Introduction: The golden standard in surgery is the one that spares most of the kidney tissue. Objective: Show a case of a bilateral kidney tumor that has been treated in our medical facility in which we used two surgical procedures to succesfully treat a bilateral kidney tumor. A case report: We are reporting about a case of a bilateral kidney tumor that has been proprely treated using a successful surgical procedure, in a way which the lifespan of the patient has been prolonged, but also their quality of life has been improved without a use of supported medical treatments.
{"title":"Kidney cell carcinoma – enucleation and standard nefrectomy in the treatment of bilateral malignant kidney tumors","authors":"S. Jagodić, Rasim Agic, Amel Mujic, Ammar Brkić","doi":"10.5457/ams.v52i1-2.649","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.649","url":null,"abstract":"Introduction: The golden standard in surgery is the one that spares most of the kidney tissue. Objective: Show a case of a bilateral kidney tumor that has been treated in our medical facility in which we used two surgical procedures to succesfully treat a bilateral kidney tumor. A case report: We are reporting about a case of a bilateral kidney tumor that has been proprely treated using a successful surgical procedure, in a way which the lifespan of the patient has been prolonged, but also their quality of life has been improved without a use of supported medical treatments.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41375085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anton's syndrome (AS) describes the condition in which patient deny their blindness despite objective evidence of visual loss, and moreover confabulate to support their stance. It is a rare extension of cortical blindness in which, in addition to the injury to the occipital cortex, other cortical centers are also affected, with patients typically behaving as if they were sighted. This case presents a 76-year-old patient with verified cortical blindness as a result of a stroke. The patient persistently denied vision loss. At the same time, she confabulated to see people and objects in her environment clearly. This syndrome may be unrecognized in routine neurological practice. A suspicion of cortical blindness and AS should be considered in patients with atypical visual loss and evidence of occipital lobe injury. Cerebrovascular disease is the most common cause of AS, as in our patient. Recovery of visual function will depend on the underlying etiology, with cases due to occipital lobe infarction after cerebrovascular events being less likely to result in complete recovery. Management in these circumstances should focus on secondary prevention and rehabilitation.
{"title":"Case report: Anton's syndrome due to ishemic cerebrovascular disease","authors":"Ajla Muratovic, M. Vidović","doi":"10.5457/ams.v52i1-2.628","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.628","url":null,"abstract":"Anton's syndrome (AS) describes the condition in which patient deny their blindness despite objective evidence of visual loss, and moreover confabulate to support their stance. It is a rare extension of cortical blindness in which, in addition to the injury to the occipital cortex, other cortical centers are also affected, with patients typically behaving as if they were sighted. This case presents a 76-year-old patient with verified cortical blindness as a result of a stroke. The patient persistently denied vision loss. At the same time, she confabulated to see people and objects in her environment clearly. This syndrome may be unrecognized in routine neurological practice. A suspicion of cortical blindness and AS should be considered in patients with atypical visual loss and evidence of occipital lobe injury. Cerebrovascular disease is the most common cause of AS, as in our patient. Recovery of visual function will depend on the underlying etiology, with cases due to occipital lobe infarction after cerebrovascular events being less likely to result in complete recovery. Management in these circumstances should focus on secondary prevention and rehabilitation.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43570116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Thyroid dysfunction (TD) and diabetes mellitus (DM) are the two most common chronic endocrine disorders with variable prevalence among different populations. Both insulin and thyroid hormones are affected by autoimmune pathology and they do affect cellular metabolism, being a part of the metabolic syndrome. However, the correlations between T2DM and TD have not yet been sufficiently defined, followed by ambivalent results from previous studies.Objectives: The study was conducted to compare the metabolic parameters of patients with T2DM with and those without AITD so as to determine the existence of a correlation between these and hormonal parameters (TSH, FT4).Design and methods: This are documented observational case-control study that included 31 subjects with T2DM and AITD and 25 with T2DM without AITD. Sessions were conducted at the Clinic for Internal Medicine of the University Clinical Center in Tuzla. Individual metabolic parameters were analyzed, and in a broad evaluation, the values of hormonal and immune parameters were monitored and documented.Results: There were no differences in age, gender and BMI of the examined groups. There was a statistically significant difference between the values related to OS, SKT, DKT, PGN, 2h ppPG, and HbA1c. A statistically significant correlation was found between TSH and females, FT4 and BMI (rS = 0.375 pvalue = 0.045) as wellas a correlation between TSH and HbA1c (rS = 0.313 pvalue = 0.019) and TSH and 2x ppPG (rS = 0.281, pvalue = 0.036).Conclusion: The expression of metabolic control parameters is strongest in the group of patients with diabetes and AITD. Their identification as a risk factor and the detection of their subclinical signs are extremely important for the early implementation of preventive and therapeutic strategies, which could change the course of diabetic complications and significantly improve prognosis of diabetes.
