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Two co-inherited SNPs of the telomerase reverse transcriptase (TERT) gene are associated with Iraqi patients with lung cancer. 端粒酶逆转录酶(TERT)基因的两个共遗传 SNP 与伊拉克肺癌患者有关。
IF 2.5 0 LITERARY REVIEWS Pub Date : 2023-10-27 DOI: 10.5937/jomb0-41553
Zahraa K Lawi, Ahmed H Alkhammas, Malek Elerouri, Amara Ibtissem Ben, Mohammed Baqur S Al-Shuhaib

Background: The telomerase reverse transcriptase (TERT) gene is essential polymorphic loci linked to most malignant tumors. This study assessed the association between the TERT gene and non-small cell lung carcinoma (NSCLC) in Iraq.

Methods: Genomic DNA samples were extracted from a total of 200 samples of blood. Four specific PCR fragments were designed to amplify four high-frequency rs2735940, rs2736098, rs2736100, and rs10069690 SNPs within the TERT gene. Single-strand conformation polymorphism (SSCP) followed by sequencing reactions were used for genotyping and validating the amplified fragments.

背景:端粒酶逆转录酶(TERT)基因是与大多数恶性肿瘤相关的重要多态性位点。本研究评估了 TERT 基因与伊拉克非小细胞肺癌(NSCLC)之间的关系:方法:从总共 200 份血液样本中提取基因组 DNA 样本。设计了四个特异性 PCR 片段,以扩增 TERT 基因中的四个高频 SNPs:rs2735940、rs2736098、rs2736100 和 rs10069690。利用单链构象多态性(SSCP)和测序反应对扩增片段进行基因分型和验证。
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引用次数: 0
Coercive Condom Use Resistance: A Scoping Review. 强制使用安全套的阻力:范围审查。
IF 2.4 0 LITERARY REVIEWS Pub Date : 2023-09-01 Epub Date: 2023-07-20 DOI: 10.1037/vio0000481
Kelly Cue Davis, Robin Stewart, Mitchell Kirwan, Weiqi Chen, Julia F Hammett

Objective: Sexual aggression research has recently expanded to include empirical investigations of coercion during condom negotiation and use. This scoping review presents and discusses peer-reviewed, quantitative, English-language studies conducted on coercive condom use resistance (CUR) behavior and intentions.

Method: Our systematic literature search yielded 20 articles that assessed coercive CUR perpetration behaviors or intentions and met other inclusion criteria. Data on rates and correlates of coercive CUR behavior and intentions were extracted.

Results: Identified studies used varied methods including cross-sectional surveys, 3-month longitudinal studies, and alcohol administration experiments, primarily with young adult samples. Overall, results indicated that a substantial minority (up to 42.6%) of sampled individuals endorsed lifetime perpetration of coercive CUR, with men reporting higher prevalence of coercive CUR perpetration than women. The majority of studies (70%) assessed coercive CUR through the Condom Use Resistance Tactics Scale (Davis et al., 2014). Although correlates largely differed by gender, alcohol-related variables emerged as risk factors for both men and women.

Conclusions: Burgeoning evidence indicates that coercive CUR is relatively common, and, particularly for men, risk factors are similar to those associated with sexual aggression more generally. Review findings demonstrate that continued research in this area is warranted and should expand to include more diverse populations, to consider other risk factors and sequelae, and to utilize novel methodological approaches.

