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What is the dietary intake and nutritional status of defence members: a systematic literature review 国防人员的膳食摄入量和营养状况如何:系统文献综述
IF 5.7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-16 DOI: 10.1017/s0954422424000143
Jessica Bayes, Emily Burch, Romy Lauche, Jon Wardle
Optimal diet and nutrition is vital for military readiness, performance and recovery. Previous research on military diets has primarily focused on the nutritional composition of field/combat rations and dietary intake during deployment. There is accumulating research exploring the usual free-living dietary intake and nutritional status of defence members in garrison (i.e. military bases on which personnel are stationed). However, no comprehensive review has been conducted to assess the overall dietary quality of defence members internationally. Therefore, this review assessed the diets of military populations against national nutritional guidelines and Military Dietary Reference Intakes (MDRI). A systematic literature review of original research was conducted. CINAHL, Medline (EBSCO), Scopus (Elsevier), PubMed and AMED databases were searched up to the 20/02/2023. A total of thirty-six studies met the inclusion criteria. The overall quality of included studies was high, with a low risk of bias. The diet quality scores indicate poor to fair diet quality among defence members. Defence members display low intakes of fruits, vegetables, wholegrains, seafood, plant protein and nuts and high intakes of added sugars, trans fat and processed meat. Results also indicated suboptimal intake of fibre, essential fatty acids, vitamin A, vitamin E, folate, Mg, Zn and iodine. This may lead to reduced performance, increased risk of chronic diseases and mental health disorders. More research is needed to assess the long-term consequences of poor diet quality in defence members. These results require the attention of policymakers to ensure that military education and food environment is supportive of healthy eating.
最佳饮食和营养对军队的战备、表现和恢复至关重要。以往对军事饮食的研究主要集中在野战/战斗口粮的营养成分和部署期间的饮食摄入量。对驻军(即人员驻扎的军事基地)国防人员平时自由生活饮食摄入量和营养状况的探索研究也在不断积累。然而,目前还没有对国际上国防人员的整体饮食质量进行全面评估。因此,本综述根据国家营养指南和军用膳食参考摄入量 (MDRI) 对军人的膳食进行了评估。对原始研究进行了系统的文献综述。检索了截至 2023 年 2 月 20 日的 CINAHL、Medline (EBSCO)、Scopus (Elsevier)、PubMed 和 AMED 数据库。共有 36 项研究符合纳入标准。纳入研究的总体质量较高,偏倚风险较低。膳食质量评分表明,国防军成员的膳食质量从较差到一般不等。国防军成员的水果、蔬菜、全谷物、海鲜、植物蛋白和坚果摄入量较低,而添加糖、反式脂肪和加工肉类的摄入量较高。结果还表明,纤维、必需脂肪酸、维生素 A、维生素 E、叶酸、镁、锌和碘的摄入量不足。这可能会导致学习成绩下降、慢性疾病和精神疾病风险增加。需要进行更多的研究,以评估不良饮食质量对国防人员造成的长期后果。这些结果需要决策者的关注,以确保军事教育和饮食环境有利于健康饮食。
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引用次数: 0
Ceramides as the molecular link between impaired lipid metabolism, saturated fatty acid intake and insulin resistance: are all saturated fatty acids to be blamed for ceramide-mediated lipotoxicity? 神经酰胺是脂质代谢受损、饱和脂肪酸摄入量和胰岛素抵抗之间的分子联系:神经酰胺介导的脂肪毒性是否应归咎于所有饱和脂肪酸?
IF 5.7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-12 DOI: 10.1017/s0954422424000179
Domenico Sergi, Enrico Zauli, Claudio Celeghini, Maurizio Previati, Giorgio Zauli
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has reached epidemic proportions worldwide, posing a huge treat on people’s health and quality of life. From a pathogenetic prospective, T2DM is driven by insulin resistance defined as a blunted response of tissues to insulin which leads to chronic hyperglycaemia. Mechanistically, lipotoxicity and particularly the intracellular accumulation of ceramides in the skeletal muscle and the liver, is a primary metabolic aberration underpinning insulin resistance. Indeed, intracellular ceramide accumulation can hamper insulin signal transduction pathway thereby promoting insulin resistance. This review will provide an updated overview of the metabolic defects underlaying ceramide buildup and the molecular mechanism by which ceramides imping upon insulin signalling. Additionally, the role of specific ceramide subspecies as potential biomarkers for T2DM and the role of both long- and medium-chain saturated fatty acids as a modulator of ceramide metabolism will be discussed.
2 型糖尿病(T2DM)是一种代谢紊乱疾病,在全球范围内已达到流行病的程度,对人们的健康和生活质量造成了巨大的影响。从病理角度看,T2DM 是由胰岛素抵抗驱动的,胰岛素抵抗被定义为组织对胰岛素的反应迟钝,从而导致慢性高血糖。从机理上讲,脂肪毒性,尤其是骨骼肌和肝脏中神经酰胺的细胞内蓄积,是胰岛素抵抗的主要代谢畸变基础。事实上,细胞内神经酰胺的积累会阻碍胰岛素信号转导途径,从而促进胰岛素抵抗。本综述将概述神经酰胺积累所导致的代谢缺陷,以及神经酰胺影响胰岛素信号传导的分子机制。此外,还将讨论特定神经酰胺亚种作为 T2DM 潜在生物标志物的作用,以及长链和中链饱和脂肪酸作为神经酰胺代谢调节剂的作用。
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引用次数: 0
Culinary medicine and healthy ageing: a comprehensive review. 烹饪医学与健康老龄化:全面回顾。
IF 5.7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-08-22 DOI: 10.1017/S0954422423000148
Jara Domper, Lucía Gayoso, Leticia Goni, Victor de la O, Usune Etxeberria, Miguel Ruiz-Canela