{"title":"Diabetes and thyroid through the prism of some metabolic abnormalities","authors":"Jasmina Pašić, Mithat Hajder, Lejla Jasarevic, Mirela Basic Denjagic, Danijela Loncar, Larisa Dizdarevic Hudic, Maida Kovacevic, Senada Husarić, Rijad Pasic","doi":"10.5457/ams.v52i1-2.626","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.626","url":null,"abstract":"Introduction: Thyroid dysfunction (TD) and diabetes mellitus (DM) are the two most common chronic endocrine disorders with variable prevalence among different populations. Both insulin and thyroid hormones are affected by autoimmune pathology and they do affect cellular metabolism, being a part of the metabolic syndrome. However, the correlations between T2DM and TD have not yet been sufficiently defined, followed by ambivalent results from previous studies.Objectives: The study was conducted to compare the metabolic parameters of patients with T2DM with and those without AITD so as to determine the existence of a correlation between these and hormonal parameters (TSH, FT4).Design and methods: This are documented observational case-control study that included 31 subjects with T2DM and AITD and 25 with T2DM without AITD. Sessions were conducted at the Clinic for Internal Medicine of the University Clinical Center in Tuzla. Individual metabolic parameters were analyzed, and in a broad evaluation, the values of hormonal and immune parameters were monitored and documented.Results: There were no differences in age, gender and BMI of the examined groups. There was a statistically significant difference between the values related to OS, SKT, DKT, PGN, 2h ppPG, and HbA1c. A statistically significant correlation was found between TSH and females, FT4 and BMI (rS = 0.375 pvalue = 0.045) as wellas a correlation between TSH and HbA1c (rS = 0.313 pvalue = 0.019) and TSH and 2x ppPG (rS = 0.281, pvalue = 0.036).Conclusion: The expression of metabolic control parameters is strongest in the group of patients with diabetes and AITD. Their identification as a risk factor and the detection of their subclinical signs are extremely important for the early implementation of preventive and therapeutic strategies, which could change the course of diabetic complications and significantly improve prognosis of diabetes.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48068217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim of research: The satisfaction of proffering radiological health care contributes to the improvement and quality of health care in health care institutions, especially in the extraordinary situations, such as the viral Coronavirus disease infection where patients are being treated under special conditions. Very often, the problem regarding the understanding among the patients and the healthcare workers can occur. The primary purpose of the research is to determine the contentment of infected Covid-19 patients with the provided service of the radiological diagnostics department as well as the healthcare workers and medical radiology engineers.Materials and methods: The study was conducted at the Public Health Institution „Br?ko District Health Center“( Dispensary for lung diseases) and TBC (ATD). The number of participants was 700 (n=700). The research was conducted during the months of May, June and July (2020.). The questionnaire consisted of 19 questions, , six of which regarded the sociodemographic information, and the remaining 13 research questions were done according to a Likert-type scale (1- strongly disagree, 2- disagree, 3- neither agree nor disagree, 4- agree, 5- strongly agree). Laschinger's customized and standardized questionnaire called HCAHPS (Hospital Consumer Assessment of Healthcare Providers and Systems), a questionnaire about the patient's contentment with the quality of health care, was used for the purpose of research analysis (1). The Pearson correlation coefficient and the ANOVA test were used for statistical data processing.Results: The given results have shown that the patients rated the quality of health care with a number 4 which indicates that they are satisfied with the provided quality. When asked about level of adequate care during their imaging, patients were less satisfied with nurses and technicians in comparison to the medical radiology engineers.Conclusion: The obtained results can contribute to a better understanding of patients as well as the improvement of health systems in the form of new health care reforms, as well as to make progress in educating health workers how to communicate with patients.Key words: SARS-CoV-2 virus, radiological diagnostics, satisfaction with the provided health care, quality of health care.
