Journal of Cranio-Maxillofacial Surgery最新文献_第6页

Effect of platelet-rich fibrin on the recovery after third molar surgery: A systematic review and meta-analysis 富血小板纤维蛋白对第三磨牙手术后恢复的影响：系统回顾与元分析

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jcms.2024.06.022

This meta-analysis aimed to elucidate the effects of platelet-rich fibrin (PRF) on the recovery of alveolar bone after surgical removal of the mandibular third molars.

PubMed, Cochrane Library, Web of Science, and Embase databases were searched from the inception to February 2023 for relevant studies on the application of PRF after the extraction of impacted mandibular third molars, with the language limited to English. Literature screening was conducted by two independent researchers. The Cochrane risk-of-bias tool was adopted for quality evaluation, and Stata 15.0 was used for statistical analysis. A total of 33 randomized controlled trials were included in the present study. Following surgical removal of the mandibular third molars, 1139 tooth sockets were filled with PRF, while 1138 sockets were sutured after conventional saline irrigation. The meta-analyses showed that PRF can relieve pain [(RR 0.454; 95% CI 0.23, 0.891); (SMD −0.74; 95% CI −0.97, 0.52)], improve swelling (SMD −1.48; 95% CI −1.90, −1.06), alleviate trismus (SMD −0.35; 95% CI −0.51, −0.19), reduce dry socket (SMD −0.18; 95% CI −030, −0.05), and promote bone tissue healing (SMD 2.34; 95% CI 0.18, 4.51). The current study confirms that PRF can reduce some postoperative complications. Local application of PRF after lower third molar extraction is a viable method for relieving pain and swelling, reducing the incidence of dry socket and trismus, and increasing bone density. However, whether it can promote soft tissue healing remains unclear. For patients undergoing complicated surgical extraction, local application of PRF into the sockets might be a good option.

这项荟萃分析旨在阐明富血小板纤维蛋白（PRF）对下颌第三磨牙手术拔除后牙槽骨恢复的影响。我们在 PubMed、Cochrane Library、Web of Science 和 Embase 数据库中检索了从开始到 2023 年 2 月有关下颌第三磨牙拔除后应用 PRF 的相关研究，语言仅限于英语。文献筛选由两名独立研究人员进行。采用 Cochrane 偏倚风险工具进行质量评估，并使用 Stata 15.0 进行统计分析。本研究共纳入了 33 项随机对照试验。在手术拔除下颌第三磨牙后，1139 个牙槽窝被填充了 PRF，而 1138 个牙槽窝则在常规生理盐水冲洗后进行了缝合。荟萃分析表明，PRF 可以缓解疼痛[（RR 0.454；95% CI 0.23，0.891）；（SMD -0.74；95% CI -0.97，0.52）]，改善肿胀（SMD -1.48；95% CI -1.90, -1.06）、减轻咀嚼障碍（SMD -0.35；95% CI -0.51，-0.19）、减少干槽症（SMD -0.18；95% CI -030，-0.05）、促进骨组织愈合（SMD 2.34；95% CI 0.18，4.51）。目前的研究证实，PRF 可以减少一些术后并发症。下第三磨牙拔除术后局部应用PRF是一种可行的方法，可以缓解疼痛和肿胀，降低干槽症和三凹症的发生率，并增加骨密度。然而，它是否能促进软组织愈合仍不清楚。对于接受复杂手术拔牙的患者来说，在牙槽内局部应用PRF可能是一个不错的选择。

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引用次数: 0

“Skeletal surgical approach in Down Syndrome with Obstructive Sleep Apnea.” "唐氏综合症合并阻塞性睡眠呼吸暂停的骨骼手术方法"

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jcms.2024.08.001

Miren de las Fuentes Monreal , Ana Laura Capote Moreno , Rybel Wix Ramos , Mario Fernando Muñoz-Guerra , Pilar Rubio Bueno

Failing to address Obstructive Sleep Apnea (OSA) in Down Syndrome (DS) patients can have serious consequences, leading to increased mortality. Moreover, a notable portion of individuals find it challenging to tolerate Continuous Positive Airway Pressure (CPAP). Therefore, this study aims to share our experiences in treating adult DS patients with moderate to severe OSA who don't tolerate CPAP using various surgical approaches.

A retrospective analytical study including 20 DS with moderate to severe/very severe OSA who had no tolerance to Continuous Positive Airway Pressure (CPAP) was conducted. Regarding the individual skeletal characteristics of each patient various orthognathic surgery techniques were performed. Two in-hospital polysomnographies (PSG) were undertaken for every patient; one before the surgical procedure, while another was performed between 6 and 60 months of the follow-up post-surgery period.

