World Allergy Organization Journal最新文献_第7页

Prioritising patient-centred care in the management of chronic urticaria in Asia-Pacific countries 在亚太地区慢性荨麻疹的治疗中优先考虑以患者为中心的护理方法

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-11-01 DOI: 10.1016/j.waojou.2024.100984

Marysia Tiongco-Recto MD , Kent Woo MD , Wen-Hung Chung MD PhD , Gilbert T. Chua MBBS , Kiran Godse MD PhD , Ma Teresita Gabriel MD , Alexander Headley MBBS , Irene Lee Chew Kek MBBS , Kanokvalai Kulthanan MD , Mongkol Lao-Araya MD , Liwen Ma MD , Le Huyen My MD PhD , Siriwan Wananukul MD , Dinesh Nagrale MD

Background

Chronic urticaria (CU), in both inducible and spontaneous forms, is associated with a substantial burden in the Asia-Pacific region (APAC). Patient-centred care recognises patients desire to be involved in decisions regarding their health. Although patient-centred approaches have previously not been studied in the context of CU management, they have demonstrated benefits in the management of other chronic conditions.

Methods

Information and opinions regarding the barriers and solutions to the implementation of patient-centred approaches to the management of CU were gathered from a group of 13 expert dermatologists and allergist/immunologists from APAC through surveys and a face-to-face meeting.

Results

Barriers identified there included a lack of awareness of CU amongst patients, delays in consulting healthcare providers, financial constraints, and low adherence. Particular issues raised included a lack of suitable online information for patients (83% of experts), and patients accessing oral corticosteroids without a prescription. Compliance issues were also identified as key reasons for inadequate responses to treatments (67% of experts). Solutions proposed by the authors were improving patients' knowledge about their condition (92% strongly agree, 8% agree), physicians’ consideration of patient characteristics when choosing treatments (92% strongly agree, 8% agree), implementing shared decision-making (85% strongly agree, 15% agree), and using patient-reported outcome measures (70% strongly agree, 23% agree).

Conclusion

Expert opinion within APAC supports the use of patient-centred approaches to improve the management of CU. We provide several recommendations focusing on patient education and involvement in disease management as well as disease monitoring methods that can be implemented by physicians in APAC.

背景慢性荨麻疹（CU），包括诱发性和自发性两种形式，在亚太地区（APAC）造成了巨大的负担。以患者为中心的医疗服务承认患者希望参与有关其健康的决策。方法通过调查和面对面会议的形式，从亚太地区的 13 位皮肤科专家和过敏/免疫科专家那里收集了有关实施以患者为中心的方法来管理 CU 的障碍和解决方案的信息和意见。提出的具体问题包括缺乏适合患者的在线信息（83% 的专家），以及患者在没有处方的情况下获得口服皮质类固醇。依从性问题也被认为是治疗效果不佳的主要原因（67% 的专家）。作者提出的解决方案包括提高患者对自身病情的了解（92%非常同意，8%同意），医生在选择治疗方法时考虑患者的特点（92%非常同意，8%同意），实施共同决策（85%非常同意，15%同意），以及使用患者报告的结果测量（70%非常同意，23%同意）。我们提供了几项建议，重点是患者教育和参与疾病管理以及疾病监测方法，可供亚太地区的医生实施。

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引用次数: 0

Investigating the causal association between heme oxygenase-1 and asthma: A bidirectional two-sample Mendelian randomization analysis in a European population 调查血红素加氧酶-1与哮喘之间的因果关系：欧洲人群中的双向双样本孟德尔随机分析

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-24 DOI: 10.1016/j.waojou.2024.100987

Wen Liu , Zhen Liu , Xiao-di Sun , Zeng-qiang Liu , Yuan-yuan Dong , Shi Qiu

Background

The association between heme oxygenase-1 (HO-1) and asthma has been a subject of debate in both observational and experimental studies. We aimed to evaluate the potential causal relationship between HO-1 and asthma.

