Pub Date : 2022-04-07DOI: 10.1007/s11841-021-00890-0
Harjeet Singh, S. Kahlon
{"title":"Guru Nanak’s Siddh Gosti: a Dialogue Between Established and Emerging Discourse","authors":"Harjeet Singh, S. Kahlon","doi":"10.1007/s11841-021-00890-0","DOIUrl":"https://doi.org/10.1007/s11841-021-00890-0","url":null,"abstract":"","PeriodicalId":53798,"journal":{"name":"Sophia-Educacion","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47435122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-05DOI: 10.1007/s11841-021-00881-1
Stalin Joseph Correya
{"title":"Never Waking into Reality: Narrative Self in the Madhyamaka","authors":"Stalin Joseph Correya","doi":"10.1007/s11841-021-00881-1","DOIUrl":"https://doi.org/10.1007/s11841-021-00881-1","url":null,"abstract":"","PeriodicalId":53798,"journal":{"name":"Sophia-Educacion","volume":"62 1","pages":"159-177"},"PeriodicalIF":0.1,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41486885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08DOI: 10.21203/rs.3.rs-1370473/v1
Aneel Aggarwal, Jithesh Kottur
Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (SAM; 1.62Å), S-adenosylhomocysteine (SAH; 1.55Å) and Sinefungin (SFG; 1.41Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.
{"title":"High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development.","authors":"Aneel Aggarwal, Jithesh Kottur","doi":"10.21203/rs.3.rs-1370473/v1","DOIUrl":"10.21203/rs.3.rs-1370473/v1","url":null,"abstract":"<p><p>Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core bound to S-adenosylmethionine (SAM; 1.62Å), S-adenosylhomocysteine (SAH; 1.55Å) and Sinefungin (SFG; 1.41Å). We identify features of the methyltransferase core that are crucial for the development of antivirals and show SAH as the best scaffold for the design of antivirals against SARS-CoV-2 and other pathogenic coronaviruses.</p>","PeriodicalId":53798,"journal":{"name":"Sophia-Educacion","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74252798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-03DOI: 10.1007/s11841-021-00893-x
G. Rae
{"title":"The Ethical Self in the Later Foucault: the Question of Normativity","authors":"G. Rae","doi":"10.1007/s11841-021-00893-x","DOIUrl":"https://doi.org/10.1007/s11841-021-00893-x","url":null,"abstract":"","PeriodicalId":53798,"journal":{"name":"Sophia-Educacion","volume":"62 1","pages":"381-403"},"PeriodicalIF":0.1,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45114475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1007/s11841-022-00902-7
A. Kopka
{"title":"Air Democracy: on the Principles of Breathing Together","authors":"A. Kopka","doi":"10.1007/s11841-022-00902-7","DOIUrl":"https://doi.org/10.1007/s11841-022-00902-7","url":null,"abstract":"","PeriodicalId":53798,"journal":{"name":"Sophia-Educacion","volume":"61 1","pages":"135 - 149"},"PeriodicalIF":0.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46794197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号