首页 > 最新文献

Pulmonology最新文献

英文 中文
Infections in lung transplanted patients: A review 肺移植患者的感染:综述。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2022.04.010
M. Dettori , N. Riccardi , D. Canetti , R.M. Antonello , A.F. Piana , A. Palmieri , P. Castiglia , A.A. Azara , M.D. Masia , A. Porcu , G.C. Ginesu , M.L. Cossu , M. Conti , P. Pirina , A. Fois , I. Maida , G. Madeddu , S. Babudieri , L. Saderi , G. Sotgiu

Lung transplantation can improve the survival of patients with severe chronic pulmonary disorders. However, the short- and long-term risk of infections can increase morbidity and mortality rates.

A non-systematic review was performed to provide the most updated information on pathogen, host, and environment-related factors associated with the occurrence of bacterial, fungal, and viral infections as well as the most appropriate therapeutic options.

Bacterial infections account for about 50% of all infectious diseases in lung transplanted patients, while viruses represent the second cause of infection accounting for one third of all infections.

Almost 10% of patients develop invasive fungal infections during the first year after lung transplant. Pre-transplantation comorbidities, disruption of physical barriers during the surgery, and exposure to nosocomial pathogens during the hospital stay are directly associated with the occurrence of life-threatening infections.

Empiric antimicrobial treatment after the assessment of individual risk factors, local epidemiology of drug-resistant pathogens and possible drug-drug interactions can improve the clinical outcomes.

肺移植可以改善严重慢性肺部疾病患者的生存状况。然而,短期和长期的感染风险会增加发病率和死亡率。为了提供与细菌、真菌和病毒感染发生相关的病原体、宿主和环境因素的最新信息以及最合适的治疗方案,我们进行了一项非系统性综述。细菌感染约占肺移植患者所有感染性疾病的 50%,而病毒是第二大感染原因,占所有感染的三分之一。近 10% 的患者在肺移植后第一年内会出现侵袭性真菌感染。移植前的合并症、手术过程中物理屏障的破坏以及住院期间接触到的院内病原体与危及生命的感染的发生直接相关。在对个体风险因素、当地耐药病原体流行病学和可能的药物相互作用进行评估后,进行经验性抗菌治疗可改善临床效果。
{"title":"Infections in lung transplanted patients: A review","authors":"M. Dettori ,&nbsp;N. Riccardi ,&nbsp;D. Canetti ,&nbsp;R.M. Antonello ,&nbsp;A.F. Piana ,&nbsp;A. Palmieri ,&nbsp;P. Castiglia ,&nbsp;A.A. Azara ,&nbsp;M.D. Masia ,&nbsp;A. Porcu ,&nbsp;G.C. Ginesu ,&nbsp;M.L. Cossu ,&nbsp;M. Conti ,&nbsp;P. Pirina ,&nbsp;A. Fois ,&nbsp;I. Maida ,&nbsp;G. Madeddu ,&nbsp;S. Babudieri ,&nbsp;L. Saderi ,&nbsp;G. Sotgiu","doi":"10.1016/j.pulmoe.2022.04.010","DOIUrl":"10.1016/j.pulmoe.2022.04.010","url":null,"abstract":"<div><p>Lung transplantation can improve the survival of patients with severe chronic pulmonary disorders. However, the short- and long-term risk of infections can increase morbidity and mortality rates.</p><p>A non-systematic review was performed to provide the most updated information on pathogen, host, and environment-related factors associated with the occurrence of bacterial, fungal, and viral infections as well as the most appropriate therapeutic options.</p><p>Bacterial infections account for about 50% of all infectious diseases in lung transplanted patients, while viruses represent the second cause of infection accounting for one third of all infections.</p><p>Almost 10% of patients develop invasive fungal infections during the first year after lung transplant. Pre-transplantation comorbidities, disruption of physical barriers during the surgery, and exposure to nosocomial pathogens during the hospital stay are directly associated with the occurrence of life-threatening infections.</p><p>Empiric antimicrobial treatment after the assessment of individual risk factors, local epidemiology of drug-resistant pathogens and possible drug-drug interactions can improve the clinical outcomes.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 287-304"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722001180/pdfft?md5=3e964f561e772a66bc30323b785dbdee&pid=1-s2.0-S2531043722001180-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86194654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A contribution towards a world without tobacco – The TabacoPed study 对一个没有烟草的世界的贡献——TabacoPed研究。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2023.08.004
A. Gama da Silva , C. Constant , S. Madeira , A.R. Sousa , T. Bandeira
{"title":"A contribution towards a world without tobacco – The TabacoPed study","authors":"A. Gama da Silva ,&nbsp;C. Constant ,&nbsp;S. Madeira ,&nbsp;A.R. Sousa ,&nbsp;T. Bandeira","doi":"10.1016/j.pulmoe.2023.08.004","DOIUrl":"10.1016/j.pulmoe.2023.08.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 307-309"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001575/pdfft?md5=d6f4dc98df146a1c845a9201c6421aea&pid=1-s2.0-S2531043723001575-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of pulmonary hypertension in COPD patients living at high altitude 生活在高海拔地区的慢性阻塞性肺疾病患者肺动脉高压的患病率。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2021.12.006
C. Aguirre-Franco , CA. Torres-Duque , G. Salazar , A. Casas , C. Jaramillo , M. Gonzalez-Garcia

Background

Pulmonary hypertension (PH) is associated with poor prognosis for patients with chronic obstructive pulmonary disease (COPD). Most of the knowledge about PH in COPD has been generated at sea level, with limited information associated with high altitude (HA).