Materials and methods

A bidirectional two-sample Mendelian randomization (TSMR) study was conducted to examine the causal relationship between HO-1 and asthma. In the forward Mendelian randomization (MR) analyses, HO-1 was considered as the exposure, while asthma as the outcome. Conversely, in the reverse MR analyses, asthma was regarded as the exposure, and HO-1 as the outcome. Data for HO-1 and asthma were obtained from publicly accessible genome-wide association studies (GWAS). These causal relationships were identified through 5 MR methods, namely MR-Egger, weighted median, inverse-variance weighted (IVW), simple mode, and weighted mode. Additionally, sensitivity tests were conducted to assess the robustness of MR study. Finally, additional asthma datasets and childhood asthma were selected to validate the findings.

Results

In the forward MR analyses, according to the IVW method, genetically predicted HO-1 displays a negative correlation with the risk of asthma (OR 0.947, 95% CI 0.905–0.990). It was not found any SNP overly sensitive or disproportionately responsible for the outcome. No evidence of heterogeneity and pleiotropy between SNPs was observed. Genetically predicted asthma was not associated with HO-1 in reverse MR analyses using the IVW method. The same results were validated in additional asthma datasets and in childhood asthma.

Conclusion

The results of MR analysis revealed heme oxygenase-1 as a protective factor for asthma.

背景血红素加氧酶-1（HO-1）与哮喘之间的关系一直是观察性和实验性研究中争论的主题。我们的目的是评估 HO-1 与哮喘之间的潜在因果关系。材料与方法为研究 HO-1 与哮喘之间的因果关系，我们进行了一项双向双样本孟德尔随机化（TSMR）研究。在正向孟德尔随机分析（MR）中，HO-1 被认为是暴露因子，而哮喘被认为是结果因子。相反，在反向孟德尔随机分析中，哮喘被视为暴露，而 HO-1 被视为结果。HO-1和哮喘的数据来自公开的全基因组关联研究（GWAS）。这些因果关系是通过 5 种 MR 方法确定的，即 MR-Egger、加权中位数、逆方差加权（IVW）、简单模式和加权模式。此外，还进行了敏感性测试，以评估 MR 研究的稳健性。结果在正向 MR 分析中，根据 IVW 方法，基因预测的 HO-1 与哮喘风险呈负相关（OR 0.947，95% CI 0.905-0.990）。没有发现任何 SNP 对结果过于敏感或不成比例。没有发现 SNP 之间存在异质性和多义性。在使用 IVW 方法进行的反向 MR 分析中，遗传预测的哮喘与 HO-1 无关。结论 MR 分析结果显示血红素加氧酶-1 是哮喘的保护因子。

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引用次数: 0

Non-episodic angioedema with eosinophilia as a differential diagnosis of eosinophilia in young females 非阵发性血管性水肿伴嗜酸性粒细胞增多症与年轻女性嗜酸性粒细胞增多症的鉴别诊断

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-24 DOI: 10.1016/j.waojou.2024.100981

Yura Ha BS , Min Ju Pyo MS , Ye Eun Hong BS , So Hye Nam MD , Woo-Jung Song MD, PhD , Hyouk-Soo Kwon MD, PhD , Tae-Bum Kim MD, PhD , Yoo Sook Cho MD, PhD , Ji-Hyang Lee MD, PhD

Background

Episodic angioedema with eosinophilia, also known as Gleich's syndrome, is a differential diagnosis in patients with recurrent angioedema with higher blood eosinophils. Meanwhile, less has been elucidated regarding non-episodic angioedema with eosinophilia (NEAE). This study aimed to examine the prevalence, clinical characteristics, and disease course of NEAE.

Methods

By reviewing the electronic medical records, we identified patients with NEAE among those referred to allergy clinics due to eosinophilia from January 2021 to December 2023 at Asan Medical Center.

