{"title":"Neutrosophic G -modules","authors":"Kemale Veliyeva ?","doi":"10.29228/proc.75","DOIUrl":"https://doi.org/10.29228/proc.75","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.Alibayova S Rustamova Akhundova Mustafayev-I.Huseynova
Angiotensin-converting enzyme (ACE) is a key enzyme of the renin-angiotensin-aldosterone system (RAAS), which is directly involved in the regulation of blood pressure. It is assumed that the insertion/deletion (I/D) polymorphism of the gene of this enzyme (ACE gene) appears due to the presence/absence of ~ 287 bp Alu repeats in the 16 intron and is associated with the risk of the development of some diseases, including cardiovascular diseases, various kinds of mental disorders, Alzheimer's disease, gestational diabetes, etc. Given the lack of data on ACE gene I/D polymorphism for the Azerbaijan population, we studied polymorphism of this gene by PCR, using sequence specific pairs of primers (Hace3s and Hace3as (I), ACE-F and ACE-R (II)). DNA samples isolated from 346 individuals were divided into 4 groups: (1) patients with various mental disorders (90 patients); (2) a group of young students involved in various sports (84 male persons); (3) patients with diabetes (28 patients with I type DM (3A subgroup) and 72 patients with II type DM (3B subgroup); (4) a group of conditionally healthy people of different ages and specialties (72 persons, control). Based on the results of PCR of both primer pairs, the following genotypes were obtained: 16 individuals with genotype II (4.6%, homozygous co-dominants for the I-allele), 101 individuals with genotype DD (29.2%, homozygous co-dominants for the D-allele) and 228 individuals with genotype ID (66.2%, heterozygotes for both alleles). The frequency of occurrence was: fI=0.373, fD=0.627, ND:NI=1.681. The ratio of separate genotypes within the studied population: ID:DD=2.173; ID:II=14.125; DD:II=6.500. Comparison of the values of the dominant model for the allele D (DD+ID)/II=20.625 and the recessive model DD/(ID+II)=0.430 relative to the dominant model for the allele I (II+ID)/DD=1.152 and the recessive model II/(ID+DD)=0.048 indicates that in both models the probability of the D allele to associate with any particular trait is higher than that of the I allele (17.904 and 8.958 times, respectively). These results confirm the literature data on the association of the D allele with many pathologies or diseases. The analysis of the obtained data also revealed a significant correlation (p≤0.01) of the studied features from the D allele both within groups and between groups.
{"title":"Angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism in Azerbaijan population","authors":"G.Alibayova S Rustamova Akhundova Mustafayev-I.Huseynova","doi":"10.29228/PROC.76","DOIUrl":"https://doi.org/10.29228/PROC.76","url":null,"abstract":"Angiotensin-converting enzyme (ACE) is a key enzyme of the renin-angiotensin-aldosterone system (RAAS), which is directly involved in the regulation of blood pressure. It is assumed that the insertion/deletion (I/D) polymorphism of the gene of this enzyme (ACE gene) appears due to the presence/absence of ~ 287 bp Alu repeats in the 16 intron and is associated with the risk of the development of some diseases, including cardiovascular diseases, various kinds of mental disorders, Alzheimer's disease, gestational diabetes, etc. Given the lack of data on ACE gene I/D polymorphism for the Azerbaijan population, we studied polymorphism of this gene by PCR, using sequence specific pairs of primers (Hace3s and Hace3as (I), ACE-F and ACE-R (II)). DNA samples isolated from 346 individuals were divided into 4 groups: (1) patients with various mental disorders (90 patients); (2) a group of young students involved in various sports (84 male persons); (3) patients with diabetes (28 patients with I type DM (3A subgroup) and 72 patients with II type DM (3B subgroup); (4) a group of conditionally healthy people of different ages and specialties (72 persons, control). Based on the results of PCR of both primer pairs, the following genotypes were obtained: 16 individuals with genotype II (4.6%, homozygous co-dominants for the I-allele), 101 individuals with genotype DD (29.2%, homozygous co-dominants for the D-allele) and 228 individuals with genotype ID (66.2%, heterozygotes for both alleles). The frequency of occurrence was: fI=0.373, fD=0.627, ND:NI=1.681. The ratio of separate genotypes within the studied population: ID:DD=2.173; ID:II=14.125; DD:II=6.500. Comparison of the values of the dominant model for the allele D (DD+ID)/II=20.625 and the recessive model DD/(ID+II)=0.430 relative to the dominant model for the allele I (II+ID)/DD=1.152 and the recessive model II/(ID+DD)=0.048 indicates that in both models the probability of the D allele to associate with any particular trait is higher than that of the I allele (17.904 and 8.958 times, respectively). These results confirm the literature data on the association of the D allele with many pathologies or diseases. The analysis of the obtained data also revealed a significant correlation (p≤0.01) of the studied features from the D allele both within groups and between groups.","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
