE FIRST SIGN OF ORBITAL LYMPHOMA.","authors":"José Ignacio Vela, Marta Giró-Rosa, Marta García-Vilaró, Irene Loscos-Giménez, Daniela Rego-Lorca, Philipp Schwember","doi":"10.1097/ICB.0000000000001497","DOIUrl":"10.1097/ICB.0000000000001497","url":null,"abstract":"<p><strong>Purpose: </strong>To present an orbital extranodal marginal zone B-cell lymphoma (mucosa-associated lymphoid tissue lymphoma) with increased choroidal thickness as the first diagnostic sign.</p><p><strong>Methods: </strong>A patient presented with mild blurred vision in the left eye. Progressively increased choroidal thickness was demonstrated by enhanced depth imaging-optical coherence tomography and ocular ultrasound-confirmed diffuse choroidal effusion. Orbital MRI revealed a well-circumscribed intraconal orbital mass surrounding the optic nerve and molding around the globe. An orbital biopsy of the lesion with subsequent histologic and immunohistochemical analyses demonstrated mucosa-associated lymphoid tissue lymphoma.</p><p><strong>Results: </strong>After initial treatment with rituximab without improvement, the patient received orbital radiotherapy (36 Gy in 20 sessions). A reduction in choroidal thickness was observed during follow-up visits. Congestion of the choroidal vasculature and choroidal infiltration by the lymphoma are discussed as possible causative mechanisms.</p><p><strong>Conclusion: </strong>Enhanced depth imaging-optical coherence tomography can be a helpful tool to detect the presence of orbital lymphoid tumors in contact with the globe and to monitor response to therapy.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DISAPPEARING CHOROIDAL SPOTS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY PRECEDING RECURRENCE OF MULTIFOCAL CHOROIDITIS WITH CHORIORETINAL ATROPHY. OCT血管造影术中脉络膜斑点消失伴脉络膜视网膜萎缩的多灶性脉络膜炎复发。
Q3 Medicine Pub Date : 2025-01-01 DOI: 10.1097/ICB.0000000000001501
Alessandro Marchese, Avram Bar-Meir, Lee M Jampol, Rukhsana G Mirza

Purpose: To describe idiopathic multifocal choroiditis with chorioretinal atrophy developing choroidal flow voids on optical coherence tomography angiography that preceded a recurrence of the disease.

Methods: Case report.

Results: A 24-year-old woman presented with visual field changes and occasional photopsias. Systemic workup for syphilis, tuberculosis, and sarcoidosis was negative. Clinical findings and multimodal imaging were consistent with idiopathic multifocal choroiditis with chorioretinal atrophy, complicated by inactive choroidal neovascularization in her right eye. She was treated with systemic corticosteroids with a taper over 3 months without change in her examination. She was then stable for 2 years. At that point, the patient experienced increased photopsias, but her examination result was unchanged. Optical coherence tomography angiography showed multiple flow voids in the choroid that were not present 6 months ago. No lesions were seen on other imaging modalities. Structural optical coherence tomography showed some subtle hyperreflectivity throughout the choroid that was previously absent. Given the unknown significance of these flow voids, the patient was asked to return for follow-up in 1 month. Her photopsias improved, and her vision remained normal. On repeat examination after 1 month, the patient had developed a few subtle yellow lesions in the superonasal quadrant of the left eye. There were no macular lesions. The repeat optical coherence tomography angiography revealed that the flow voids were fading.

Conclusion: Imaging findings using optical coherence tomography angiography in our patient with idiopathic multifocal choroiditis showed choroidal flow voids that preceded clinical recurrence, not detected by other imaging modalities. Future studies should determine whether optical coherence tomography angiography can be used to detect subclinical lesions preceding clinical recurrences of idiopathic multifocal choroiditis.

目的:描述特发性多灶性脉络膜炎(iMFC)伴脉络膜视网膜萎缩,在疾病复发前的光学相干断层扫描血管造影术(OCTA)上出现脉络膜流动空洞。方法:病例报告。结果:一名24岁的女性出现视野改变和偶尔的畏光。梅毒、肺结核和结节病的系统检查结果为阴性。临床表现和多模式成像与iMFC一致,伴有脉络膜视网膜萎缩,并伴有右眼脉络膜新生血管不活跃。她接受了全身皮质类固醇治疗,在3个月内逐渐减少,检查没有变化。当时她稳定了两年。在这一点上,患者出现了增光症状,但她的检查没有变化。OCTA显示脉络膜出现多个6个月前未出现的流动性空洞。在其他成像模式中未发现病变。结构OCT在整个脉络膜上显示出一些以前不存在的细微的高反射率。考虑到这些流动空隙的未知意义,患者被要求在一个月后返回进行随访。她的光感有所改善,视力保持正常。在一个月后的重复检查中,患者在左眼的鼻上象限出现了一些细微的黄色病变。没有黄斑病变。重复的OCTA显示流动空隙正在消退。结论:在我们的iMFC患者中,使用OCTA的成像结果显示临床复发前的脉络膜流动空隙,而其他成像方式没有检测到。未来的研究应确定OCTA是否可用于检测iMFC临床复发前的亚临床病变。
{"title":"DISAPPEARING CHOROIDAL SPOTS ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY PRECEDING RECURRENCE OF MULTIFOCAL CHOROIDITIS WITH CHORIORETINAL ATROPHY.","authors":"Alessandro Marchese, Avram Bar-Meir, Lee M Jampol, Rukhsana G Mirza","doi":"10.1097/ICB.0000000000001501","DOIUrl":"10.1097/ICB.0000000000001501","url":null,"abstract":"<p><strong>Purpose: </strong>To describe idiopathic multifocal choroiditis with chorioretinal atrophy developing choroidal flow voids on optical coherence tomography angiography that preceded a recurrence of the disease.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 24-year-old woman presented with visual field changes and occasional photopsias. Systemic workup for syphilis, tuberculosis, and sarcoidosis was negative. Clinical findings and multimodal imaging were consistent with idiopathic multifocal choroiditis with chorioretinal atrophy, complicated by inactive choroidal neovascularization in her right eye. She was treated with systemic corticosteroids with a taper over 3 months without change in her examination. She was then stable for 2 years. At that point, the patient experienced increased photopsias, but her examination result was unchanged. Optical coherence tomography angiography showed multiple flow voids in the choroid that were not present 6 months ago. No lesions were seen on other imaging modalities. Structural optical coherence tomography showed some subtle hyperreflectivity throughout the choroid that was previously absent. Given the unknown significance of these flow voids, the patient was asked to return for follow-up in 1 month. Her photopsias improved, and her vision remained normal. On repeat examination after 1 month, the patient had developed a few subtle yellow lesions in the superonasal quadrant of the left eye. There were no macular lesions. The repeat optical coherence tomography angiography revealed that the flow voids were fading.</p><p><strong>Conclusion: </strong>Imaging findings using optical coherence tomography angiography in our patient with idiopathic multifocal choroiditis showed choroidal flow voids that preceded clinical recurrence, not detected by other imaging modalities. Future studies should determine whether optical coherence tomography angiography can be used to detect subclinical lesions preceding clinical recurrences of idiopathic multifocal choroiditis.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Retinal Cases and Brief Reports
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