{"title":"PATIENTS SATISFACTION WITH DIAGNOSTIC RADIOLOGY SERVICES AT RADIOLOGICAL DEPARTMENT OF BR?KO HEALTH CENTAR","authors":"Adnan Kamenjasevic, N. Mešanović","doi":"10.5457/ams.v52i1-2.650","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.650","url":null,"abstract":" Aim of research: The satisfaction of proffering radiological health care contributes to the improvement and quality of health care in health care institutions, especially in the extraordinary situations, such as the viral Coronavirus disease infection where patients are being treated under special conditions. Very often, the problem regarding the understanding among the patients and the healthcare workers can occur. The primary purpose of the research is to determine the contentment of infected Covid-19 patients with the provided service of the radiological diagnostics department as well as the healthcare workers and medical radiology engineers.Materials and methods: The study was conducted at the Public Health Institution „Br?ko District Health Center“( Dispensary for lung diseases) and TBC (ATD). The number of participants was 700 (n=700). The research was conducted during the months of May, June and July (2020.). The questionnaire consisted of 19 questions, , six of which regarded the sociodemographic information, and the remaining 13 research questions were done according to a Likert-type scale (1- strongly disagree, 2- disagree, 3- neither agree nor disagree, 4- agree, 5- strongly agree). Laschinger's customized and standardized questionnaire called HCAHPS (Hospital Consumer Assessment of Healthcare Providers and Systems), a questionnaire about the patient's contentment with the quality of health care, was used for the purpose of research analysis (1). The Pearson correlation coefficient and the ANOVA test were used for statistical data processing.Results: The given results have shown that the patients rated the quality of health care with a number 4 which indicates that they are satisfied with the provided quality. When asked about level of adequate care during their imaging, patients were less satisfied with nurses and technicians in comparison to the medical radiology engineers.Conclusion: The obtained results can contribute to a better understanding of patients as well as the improvement of health systems in the form of new health care reforms, as well as to make progress in educating health workers how to communicate with patients.Key words: SARS-CoV-2 virus, radiological diagnostics, satisfaction with the provided health care, quality of health care.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44917300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Čičkušić, R. Hodžić, Š. Kikanović, Asja Hotic Hadziefendic, Adnan Cickusic, Mirza Imamović
Introduction: One of the most important goals in rehabilitating patients affected by stroke is re-establishing independent movement by activating as many motor patterns as possible and changing existing preexisting abnormal motor patterns Objective: To determine recovery level with the accent on motor functions recovery in a patient affected by an ischemic stroke for the first time. The study included patients with anterior circulation syndrome, posterior circulation syndrome, and lacunar syndrome in the acute and post-acute phases of physical therapy and rehabilitation.Material and methods: We conducted a prospective study, which included a total of 90 patients with the first onset of ischemic stroke. The first group consisted of 30 patients with the anterior circulation syndrome of; the second group of 30 patients with the posterior circulation syndrome and the third group of 30 patients with the lacunar syndrome. At the beginning of their early rehabilitation treatment at the Clinic of Physical Medicine and Rehabilitation, the Bamford Scale was used in the initial assessment of the clinical classification of stroke. After the rehabilitation treatment and six months after the stroke, an assessment of motor functions and improvement in overall functionality was performed using a six-minute walk test.Results: The six-minute walk test in all the studied groups showed significant improvement six months after the stroke compared to testing done immediately after their rehabilitation treatment (p = 0.01 anterior circulation, p = 0.05 posterior circulation, p = 0.01 lacunar syndrome). The six-minute walk test was statistically significantly better in patients with lacunar syndrome compared to patients with posterior circulation syndrome after the rehabilitation treatment (p = 0.005) and six months after stroke; p = 0.02.Conclusion: The importance of rehabilitation in the acute and post-acute phases of patients with first ischemic stroke is evident. The six-minute walk test in all studied groups showed statistically significant improvement after six months post-stroke period compared to post-rehabilitation testing. The results were statistically significantly better in patients with lacunar syndrome compared to patients with posterior circulation syndrome after the physical treatment and the time period of six months after the stroke.