Objectives

To assess the prevalence and severity of PH in COPD patients living in a HA city (2,640 m).

Methods

Cross-sectional study in COPD patients with forced expiratory volume in the first second / forced vital capacity ratio (FEV1/FVC) post-bronchodilator <0,7. Transthoracic echocardiography (TTE), spirometry, carbon monoxide diffusing capacity, and arterial blood gasses tests were performed. Patients were classified according to the severity of airflow limitation. PH was defined by TTE as an estimated systolic pulmonary artery pressure (sPAP) > 36 mmHg or indirect PH signs; severe PH as sPAP > 60 mmHg; and disproportionate PH as an sPAP > 60 mmHg with non-severe airflow limitation (FEV1 > 50% predicted).

Results

We included 176 COPD patients. The overall estimated prevalence of PH was 56.3% and the likelihood of having PH increased according to airflow-limitation severity: mild (31.6%), moderate (54.9%), severe (59.6%) and very severe (77.8%) (p = 0.038). The PH was severe in 7.3% and disproportionate in 3.4% of patients.

Conclusions

The estimated prevalence of PH in patients with COPD at HA is high, particularly in patients with mild to moderate airflow limitation, and greater than that described for COPD patients at low altitude. These results suggest a higher risk of developing PH for COPD patients living at HA compared to COPD patients with similar airflow limitation living at low altitude.

背景:肺动脉高压(PH)与慢性阻塞性肺疾病(COPD)患者的不良预后有关。有关慢性阻塞性肺疾病(COPD)肺动脉高压的大部分知识都是在海平面上获得的,与高海拔地区(HA)相关的信息非常有限:评估居住在高海拔城市(海拔 2,640 米)的慢性阻塞性肺疾病患者 PH 的患病率和严重程度:方法:对第一秒用力呼气容积/用力生命容量比(FEV1/FVC)在支气管舒张后为 36 mmHg 或有间接 PH 征兆的慢性阻塞性肺病患者进行横断面研究;严重 PH 指 sPAP > 60 mmHg;不相称 PH 指 sPAP > 60 mmHg 但气流受限不严重(FEV1 > 50%预测值):我们共纳入了 176 名慢性阻塞性肺病患者。据估计,PH 的总患病率为 56.3%,根据气流受限严重程度的不同,PH 的患病率也有所上升:轻度(31.6%)、中度(54.9%)、重度(59.6%)和极重度(77.8%)(P = 0.038)。7.3%的患者PH值为重度,3.4%的患者PH值不成比例:结论:在高海拔地区的慢性阻塞性肺病患者中,尤其是轻度至中度气流受限的患者中,PH 的估计发病率较高,且高于低海拔地区慢性阻塞性肺病患者的发病率。这些结果表明,与生活在低海拔地区、气流受限程度相似的慢性阻塞性肺病患者相比,生活在医管局的慢性阻塞性肺病患者患 PH 的风险更高。
{"title":"Prevalence of pulmonary hypertension in COPD patients living at high altitude","authors":"C. Aguirre-Franco ,&nbsp;CA. Torres-Duque ,&nbsp;G. Salazar ,&nbsp;A. Casas ,&nbsp;C. Jaramillo ,&nbsp;M. Gonzalez-Garcia","doi":"10.1016/j.pulmoe.2021.12.006","DOIUrl":"10.1016/j.pulmoe.2021.12.006","url":null,"abstract":"<div><h3>Background</h3><p>Pulmonary hypertension (PH) is associated with poor prognosis for patients with chronic obstructive pulmonary disease (COPD). Most of the knowledge about PH in COPD has been generated at sea level, with limited information associated with high altitude (HA).</p></div><div><h3>Objectives</h3><p>To assess the prevalence and severity of PH in COPD patients living in a HA city (2,640 m).</p></div><div><h3>Methods</h3><p>Cross-sectional study in COPD patients with forced expiratory volume in the first second / forced vital capacity ratio (FEV<sub>1</sub>/FVC) post-bronchodilator &lt;0,7. Transthoracic echocardiography (TTE), spirometry, carbon monoxide diffusing capacity, and arterial blood gasses tests were performed. Patients were classified according to the severity of airflow limitation. PH was defined by TTE as an estimated systolic pulmonary artery pressure (sPAP) &gt; 36 mmHg or indirect PH signs; severe PH as sPAP &gt; 60 mmHg; and disproportionate PH as an sPAP &gt; 60 mmHg with non-severe airflow limitation (FEV<sub>1</sub> &gt; 50% predicted).</p></div><div><h3>Results</h3><p>We included 176 COPD patients. The overall estimated prevalence of PH was 56.3% and the likelihood of having PH increased according to airflow-limitation severity: mild (31.6%), moderate (54.9%), severe (59.6%) and very severe (77.8%) (<em>p</em> = 0.038). The PH was severe in 7.3% and disproportionate in 3.4% of patients.</p></div><div><h3>Conclusions</h3><p>The estimated prevalence of PH in patients with COPD at HA is high, particularly in patients with mild to moderate airflow limitation, and greater than that described for COPD patients at low altitude. These results suggest a higher risk of developing PH for COPD patients living at HA compared to COPD patients with similar airflow limitation living at low altitude.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 247-253"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000046/pdfft?md5=685dbc48802c7fba0677dc8269435514&pid=1-s2.0-S2531043722000046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise capacity, lung and respiratory muscle function in substance use disorders 药物使用失调症患者的运动能力、肺功能和呼吸肌功能。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2021.12.009
R. Mustafaoglu , A. Gorek Dilektaslı , R. Demir , E. Zirek , T. Birinci , E. Kaya Mutlu , C. Evren , A. Razak Ozdincler