Culinary medicine (CM) represents a novel strategy to promote healthy ageing, as it improves adherence to healthy dietary patterns by providing nutritional education and training in cooking skills. We conducted a comprehensive review of the current scientific literature (2011-2022) concerning CM programmes implemented among participants over the age of 40. This review includes fourteen culinary-nutritional interventions. Each CM programme was analysed according to seven variables: health goal, study design, theoretical basis of the intervention, intervention duration, main outcomes, culinary intervention and the effectiveness of intervention. Although CM programmes showed low effectiveness in achieving positive results on psychosocial outcomes, they were successful in improving dietary intake and health-related outcomes. The interventions lasting for at least 5 months and employing study designs with two or more groups seemed to be important factors associated with achieving significant results. Significant results were observed regardless of the prevention phase defined as the health objective of the CM programme. The use of theoretical frameworks as an educational resource did not influence the effectiveness of the interventions. Other variables such as the inclusion of culinary outcomes, the optimisation of the culinary curriculum taught to the participants and the participation of a chef in the intervention are factors that should be taken into account. In addition, several educational components (cooking classes, hands-on cooking, free food delivery, individualized counselling) were promising for achieving health outcomes in ageing people. Our review has shown that CM programmes can be a powerful tool to improve the health status of ageing people.

烹饪医学(Culinary Medicine,CM)是促进健康老龄化的一种新策略,因为它通过提供营养教育和烹饪技能培训,提高了对健康饮食模式的坚持。我们对目前有关针对 40 岁以上参与者实施的烹饪医学计划的科学文献(2011-2022 年)进行了全面回顾。该综述包括 14 项烹饪营养干预措施。我们根据健康目标、研究设计、干预的理论基础、干预持续时间、主要结果、烹饪干预和干预效果等七个变量对每项烹饪干预计划进行了分析。虽然中餐方案在取得积极的社会心理成果方面效果不佳,但在改善饮食摄入量和健康相关成果方面却很成功。干预时间至少持续 5 个月以及采用两组或更多组的研究设计似乎是取得显著效果的重要因素。无论将预防阶段定义为 CM 计划的健康目标是什么,都能观察到显著的结果。使用理论框架作为教育资源并不影响干预措施的有效性。其他变量,如纳入烹饪成果、优化向参与者教授的烹饪课程以及厨师参与干预等,都是应该考虑的因素。此外,一些教育内容(烹饪课程、亲手烹饪、免费送餐、个性化咨询)也很有希望为老年人带来健康成果。我们的研究表明,中餐计划可以成为改善老年人健康状况的有力工具。
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引用次数: 0
The use of sentiment and emotion analysis and data science to assess the language of nutrition-, food- and cooking-related content on social media: a systematic scoping review. 使用情感和情绪分析以及数据科学评估社交媒体上与营养、食品和烹饪相关的内容语言:系统性范围审查。
IF 5.1 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-03-30 DOI: 10.1017/S0954422423000069
Annika Molenaar, Eva L Jenkins, Linda Brennan, Dickson Lukose, Tracy A McCaffrey