COVID-19 as a public health concern of the world has spread worldwide and a combination of vari-ous methods including tomography imaging, reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA) and cell culturing were developed to detect and identify SARS-CoV-2. Due to the absence of specific antiviral agents or vaccines for COVID-19 treat-ment, early detection and identification are vital. An alternative, sensitive, fast point-of-care (POC) detection tool that can be routinely used by health care providers utilizing biological fluids as a specimen before starting an emergency process is desired. Efforts are underway to develop more effective diagnostic and surveillance technologies with loop-mediated isothermal amplification (LAMP) tests, antibody testing and microfluidic RT-PCR devices (Lab-on-a-chip). Point-of-care diagnostics are promising candidates in SARS-Cov-2 detection and encourage scientists to improve their technologies beyond conception. The reverse transcription LAMP (RT-LAMP) method developed for SARS-CoV-2 could detect the virus even in saliva samples in less than an hour (Harapan et al., 2020). Lab-on-a-chip devices contain a small size chip, microchannel, microelectrodes and microheater. Cell ly-sis, DNA extraction and PCR amplification stages could be integrated on these microchips (Sharma et al., 2020). Because of the rapid detection, small volume of the specimen and integration with PCR in a portable tiny system, these devices are promising for SARS-CoV-2 detection (Huang et al., 2018). The validity and sensitivity of all the above-mentioned methods need to be improved for salivary specimen usage; in case of improvement, they might provide an opportunity for salivary detection of the virus without a waiting period and complex analytical infrastructure.
COVID-19作为全球公共卫生问题已在全球范围内蔓延，并开发了多种方法，包括断层扫描成像、逆转录聚合酶链反应(RT-PCR)、酶联免疫吸附试验(ELISA)和细胞培养，以检测和鉴定SARS-CoV-2。由于缺乏治疗COVID-19的特异性抗病毒药物或疫苗，因此早期发现和识别至关重要。需要一种替代的、灵敏的、快速的即时检测工具，这种工具可以在开始紧急处理之前由卫生保健提供者常规使用，利用生物液体作为标本。人们正在努力开发更有效的诊断和监测技术，包括环介导的等温扩增(LAMP)测试、抗体测试和微流控RT-PCR设备(芯片实验室)。即时诊断是检测SARS-Cov-2的有希望的候选方法，并鼓励科学家在概念之外改进他们的技术。针对SARS-CoV-2开发的逆转录LAMP (RT-LAMP)方法甚至可以在不到一小时的时间内从唾液样本中检测到该病毒(Harapan et al.， 2020)。芯片实验室设备包含小尺寸芯片、微通道、微电极和微加热器。细胞裂解、DNA提取和PCR扩增阶段可以集成在这些微芯片上(Sharma et al.， 2020)。由于检测速度快，样品体积小，并且在便携式微型系统中与PCR相结合，这些设备有望用于SARS-CoV-2检测(Huang et al.， 2018)。上述方法的有效性和敏感性有待进一步提高;在改进的情况下，它们可能为唾液检测病毒提供机会，而无需等待时间和复杂的分析基础设施。
{"title":"Rapid and simple detection of SARS-CoV-2 with point-of-care COVID-19 testing","authors":"A. Eftekhari, A. Nasibova, R. Khalilov","doi":"10.29228/PROC.78","DOIUrl":"https://doi.org/10.29228/PROC.78","url":null,"abstract":"COVID-19 as a public health concern of the world has spread worldwide and a combination of vari-ous methods including tomography imaging, reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA) and cell culturing were developed to detect and identify SARS-CoV-2. Due to the absence of specific antiviral agents or vaccines for COVID-19 treat-ment, early detection and identification are vital. An alternative, sensitive, fast point-of-care (POC) detection tool that can be routinely used by health care providers utilizing biological fluids as a specimen before starting an emergency process is desired. Efforts are underway to develop more effective diagnostic and surveillance technologies with loop-mediated isothermal amplification (LAMP) tests, antibody testing and microfluidic RT-PCR devices (Lab-on-a-chip). Point-of-care diagnostics are promising candidates in SARS-Cov-2 detection and encourage scientists to improve their technologies beyond conception. The reverse transcription LAMP (RT-LAMP) method developed for SARS-CoV-2 could detect the virus even in saliva samples in less than an hour (Harapan et al., 2020). Lab-on-a-chip devices contain a small size chip, microchannel, microelectrodes and microheater. Cell ly-sis, DNA extraction and PCR amplification stages could be integrated on these microchips (Sharma et al., 2020). Because of the rapid detection, small volume of the