Background

Substance use disorder (SUD) causes conditions such as cognitive and behavioral disorders, anxiety, depression, and social isolation it also causes acute airway inflammation by affecting airway bronchial dynamics. The current study aimed to investigate the lung function, respiratory muscle strength, and exercise capacity in patients with SUD.

Methods

One hundred-eighty three patients with SUD, a total of 119 healthy controls, 54 of whom were cigarette smokers and 65 of whom were non-smokers were included in the study. Spirometric tests, respiratory muscle strength (MIP and MEP), and the 6-Minute Walk Test (6-MWT) were assessed. The III National Health and Nutrition Examination Survey were used to evaluate respiratory symptoms in patients with SUD and cigarette smokers.

Results

86.3% of the SUD patients included in the study were using heroin, 9.2% were cannabis, and 5.5% were spice. The most common symptom in both SUD patients and cigarette smokers was shortness of breath, wheezing, and sputum production. After post-hoc tests, the FVC (p = 0.002), FVC (%predicted) (p < 0.0001), FEV1 (p = 0.002), FEV1 (%predicted) (p < 0.0001), FEV1/FVC (%) (p < 0.0001), PEF (p < 0.0001) and FEF%25-75 (p < 0.0001) lung function parameters were significantly lower in SUD patients than non-smokers. In addition, it was found that MIP (p < 0.0001), MIP (%predicted) (p < 0.0001), MEP (p < 0.0001), and MEP (%predicted) (p < 0.0001) values of SUD patients were significantly lower than non-smokers.

Conclusion

The study findings indicate that substance use has an effect on lung functions and the most commonly reported symptoms are shortness of breath, wheezing, and sputum production. In addition, respiratory muscle strength and exercise capacity were decreased in SUD patients compared to non-smokers.