Results

Among 687 patients with eosinophilia, 58 (8.4%) were diagnosed with and treated for NEAE. All patients were females, with a mean age of 31.79 years. The mean absolute blood eosinophil count was 4468.76 cells/μL. All patients reported symmetric angioedema of the lower legs, and 37 (63.8%) had additional angioedema of the upper arms. Twenty-five (43.1%) patients reported a preceding event prior to onset of angioedema. Systemic corticosteroids (mean total dose 1745 ± 508.49 mg) were prescribed to all patients, with a treatment duration of approximately 40 days to achieve resolution. Following the resolution of angioedema, 6 patients experienced persistent arthralgia, 1 developed chronic spontaneous urticaria, and 1 developed hypereosinophilic syndrome.

Conclusions

NEAE is an essential differential diagnosis in young female patients with eosinophilia, particularly those presenting with symmetric peripheral angioedema.

背景嗜酸性粒细胞增多的阵发性血管性水肿又称格莱希综合征，是反复发作的血管性水肿患者血液中嗜酸性粒细胞增多的鉴别诊断之一。与此同时，关于非阵发性血管性水肿伴嗜酸性粒细胞增多症（NEAE）的研究较少。本研究旨在探讨 NEAE 的发病率、临床特征和病程。方法通过查阅电子病历，我们在牙山医疗中心 2021 年 1 月至 2023 年 12 月期间因嗜酸性粒细胞增多症转诊至过敏诊所的患者中发现了 NEAE 患者。结果在 687 名嗜酸性粒细胞增多症患者中，有 58 人（8.4%）被诊断为 NEAE 并接受了治疗。所有患者均为女性，平均年龄为 31.79 岁。血液中嗜酸性粒细胞绝对计数的平均值为 4468.76 cells/μL。所有患者的小腿都出现了对称性血管性水肿，37 名患者（63.8%）的上臂也出现了血管性水肿。25名患者（43.1%）报告在出现血管性水肿前曾有过类似症状。所有患者均接受了全身皮质类固醇治疗（平均总剂量为 1745 ± 508.49 毫克），治疗时间约为 40 天。结论嗜酸性粒细胞增多症是年轻女性嗜酸性粒细胞增多症患者，尤其是伴有对称性周围血管性水肿患者的重要鉴别诊断。

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引用次数: 0

Retrospective evaluation of pediatric anaphylaxis cases according to WAO and NIAID/FAAN/EAACI criteria: A single center experience 根据 WAO 和 NIAID/FAAN/EAACI 标准对儿科过敏性休克病例进行回顾性评估：单中心经验

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-24 DOI: 10.1016/j.waojou.2024.100982

Funda Aytekin Güvenir MD , Gökhan Yörüsün MD , Ragıp Dere MD , Ahmet Selmanoğlu MD , Zeynep Şengül Emeksiz MD , Emine Dibek Mısırlıoğlu MD

Background

Anaphylaxis is an emergency that must be correctly recognized and treated by every health care professional. With the update of the World Allergy Organization (WAO) criteria in 2020, differences between the European Academy of Allergy and Immunology (EAACI)/The National Institute of Allergy and Infectious Diseases (NIAID) and the Food Allergy and Anaphylaxis Network (FAAN) and WAO criteria have come to the fore.

Objective

The aim of our study is to compare the effectiveness of these 2 criteria in diagnosing anaphylaxis in pediatric patients.

Methods

Patients aged 0–18 years who applied to Ankara Bilkent City Hospital Pediatric Immunology and Allergy Clinic between September 1, 2020 and September 1, 2023 due to systemic allergic reaction and were diagnosed with anaphylaxis were evaluated retrospectively. The clinical findings of the patients were re-evaluated accordingto WAO 2020 and NIAID/FAAN/EAACI criteria.