{"title":"MEASUREMENT OF WALKING IMPAIRMENT RECOVERY AFTER STROKE","authors":"A. Čičkušić, R. Hodžić, Š. Kikanović, Asja Hotic Hadziefendic, Adnan Cickusic, Mirza Imamović","doi":"10.5457/ams.v52i1-2.646","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.646","url":null,"abstract":"Introduction: One of the most important goals in rehabilitating patients affected by stroke is re-establishing independent movement by activating as many motor patterns as possible and changing existing preexisting abnormal motor patterns Objective: To determine recovery level with the accent on motor functions recovery in a patient affected by an ischemic stroke for the first time. The study included patients with anterior circulation syndrome, posterior circulation syndrome, and lacunar syndrome in the acute and post-acute phases of physical therapy and rehabilitation.Material and methods: We conducted a prospective study, which included a total of 90 patients with the first onset of ischemic stroke. The first group consisted of 30 patients with the anterior circulation syndrome of; the second group of 30 patients with the posterior circulation syndrome and the third group of 30 patients with the lacunar syndrome. At the beginning of their early rehabilitation treatment at the Clinic of Physical Medicine and Rehabilitation, the Bamford Scale was used in the initial assessment of the clinical classification of stroke. After the rehabilitation treatment and six months after the stroke, an assessment of motor functions and improvement in overall functionality was performed using a six-minute walk test.Results: The six-minute walk test in all the studied groups showed significant improvement six months after the stroke compared to testing done immediately after their rehabilitation treatment (p = 0.01 anterior circulation, p = 0.05 posterior circulation, p = 0.01 lacunar syndrome). The six-minute walk test was statistically significantly better in patients with lacunar syndrome compared to patients with posterior circulation syndrome after the rehabilitation treatment (p = 0.005) and six months after stroke; p = 0.02.Conclusion: The importance of rehabilitation in the acute and post-acute phases of patients with first ischemic stroke is evident. The six-minute walk test in all studied groups showed statistically significant improvement after six months post-stroke period compared to post-rehabilitation testing. The results were statistically significantly better in patients with lacunar syndrome compared to patients with posterior circulation syndrome after the physical treatment and the time period of six months after the stroke.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47469696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This research paper is an expression of a desire to view COVID 19 from the perspective of a spontaneous hemorrhage induced on different organ systems. Introduction of a stratified approach to the problem of hemorrhage has become an imperative in medical treatment. Aim: To determine the real figure of spontaneous hemorrhage cases in severe forms of infections caused by Covid 19.Material and methods: The research included 745 patients that suffered from severe forms of infections caused by Covid 19 who were treated in a Respiratory clinic in Tuzla University Clinical Center during 2020 and 2021. The spontaneous hemorrhage was determined on the grounds of laboratory parameters of blood counts and CRP, hemodynamic monitoring of TA and pulse, and CT imagining diagnostic technique.Results: The study presents information about the medical treatment outcome in the case of 5 patients (0,67%) who experienced spontaneous hemorrhage as a part of Covid 19 infection in relation to the total number of 745 patients who were treated during that period in the Respiratory clinic as Covid patients with severe forms of infection. Out of 5 patients who acquired spontaneous hemorrhage 3 were operated. For 4 patients the outcome was lethal. One of the female patients who was in the group of those who were not operated and who had undergone a conservative treatment has survived. In our group of analyzed patients two patients suffered from the hematoma of the front abdominal wall, two had retroperitoneal hematoma and one patient acquired hemorrhage in the abdomen and thoracic with the developing DIC.Conclusion: Relatively low percentage of cases developing spontaneous hemorrhage 5 (0, 67%) but relatively high mortality rate in the cases where it did occur, 4 out of 5 monitored patients, requires certain suggestions that are being presented in this study as to how to approach the cases of spontaneous hemorrhage in the severe forms of Covid 19 infections in more consistent manner in order to improve the outcome of the medical treatment of these cases.