Polysomnographic variables were analyzed in this study such as AHI, ODI, and T90, which all showed statistically significant improvement after surgery with a p value in the Wilcoxon test <0,01. These results have remained stable over time, with no recurrences of OSA observed over the five years of follow-up. Thus, orthognathic surgery may be the only viable option for individuals with DS who are unable to tolerate CPAP.

如果不能解决唐氏综合症（DS）患者的阻塞性睡眠呼吸暂停（OSA）问题，可能会造成严重后果，导致死亡率上升。此外，有相当一部分患者难以耐受持续气道正压（CPAP）。因此，本研究旨在分享我们采用各种手术方法治疗不能耐受 CPAP 的中重度 OSA 成年 DS 患者的经验。这项回顾性分析研究包括 20 名患有中度至重度/极重度 OSA 且不能耐受持续气道正压（CPAP）的 DS 患者。针对每位患者的骨骼特点，采用了不同的正颌外科技术。对每位患者进行了两次院内多导睡眠图检查（PSG），一次在手术前，另一次在术后 6 至 60 个月的随访期间进行。本研究分析了多导睡眠图变量，如 AHI、ODI 和 T90，这些变量在术后均有统计学意义上的显著改善。

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引用次数: 0

Timing of oral and maxillofacial surgery in infected COVID-19 subjects: A retrospective cohort study 受感染的 COVID-19 受试者进行口腔颌面外科手术的时机：回顾性队列研究

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jcms.2024.06.008

This study aims to investigate the association of time to oral and maxillofacial surgery after Covid-19 infection with the risk of postoperative complications in a population from China.

In the current study, a total of 1342 consecutive patients underwent general anesthesia (GA) in the maxillofacial district of the Chinese Oral and Maxillofacial COVID Collaborative, which consists of 27 teaching hospitals. Pulmonary, cardiovascular and thrombotic complications were monitored for 1 month after GA surgery (GAS) and their incidence was reported for the first 30 days.

Post-operative complications were observed in 4 of 1076 cases (0.37%) who had suffered from mild Omicron infection and in none of the controls. Results from the Quasi-Poisson multivariate regression models showed that Omicron infection was not associated with increased post-operative complications compared to controls. Among the infected patients, delays of >4 but not >6 weeks were associated with lower OR of complications (0.08, 95% CI 0.01–0.78 and 0.06, 95% CI 0.01–1.80, respectively).

Findings of this study suggest that delaying surgery for a period of 4–6 weeks following infection can provide a protective effect.

本研究旨在调查中国人群中Covid-19感染后口腔颌面外科手术时间与术后并发症风险的关系。在本研究中，共有1342名连续患者在中国口腔颌面COVID协作组（由27家教学医院组成）的颌面区接受了全身麻醉（GA）。在 1076 例病例中，有 4 例（0.37%）患有轻度奥米加氏感染，而对照组病例中没有人出现术后并发症。准泊松多元回归模型的结果显示，与对照组相比，奥米克龙感染与术后并发症的增加无关。在感染患者中，延迟 4 周而不是 6 周与较低的并发症发生率相关（分别为 0.08，95% CI 0.01-0.78 和 0.06，95% CI 0.01-1.80）。

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引用次数: 0

A method for accuracy of placement analysis on radiolucent polyether-ether-keton facial implants: A case series 放射聚醚醚酮面部植入物位置准确性分析方法：病例系列

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jcms.2024.06.009

Facial asymmetry is defined as a bilateral difference between facial components. Correction, often desired by the patient, can be performed with the aim of bone born patient-specific solid implants designed using 3D CAD software. This treatment is embedded in the daily practice of today's healthcare. However, an analysis of the implant's accuracy of placement has not been reported. This case series describes the accuracy analysis of bone born aesthetic facial implants manufactured out of polyether-ether-ketone (PEEK). The accuracy analysis was based on postoperative (cone beam) computed tomography ((CB)CT) data and preoperative 3D planning. The analysis showed a median entry point error of 0.7 mm (min: 0.1, max: 3.3, interquartile range: 0.78). The median maximal orientation error was 5.5° (min: 0.1, max: 36.8, interquartile range: 7.13). Both parameters showed an excellent intraobserver and interobserver agreement with an ICC above 0.84. The described cases show that the analysis method is an objective approach for determining the accuracy of PSI placement and indicates that these implants can be placed accurately on the osseous face.

