World Allergy Organization Journal最新文献

{"title":"Hypereosinophilia syndrome with severe cutaneous manifestations, a diagnostic and therapeutic challenge: A Case Report","authors":"Mohammad Hasan Bemanian , Saman Tavakoli ∗ , Mojtaba Ranjbar , Somayeh Heidary Ghadikolaii , Seyedehshabnam Seyedsalehi","doi":"10.1016/j.waojou.2026.101294","DOIUrl":"10.1016/j.waojou.2026.101294","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101294"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunologic evaluation of Cluster subcutaneous immunotherapy in allergic rhinitis","authors":"Yaghoub Mahboubi o","doi":"10.1016/j.waojou.2026.101330","DOIUrl":"10.1016/j.waojou.2026.101330","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101330"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic spontaneous urticaria and sinus tachycardia misdiagnosed as Anaphylaxis","authors":"Sami Aqel , Dalal Mudawi , Maryam Ali Al-Nesf , Tayseer Ibrahim , Hassan Mobayed","doi":"10.1016/j.waojou.2026.101268","DOIUrl":"10.1016/j.waojou.2026.101268","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101268"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal Monoclonal Antibody “Molecular Shield” as a Novel Preventive Strategy for Seasonal Allergic Rhinitis","authors":"Sinan Mufeed Kuniyil ShaffiMohammed","doi":"10.1016/j.waojou.2026.101297","DOIUrl":"10.1016/j.waojou.2026.101297","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101297"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147449077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exenatide-Induced Urticaria: A Case Report and Review of the Literature","authors":"Reem Faiz Hussein Eisa, Marwa Elaziz, Vajeeha Haider, Abdullah Mohamed M. Elsafti Elsaeidy","doi":"10.1016/j.waojou.2026.101263","DOIUrl":"10.1016/j.waojou.2026.101263","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101263"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147449104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing Viral Respiratory Infections with Lysate Probiotic Nasal Spray: A Controlled Trial","authors":"Nasrin Moazzen, Hamid Ahanchian, Tahere Sadeghi, Maryam Bagherian, Bahman Khameneh","doi":"10.1016/j.waojou.2026.101316","DOIUrl":"10.1016/j.waojou.2026.101316","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101316"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147449106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Barriers and Improving Compliance with Penicillin De-labeling Following Negative Allergy Testing: A Quality Improvement Initiative","authors":"Sherin Rahim Thalappil , Dalal Sideeg Abass Mudawi , Asaad Omer Ahmed Imameldin , Sara Saeed Ibrahim Mohamed , Hassan Mobayedh , Mariam Al-Nesf , Salma Taha","doi":"10.1016/j.waojou.2026.101256","DOIUrl":"10.1016/j.waojou.2026.101256","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101256"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147449208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective cohort study of ultra-rush subcutaneous immunotherapy in dust mite-induced allergic rhinitis","authors":"Yishan Xiong MD ,&nbsp;Wenqi Luo MS ,&nbsp;Hao Peng MS ,&nbsp;Li Shen MS ,&nbsp;Zhiqun Huang MD ,&nbsp;Jieqing Yu MD ,&nbsp;Jing Ye MD, PhD","doi":"10.1016/j.waojou.2026.101334","DOIUrl":"10.1016/j.waojou.2026.101334","url":null,"abstract":"<div><h3>Background</h3><div>Allergic rhinitis (AR) is a prevalent disease with a considerable global burden. Allergen immunotherapy (AIT) represents the cornerstone causal treatment for AR. While accelerated schedules such as Cluster Subsutaneous Immunotherapy (Cluster SCIT) shorten the initial buildup phase than Conventional treatment, the even more rapid Ultra-Rush Subcutaneous Immunotherapy (UR-SCIT) lacks a head-to-head, prospective comparison regarding its efficacy and safety.</div></div><div><h3>Methods</h3><div>A total of 57 patients with house dust mite induced AR were included in this study and followed up for 12 months. Allocation to the 2 treatment groups (UR-SCIT and Cluster SCIT) was based on patient preference. Treatment efficacy was assessed using Visual Analogue Scale (VAS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Combined Symptom and Medication Score (CSMS). Additionally, skin prick test (SPT), nasal allergen challenge (NAC), fractional exhaled nitric oxide (FeNO), and fractional nasal nitric oxide (FnNO) were measured at baseline (M0) and at the 12-month follow-up (M12). Eosinophils (EOS) and eosinophil percentage (EOS%) in blood、serum levels of IL-4, IL-5, IL-10, IL-13, IL-33, total IgE, dust mite-specific IgE (sIgE), dust mite-specific IgG4 (sIgG4),the ratio of sIgG4/sIgE and sIgE/tIgE were detected at months 0, 6, and 12. To evaluate safety, local and systemic adverse reactions were recorded during the treatment period.