Results

Included in the study were 492 patients who met the inclusion criteria. Median age was 3.8 years (IQR: 0.9–11.4). The majority of patients were male (59.6%). There were 466 patients (94.1%) diagnosed with anaphylaxis according to both NIAID/FAAN/EAACI and WAO criteria. Three patients (0.6%) with isolated laryngeal involvement and 23 (4.7%) patients with isolated respiratory findings (bronchospasm) were diagnosed only according to WAO Criterion 2, for a total of 26 patients (5.3%).

Conclusion

Although the majority of patients were diagnosed with both criteria, 5.3% were diagnosed only according to the WAO criteria. After contact with a suspected or known allergen, the presence of isolated respiratory or laryngeal findings without skin findings should be a warning before anaphylaxis progresses to more serious stages.

背景过敏性休克是一种急症，每位医护人员都必须正确认识和处理。随着世界过敏组织（WAO）标准在2020年的更新，欧洲过敏与免疫学学会（EAACI）/美国国家过敏与传染病研究所（NIAID）和食物过敏与过敏性休克网络（FAAN）与WAO标准之间的差异凸显出来。方法回顾性评估 2020 年 9 月 1 日至 2023 年 9 月 1 日期间因全身过敏反应前往安卡拉比尔肯特市医院儿科免疫和过敏门诊就诊并被诊断为过敏性休克的 0-18 岁患者。根据 WAO 2020 和 NIAID/FAAN/EAACI 标准重新评估了患者的临床结果。中位年龄为 3.8 岁（IQR：0.9-11.4）。大多数患者为男性（59.6%）。有 466 名患者（94.1%）根据 NIAID/FAAN/EAACI 和 WAO 标准被诊断为过敏性休克。有 3 名患者（0.6%）仅根据 WAO 标准 2 诊断出喉部受累，23 名患者（4.7%）仅根据 WAO 标准 2 诊断出呼吸道症状（支气管痉挛），共计 26 名患者（5.3%）。接触疑似或已知过敏原后，在过敏性休克发展到更严重的阶段之前，出现孤立的呼吸道或喉部症状而无皮肤症状应是一个警告。

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引用次数: 0

A 300 IR 5-grass pollen sublingual immunotherapy tablet-specific systematic review and meta-analysis confirms its clinical benefits for patients with allergic rhinoconjunctivitis with or without asthma 一项针对 300 IR 5-禾本科花粉舌下免疫疗法片剂的系统综述和荟萃分析证实了该疗法对伴有或不伴有哮喘的过敏性鼻结膜炎患者的临床疗效

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-24 DOI: 10.1016/j.waojou.2024.100985

Danilo Di Bona MD, PhD , Giovanni Paoletti MD , Michal Ordak PhD , Silvano Dragonieri MD, PhD , Josiane Cognet-Sice PharmD , Silvia Scurati PhD , Giorgio Walter Canonica MD

Background

In the realm of allergen immunotherapy (AIT), the quality of evidence varies across different products, making it unjustifiable to extend overall conclusions to all AIT products, as highlighted by WAO and EAACI.

Objective

To confirm the efficacy of the 300 IR 5-grass pollen sublingual AIT (SLIT)-tablet through a specific meta-analysis of randomized controlled trials (RCTs) involving patients with allergic rhino-conjunctivitis (ARC) with/without mild/intermittent asthma.

Methods

Data from published RCTs on the 300 IR 5-grass SLIT-tablet were gathered from electronic databases (MEDLINE, ISI Web of Science, LILACS, the Cochrane Library and ClinicalTrial.gov) and manual searches up to November 2023. Populations, treatments, and outcome data were combined. Efficacy was assessed based on symptom score (SS) and medication score (MS), measured as standardized mean difference (SMD) or mean difference (MD).

Results

Results from 5 RCTs comprising 1468 patients revealed a significant reduction in SS (SMD, −0.36; 95%confidence interval [CI], −0.52 to −0.19; P < 0.05) and MS (SMD, −0.29; 95%CI, −0.40 to −0.19; P < 0.05) compared to placebo. The difference of −0.36 SMD for SS corresponds to a MD of −1.26 SS points, greater than the minimal important difference. Subgroup analysis did not show differences in efficacy according to age, asthma status, and geographic location of the study (USA, Canada, Europe, Russia). No safety issues were reported.