目的:性侵犯研究近来已扩展到对安全套谈判和使用过程中的胁迫行为进行实证调查。这篇范围界定综述介绍并讨论了经同行评审的、定量的、关于胁迫性安全套使用阻力(CUR)行为和意图的英文研究:我们通过系统性文献检索获得了 20 篇评估胁迫性 CUR 行为或意图并符合其他纳入标准的文章。我们提取了胁迫性 CUR 行为和意向的发生率和相关性数据:已确定的研究采用了不同的方法,包括横截面调查、为期 3 个月的纵向研究和酒精管理实验,主要以年轻人为样本。总体而言,研究结果表明,相当少数(高达 42.6%)的抽样个体认可终生实施胁迫性 CUR,男性报告的胁迫性 CUR 实施率高于女性。大多数研究(70%)通过 "安全套使用抵制策略量表"(Davis 等人,2014 年)对胁迫性 CUR 进行了评估。虽然相关因素在很大程度上因性别而异,但与酒精相关的变量成为男性和女性的风险因素:越来越多的证据表明,胁迫性 CUR 比较常见,尤其是对男性而言,其风险因素与一般的性侵犯相关因素相似。综述结果表明,有必要在这一领域继续开展研究,并应扩大研究范围,纳入更多不同的人群,考虑其他风险因素和后遗症,并采用新颖的方法。
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引用次数: 0
The Jim Croce Question 吉姆·克罗齐问题
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0024
Michael J. Hess, K. Hartman, Joanne Jacobson, Karen Babine, Erin Wisti, Elaine Herrick Lee, Allison Ellis, J. Winn, Erin Langner, Margaret Nowaczyk, C. Stoddard, Chris Arthur, Tanya Bomsta, J. J. Sullivan, Annie Penfield, S. Church, P. Hicks, Hannah D. Markley, P. Haney, J. Price, Tom Montgomery Fate, J. Franklin, Patrick Madden, Peggy Shinner, Melissa Lauer
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引用次数: 0
Crossings 口岸
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0091
Allison Ellis
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引用次数: 0
Four Elegies 四首挽歌
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0077
Elaine Herrick Lee
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引用次数: 0
Chart Notes 图表的笔记
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0161
J. J. Sullivan
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引用次数: 0
Shoulder Season 肩膀的季节
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0165
Annie Penfield
Walking to the barn, I navigate ruts and ice. The uneven terrain is a consequence of last week's thaw and then this morning's freeze. Last week, frost lurched from the ground with rising temperatures and rain ran off the snowbanks and pooled outside horse stalls, and the snow compacted to a thick crust. This morning, the maples bend in the wind, and small branches litter the ground. The woods snap and crackle. The ground is slick and unforgiving. I tread with care to the barn to feed my horses. This is March, the shoulder season, a vacillation of thaw and freeze, as we stagger into the next season. We will have at least two months of slip and slide, mud and snow, sleet and rain, that we call mud season before we land in spring. We all feel the limitation, the grey skies, the roads frozen in ruts, and small packed islands within the difficult to penetrate crust. We bump up against the limitation, ready to tip into something new, but the world surrounding isn't ready to receive us.My mother had lost motivation to change before driving us to school in the morning.” My oldest daughter remembers me in a way that makes me wince when I read her words. In her story, I am disheveled and distracted. Living in flannel pajamas and muttering. She remembers me in the way that I am frozen. Her memory shifts my focus from her father's disappearance to my emotional absence. I slip from holding it together to see how I was