International Breastfeeding Journal最新文献

Kalhor et al. (2025) conducted a systematic review and meta-analysis on predictors of exclusive breastfeeding, offering valuable insights but facing methodological challenges. Despite a robust search strategy, PROSPERO registration, and use of the Newcastle-Ottawa Scale, heterogeneity remained high (I² >85%), with limited exploration through prediction intervals. Combining diverse designs and minimal subgroup justification reduced interpretability. Future reviews should incorporate prediction intervals, sensitivity analyses, and clearer subgroup rationale to enhance methodological transparency and reproducibility.

Background: Pompe disease is an autosomal recessively inherited lysosomal storage disorder, caused by enzyme deficiency of acid alpha-glucosidase (GAA). This deficiency leads to the accumulation of glycogen in lysosomes and subsequent muscle dysfunction, thus affecting heart and skeletal muscle. Since 2006, enzyme replacement therapy (ERT) is available. The use of ERT during pregnancy and lactation remains a topic of concern due to limited data on the safety of ERT during these periods. Despite this, some previous case reports suggest that ERT is safe during pregnancy and lactation.

Case presentation: In this case series, we collected the data on five pregnancies in three women with late-onset Pompe disease who were on ERT and continued it during pregnancy and lactation. In two of the children, during the lactation period activity levels of alglucosidase alfa were measured in breastmilk on dried blood spots.

Conclusion: These case reports add to the literature experience by presenting the information on five so far not reported pregnancies in three women with late-onset Pompe disease, where ERT was continued during pregnancy and lactation. The results showed that acid alpha-glucosidase activity in milk from a woman with Pompe disease in two different breastfeeding periods was in the same range as acid alpha glucosidase activity in milk from five healthy women. As for the outcome in the five children, all have age-appropriated growth and development, confirming that ERT in this cohort was feasible and safe. These findings reinforce the safety of continuing ERT during pregnancy and breastfeeding in Pompe disease. Breastfeeding not only is the age adequate nutrition but also supports the well-being and development of the child as well as benefits maternal health. The value of breastfeeding being the recommended form of nutrition for infants cannot be emphasized enough. Thus, breastfeeding has to be especially supported in situations where there is a chronic disease/condition or medication. Further reports and appropriate guidelines are needed to soundly provide good advice to women with Pompe disease (or Morbus Pompe) during pregnancy and breastfeeding.

Background: Online breastfeeding peer support, which provides information, advice, emotional support, reassurance, and a sense of shared experience, is increasingly delivered through mobile applications as a relatively new form of digital peer support. This study examined the feasibility of a breastfeeding peer support application from the viewpoints of peer supporters and breastfeeding mothers.

Methods: A feasibility study with both qualitative and quantitative data, combining the perspectives of peer supporters and breastfeeding mothers, was conducted in Finland in 2022. The qualitative data were collected from breastfeeding peer supporters (n = 8) via focus groups and analyzed via content analysis. The quantitative data from breastfeeding mothers (n = 81) were collected via a structured survey embedded in the Breastfeeding Peer Support Application and analyzed with descriptive statistics.

Results: Four main categories describing the perspective of eight experienced peer supporters were created. First, controlling the burden of peer support was possible, as peer supporters were able to regulate their availability in the App. Second, peer supporters had a strong sense of duty, and some of the features of the App helped them avoid overusing their resources, but others did not. Thus, the peer supporters had to balance the sense of duty and the features of the App. Third, peer support contacts with breastfeeding mothers were mostly rewarding, but a few suddenly breaking and disappearing contacts caused frustration and insecurity. Both short and easy-to-solve contacts and long-term contacts were rewarding. The fourth main category illustrates that real-time support via the App is present and responds well to the increasing need for online support. On the basis of the survey completed by breastfeeding mothers (n = 81), they were satisfied with the App; it was ranked high in acceptability, appropriateness and usability regardless of mothers' age, education or number of children.

Conclusions: The breastfeeding peer support application was shown to be a feasible tool from the perspectives of both trained peer supporters and breastfeeding mothers and was easily integrated into their daily lives. Most mothers found effective solutions to their breastfeeding challenges. Overall, the App was regarded as a highly promising tool for supporting breastfeeding.

Trial registration: N/A.