Conclusion

This product-specific meta-analysis reinforces the evidence of clinical benefits associated with the 300 IR 5-grass SLIT-tablet, suggesting its appropriateness as a therapeutic choice for patients with ARC, irrespective of concurrent asthma, and exhibiting a favorable safety profile.

背景在过敏原免疫疗法（AIT）领域，不同产品的证据质量参差不齐，因此，正如 WAO 和 EAACI 所强调的那样，将总体结论推广到所有 AIT 产品是不合理的。目的通过对涉及过敏性鼻结膜炎（ARC）伴/不伴轻度/间歇性哮喘患者的随机对照试验（RCT）进行特定的荟萃分析，确认 300 IR 5-禾本科花粉舌下 AIT（SLIT）片剂的疗效。方法从电子数据库（MEDLINE、ISI Web of Science、LILACS、Cochrane 图书馆和 ClinicalTrial.gov）和截至 2023 年 11 月的人工搜索中收集已发表的有关 300 IR 5-grass SLIT 片剂的 RCT 数据。对人群、治疗方法和结果数据进行了合并。根据症状评分（SS）和用药评分（MS）评估疗效，以标准化均值差（SMD）或均值差（MD）衡量。结果5项RCT的结果显示，与安慰剂相比，1468名患者的SS（SMD，-0.36；95%置信区间[CI]，-0.52至-0.19；P< 0.05）和MS（SMD，-0.29；95%CI，-0.40至-0.19；P< 0.05）显著降低。SS的SMD为-0.36，相当于MD为-1.26 SS点，大于最小重要差异。分组分析显示，不同年龄、哮喘状况和研究地点（美国、加拿大、欧洲、俄罗斯）的疗效没有差异。结论这项针对特定产品的荟萃分析加强了与 300 IR 5-grass SLIT 片剂相关的临床疗效证据，表明该药物适合作为 ARC 患者的治疗选择，无论是否同时患有哮喘，并且具有良好的安全性。

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引用次数: 0

Japanese version of the food allergy quality of life questionnaire 10: An easy-to-use instrument 食物过敏生活质量问卷 10 日语版：简便易用的工具

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-24 DOI: 10.1016/j.waojou.2024.100979

Shigenori Kabashima MD, PhD , Kiwako Hanada Yamamoto MD, PhD , Yumiko Miyaji MD , Yuri Endo Kram MD , Mami Shimada MD , Seiko Hirai MD , Hiroya Ogita MD , Tomoyuki Kiguchi MD , Yusuke Inuzuka MD, PhD , Kenji Toyokuni MD, PhD , Makoto Irahara MD, PhD , Fumi Ishikawa MD , Miori Sato MD , Mayako Saito-Abe MD, PhD , Hiroki Yasudo MD, PhD , Tatsuki Fukuie MD, PhD , Ichiro Nomura MD, PhD , Audrey DunnGalvin PhD , Yukihiro Ohya MD, PhD

Background

The health-related quality of life (HRQL) of people with food allergies should be evaluated to provide high-quality medical care. Currently, there is no available easy-to-use and reliable instrument for assessing HRQL clinically in Japan.

Methods

The Food Allergy Quality of Life Questionnaire 10 (FAQLQ10) in English was translated into Japanese, and this was referred to as the Japanese version of the Food Allergy Quality of Life Questionnaire 10 (FAQLQ10-J). Participants aged up to 18 years, who had food allergy, and their parents were instructed to complete the FAQLQ10-J and the Food Allergy Independent Measure, a self-report instrument. For comparison, participants without food allergies were also included in the survey.