Social media data are rapidly evolving and accessible, which presents opportunities for research. Data science techniques, such as sentiment or emotion analysis which analyse textual emotion, provide an opportunity to gather insight from social media. This paper describes a systematic scoping review of interdisciplinary evidence to explore how sentiment or emotion analysis methods alongside other data science methods have been used to examine nutrition, food and cooking social media content. A PRISMA search strategy was used to search nine electronic databases in November 2020 and January 2022. Of 7325 studies identified, thirty-six studies were selected from seventeen countries, and content was analysed thematically and summarised in an evidence table. Studies were published between 2014 and 2022 and used data from seven different social media platforms (Twitter, YouTube, Instagram, Reddit, Pinterest, Sina Weibo and mixed platforms). Five themes of research were identified: dietary patterns, cooking and recipes, diet and health, public health and nutrition and food in general. Papers developed a sentiment or emotion analysis tool or used available open-source tools. Accuracy to predict sentiment ranged from 33·33% (open-source engine) to 98·53% (engine developed for the study). The average proportion of sentiment was 38·8% positive, 46·6% neutral and 28·0% negative. Additional data science techniques used included topic modelling and network analysis. Future research requires optimising data extraction processes from social media platforms, the use of interdisciplinary teams to develop suitable and accurate methods for the subject and the use of complementary methods to gather deeper insights into these complex data.

社交媒体数据发展迅速且易于获取,这为研究提供了机会。情感或情绪分析等分析文本情感的数据科学技术为从社交媒体中收集洞察力提供了机会。本文对跨学科证据进行了系统的范围界定,以探讨如何将情感或情绪分析方法与其他数据科学方法一起用于研究营养、食品和烹饪社交媒体内容。在 2020 年 11 月至 2022 年 1 月期间,采用 PRISMA 检索策略对九个电子数据库进行了检索。在已确定的 7325 项研究中,从 17 个国家选出了 36 项研究,对研究内容进行了专题分析,并在证据表中进行了总结。研究发表于 2014 年至 2022 年,使用了来自七个不同社交媒体平台(Twitter、YouTube、Instagram、Reddit、Pinterest、新浪微博和混合平台)的数据。研究确定了五个主题:饮食模式、烹饪与食谱、饮食与健康、公共卫生与营养以及一般食品。论文开发了情感或情绪分析工具,或使用了可用的开源工具。预测情感的准确率从 33-33%(开源引擎)到 98-53%(为本研究开发的引擎)不等。情感的平均比例为正面 38-8%,中性 46-6%,负面 28-0%。使用的其他数据科学技术包括主题建模和网络分析。未来的研究需要优化社交媒体平台的数据提取流程,使用跨学科团队开发适合该主题的准确方法,并使用补充方法收集对这些复杂数据的更深入见解。
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引用次数: 0
Scientific evidence of foods that improve the lifespan and healthspan of different organisms. 有科学证据表明,食物能改善不同生物的寿命和健康状况。
IF 5.1 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-07-20 DOI: 10.1017/S0954422423000136
So-Hyun Park, Da-Hye Lee, Dae-Hee Lee, Chang Hwa Jung

Age is a risk factor for numerous diseases. Although the development of modern medicine has greatly extended the human lifespan, the duration of relatively healthy old age, or 'healthspan', has not increased. Targeting the detrimental processes that can occur before the onset of age-related diseases can greatly improve health and lifespan. Healthspan is significantly affected by what, when and how much one eats. Dietary restriction, including calorie restriction, fasting or fasting-mimicking diets, to extend both lifespan and healthspan has recently attracted much attention. However, direct scientific evidence that consuming specific foods extends the lifespan and healthspan seems lacking. Here, we synthesized the results of recent studies on the lifespan and healthspan extension properties of foods and their phytochemicals in various organisms to confirm how far the scientific research on the effect of food on the lifespan has reached.