{"title":"Spontaneous hemorrhage in severe forms of Covid 19 infections","authors":"F. Pašić, Haris Elezovic, Maid Omerović, A. Pašić","doi":"10.5457/ams.v52i1-2.633","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.633","url":null,"abstract":"Background: This research paper is an expression of a desire to view COVID 19 from the perspective of a spontaneous hemorrhage induced on different organ systems. Introduction of a stratified approach to the problem of hemorrhage has become an imperative in medical treatment. Aim: To determine the real figure of spontaneous hemorrhage cases in severe forms of infections caused by Covid 19.Material and methods: The research included 745 patients that suffered from severe forms of infections caused by Covid 19 who were treated in a Respiratory clinic in Tuzla University Clinical Center during 2020 and 2021. The spontaneous hemorrhage was determined on the grounds of laboratory parameters of blood counts and CRP, hemodynamic monitoring of TA and pulse, and CT imagining diagnostic technique.Results: The study presents information about the medical treatment outcome in the case of 5 patients (0,67%) who experienced spontaneous hemorrhage as a part of Covid 19 infection in relation to the total number of 745 patients who were treated during that period in the Respiratory clinic as Covid patients with severe forms of infection. Out of 5 patients who acquired spontaneous hemorrhage 3 were operated. For 4 patients the outcome was lethal. One of the female patients who was in the group of those who were not operated and who had undergone a conservative treatment has survived. In our group of analyzed patients two patients suffered from the hematoma of the front abdominal wall, two had retroperitoneal hematoma and one patient acquired hemorrhage in the abdomen and thoracic with the developing DIC.Conclusion: Relatively low percentage of cases developing spontaneous hemorrhage 5 (0, 67%) but relatively high mortality rate in the cases where it did occur, 4 out of 5 monitored patients, requires certain suggestions that are being presented in this study as to how to approach the cases of spontaneous hemorrhage in the severe forms of Covid 19 infections in more consistent manner in order to improve the outcome of the medical treatment of these cases.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41453372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Olooto, Monisola A Ayodele, Joseph O Soola, Hammed A Adenusi, Frank E Agidingbi
Background: The number of people with Diabetes mellitus (DM) is steadily rising globally and its socio-economic effects extend beyond the individual to affect their families and whole societies.Aim: This study aimed at determining the Plasma Lipid Profile, Glycated Haemoglobin (HbA1C) and Histone Deacetylase (HDAC) enzyme activities as indicator of Glycaemic control in Type 2 Diabetes mellitus.Methods: A total of 100 newly diagnosed DM patients and 50 control subjects were recruited. The weight, height, body mass index (BMI), waist circumference (WC), and blood pressure of each participant were determined. Also, fasting plasma glucose (FPG), triglycerides, total Cholesterol (TC), high density lipoprotein (HDLC) and HDAC activities were measured using standard methods. Low density lipoprotein (LDLC) was computed.Results: A significant increase in mean age, FPG, systolic and diastolic blood pressure, HbA1c total cholesterol, triglyceride, and low density lipoprotein, and HDAC activities; and a decrease in plasma HDLC were observed among the diabetics when compared with the controls. A direct but significant correlation existed between HDAC activities and FPG, WC, and duration of diabetes; and between HbA1C and FBG, TC, LDLC, HDLC, and duration of diabetes; a direct but non-significant correlation existed between HDAC and HbA1C, HDLC; an inverse and significant correlation existed between BMI and TC, Triglyceride and LDLC.Conclusion: It could be inferred from thia study that plasma HDAC activities is directly related to FPGÂ as it was found to increase with increasing FPG, indicating its likely role in metabolism.
