Pub Date : 2019-03-09DOI: 10.37290/ijpp2641-7197.14:9-17
S. Latvala, S. Philipp, M. Lehtinen, L. Lehtoranta, A. Ouwehand
This review summarizes health benefits of a combination of a four-strain probiotic consisting of L. paracasei Lpc-37, B. lactis Bl-04, L. acidophilus La-14, and L. plantarum Lp-115. The safety of the individual strains for absence of transferable antibiotic resistance and adverse events in human intervention studies has been documented. The strains have been shown, both in vitro and in human studies, to survive gastro-intestinal transit and transiently colonize the intestine in a dose-dependent manner. In digestive health, the strains have shown to modulate the intestinal microbiota and reduce risk for both diarrhea and constipation. In vitro, animal and human studies have shown these strains to positively modulate many immune markers, in particular anti-inflammatory markers. These modifications also suggest a reduced risk for respiratory tract infections and seasonal respiratory allergies. The strains contributed positively to weight management in humans and reduced markers of metabolic syndrome in animal models. Finally, one of the strains (L. acidophilus La-14) was shown to colonize the vagina and contribute to reduced risk for recurrent bacterial vaginosis, vulvovaginal candidiasis and urinary tract infection. The combination of these four strains can therefore be expected to provide a broad spectrum of health benefits.
{"title":"Health Benefits of a Combination Probiotics; FlorMidabil™","authors":"S. Latvala, S. Philipp, M. Lehtinen, L. Lehtoranta, A. Ouwehand","doi":"10.37290/ijpp2641-7197.14:9-17","DOIUrl":"https://doi.org/10.37290/ijpp2641-7197.14:9-17","url":null,"abstract":"This review summarizes health benefits of a combination of a four-strain probiotic consisting of L. paracasei Lpc-37, B. lactis Bl-04, L. acidophilus La-14, and L. plantarum Lp-115. The safety of the individual strains for absence of transferable antibiotic resistance and adverse events in human intervention studies has been documented. The strains have been shown, both in vitro and in human studies, to survive gastro-intestinal transit and transiently colonize the intestine in a dose-dependent manner. In digestive health, the strains have shown to modulate the intestinal microbiota and reduce risk for both diarrhea and constipation. In vitro, animal and human studies have shown these strains to positively modulate many immune markers, in particular anti-inflammatory markers. These modifications also suggest a reduced risk for respiratory tract infections and seasonal respiratory allergies. The strains contributed positively to weight management in humans and reduced markers of metabolic syndrome in animal models. Finally, one of the strains (L. acidophilus La-14) was shown to colonize the vagina and contribute to reduced risk for recurrent bacterial vaginosis, vulvovaginal candidiasis and urinary tract infection. The combination of these four strains can therefore be expected to provide a broad spectrum of health benefits.","PeriodicalId":53704,"journal":{"name":"International Journal of Probiotics and Prebiotics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46882948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-29DOI: 10.37290/ijpp2641-7197.14:1-8
Banin Maghfirotin Marta, U. Tyas, Cahyanto Muhammad Nur, Widada Jaka, Rahayu Endang Sutriswati
Consumption of probiotics is known to influence the gut microbiota. The aim of this study was to assess the effect of probiotic powder containing Lactobacillus plantarum Dad-13 on bacterial composition in the gut by examining fecal samples of school-age children in Yogyakarta, Indonesia. This is a randomized, double-blind, placebo-controlled study. A total of 40 healthy subjects were recruited for this study and were divided into two groups: placebo group and probiotic group. The placebo group consumed skim milk and the probiotic group consumed probiotic powder containing L. plantarum Dad-13 (2 × 109 CFU/g) for 65 days. The results showed that placebo intake had no significant effect on gut microbiota; however, probiotic caused a significant increase in L. plantarum and Lactobacillus population, while decreasing the population of E. coli and non-E. coli coliform bacteria by 55% and 75%, respectively and Bifidobacteria count did not change significantly. The study concluded that consumption of probiotic powder L. plantarum Dad-13 could increase propionic acid thereby decreasing the gut pH which has an effect on the microbial population.
{"title":"Effects of Consumption of Probiotic Powder Containing Lactobacillus Plantarum Dad-13 on Fecal Bacterial Population in School-Age Children in Indonesia","authors":"Banin Maghfirotin Marta, U. Tyas, Cahyanto Muhammad Nur, Widada Jaka, Rahayu Endang Sutriswati","doi":"10.37290/ijpp2641-7197.14:1-8","DOIUrl":"https://doi.org/10.37290/ijpp2641-7197.14:1-8","url":null,"abstract":"Consumption of probiotics is known to influence the gut microbiota. The aim of this study was to assess the effect of probiotic powder containing Lactobacillus plantarum Dad-13 on bacterial composition in the gut by examining fecal samples of school-age children in Yogyakarta, Indonesia. This is a randomized, double-blind, placebo-controlled study. A total of 40 healthy subjects were recruited for this study and were divided into two groups: placebo group and probiotic group. The placebo group consumed skim milk and the probiotic group consumed probiotic powder containing L. plantarum Dad-13 (2 × 109 CFU/g) for 65 days. The results showed that placebo intake had no significant effect on gut microbiota; however, probiotic caused a significant increase in L. plantarum and Lactobacillus population, while decreasing the population of E. coli and non-E. coli coliform bacteria by 55% and 75%, respectively and Bifidobacteria count did not change significantly. The study concluded that consumption of probiotic powder L. plantarum Dad-13 could increase propionic acid thereby decreasing the gut pH which has an effect on the microbial population.","PeriodicalId":53704,"journal":{"name":"International Journal of Probiotics and Prebiotics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48663390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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