年龄是许多疾病的风险因素。虽然现代医学的发展大大延长了人类的寿命,但相对健康的老年期(或称 "健康期")并没有延长。针对老年相关疾病发病前可能出现的有害过程,可以大大改善健康和寿命。一个人吃什么、什么时候吃和吃多少对健康寿命有很大影响。通过限制饮食(包括限制卡路里摄入量、禁食或模拟禁食)来延长寿命和健康期限的做法近来备受关注。然而,似乎还缺乏直接的科学证据证明食用特定的食物可以延长寿命和延长健康寿命。在此,我们综合了近年来关于食物及其植物化学物质在不同生物体中延长寿命和健康寿命特性的研究结果,以证实食物对寿命影响的科学研究已达到何种程度。
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引用次数: 0
Re-assessing the role of peri-operative nutritional therapy in patients with pancreatic cancer undergoing surgery: a narrative review. 术前营养治疗在癌症手术患者中的作用:叙述性综述。
IF 5.7 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-09-05 DOI: 10.1017/S0954422423000100
Zoi Bouloubasi, Dimitrios Karayiannis, Zoe Pafili, Avra Almperti, Konstantina Nikolakopoulou, Grigoris Lakiotis, George Stylianidis, Vasilios Vougas

Pancreatic cancer is the most common medical condition that requires pancreatic resection. Over the last three decades, significant improvements have been made in the conditions and procedures related to pancreatic surgery, resulting in mortality rates lower than 5%. However, it is important to note that the morbidity in pancreatic surgery remains r latively high, with a percentage range of 30-60%. Pre-operative malnutrition is considered to be an independent risk factor for post-operative complications in pancreatic surgery, such as impaired wound healing, higher infection rates, prolonged hospital stay, hospital readmission, poor prognosis, and increased morbidity and mortality. Regarding the post-operative period, it is crucial to provide the best possible management of gastrointestinal dysfunction and to handle the consequences of alterations in food digestion and nutrient absorption for those undergoing pancreatic surgery. The European Society for Clinical Nutrition and Metabolism (ESPEN) suggests that early oral feeding should be the preferred way to initiate nourishing surgical patients as it is associated with lower rates of complications. However, there is ongoing debate about the optimal post-operative feeding approach. Several studies have shown that enteral nutrition is associated with a shorter time to recovery, superior clinical outcomes and biomarkers. On the other hand, recent data suggest that nutritional goals are better achieved with parenteral feeding, either exclusively or as a supplement. The current review highlights recommendations from existing evidence, including nutritional screening and assessment and pre/post-operative nutrition support fundamentals to improve patient outcomes. Key areas for improvement and opportunities to enhance guideline implementation are also highlighted.

癌症是最常见的需要切除胰腺的疾病。在过去的三十年里,胰腺手术的相关条件和程序得到了显著改善,死亡率低于5%。然而,值得注意的是,胰腺手术的发病率仍然相对较高,其百分比范围为30-60%。术前营养不良被认为是胰腺手术术后并发症的独立风险因素,如伤口愈合受损、感染率升高、住院时间延长、再次入院、预后不良以及发病率和死亡率增加。关于术后时期,至关重要的是为接受胰腺手术的患者提供尽可能好的胃肠道功能障碍管理,并处理食物消化和营养吸收变化的后果。欧洲临床营养与代谢学会(ESPEN)建议,早期口服喂养应是启动营养手术患者的首选方式,因为这与较低的并发症发生率有关。然而,关于最佳术后喂养方法,目前仍存在争议。几项研究表明,肠内营养与较短的恢复时间、优越的临床结果和生物标志物有关。另一方面,最近的数据表明,胃肠外喂养可以更好地实现营养目标,无论是单独喂养还是作为补充。目前的综述强调了现有证据的建议,包括营养筛查和评估以及改善患者预后的术前/术后营养支持基础。还强调了需要改进的关键领域和加强准则执行的机会。
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引用次数: 0
A review and evaluation of study design considerations for omega-3 fatty acid supplementation trials in physically trained participants. 回顾和评估针对体能训练参与者的欧米伽-3 脂肪酸补充剂试验的研究设计注意事项。
IF 5.1 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-01-09 DOI: 10.1017/S095442242300001X
Ryan Anthony, Michael J Macartney, Jeffery L Heileson, Peter L McLennan, Gregory E Peoples