{"title":"Plasma Histone Deacetylase activities, Lipid Profile, and Glycated Haemoglobin levels as indicator of Glycemic control in Type 2 Diabetes Mellitus","authors":"W. Olooto, Monisola A Ayodele, Joseph O Soola, Hammed A Adenusi, Frank E Agidingbi","doi":"10.5457/ams.v52i1-2.556","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.556","url":null,"abstract":"Background: The number of people with Diabetes mellitus (DM) is steadily rising globally and its socio-economic effects extend beyond the individual to affect their families and whole societies.Aim: This study aimed at determining the Plasma Lipid Profile, Glycated Haemoglobin (HbA1C) and Histone Deacetylase (HDAC) enzyme activities as indicator of Glycaemic control in Type 2 Diabetes mellitus.Methods: A total of 100 newly diagnosed DM patients and 50 control subjects were recruited. The weight, height, body mass index (BMI), waist circumference (WC), and blood pressure of each participant were determined. Also, fasting plasma glucose (FPG), triglycerides, total Cholesterol (TC), high density lipoprotein (HDLC) and HDAC activities were measured using standard methods. Low density lipoprotein (LDLC) was computed.Results: A significant increase in mean age, FPG, systolic and diastolic blood pressure, HbA1c total cholesterol, triglyceride, and low density lipoprotein, and HDAC activities; and a decrease in plasma HDLC were observed among the diabetics when compared with the controls. A direct but significant correlation existed between HDAC activities and FPG, WC, and duration of diabetes; and between HbA1C and FBG, TC, LDLC, HDLC, and duration of diabetes; a direct but non-significant correlation existed between HDAC and HbA1C, HDLC; an inverse and significant correlation existed between BMI and TC, Triglyceride and LDLC.Conclusion: It could be inferred from thia study that plasma HDAC activities is directly related to FPGÂ as it was found to increase with increasing FPG, indicating its likely role in metabolism.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43762316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tarik Bujaković, Ema Kacar Bujakovic, S. Delibegović, A. Vujadinović
Stress fractures of the femur are relativly uncommon. They can mimic other pathological entities, such as tumors, and can be the sourse of some diagnostic problems. The cause of stress fractures is often multifactorial and various modifiable and non-modifiable factors have been proposed to play a role: ethicity, high bone turnover, vitamin D insufficiency, nicotine and alcohol abuse, steroid use, low bone density, low adult weight, anorexia, or bisphosphonate therapy. Hence they might be missed in other groups of patients that present with anterior thigh pain without history of significant trauma. We report a stress fracture that mimicked tumoral process of the long bone, but patho-histological analysis revealed that it was a non-specific inflammation. Symptoms often mislead the clinicians, and because they mimic other conditions, a high index of suspicion/indication is required to uncover the true diagnosis. The importance of early detection and management needs to be conveyed, with a view to prevent complete fracture and bonedisplacement or, asin our reported case, to avoid un-necessery exploration.Â
{"title":"Stress fracture of femoral dyaphysis mimics osteosarcoma","authors":"Tarik Bujaković, Ema Kacar Bujakovic, S. Delibegović, A. Vujadinović","doi":"10.5457/ams.v52i1-2.575","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.575","url":null,"abstract":"Stress fractures of the femur are relativly uncommon. They can mimic other pathological entities, such as tumors, and can be the sourse of some diagnostic problems. The cause of stress fractures is often multifactorial and various modifiable and non-modifiable factors have been proposed to play a role: ethicity, high bone turnover, vitamin D insufficiency, nicotine and alcohol abuse, steroid use, low bone density, low adult weight, anorexia, or bisphosphonate therapy. Hence they might be missed in other groups of patients that present with anterior thigh pain without history of significant trauma. We report a stress fracture that mimicked tumoral process of the long bone, but patho-histological analysis revealed that it was a non-specific inflammation. Symptoms often mislead the clinicians, and because they mimic other conditions, a high index of suspicion/indication is required to uncover the true diagnosis. The importance of early detection and management needs to be conveyed, with a view to prevent complete fracture and bonedisplacement or, asin our reported case, to avoid un-necessery exploration. ","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48301986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Kojić, Z. Dostović, Omer C. Ibrahimagic, D. Smajlović, R. Hodžić, Amra Iljazović
Background: More than 50% of stroke patients have sleep-disordered breathing.Aim: To determine whether the location and type of stroke affect the occurrence of sleep apnea.Patients and methods: We analyzed 110 patients with acute stroke and verified sleep apnea. Acute stroke has been verified either by computerized tomography or magnetic resonance imaging of the brain. Average age was 65.13±9.27 years and it was 59% men. Number of patients without apnea in control group was the same as well as gender distribution, with average age 64±8.69 years.Results: Apnea was verified in 22% patients. The largest number of patients with and without apnea had ischemic stroke 83.6%, while 16.4% of patients had hemorrhagic stroke. Of these, there were 86.2% men and 80% women with ischemic and 13.8% men and 20% women with hemorrhagic stroke. With apnea, the largest number had a lesion in two or more places 51.8%,as well as without apnea 45.45%, but the difference was not statistically significant. According to the acute stroke, the largest number of patients with and without apnea had lesions in the left and right hemispheres 45.4%. There was no statistically significant association between apnea and localization of stroke in the left or in both hemispheres. There is a statistically significant association of AS localization in the right hemisphere with the occurrence of apnea.Conclusion: There is a statistically significant association between the localization of stroke in the right hemisphere and the occurrence of apnea.