specimen and integration with PCR in a portable tiny system, these devices are promising for SARS-CoV-2 detection (Huang et al., 2018). The validity and sensitivity of all the above-mentioned methods need to be improved for salivary specimen usage; in case of improvement, they might provide an opportunity for salivary detection of the virus without a waiting period and complex analytical infrastructure.","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main goal of the work was to study immunomodulating and strengthening plants in the flora of Azerbaijan. The frequency of use (Ui) and the value of plant species relative to each other due to their immunomodulatory properties have been evaluated by new methods. The total amount of data submitted by the person providing for each specific species is marked as Ni. The result of the ratio of immunomodulators have been shown in the diagram: the highest IQ (assessment of use) was found for Allium sp. and Thymus sp. (0.90-0.88), the next places are occupied by Rosa sp. (0.83), Salvia limbata (0.81), Altheae officinalis (0.80), Glycyrrhiza glabra (0.78), Mathricaria sp. (0.77), Humulus lupulus (0.74), Mentha sp. (0.60), Sitrus ssp. (0.27), Capsella burssa pastoris (0.21), Rumex sp. (0.18), Sambucus nigra and Helichrysum plicatum (each by 0.15), Daucus carota, Urtica dioica and Asparagus officinalis (each by 0.10, the lowest IQ).
{"title":"Immune strengthener plants in Azerbaijan flora","authors":"S. Ibadullayeva, N. Agayeva","doi":"10.29228/PROC.83","DOIUrl":"https://doi.org/10.29228/PROC.83","url":null,"abstract":"The main goal of the work was to study immunomodulating and strengthening plants in the flora of Azerbaijan. The frequency of use (Ui) and the value of plant species relative to each other due to their immunomodulatory properties have been evaluated by new methods. The total amount of data submitted by the person providing for each specific species is marked as Ni. The result of the ratio of immunomodulators have been shown in the diagram: the highest IQ (assessment of use) was found for Allium sp. and Thymus sp. (0.90-0.88), the next places are occupied by Rosa sp. (0.83), Salvia limbata (0.81), Altheae officinalis (0.80), Glycyrrhiza glabra (0.78), Mathricaria sp. (0.77), Humulus lupulus (0.74), Mentha sp. (0.60), Sitrus ssp. (0.27), Capsella burssa pastoris (0.21), Rumex sp. (0.18), Sambucus nigra and Helichrysum plicatum (each by 0.15), Daucus carota, Urtica dioica and Asparagus officinalis (each by 0.10, the lowest IQ).","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"40 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A possible method of inhibition of virus COVID-19 reproduction through induction of intra-cellular synthesis and upregulation of interferon I","authors":"A. Mekhtiev","doi":"10.29228/PROC.84","DOIUrl":"https://doi.org/10.29228/PROC.84","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the uniform convergence of Fourier series expansions in the system of eigenfunctions of the equation of a vibrating rod at one end of which the mass is concentrated","authors":"Abderrahim Guerfi-Abdelouaheb Ardjouni","doi":"10.29228/proc.30","DOIUrl":"https://doi.org/10.29228/proc.30","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uniform convergence of the Fourier series expansions in the subsystems of root functions of some spectral problem for ordinary differential equations of fourth order","authors":"K. Abdullayeva","doi":"10.29228/proc.39","DOIUrl":"https://doi.org/10.29228/proc.39","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. M. Cavadova, G. Dadashova, M. N. Azimova, N. N. Qabiyeva
{"title":"Clinical features and characteristics of myocardial injure in COVID-19 (data from multicenter studies)","authors":"T. M. Cavadova, G. Dadashova, M. N. Azimova, N. N. Qabiyeva","doi":"10.29228/PROC.80","DOIUrl":"https://doi.org/10.29228/PROC.80","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"http://trans.imm.az/volumes/40-1/4001-04.pdf","authors":"Akbar B. Aliev? · Samira O. Rustamova","doi":"10.29228/proc.60","DOIUrl":"https://doi.org/10.29228/proc.60","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Some general families of the Hurwitz-Lerch zeta functions and their applications: recent developments and directions for further researches","authors":"H. M. Srivastava","doi":"10.29228/proc.7","DOIUrl":"https://doi.org/10.29228/proc.7","url":null,"abstract":"","PeriodicalId":54068,"journal":{"name":"Proceedings of the Institute of Mathematics and Mechanics","volume":"1 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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