面部不对称是指面部各部分之间的双侧差异。患者通常希望通过使用三维 CAD 软件设计的骨性患者专用固体植入物来进行矫正。这种治疗方法已融入当今医疗保健的日常实践中。然而，对种植体植入准确性的分析还未见报道。本病例系列描述了对聚醚醚酮（PEEK）制造的骨性面部美容植入物的准确性分析。准确性分析基于术后（锥束）计算机断层扫描（CB）CT 数据和术前三维规划。分析结果显示，切入点误差的中位数为 0.7 毫米（最小：0.1，最大：3.3，四分位间范围：0.78）。最大方向误差中位数为 5.5°（最小：0.1，最大：36.8，四分位间范围：7.13）。这两个参数在观察者内部和观察者之间的一致性都非常好，ICC 均超过 0.84。所描述的病例表明，该分析方法是确定 PSI 植入准确性的客观方法，并表明这些种植体可以准确地植入骨面。

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引用次数: 0

Assessment of the relationship between the three-dimensional precise location of the mandibular third molar and the volume ratio of the impacted mandibular third molar to the mandibular angle, and the patterns of mandibular angle fracture: A retrospective study 评估下颌第三磨牙的三维精确定位和受撞击的下颌第三磨牙与下颌角的体积比之间的关系，以及下颌角骨折的模式：一项回顾性研究。

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jcms.2024.08.009

Pei Gong , Liya Wang , Luyang Zhao , Puyuan Zheng , Jie Long

This study aimed to evaluate the relationship between the precise three-dimensional location of the third molar (M3) and mandibular angle fracture (MAF) patterns and to assess the effect of the volume ratio occupied by M3 in the mandibular angle on fracture patterns. The location of M3 was assessed in 218 patients with MAF using computed tomography reconstruction. The bone volume of the mandibular angle and the bone volume occupied by M3 were measured to calculate the volume ratio of M3 to the mandibular angle (M3/MA). MAF patterns were categorized into simple fracture (Type I), displaced fracture (Type II), and comminuted fracture (Type III) based on fracture severity. The results showed that the location of M3 significantly influenced MAF patterns (vertical position: P = .001; horizontal position: P = .002; angulation: P = .027, respectively) and the volume ratio of M3/MA was significantly higher for Type III fracture than Types I and II (P < .001). Regression analysis showed that the horizontal position and angulation of M3 and the volume ratio of M3/MA were the main predictors for comminuted MAF. A larger volume ratio (odds ratio [OR], 1.201; 95% confidence interval [CI], 1.037–1.391; P < .014), Class III position (OR, 7.978; 95% CI, 1.275–49.910; P < .026), and horizontal angulation (OR, 7.212; 95% CI, 1.028–50.581; P < .047) of the M3 were more prone to comminuted MAF than simple fracture. Our findings indicate that the location of M3 significantly affects MAF patterns, and that M3 may weaken the mandibular angle by occupying more bone space, thereby increasing the risk of a comminuted fracture.

本研究旨在评估第三磨牙（M3）的精确三维位置与下颌角骨折（MAF）模式之间的关系，并评估M3在下颌角所占体积比对骨折模式的影响。使用计算机断层扫描重建技术对 218 名下颌角骨折患者的 M3 位置进行了评估。通过测量下颌角的骨量和M3占据的骨量，计算出M3与下颌角的体积比（M3/MA）。根据骨折严重程度，将 MAF 模式分为简单骨折（I 型）、移位骨折（II 型）和粉碎性骨折（III 型）。结果显示，M3 的位置对 MAF 模式有显著影响（垂直位置：P = 0.001；水平位置：P = 0.001）：P = .001；水平位置：P = .002; Angulation：P = .027），III型骨折的M3/MA体积比明显高于I型和II型（P = .001；P = .002；P = .027）。

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引用次数: 0

MRI tumour volumetry as a new staging tool in diagnosis and therapy of oral cancer 磁共振成像肿瘤体积测量法作为口腔癌诊断和治疗的新分期工具。

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-10-01 DOI: 10.1016/j.jcms.2024.03.012

Philipp Thoenissen , Tim Engelmann , Anja Heselich , Ria Winkelmann , Iris Burck , Robert Sader , Shahram Ghanaati

引用次数: 0

Virtual surgical planning in tripod zygomatico-maxillary complex fractures: A prospective comparison between two different strategies. 三脚架颧颌面复合体骨折的虚拟手术规划：两种不同策略的前瞻性比较。

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-09-29 DOI: 10.1016/j.jcms.2024.08.020

Umberto Committeri, Roberta Magliulo, Emanuele Carraturo, Antonio Arena, Vincenzo Abbate, Giovanni Salzano, Stefania Troise, Simona Barone, Cristiana Germano, Luigi Angelo Vaira, Francesco Giovacchini, Rosanna Cataldo, Maria Gabriella Grassia, Luigi Califano, Pasquale Piombino