Long-chain omega-3 polyunsaturated fatty acid (LC n-3 PUFA) supplements, rich in eicosapentaenoic acid and/or docosahexaenoic acid, are increasingly being recommended within athletic institutions. However, the wide range of doses, durations and study designs implemented across trials makes it difficult to provide clear recommendations. The importance of study design characteristics in LC n-3 PUFA trials has been detailed in cardiovascular disease research, and these considerations may guide LC n-3 PUFA study design in healthy cohorts. This systematic review examined the quality of studies and study design considerations used in evaluating the evidence for LC n-3 PUFA improving performance in physically trained adults. SCOPUS, PubMed and Web of Science electronic databases were searched to identify studies that supplemented LC n-3 PUFA in physically trained participants. Forty-six (n = 46) studies met inclusion. Most studies used a randomised control design. Risk of bias, assessed using the design-appropriate Cochrane Collaboration tool, revealed that studies had a predominant judgment of 'some concerns', 'high risk' or 'moderate risk' in randomised controlled, randomised crossover or non-randomised studies, respectively. A custom five-point quality assessment scale demonstrated that no study satisfied all recommendations for LC n-3 PUFA study design. This review has highlighted that the disparate range of study designs is likely contributing to the inconclusive state of outcomes pertaining to LC n-3 PUFA as a potential ergogenic aid. Further research must adequately account for the specific LC n-3 PUFA study design considerations, underpinned by a clear hypothesis, to achieve evidence-based dose, duration and composition recommendations for physically trained individuals.

越来越多的体育机构推荐补充富含二十碳五烯酸和/或二十二碳六烯酸的长链欧米伽-3 多不饱和脂肪酸(LC n-3 PUFA)。然而,由于各种试验的剂量、持续时间和研究设计各不相同,因此很难提供明确的建议。心血管疾病研究已详细阐述了低聚糖 n-3 PUFA 试验中研究设计特征的重要性,这些考虑因素可指导健康队列中低聚糖 n-3 PUFA 的研究设计。本系统综述考察了在评估低聚果糖 n-3 PUFA 可提高体能训练成年人表现的证据时所使用的研究质量和研究设计注意事项。我们检索了 SCOPUS、PubMed 和 Web of Science 电子数据库,以确定在体能训练参与者中补充 LC n-3 PUFA 的研究。符合纳入条件的研究有 46 项(n = 46)。大多数研究采用随机对照设计。使用与设计相适应的 Cochrane 协作工具对偏倚风险进行评估后发现,在随机对照研究、随机交叉研究或非随机研究中,对偏倚风险的主要判断分别为 "有一些担忧"、"高风险 "或 "中等风险"。定制的五点质量评估量表显示,没有一项研究符合关于低聚果糖 n-3 PUFA 研究设计的所有建议。本综述强调,不同的研究设计很可能是导致有关低聚果糖 n-3 PUFA 作为一种潜在助力因素的研究结果尚无定论的原因。进一步的研究必须以明确的假设为基础,充分考虑具体的低聚糖 n-3 PUFA 研究设计因素,从而为体能训练者提供以证据为基础的剂量、持续时间和成分建议。
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引用次数: 0
Advancing college food security: priority research gaps. 促进高校粮食安全:优先研究领域。
IF 5.1 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-05-09 DOI: 10.1017/S0954422423000094
Matthew J Landry, Emily Heying, Zubaida Qamar, Rebecca L Hagedorn-Hatfield, Mateja R Savoie-Roskos, Cara L Cuite, Victoria A Zigmont, Kendra OoNorasak, Susan Chen