Results

The FAQLQ10-J, which included forms for individuals aged 8–12 years, teenagers, and caregivers was developed. The responders completed each form within approximately 3 min. An analysis of responses showed that each form had a good internal consistency, test–retest reliability, construct validity, and discriminant validity. Moreover, based on an examination of the relationship between demographic data and FAQLQ10-J scores, items such as possession of an adrenaline auto-injector, participant age, and number of eliminated foods might influence HRQL.

Conclusions

We developed the FAQLQ10-J, which is a simple, reliable, and effective tool for assessing HRQL among Japanese individuals with food allergy. Its use may provide a more detailed understanding of HRQL among individuals with food allergy in clinical settings and may facilitate the development of more individual-oriented treatments.

背景为了提供高质量的医疗服务，应该对食物过敏患者的健康相关生活质量（HRQL）进行评估。方法将食物过敏生活质量问卷 10 (FAQLQ10) 的英文版翻译成日文，并将其称为食物过敏生活质量问卷 10 的日文版 (FAQLQ10-J)。患有食物过敏症的 18 岁以下参与者及其父母在指导下完成了 FAQLQ10-J 和食物过敏症独立测量（一种自我报告工具）。为了进行比较，调查还包括没有食物过敏的参与者。答卷者在大约 3 分钟内完成了每份表格。对回答进行的分析表明，每份表格都具有良好的内部一致性、重测可靠性、构建有效性和判别有效性。此外，根据人口统计学数据与 FAQLQ10-J 分数之间关系的研究，拥有肾上腺素自动注射器、参与者年龄和排除食物的数量等项目可能会影响 HRQL。使用该工具可以更详细地了解临床环境中食物过敏患者的 HRQL，并有助于开发更多面向个体的治疗方法。

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引用次数: 0

Adherence to a modified Mediterranean diet and in association with asthma and wheezing in schoolchildren: A cross-sectional study 坚持改良地中海饮食与学龄儿童哮喘和喘息的关系：横断面研究

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-18 DOI: 10.1016/j.waojou.2024.100948

Faezeh Poursoleiman PhD , Bahareh Sasanfar PhD , Nasrin Behniafard MD , Zahra Nafei MD , Elahe Akbarian MS , Abbas Khalili MD , Amin Salehi-Abargouei PhD

Background

Limited investigations have focused on the association between the Mediterranean dietary (MeD) and asthma among children and adolescents. We aimed to study the associations between a modified Mediterranean dietary pattern and asthma symptoms in children living in Iran.

Method

This cross-sectional study was conducted among 7667 children and adolescence. Data on dietary intakes, asthma symptoms and other possible confounders, were collected using a questionnaire completed by parents. The relationship between Mediterranean diet (MeD) and asthma was assessed using logistic regression.

Results

We found that participants in the highest quartile of MeD score had 32% lower odds of wheezing in the past 12 months in the whole population when compared with those in the lowest quartile (OR: 0.68; 95% CI: 0.51–0.90; P_trend < 0.001). Regarding the wheezing, a linear reducing trend was observed in girls (OR: 0.88; 95% CI: 0.62–1.25; P_trend = 0.04); and a significant protective association was seen among boys (OR: 0.45; 95% CI: 0.28–0.73; P_trend < 0.001). Analyses by gender showed, girls and boys in the highest quartile had 68% and 51% lower odds of current asthma in comparison with the first quartile.

Conclusion

Mediterranean-style diet emphasizing high in fruits, vegetables, and cereals and low in fast foods is associated with reduced wheezing as an asthma-related symptom. On the other hand, meat intake has adverse correlation with asthma prevalence. No association was found between this dietary pattern and asthma. Further prospective investigations should be conducted to confirm these findings.