falling apart.I came to know this vision of me when she took a creative writing class her sophomore year in college, and she sent me the story about her father's five-day disappearance, the grand finale binge before he sobered up. She was in fifth grade at the time. Only she remembers her father's drinking and disappearances. Her younger siblings, although younger only by a few years, do not remember. They did not tally the days in their journals that he was missing. They did not lie awake in bed watching for headlights to travel the long driveway to the house.My daughter remembers me within the absence of her father. How two suddenly became less than one. She had her first ever dance during that time. She remembers the skirt she wore, the macarena, the boy who reached for her hand. She remembers standing in the driveway watching the neighbor's red taillights fade as she delayed entering the house, prolonging the fullness and kindness of her night, before entering the quiet house with a newly hollow mother. I would be waiting, “still in her pajamas from the night before, and ask me how it went. Neither of us would mention his absence and I wouldn't ask, not wanting to breach the unspoken-ness, not wanting her to know that I stayed up every night, hoping to catch his headlights as they descended the final curve in our driveway.”I don't remember the dance. The gold skirt still hangs in our cedar closet. I do remember taking the dress to a friend's mother to have it altered for the dance. Randi added a thin organza orange ribbon to the hem “to add
我沿着车辙和冰面向谷仓走去。不平坦的地形是上周解冻和今天早上冻结的结果。上周,随着气温的上升,地面上的霜冻突然冒了出来,雨水从雪堆上流下,聚集在马厩外面,雪被压实成了厚厚的一层。今晨,枫树被风吹弯了,小树枝散落在地上。树林噼啪作响。地面又滑又硬。我小心翼翼地走到牲口棚喂马。这是三月,一个冬歇的季节,我们摇摇晃晃地进入下一个季节。在我们春天着陆之前,我们至少要经历两个月的打滑、泥和雪、雨夹雪和雨,我们称之为泥季。我们都能感受到它的局限:灰暗的天空,被车辙冻住的道路,以及难以穿透的地壳中拥挤的小岛。我们遇到了限制,准备进入一些新的东西,但周围的世界还没有准备好接受我们。在早上开车送我们去学校之前,我母亲已经失去了改变的动力。”我的大女儿对我的记忆让我在读她的话时畏缩。在她的故事里,我衣冠不整,心烦意乱。穿着法兰绒睡衣,喃喃自语。她记得我,就像我被冻住了一样。她的记忆把我的注意力从她父亲的失踪转移到了我的情感缺失上。我失去了坚持,看到自己是如何分崩离析的。当她在大学二年级上创意写作课时,我开始了解到我的这个形象,她给我发了一个关于她父亲失踪五天的故事,在他清醒之前的最后一场狂欢。她当时上五年级。只有她记得她父亲的酗酒和失踪。她的弟弟妹妹虽然只比她小几岁,却不记得了。他们没有在日记里记录他失踪的天数。他们不会醒着躺在床上,等着车灯穿过长长的车道回到家里。我女儿在她父亲不在的时候还记得我。两个人突然变得比一还小。在那段时间里,她第一次跳舞。她记得她穿的裙子,马卡雷纳,那个向她伸出手的男孩。她记得自己站在车道上,看着邻居的红色尾灯渐渐暗淡,她推迟了进屋的时间,延长了这个充实而美好的夜晚,然后带着刚刚空虚的母亲走进了安静的房子。我会一直等着,”她还穿着前一天晚上穿的睡衣,然后问我过得怎么样。我们俩都没提他不在,我也没问,不想打破这种沉默,不想让她知道我每晚都熬夜,希望在他们驶下车道的最后一个弯道时,能看到他的车灯。”我不记得舞会了。那条金色的裙子还挂在我们的杉木衣橱里。我记得我把裙子拿给一个朋友的妈妈改了一下,以便参加舞会。兰迪在裙摆上加了一条薄的橙色透明硬纱缎带,为金色的严肃感“增添一些流行感”。我把裙子捡起来,小心翼翼地举着那条金色裙子,沿着她的石径向她的车走去。头顶上,正午的太阳高高地挂在蓝天上。车道变软了。融化的程度有:软冰、泥、软土、泥。我骑着马在车道上走着,浑身湿气。在松软的道路上,他的脚步轻快起来,我决定冒险进入雪地。它的蹄子踉踉跄跄地穿过地壳,最后穿过下面的颗粒层,然后迅速下沉。他把腿从僵硬狭窄的洞里抽出来,蹒跚地向前迈了两大步。他不愿意走路,而我骑车的原因也不是他那矫健的动作。我骑着马在地球上快速移动。我们沿路小跑。被他的蹄子踩到的鹅卵石在我们面前飞来飞去。一块路,一块霜隆起,在马蹄下塌陷。我学习的基础上采取最好的课程。我保持松散,当他跌倒时跟着他移动。道路在马蹄下起伏。邻居家传来狗叫声。他的耳朵转动以探测声音。我朝那个方向看。我把观察世界的镜头从我的身上移到我的马身上。我模糊了界限;我们一起行动。骑马的魅力之一在于对感官的提升,还有运动的便捷和陪伴。我超越了每天的待办事项清单。我把注意力转移到驾驶上,用他能理解的方式和他交流,找到我们安全前进的路。我的马替我驮东西。我女儿记得,我带她们去一家大商店为她们父亲的生日买礼物,那是几天后的事了,父亲可能还在想念她。孩子们非常兴奋,因为我以前从来没有这样做过。它就像一个禁地:一排排五颜六色的书和游戏,还有大垫子作为阅读区。他们跑过过道,依偎在豆袋椅上。 