Despite over a decade of both quantitative and qualitative studies, food insecurity among US college/university students remains a pervasive problem within higher education. The purpose of this perspective piece was to highlight research gaps in the area of college food insecurity and provide rationale for the research community to focus on these gaps going forward. A group of food insecurity researchers from a variety of higher education institutions across the United States identified five thematic areas of research gaps: screening and estimates of food insecurity; longitudinal changes in food insecurity; impact of food insecurity on broader health and academic outcomes; evaluation of impact, sustainability and cost effectiveness of existing programmes and initiatives; and state and federal policies and programmes. Within these thematic areas, nineteen specific research gaps were identified that have limited or no peer-reviewed, published research. These research gaps result in a limited understanding of the magnitude, severity and persistence of college food insecurity, the negative short- and long-term impacts of food insecurity on health, academic performance and overall college experience, and effective solutions and policies to prevent or meaningfully address food insecurity among college students. Research in these identified priority areas may help accelerate action and interdisciplinary collaboration to alleviate food insecurity among college students and play a critical role in informing the development or refinement of programmes and services that better support college student food security needs.

尽管进行了十多年的定量和定性研究,但美国大专院校学生的食物不安全问题仍然是高等教育中的一个普遍问题。本视角文章旨在强调大学生食物不安全领域的研究缺口,并为研究界今后关注这些缺口提供依据。一组来自美国各高等教育机构的粮食不安全研究人员确定了五个专题领域的研究差距:粮食不安全的筛查和估计;粮食不安全的纵向变化;粮食不安全对更广泛的健康和学术成果的影响;现有计划和倡议的影响、可持续性和成本效益评估;以及州和联邦政策和计划。在这些专题领域中,确定了 19 个具体的研究缺口,这些缺口只有有限的或没有经过同行评审的公开研究。这些研究空白导致人们对大学生粮食不安全的规模、严重性和持续性,粮食不安全对健康、学业成绩和整体大学生活的短期和长期负面影响,以及预防或有意义地解决大学生粮食不安全问题的有效解决方案和政策的了解有限。在这些已确定的优先领域开展研究,可能有助于加快行动和跨学科合作,以减轻大学生的粮食不安全状况,并在为制定或完善更好地支持大学生粮食安全需求的计划和服务提供信息方面发挥关键作用。
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引用次数: 0
Protective effects of polydatin against bone and joint disorders: the in vitro and in vivo evidence so far. 多糖对骨关节疾病的保护作用:迄今为止的体外和体内证据。
IF 5.1 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-04-24 DOI: 10.1017/S0954422423000082
Zhen Zhang, Zhicheng Sun, Runze Jia, Dingyu Jiang, Zhenchao Xu, Yilu Zhang, Yun-Qi Wu, Xiyang Wang

Polydatin is an active polyphenol displaying multifaceted benefits. Recently, growing studies have noticed its potential therapeutic effects on bone and joint disorders (BJDs). Therefore, this article reviews recent in vivo and in vitro progress on the protective role of polydatin against BJDs. An insight into the underlying mechanisms is also presented. It was found that polydatin could promote osteogenesis in vitro, and symptom improvements have been disclosed with animal models of osteoporosis, osteosarcoma, osteoarthritis and rheumatic arthritis. These beneficial effects obtained in laboratory could be mainly attributed to the bone metabolism-regulating, anti-inflammatory, antioxidative, apoptosis-regulating and autophagy-regulating functions of polydatin. However, studies on human subjects with BJDs that can lead to early identification of the clinical efficacy and adverse effects of polydatin have not been reported yet. Accordingly, this review serves as a starting point for pursuing clinical trials. Additionally, future emphasis should also be devoted to the low bioavailability and prompt metabolism nature of polydatin. In summary, well-designed clinical trials of polydatin in patients with BJD are in demand, and its pharmacokinetic nature must be taken into account.