{"title":"Localization and type of acute stroke in relation to sleep apnea","authors":"B. Kojić, Z. Dostović, Omer C. Ibrahimagic, D. Smajlović, R. Hodžić, Amra Iljazović","doi":"10.5457/ams.v52i1-2.631","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.631","url":null,"abstract":"Background: More than 50% of stroke patients have sleep-disordered breathing.Aim: To determine whether the location and type of stroke affect the occurrence of sleep apnea.Patients and methods: We analyzed 110 patients with acute stroke and verified sleep apnea. Acute stroke has been verified either by computerized tomography or magnetic resonance imaging of the brain. Average age was 65.13±9.27 years and it was 59% men. Number of patients without apnea in control group was the same as well as gender distribution, with average age 64±8.69 years.Results: Apnea was verified in 22% patients. The largest number of patients with and without apnea had ischemic stroke 83.6%, while 16.4% of patients had hemorrhagic stroke. Of these, there were 86.2% men and 80% women with ischemic and 13.8% men and 20% women with hemorrhagic stroke. With apnea, the largest number had a lesion in two or more places 51.8%,as well as without apnea 45.45%, but the difference was not statistically significant. According to the acute stroke, the largest number of patients with and without apnea had lesions in the left and right hemispheres 45.4%. There was no statistically significant association between apnea and localization of stroke in the left or in both hemispheres. There is a statistically significant association of AS localization in the right hemisphere with the occurrence of apnea.Conclusion: There is a statistically significant association between the localization of stroke in the right hemisphere and the occurrence of apnea.","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44094275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merima Imamović, E. Horozić, Vedad Salkovic, Armina Pasalic, Nermina Hadžić
Metal complexes due to their antibacterial, antifungal, antitumor and antioxidant properties have been extremely studied today. A large number of metal complexes have the ability to neutralize free radicals, which most often occur as a result of metabolic processes in the body, smoking, exposure to radiation and chemical substances. Testing the antioxidant capacity of metal complexes can be tested by various methods in vitro and in vivo. This paper will present the efficiency of neutralization of free radicals by metal complexes synthesized in the past few years using different ligands, as well as the most commonly used methods for testing the antioxidant capacity of this group of compounds.Â
{"title":"Metal complexes as potential agents for neutralizing free radicals: a review of in vitro studies","authors":"Merima Imamović, E. Horozić, Vedad Salkovic, Armina Pasalic, Nermina Hadžić","doi":"10.5457/ams.v52i1-2.618","DOIUrl":"https://doi.org/10.5457/ams.v52i1-2.618","url":null,"abstract":"Metal complexes due to their antibacterial, antifungal, antitumor and antioxidant properties have been extremely studied today. A large number of metal complexes have the ability to neutralize free radicals, which most often occur as a result of metabolic processes in the body, smoking, exposure to radiation and chemical substances. Testing the antioxidant capacity of metal complexes can be tested by various methods in vitro and in vivo. This paper will present the efficiency of neutralization of free radicals by metal complexes synthesized in the past few years using different ligands, as well as the most commonly used methods for testing the antioxidant capacity of this group of compounds. ","PeriodicalId":53635,"journal":{"name":"Acta Medica Saliniana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45015269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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