与我们平时读书的安静的小空间相比,这里热闹非凡。在她的记忆中,这是一个门槛——进入被抵制的商店也就进入了一个单亲家庭。它确实标志着一种背离。我为什么要这么做?我是在寻求匿名吗?选择和陌生人在一起,问一些善意的问题,避免更亲密的问题。避免与熟悉的人接触,因为他们可能会问我怎么样,我茫然的表情,飞快的眼睛,我完全没有幽默感。或者问问我丈夫的情况,可能还会提到,就像他们几天前在杂货店里说的那样,他们有一段时间没见到他了。我也是,我好几天没见到他了。我希望他没有死在河里。这种情况以前也发生过。我不能请求帮助;我不知道他会失踪多久,也不知道他会不会回来,也不知道我们面临着什么。在我日常生活的环境中,没有任何东西能告诉我前方是否有危险。或者我只是想分散孩子们对他们父亲失踪的注意力,还有我的法兰绒睡衣。我的悲伤已经深深埋在冷漠的外壳下。我想给他们一些有趣的东西,感受一些快乐而不是我的沮丧,逃离我们陷入的循环:清醒的几周之后是失踪的几天。一月开始了一个循环,新年发誓戒酒,但在26日24小时不喝酒,打破了这个循环,二月再次戒酒三周,然后消失两天,每个月都是这样,消失的时间越来越长,直到四月,我们在一家书店里,消失了第四天。这些礼物是一个愿望,希望今年的生日能像往年一样,“他回家时能看到彩带、白蛋糕和奶油山核桃冰淇淋——因为那是他的最爱。”但他没有像预期的那样回来。“我下楼时,扎着辫子,发现这第六个早晨和之前的五个早晨一模一样。所以,我一个人站在厨房里,寻找一些东西,一个人,似乎不想被找到,我崩溃了。”只是她告诉我不是她父亲缺席,而是家庭作业。我说我会和老师谈谈;我没说她失踪的父亲。我记得一个星期后,他回来后,我去找老师。我们家正处于危机之中,我说着关上了他教室的门。我还记得当门关上时,他脸上惊恐的表情,我在安静的教室里独自转向他。我丈夫是个酒鬼;我们正在寻求帮助。不过现在我意识到,帮助并不包括孩子们。他们没有来诊所参加家庭之夜。他们和祖父母呆在家里,切胡萝卜做晚餐,而我们则去咨询。我们在研究一种新的方式来倾听彼此。从我孩子的眼中,我看到了十二年前的我,我很脆弱。痛苦就像枫树在风中僵硬的枝条发出噼啪声。只有弯曲了那么多,小树枝和树枝,折断,散落在积雪覆盖的草地上,滑过地面。只是我没有崩溃。我开车送他们去学校——沉默而冰冷。这么多年过去了,现在回想起这段往事,我问自己,我是如何解冻并继续前进的?他在生日那天晚上回到家,所有的孩子都在楼上的床上睡着了。那是四月的最后一天。雪早就融化了。道路会很潮湿,但不再陷在泥里。树木会发芽。水仙花过去了。马在马厩里吃干草。那天晚上他决定戒酒,于是我们进入了戒酒的季节。她写道:“我不记得了……道歉,但我记得的是,所有的困惑和怨恨都烟消云散了。它消失了,伴随着早晨的煎饼和后院的足球的承诺,他的耳朵扮演我的故事和歌曲的受害者,除了离开的问题,因为一切都结束了,他在这里,虽然悔恨是银色的,但幸福也是银色的,因为它是年龄和智慧的颜色,灰色的汽车回到了车库,夜晚的月亮照亮了他俯下身吻我的脸。”对她来说,是的,似乎已经跨过了一个门槛。不是我,我踉踉跄跄地进入了下一季,但我还是设法脱下了睡衣。我穿好衣服,开车去学校,骑上马,然后去上班。我并没有突然解冻。每一份煎饼和学校午餐,每一次他指导的练习和他记得的许可单,每天晚上车停在车库里,厨房柜台上留下的每一张便条都是一件差事,而不是缺勤,这些都加深了我们的分歧,从酗酒的不可预知的生活到两个父母一起分担负担。我的老二,那个在高中时期和我一起比赛赛马的孩子,不记得她父亲的失踪。有时这是一种祝福,但有时这是我最大的恐惧。她读过我和她姐姐的故事。
{"title":"Shoulder Season","authors":"Annie Penfield","doi":"10.14321/fourthgenre.25.1.0165","DOIUrl":"https://doi.org/10.14321/fourthgenre.25.1.0165","url":null,"abstract":"Walking to the barn, I navigate ruts and ice. The uneven terrain is a consequence of last week's thaw and then this morning's freeze. Last week, frost lurched from the ground with rising temperatures and rain ran off the snowbanks and pooled outside horse stalls, and the snow compacted to a thick crust. This morning, the maples bend in the wind, and small branches litter the ground. The woods snap and crackle. The ground is slick and unforgiving. I tread with care to the barn to feed my horses. This is March, the shoulder season, a vacillation of thaw and freeze, as we stagger into the next season. We will have at least two months of slip and slide, mud and snow, sleet and rain, that we call mud season before we land in spring. We all feel the limitation, the grey skies, the roads frozen in ruts, and small packed islands within the difficult to penetrate crust. We bump up against the limitation, ready to tip into something new, but the world surrounding isn't ready to receive us.My mother had lost motivation to change before driving us to school in the morning.” My oldest daughter remembers me in a way that makes me wince when I read her words. In her story, I am disheveled and distracted. Living in flannel pajamas and muttering. She remembers me in the way that I am frozen. Her memory shifts my focus from her father's disappearance to my