背景:物质使用障碍(SUD)会导致认知和行为障碍、焦虑、抑郁和社会隔离等症状,还会通过影响气道支气管动力学而引起急性气道炎症。本研究旨在调查 SUD 患者的肺功能、呼吸肌强度和运动能力:研究纳入了 183 名 SUD 患者和 119 名健康对照者,其中 54 人为吸烟者,65 人为非吸烟者。研究人员对肺活量测试、呼吸肌力量(MIP 和 MEP)以及 6 分钟步行测试(6-MWT)进行了评估。第三次全国健康与营养调查用于评估 SUD 患者和吸烟者的呼吸道症状:86.3%的 SUD 患者吸食海洛因,9.2%吸食大麻,5.5%吸食香料。吸毒成瘾患者和吸烟者最常见的症状都是气短、喘息和痰多。经过事后检验,FVC (p = 0.002)、FVC (%predicted) (p 1 (p = 0.002)、FEV1 (%predicted) (p 1/FVC (%) (p %25-75 (p 结论:研究结果表明,药物使用对肺功能有影响,最常报告的症状是气短、喘息和痰多。此外,与非吸烟者相比,吸食成瘾患者的呼吸肌强度和运动能力均有所下降。
{"title":"Exercise capacity, lung and respiratory muscle function in substance use disorders","authors":"R. Mustafaoglu ,&nbsp;A. Gorek Dilektaslı ,&nbsp;R. Demir ,&nbsp;E. Zirek ,&nbsp;T. Birinci ,&nbsp;E. Kaya Mutlu ,&nbsp;C. Evren ,&nbsp;A. Razak Ozdincler","doi":"10.1016/j.pulmoe.2021.12.009","DOIUrl":"10.1016/j.pulmoe.2021.12.009","url":null,"abstract":"<div><h3>Background</h3><p>Substance use disorder (SUD) causes conditions such as cognitive and behavioral disorders, anxiety, depression, and social isolation it also causes acute airway inflammation by affecting airway bronchial dynamics. The current study aimed to investigate the lung function, respiratory muscle strength, and exercise capacity in patients with SUD.</p></div><div><h3>Methods</h3><p>One hundred-eighty three patients with SUD, a total of 119 healthy controls, 54 of whom were cigarette smokers and 65 of whom were non-smokers were included in the study. <strong>S</strong>pirometric tests, respiratory muscle strength (MIP and MEP), and the 6-Minute Walk Test (6-MWT) were assessed. The III National Health and Nutrition Examination Survey were used to evaluate respiratory symptoms in patients with SUD and cigarette smokers.</p></div><div><h3>Results</h3><p>86.3% of the SUD patients included in the study were using heroin, 9.2% were cannabis, and 5.5% were spice. The most common symptom in both SUD patients and cigarette smokers was shortness of breath, wheezing, and sputum production. After post-hoc tests, the FVC (<em>p</em> = 0.002), FVC (%predicted) (<em>p</em> &lt; 0.0001), FEV<sub>1</sub> (<em>p =</em> 0.002), FEV1 (%predicted) (<em>p &lt;</em> 0.0001), FEV<sub>1</sub>/FVC (%) (<em>p &lt;</em> 0.0001), PEF (<em>p &lt;</em> 0.0001) and FEF<sub>%25-75</sub> (<em>p &lt;</em> 0.0001) lung function parameters were significantly lower in SUD patients than non-smokers. In addition, it was found that MIP (<em>p &lt;</em> 0.0001), MIP (%predicted) (<em>p &lt;</em> 0.0001), MEP (<em>p &lt;</em> 0.0001), and MEP (%predicted) (<em>p &lt;</em> 0.0001) values of SUD patients were significantly lower than non-smokers.</p></div><div><h3>Conclusion</h3><p>The study findings indicate that substance use has an effect on lung functions and the most commonly reported symptoms are shortness of breath, wheezing, and sputum production. In addition, respiratory muscle strength and exercise capacity were decreased in SUD patients compared to non-smokers.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 254-264"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S253104372200006X/pdfft?md5=4a187dbf14500f064e3cbd9cc3870cf6&pid=1-s2.0-S253104372200006X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking the hidden threat: COPD awareness and knowledge in Portugal 揭开隐藏威胁的面纱:葡萄牙人对慢性阻塞性肺病的认识和知识 葡萄牙人对慢性阻塞性肺病的认识和知识研究
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2023.11.005
Ana Sofia Oliveira , Nuno Cortesão , Joana Gomes , Paula Pinto , Teresa Shiang , Tiago Alfaro , Cidália Rodrigues , Luís Ferreira , Ana Barros , António Morais
{"title":"Unmasking the hidden threat: COPD awareness and knowledge in Portugal","authors":"Ana Sofia Oliveira ,&nbsp;Nuno Cortesão ,&nbsp;Joana Gomes ,&nbsp;Paula Pinto ,&nbsp;Teresa Shiang ,&nbsp;Tiago Alfaro ,&nbsp;Cidália Rodrigues ,&nbsp;Luís Ferreira ,&nbsp;Ana Barros ,&nbsp;António Morais","doi":"10.1016/j.pulmoe.2023.11.005","DOIUrl":"10.1016/j.pulmoe.2023.11.005","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 207-209"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723002039/pdfft?md5=2ce5a8fe8a0972923e0f84ad020a6775&pid=1-s2.0-S2531043723002039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139422571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between respiratory distress time and invasive mechanical ventilation in COVID-19 patients: A multicentre regional cohort study COVID-19 患者呼吸窘迫时间与有创机械通气之间的关系:一项多中心地区队列研究。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2022.03.004
S. Busani , I. Coloretti , M. Baciarello , V. Bellini , M. Sarti , E. Biagioni , R. Tonelli , A. Marchioni , E. Clini , G. Guaraldi , C. Mussini , M. Meschiari , T. Tonetti , L. Pisani , S. Nava , E. Bignami , M.V. Ranieri , M. Girardis

Aim

To determine whether the duration of respiratory distress symptoms in severe COVID-19 pneumonia affects the need for invasive mechanical ventilation and clinical outcomes.

Materials and methods

An observational multicentre cohort study of patients hospitalised in five COVID-19–designated ICUs of the University Hospitals of Emilia-Romagna Region. Patients included were adults with pneumonia due to SARS-CoV-2 with PaO₂/FiO₂ ratio <300 mmHg, respiratory distress symptoms, and need for mechanical ventilation (invasive or non-invasive). Exclusion criteria were an uncertain time of respiratory distress, end-of-life decision, and mechanical respiratory support before hospital admission.