多糖酚是一种活性多酚,具有多方面的功效。最近,越来越多的研究注意到它对骨关节疾病(BJDs)的潜在治疗作用。因此,本文回顾了多酚类化合物在体内和体外对骨关节疾病的保护作用方面的最新进展。文章还对其潜在机制进行了深入探讨。研究发现,多糖铁在体外可促进成骨,骨质疏松症、骨肉瘤、骨关节炎和风湿性关节炎等动物模型的症状也有所改善。在实验室中取得的这些有益效果主要归功于多糖宁的骨代谢调节、抗炎、抗氧化、细胞凋亡调节和自噬调节功能。然而,对患有 BJD 的人类受试者进行的研究尚未见报道,因此无法及早确定多达汀的临床疗效和不良反应。因此,本综述可作为临床试验的起点。此外,今后还应重视多拉丁的低生物利用度和快速代谢特性。总之,我们需要对多拉丁在 BJD 患者中的应用进行精心设计的临床试验,同时必须考虑到其药代动力学特性。
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引用次数: 0
Health effects of 100% fruit and vegetable juices: evidence from human subject intervention studies. 100%果汁和蔬菜汁对健康的影响:来自人类受试者干预研究的证据。
IF 5.1 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-06-01 Epub Date: 2023-09-01 DOI: 10.1017/S095442242300015X
Irene Rossi, Cristiana Mignogna, Daniele Del Rio, Pedro Mena

The health effects of 100% fruit and vegetable juices (FVJ) represent a controversial topic. FVJ contain notable amounts of free sugars, but also vitamins, minerals, and secondary compounds with proven biological activities like (poly)phenols and carotenoids. The review aimed to shed light on the potential impact of 100% FVJ on human subject health, comprehensively assessing the role each type of juice may have in specific health outcomes for a particular target population, as reported in dietary interventions. The effects of a wide range of FVJ (orange, grapefruit, mandarin, lemon, apple, white, red, and Concord grapes, pomegranate, cranberry, chokeberry, blueberry, other minor berries, sweet and tart cherry, plum, tomato, carrot, beetroot, and watermelon, among others) were evaluated on a series of outcomes (anthropometric parameters, body composition, blood pressure and vascular function, lipid profile, glucose homeostasis, biomarkers of inflammation and oxidative stress, cognitive function, exercise performance, gut microbiota composition and bacterial infections), providing a thorough picture of the contribution of each FVJ to a health outcome. Some juices demonstrated their ability to exert potential preventive effects on some outcomes while others on other health outcomes, emphasising how the differential composition in bioactive compounds defines juice effects. Research gaps and future prospects were discussed. Although 100% FVJ appear to have beneficial effects on some cardiometabolic health outcomes, cognition and exercise performance, or neutral effects on anthropometric parameters and body composition, further efforts are needed to better understand the impact of 100% FVJ on human subject health.

100%果蔬汁(FVJ)对健康的影响是一个有争议的话题。FVJ含有大量的游离糖,但也含有维生素、矿物质和已证实具有生物活性的次生化合物,如(多)酚和类胡萝卜素。该综述旨在阐明100%FVJ对人类受试者健康的潜在影响,全面评估每种果汁在特定目标人群的特定健康结果中可能发挥的作用,正如饮食干预中所报道的那样。评估了多种FVJ(橙色、葡萄柚、柑橘、柠檬、苹果、白色、红色和康科德葡萄、石榴、蔓越莓、樱桃、蓝莓、其他小浆果、甜樱桃和酸樱桃、李子、番茄、胡萝卜、甜菜根和西瓜等)对一系列结果的影响(人体测量参数、身体成分、血压和血管功能、脂质概况、葡萄糖稳态、炎症和氧化应激的生物标志物、认知功能、运动表现、肠道微生物群组成和细菌感染),全面了解每种FVJ对健康结果的贡献。一些果汁展示了它们对某些结果发挥潜在预防作用的能力,而另一些果汁则对其他健康结果发挥潜在的预防作用,强调了生物活性化合物的不同组成如何定义果汁效果。讨论了研究差距和未来前景。尽管100%FVJ似乎对某些心脏代谢健康结果、认知和运动表现有有益影响,或对人体测量参数和身体成分有中性影响,但仍需要进一步努力,以更好地了解100%FVJ对人类受试者健康的影响。
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Nutrition Research Reviews
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