emotional absence. I slip from holding it together to see how I was falling apart.I came to know this vision of me when she took a creative writing class her sophomore year in college, and she sent me the story about her father's five-day disappearance, the grand finale binge before he sobered up. She was in fifth grade at the time. Only she remembers her father's drinking and disappearances. Her younger siblings, although younger only by a few years, do not remember. They did not tally the days in their journals that he was missing. They did not lie awake in bed watching for headlights to travel the long driveway to the house.My daughter remembers me within the absence of her father. How two suddenly became less than one. She had her first ever dance during that time. She remembers the skirt she wore, the macarena, the boy who reached for her hand. She remembers standing in the driveway watching the neighbor's red taillights fade as she delayed entering the house, prolonging the fullness and kindness of her night, before entering the quiet house with a newly hollow mother. I would be waiting, “still in her pajamas from the night before, and ask me how it went. Neither of us would mention his absence and I wouldn't ask, not wanting to breach the unspoken-ness, not wanting her to know that I stayed up every night, hoping to catch his headlights as they descended the final curve in our driveway.”I don't remember the dance. The gold skirt still hangs in our cedar closet. I do remember taking the dress to a friend's mother to have it altered for the dance. Randi added a thin organza orange ribbon to the hem “to add ","PeriodicalId":53750,"journal":{"name":"Fourth Genre-Explorations in Nonfiction","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134942342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overlay 覆盖
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.1117/3.322162.ch5
C. Stoddard
{"title":"Overlay","authors":"C. Stoddard","doi":"10.1117/3.322162.ch5","DOIUrl":"https://doi.org/10.1117/3.322162.ch5","url":null,"abstract":"","PeriodicalId":53750,"journal":{"name":"Fourth Genre-Explorations in Nonfiction","volume":"25 1","pages":"128 - 146"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44353477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Craft Essay on Trauma 一篇关于创伤的手工文章
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0105
J. Winn
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引用次数: 0
One by One, the Stars 一个接一个,星星
0 LITERARY REVIEWS Pub Date : 2023-02-01 DOI: 10.14321/fourthgenre.25.1.0210
P. Haney
{"title":"One by One, the Stars","authors":"P. Haney","doi":"10.14321/fourthgenre.25.1.0210","DOIUrl":"https://doi.org/10.14321/fourthgenre.25.1.0210","url":null,"abstract":"","PeriodicalId":53750,"journal":{"name":"Fourth Genre-Explorations in Nonfiction","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47431042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Fourth Genre-Explorations in Nonfiction
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