</div></div><div><h3>Results</h3><div>In this study, both UR-SCIT and Cluster SCIT groups showed significant reductions in VAS, CSMS, RQLQ and TNSS scores at M12, alongside decreases in SPT grade. Immunological analysis revealed that both groups exhibited reduced levels of EOS, EOS%, IL-4, IL-5, IL-13 and IL-33, while IL-10 levels increased. Changes in EOS count and EOS% levels were correlated with improvements in AR symptoms. SIgG4 levels rose in both groups, but tIgE、sIgE and sIgE/tIgE ratios showed no significant changes. Adverse reaction incidence was similar in both groups, with no serious events reported.</div></div><div><h3>Conclusion</h3><div>UR-SCIT achieves therapeutic efficacy comparable to Cluster SCIT, with both demonstrating robust symptom control and favorable immunological changes. The similar safety profiles, with no serious adverse events indicate that UR-SCIT is a viable new option for AIT in clinical practice.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101334"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed hypersensitivity reactions to taxanes: Clinical presentation and outcomes of post-medication and rapid drug desensitization","authors":"Rosalaura Villarreal-González MD, PhD ,&nbsp;Leslie Astrid De la Fuente MD ,&nbsp;Alexia Moreno-Silvestre MD ,&nbsp;María Guadalupe Durán-Hernández MD ,&nbsp;Diego Armando Sánchez-Alvarado MD ,&nbsp;David Hernández-Barajas MD ,&nbsp;Oscar Vidal-Gutiérrez MD, PhD","doi":"10.1016/j.waojou.2025.101157","DOIUrl":"10.1016/j.waojou.2025.101157","url":null,"abstract":"<div><h3>Background</h3><div>Taxanes are widely used in solid tumors but may induce delayed hypersensitivity reactions (DHRs), potentially compromising treatment. The aim was to characterize taxane-related DHRs and evaluate the role of post-medication and rapid drug desensitization (RDD) in treatment continuation.</div></div><div><h3>Methods</h3><div>A retrospective, observational study at University Hospital Dr. José Eleuterio González, in Monterrey, Mexico, from January 2020 to May 2025. Patients who developed delayed HSRs following taxane administration were included. After an intravenous challenge test, a post-medication and/or a 3-bag, 12-step rapid drug desensitization (RDD) protocol was applied, adjusted per patient tolerance.</div></div><div><h3>Results</h3><div>Among 4217 patients, 325 (7.7%) developed HSRs; 28 (8.8%) were delayed. Nine cases (32.1%) were attributed to taxanes: 66.6% paclitaxel and 33.4% docetaxel. Most patients were female (88.9%), with a mean age of 52.3 years. The predominant clinical presentation was maculopapular exanthema (77.8%), mainly involving the scalp. Mean time to HSR was 3 days post-infusion, during the second chemotherapy cycle. All patients received 3–7 days of post-medication; 7 of them tolerated the new administration of the drug, while the other 2 underwent a 3-bag, 12-step desensitization.</div></div><div><h3>Conclusions</h3><div>Delayed drug hypersensitivity reactions (DHRs) are a T cell-mediated immune response that occur more than 6 h after exposure, leading to treatment discontinuation or alternative therapies. Management remains poorly defined; however, our findings suggest that pre-medication and RDD may safely support continued chemotherapy. To our knowledge, this is the most extensive reported series of taxane-related DHRs managed with post-medication and RDD in Hispanic population phenotype.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101157"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case series of three brothers with combined Immunodeficiency: shared genetics and immune dysregulation behind distinct phenotypes","authors":"Mohammad Nabavi ,&nbsp;Sima Shokri ,&nbsp;Mohammad-Hasan Bemanian ,&nbsp;Morteza Fallahpour ,&nbsp;Saman Tavakoli ,&nbsp;Seyedehshabnam Seyedsalehi","doi":"10.1016/j.waojou.2026.101292","DOIUrl":"10.1016/j.waojou.2026.101292","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"19 2","pages":"Article 101292"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}