Measurements and main results

We analysed 171 patients stratified into tertiles according to respiratory distress duration (distress time, DT) before application of mechanical ventilation support. The rate of patients requiring invasive mechanical ventilation was significantly different (p < 0.001) among the tertiles: 17/57 patients in the shortest duration, 29/57 in the intermediate duration, and 40/57 in the longest duration. The respiratory distress time significantly increased the risk of invasive ventilation in the univariate analysis (OR 5.5 [CI 2.48–12.35], p = 0.003). Multivariable regression analysis confirmed this association (OR 10.7 [CI 2.89–39.41], p < 0.001). Clinical outcomes (mortality and hospital stay) did not show significant differences between DT tertiles.

Discussion

Albeit preliminary and retrospective, our data raised the hypothesis that the duration of respiratory distress symptoms may play a role in COVID-19 patients’ need for invasive mechanical ventilation. Furthermore, our observations suggested that specific strategies may be directed towards identifying and managing early symptoms of respiratory distress, regardless of the levels of hypoxemia and the severity of the dyspnoea itself.

目的:确定重症 COVID-19 肺炎患者呼吸窘迫症状的持续时间是否会影响有创机械通气的需求和临床结果:对艾米利亚-罗马涅大区大学医院五家 COVID-19 指定重症监护病房的住院患者进行多中心队列观察研究。研究对象为因 SARS-CoV-2 感染肺炎且 PaO₂/FiO₂比值正常的成人患者:我们对 171 名患者进行了分析,根据患者使用机械通气支持前的呼吸窘迫持续时间(窘迫时间,DT)进行了分层。需要有创机械通气的患者比例存在显著差异(P 讨论):尽管是初步和回顾性的,但我们的数据提出了一个假设,即呼吸窘迫症状的持续时间可能会影响 COVID-19 患者对有创机械通气的需求。此外,我们的观察结果表明,无论低氧血症程度和呼吸困难本身的严重程度如何,都可以采取特定的策略来识别和处理早期呼吸窘迫症状。
{"title":"Association between respiratory distress time and invasive mechanical ventilation in COVID-19 patients: A multicentre regional cohort study","authors":"S. Busani ,&nbsp;I. Coloretti ,&nbsp;M. Baciarello ,&nbsp;V. Bellini ,&nbsp;M. Sarti ,&nbsp;E. Biagioni ,&nbsp;R. Tonelli ,&nbsp;A. Marchioni ,&nbsp;E. Clini ,&nbsp;G. Guaraldi ,&nbsp;C. Mussini ,&nbsp;M. Meschiari ,&nbsp;T. Tonetti ,&nbsp;L. Pisani ,&nbsp;S. Nava ,&nbsp;E. Bignami ,&nbsp;M.V. Ranieri ,&nbsp;M. Girardis","doi":"10.1016/j.pulmoe.2022.03.004","DOIUrl":"10.1016/j.pulmoe.2022.03.004","url":null,"abstract":"<div><h3>Aim</h3><p>To determine whether the duration of respiratory distress symptoms in severe COVID-19 pneumonia affects the need for invasive mechanical ventilation and clinical outcomes.</p></div><div><h3>Materials and methods</h3><p>An observational multicentre cohort study of patients hospitalised in five COVID-19–designated ICUs of the University Hospitals of Emilia-Romagna Region. Patients included were adults with pneumonia due to SARS-CoV-2 with PaO₂/FiO₂ ratio &lt;300 mmHg, respiratory distress symptoms, and need for mechanical ventilation (invasive or non-invasive). Exclusion criteria were an uncertain time of respiratory distress, end-of-life decision, and mechanical respiratory support before hospital admission.</p></div><div><h3>Measurements and main results</h3><p>We analysed 171 patients stratified into tertiles according to respiratory distress duration (distress time, DT) before application of mechanical ventilation support. The rate of patients requiring invasive mechanical ventilation was significantly different (<em>p</em> &lt; 0.001) among the tertiles: 17/57 patients in the shortest duration, 29/57 in the intermediate duration, and 40/57 in the longest duration. The respiratory distress time significantly increased the risk of invasive ventilation in the univariate analysis (OR 5.5 [CI 2.48–12.35], <em>p</em> = 0.003). Multivariable regression analysis confirmed this association (OR 10.7 [CI 2.89–39.41], <em>p</em> &lt; 0.001). Clinical outcomes (mortality and hospital stay) did not show significant differences between DT tertiles.</p></div><div><h3>Discussion</h3><p>Albeit preliminary and retrospective, our data raised the hypothesis that the duration of respiratory distress symptoms may play a role in COVID-19 patients’ need for invasive mechanical ventilation. Furthermore, our observations suggested that specific strategies may be directed towards identifying and managing early symptoms of respiratory distress, regardless of the levels of hypoxemia and the severity of the dyspnoea itself.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 282-286"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91191427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peri-Partum respiratory management in neuro-muscular disorders (IT-NEUMA-Pregn study): A proposal by an italian panel and a call for an international collaboration 神经肌肉疾病的产前呼吸管理(IT-NEUMA-Pregn 研究):意大利小组的建议和国际合作呼吁
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2023.02.006
F. Racca , Y. Longhitano , C. Zanza , G. Draisci , P.A. Stoia , E. Gollo , M. Maio , C. Grattarola , M. Astuto , R. Vaschetto , V.A.M. Sansone , G. Conti , C. Gregoretti
{"title":"Peri-Partum respiratory management in neuro-muscular disorders (IT-NEUMA-Pregn study): A proposal by an italian panel and a call for an international collaboration","authors":"F. Racca ,&nbsp;Y. Longhitano ,&nbsp;C. Zanza ,&nbsp;G. Draisci ,&nbsp;P.A. Stoia ,&nbsp;E. Gollo ,&nbsp;M. Maio ,&nbsp;C. Grattarola ,&nbsp;M. Astuto ,&nbsp;R. Vaschetto ,&nbsp;V.A.M. Sansone ,&nbsp;G. Conti ,&nbsp;C. Gregoretti","doi":"10.1016/j.pulmoe.2023.02.006","DOIUrl":"10.1016/j.pulmoe.2023.02.006","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 210-213"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723000417/pdfft?md5=710b9391eb804592f6b6af30f4d221b5&pid=1-s2.0-S2531043723000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9444455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-dependent GOAL screening performance in adults at risk for obstructive sleep apnea 阻塞性睡眠呼吸暂停高危成人的 GOAL 筛查结果与性别有关。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2022.01.004
R.L.M. Duarte , F.J. Magalhães-da-Silveira , D. Gozal