背景对地中海饮食（MeD）与儿童和青少年哮喘之间关系的调查有限。我们旨在研究改良地中海饮食模式与伊朗儿童哮喘症状之间的关系。通过由家长填写的调查问卷收集了有关饮食摄入量、哮喘症状和其他可能的混杂因素的数据。结果我们发现，与最低四分位数的人相比，地中海饮食（MeD）得分最高的四分位数的参与者在过去 12 个月中出现喘息的几率要低 32%（OR：0.68；95% CI：0.51-0.90；Ptrend <；0.001）。关于喘息，在女孩中观察到线性降低趋势（OR：0.88；95% CI：0.62-1.25；Ptrend = 0.04）；在男孩中观察到显著的保护性关联（OR：0.45；95% CI：0.28-0.73；Ptrend <；0.001）。按性别进行的分析表明，与第一四分位数相比，最高四分位数的女孩和男孩目前患哮喘的几率分别降低了 68% 和 51%。另一方面，肉类摄入量与哮喘发病率呈负相关。这种饮食模式与哮喘之间没有关联。应开展进一步的前瞻性调查来证实这些发现。

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引用次数: 0

Vitamin D, allergen sensitization, and atopic dermatitis 维生素 D、过敏原致敏和特应性皮炎

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-15 DOI: 10.1016/j.waojou.2024.100978

Öner Özdemir MD

引用次数: 0

Blood and local eosinophil levels in chronic rhinitis: Comment 慢性鼻炎患者的血液和局部嗜酸性粒细胞水平评论

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-15 DOI: 10.1016/j.waojou.2024.100977

Hinpetch Daungsupawong PhD , Viroj Wiwanitkit MD

引用次数: 0

Is there a difference between women and men in chronic spontaneous urticaria? A systematic review on gender and sex differences in CSU patients 慢性自发性荨麻疹的男女患者有差异吗？关于慢性自发性荨麻疹患者性别差异的系统综述

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal

Pub Date : 2024-10-12 DOI: 10.1016/j.waojou.2024.100974

Sarah Preis MD , Carla Claussen MD , Stefanie Ziehfreund , Tilo Biedermann MD , Sophia Horster MD , Alexander Zink MD, PhD

In recent years, there has been a notable surge in interest in gender medicine, with a growing focus on exploring gender and sex differences in skin diseases.

Although it is noticeable in clinical practice that more women than men present with chronic spontaneous urticaria (CSU) in the outpatient setting, there is currently no systematic review available which addresses gender differences in CSU. PubMed Medline, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched until July 2023. English and German randomized controlled trials, prospective and retrospective cohorts, and case-control studies that examined gender and sex differences in CSU were included. Two authors independently screened the reports for eligibility. One extracted all data, the second double-checked and critically appraised the quality and risk of bias of the studies. Twenty-six reports were included. The article reviewed differences in epidemiology, diagnostics, clinical characteristics, treatment, and quality of life in female and male patients. The findings provide limited data for the substantial impact of gender and sex in CSU patients and reveal major gaps in gender-specific care in dermatology which should be narrowed in the upcoming years to optimize patient-centered, individualized, gender-equal healthcare.

PROSPERO registration

CRD42023442958.

近年来，人们对性别医学的兴趣明显增加，越来越多的人开始关注皮肤病的性别差异。虽然在临床实践中，门诊慢性自发性荨麻疹（CSU）患者中女性明显多于男性，但目前还没有针对CSU性别差异的系统综述。我们检索了 PubMed Medline、Web of Science 和 Cochrane Central Register of Controlled Trials (CENTRAL)，直至 2023 年 7 月。纳入了研究 CSU 性别差异的英语和德语随机对照试验、前瞻性和回顾性队列研究以及病例对照研究。两位作者独立筛选了报告的合格性。其中一位作者提取了所有数据，另一位作者对研究的质量和偏倚风险进行了双重检查和严格评估。共纳入 26 篇报告。文章回顾了女性和男性患者在流行病学、诊断、临床特征、治疗和生活质量方面的差异。研究结果提供了有限的数据，说明了性别和性别对 CSU 患者的实质性影响，并揭示了皮肤病学在性别护理方面存在的主要差距，这些差距应在未来几年内缩小，以优化以患者为中心的、个性化的、性别平等的医疗服务。

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引用次数: 0