Objective

To evaluate possible sex-related differences in the performance of the GOAL, a 4-item obstructive sleep apnea (OSA) screening instrument in adults.

Methods

Between July 2019 and June 2021, this cross-sectional study included consecutively recruited patients from one Brazilian sleep laboratory undergoing overnight polysomnography. Individuals with GOAL scores ≥ 2 of a maximum of 4 points are classified at high risk for OSA diagnosis. Actual OSA severity was based on the apnea-hypopnea index: ≥ 5.0/h as any OSA, ≥ 15.0/h as moderate-to-severe OSA, and ≥ 30.0/h as severe OSA. Performance of the GOAL instrument in women and men was assessed by the discriminatory ability (obtained from area under the curve [AUC]-Receiver Operating Characteristic curves) and 2×2 contingency tables.

Results

A total of 2,978 subjects (55.3% males) were evaluated. The frequency of GOAL-defined OSA high-risk was statistically higher in men when compared to women (p < 0.001). The GOAL predictive parameters for screening all severity OSA levels were as follows: in females, sensitivity ranging from 58.2% to 78.3% and specificity ranging from 60.0% to 77.6%, while in males, sensitivity ranging from 90.5% to 96.9% and specificity from 20.7% to 46.8%. The GOAL questionnaire had similar discriminatory properties, assessed by AUC, in women and in men: i) any OSA: 0.741 vs. 0.771 (p = 0.204), ii) moderate-to-severe OSA: 0.727 vs. 0.737 (p = 0.595), and iii) severe OSA: 0.728 vs. 0.703 (p = 0.240); respectively.

Conclusions

The GOAL instrument emerges as a useful tool for screening adult individuals and displays similar performance in both women and men.

目的评估 4 项阻塞性睡眠呼吸暂停(OSA)筛查工具 GOAL 在成人中可能存在的性别差异:在 2019 年 7 月至 2021 年 6 月期间,这项横断面研究纳入了巴西一家睡眠实验室连续招募的接受夜间多导睡眠图检查的患者。在最高 4 分中,GOAL 分数≥ 2 分者被列为 OSA 诊断的高危人群。实际的 OSA 严重程度基于呼吸暂停-低通气指数:≥ 5.0/h 为任何 OSA,≥ 15.0/h 为中重度 OSA,≥ 30.0/h 为重度 OSA。通过判别能力(根据曲线下面积[AUC]-受试者操作特征曲线得出)和2×2或然率表评估了GOAL工具在女性和男性中的表现:共有 2 978 名受试者(55.3% 为男性)接受了评估。与女性相比,GOAL定义的OSA高危人群中男性的比例更高(P < 0.001)。筛查所有严重程度 OSA 的 GOAL 预测参数如下:女性的灵敏度为 58.2% 至 78.3%,特异度为 60.0% 至 77.6%;男性的灵敏度为 90.5% 至 96.9%,特异度为 20.7% 至 46.8%。根据AUC评估,GOAL问卷在女性和男性中具有相似的判别特性:i) 任何OSA:0.741 vs. 0.771 (p = 0.204);ii) 中度至重度OSA:0.727 vs. 0.737 (p = 0.595);iii) 重度OSA:0.728 vs. 0.703 (p = 0.240);分别为0.741和0.771:GOAL工具是筛查成年人的有用工具,在女性和男性中的表现相似。
{"title":"Sex-dependent GOAL screening performance in adults at risk for obstructive sleep apnea","authors":"R.L.M. Duarte ,&nbsp;F.J. Magalhães-da-Silveira ,&nbsp;D. Gozal","doi":"10.1016/j.pulmoe.2022.01.004","DOIUrl":"10.1016/j.pulmoe.2022.01.004","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate possible sex-related differences in the performance of the GOAL, a 4-item obstructive sleep apnea (OSA) screening instrument in adults.</p></div><div><h3>Methods</h3><p>Between July 2019 and June 2021, this cross-sectional study included consecutively recruited patients from one Brazilian sleep laboratory undergoing overnight polysomnography. Individuals with GOAL scores ≥ 2 of a maximum of 4 points are classified at high risk for OSA diagnosis. Actual OSA severity was based on the apnea-hypopnea index: ≥ 5.0/h as any OSA, ≥ 15.0/h as moderate-to-severe OSA, and ≥ 30.0/h as severe OSA. Performance of the GOAL instrument in women and men was assessed by the discriminatory ability (obtained from area under the curve [AUC]-Receiver Operating Characteristic curves) and 2×2 contingency tables.</p></div><div><h3>Results</h3><p>A total of 2,978 subjects (55.3% males) were evaluated. The frequency of GOAL-defined OSA high-risk was statistically higher in men when compared to women (p &lt; 0.001). The GOAL predictive parameters for screening all severity OSA levels were as follows: in females, sensitivity ranging from 58.2% to 78.3% and specificity ranging from 60.0% to 77.6%, while in males, sensitivity ranging from 90.5% to 96.9% and specificity from 20.7% to 46.8%. The GOAL questionnaire had similar discriminatory properties, assessed by AUC, in women and in men: i) any OSA: 0.741 vs. 0.771 (p = 0.204), ii) moderate-to-severe OSA: 0.727 vs. 0.737 (p = 0.595), and iii) severe OSA: 0.728 vs. 0.703 (p = 0.240); respectively.</p></div><div><h3>Conclusions</h3><p>The GOAL instrument emerges as a useful tool for screening adult individuals and displays similar performance in both women and men.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 265-271"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000186/pdfft?md5=35ca1967e5b64307a609a9dc1de92a83&pid=1-s2.0-S2531043722000186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chester step test to identify functional impairment in interstitial lung disease 切斯特阶跃试验用于鉴别间质性肺病的功能损害。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2023.08.002
C. Paixão , A. Alves , A.S. Grave , P.G. Ferreira , D. Brooks , A. Marques
{"title":"Chester step test to identify functional impairment in interstitial lung disease","authors":"C. Paixão ,&nbsp;A. Alves ,&nbsp;A.S. Grave ,&nbsp;P.G. Ferreira ,&nbsp;D. Brooks ,&nbsp;A. Marques","doi":"10.1016/j.pulmoe.2023.08.002","DOIUrl":"10.1016/j.pulmoe.2023.08.002","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 313-316"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001587/pdfft?md5=6566b06b4ab7da2d546c3c5adabb525f&pid=1-s2.0-S2531043723001587-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41120227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidisciplinary virtual management of pulmonary nodules 肺结节的多学科虚拟管理。
IF 11.7 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2024-05-01 DOI: 10.1016/j.pulmoe.2021.12.003
D. Polanco , J. González , E. Gracia-Lavedan , L. Pinilla , R. Plana , M. Molina , M. Pardina , F. Barbé

Introduction and objectives

Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the first year of operation of a multidisciplinary virtual lung nodule clinic, the population evaluated and issued decisions. Secondarily, among discharged patients, we aimed to analyze their follow-up prior to the existence of our consultation, evaluating its adherence to guidelines.

Materials and methods

Observational study including all patients evaluated at the Virtual Lung Nodule Clinic (VLNC) (March 2018- March 2019). Clinical and radiological data were recorded. Recommendations, based on 2017 Fleischner Society guidelines, were categorized into follow-up, discharge or referral to lung cancer consultation. Discharged patients were classified according to adherence to guidelines of their previous management, into adequate, prolonged and non-indicated follow-up.

Results

A total of 365 patients (58.9% men; median age 64.0 years) were included. Sixty-four percent had smoking history and 23% had chronic obstructive pulmonary disease (COPD). Most nodules were solid (87.4%) and multiple (57.5%). The median diameter was 6.00 mm. 43.8% of patients were discharged following first VLNC evaluation. Among them, 27.5% had received appropriate follow-up, but 66.9% had received poor management. Patients with prolonged follow-up (33.1%) were older (67.0 vs 60.5 years) and had larger nodules (6.00 mm vs 5.00). Non-indicated follow-up patients (33.8%) were more non-smokers (77.8% vs 31.8%) and presented smaller nodules (4.00 vs 5.00 mm).

Conclusions

During its first year of operation, the VLNC has evaluated a population with a relevant risk profile for lung cancer development, management of which should be cautious and adhere to guidelines. After the first VLNC assessment, approximately one-half of this population was discharged. It was noticeable that previous follow-up of discharged patients was found poorly adherent to guidelines, with a marked tendency to overmanagement.

导言和目标:多学科结节诊所可提供高质量的护理,并有利于遵守指南。虚拟医疗在提高患者满意度的同时,也显示出节约成本的优势。我们的目的是描述多学科虚拟肺结节门诊第一年的运行情况、评估人群和做出的决定。其次,在出院患者中,我们旨在分析他们在我们开展会诊之前的随访情况,评估其对指南的遵守情况:观察性研究,包括在虚拟肺结节诊所(VLNC)(2018 年 3 月至 2019 年 3 月)接受评估的所有患者。记录了临床和放射学数据。根据 2017 年弗莱施纳协会指南的建议,分为随访、出院或转诊至肺癌会诊。出院患者根据是否遵守之前的治疗指南,分为充分随访、延长随访和无指征随访:共纳入了 365 名患者(58.9% 为男性,中位年龄为 64.0 岁)。64%的患者有吸烟史,23%的患者患有慢性阻塞性肺病(COPD)。大多数结节为实性(87.4%)和多发性(57.5%)。中位直径为 6.00 毫米。43.8%的患者在首次VLNC评估后出院。其中,27.5%的患者接受了适当的后续治疗,但66.9%的患者治疗效果不佳。接受长期随访的患者(33.1%)年龄较大(67.0 岁对 60.5 岁),结节较大(6.00 毫米对 5.00 毫米)。未指定随访的患者(33.8%)多为非吸烟者(77.8% 对 31.8%),结节较小(4.00 毫米对 5.00 毫米):VLNC运行一年来,评估了肺癌发病风险的相关人群,对他们的管理应谨慎,并遵守相关指南。在 VLNC 首次评估后,约有二分之一的患者出院。值得注意的是,以前对出院患者的随访发现,他们对指南的遵守情况很差,有明显的过度管理倾向。
{"title":"Multidisciplinary virtual management of pulmonary nodules","authors":"D. Polanco ,&nbsp;J. González ,&nbsp;E. Gracia-Lavedan ,&nbsp;L. Pinilla ,&nbsp;R. Plana ,&nbsp;M. Molina ,&nbsp;M. Pardina ,&nbsp;F. Barbé","doi":"10.1016/j.pulmoe.2021.12.003","DOIUrl":"10.1016/j.pulmoe.2021.12.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the first year of operation of a multidisciplinary virtual lung nodule clinic, the population evaluated and issued decisions. Secondarily, among discharged patients, we aimed to analyze their follow-up prior to the existence of our consultation, evaluating its adherence to guidelines.</p></div><div><h3>Materials and methods</h3><p>Observational study including all patients evaluated at the Virtual Lung Nodule Clinic (VLNC) (March 2018- March 2019). Clinical and radiological data were recorded. Recommendations, based on 2017 Fleischner Society guidelines, were categorized into follow-up, discharge or referral to lung cancer consultation. Discharged patients were classified according to adherence to guidelines of their previous management, into adequate, prolonged and non-indicated follow-up.</p></div><div><h3>Results</h3><p>A total of 365 patients (58.9% men; median age 64.0 years) were included. Sixty-four percent had smoking history and 23% had chronic obstructive pulmonary disease (COPD). Most nodules were solid (87.4%) and multiple (57.5%). The median diameter was 6.00 mm. 43.8% of patients were discharged following first VLNC evaluation. Among them, 27.5% had received appropriate follow-up, but 66.9% had received poor management. Patients with prolonged follow-up (33.1%) were older (67.0 vs 60.5 years) and had larger nodules (6.00 mm vs 5.00). Non-indicated follow-up patients (33.8%) were more non-smokers (77.8% vs 31.8%) and presented smaller nodules (4.00 vs 5.00 mm).</p></div><div><h3>Conclusions</h3><p>During its first year of operation, the VLNC has evaluated a population with a relevant risk profile for lung cancer development, management of which should be cautious and adhere to guidelines. After the first VLNC assessment, approximately one-half of this population was discharged. It was noticeable that previous follow-up of discharged patients was found poorly adherent to guidelines, with a marked tendency to overmanagement.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 239-246"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000010/pdfft?md5=a36cd1d9941ab4bc906fd3f88feed186&pid=1-s2.0-S2531043722000010-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Pulmonology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1