Multifragmentary and displaced zygomaticomaxillary complex (ZMC) fractures are often a challenge for the maxillofacial surgeon. The aim of this study was to evaluate the improved performance in the management of patients with tripod fracture of the orbito-zygomaticomaxillary complex, using two different methods of virtual surgical planning - virtual reduction and mirroring - compared with traditional management. A cohort of 60 patients was selected and divided into three groups, each consisting of 20 individuals. Patients in the first group were managed using the virtual reduction method, those in the second group using the mirroring method, and those in the third group using a traditional surgical approach. Having achieved virtual fracture reduction, a stereolithographic model was printed, on which preplating of the plates was performed. The results showed that virtual reduction was the most accurate in absolute terms, with a mean discrepancy in juxtaposition of the preoperative and postoperative CT images of 0.175 mm (SD ± 0.147), compared with 0.403 (SD ± 0.166) for the mirror method (and traditional method (0.875, SD ± 0.112; p > 0.0001). The average surgical time for virtual reduction (89.5 min) was faster than for mirroring (94.25 min) and for the traditional approach (96.75 min). In conclusion, the use of virtual surgical planning allows greater intraoperative accuracy, reduced surgical time, and reduced postoperative complications compared with traditional surgery. Of the two methods, virtual reduction performed best for the outcomes decribed.

对于颌面外科医生来说，多段和移位的颧颌面复合体（ZMC）骨折往往是一项挑战。本研究的目的是评估采用虚拟手术规划的两种不同方法（虚拟还原和镜像）与传统方法相比，在治疗眶颧颌面复合体三脚架骨折患者方面的改进效果。研究人员选取了 60 名患者，将其分为三组，每组 20 人。第一组采用虚拟骨折复位法，第二组采用镜像法，第三组采用传统手术法。在实现虚拟骨折复位后，打印出立体光刻模型，并在该模型上预镀钢板。结果显示，虚拟骨折复位术的绝对精确度最高，术前和术后 CT 图像并列的平均差异为 0.175 毫米（标准差 ± 0.147），而镜像法为 0.403 毫米（标准差 ± 0.166）（传统方法为 0.875 毫米，标准差 ± 0.112；P > 0.0001）。虚拟缩小术的平均手术时间（89.5 分钟）比镜像法（94.25 分钟）和传统方法（96.75 分钟）更快。总之，与传统手术相比，使用虚拟手术规划可以提高术中准确性，缩短手术时间，减少术后并发症。在两种方法中，虚拟缩窄术的效果最好。

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引用次数: 0

Evaluation of grafts fixation techniques for temporomandibular joint reconstruction with medial femoral condyle flap: A numerical study. 股骨内侧髁状突皮瓣用于颞下颌关节重建的移植物固定技术评估：数值研究

IF 3.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-09-09 DOI: 10.1016/j.jcms.2024.09.001

Haoliang Chen,Yongheng Li,Tianyi Lin,Qiang Chen,Yang He

Reconstruction for large-scale temporomandibular joint (TMJ) defects can be challenging. Previously, we utilized the medial femoral condyle (MFC) flap for TMJ reconstruction. However, the optimal fixation method remains uncertain. In this study, ﬁnite element analysis was used to study the effects of three different fixation types of bone graft: overlap type, bevel type, and flush type. Models of different fixation types of MFC flap were reconstructed from CT images. A standard internal fixation model for extracapsular condylar fracture was also included as a control. Displacement of bone graft, deformation of plates and screws, and stress distribution of plates, screws, and cortical and cancellous of the bone graft were analyzed by ﬁnite element analysis to investigate their biomechanical features. The displacement of the bone graft and deformation of plates and screws in three different fixation types showed no significant difference. The overlap type and flush type of fixation displayed the lowest and highest stress respectively. All three fixation types could satisfy the mechanical requirement and face no risk of breakage and the major displacement of the MFC bone graft. These results provide insights into the optimal fixation approach for MFC bone grafts, offering valuable guidance and reference for clinical application.

大面积颞下颌关节（TMJ）缺损的重建具有挑战性。以前，我们利用股骨内侧髁（MFC）皮瓣重建颞下颌关节。然而，最佳的固定方法仍不确定。在这项研究中，我们使用有限元分析法研究了三种不同的植骨固定方式：重叠式、斜面式和齐平式的效果。根据 CT 图像重建了不同固定类型的 MFC 皮瓣模型。同时还包括一个髁突外骨折的标准内固定模型作为对照。通过有限元分析法分析了植骨的位移、钢板和螺钉的变形，以及钢板、螺钉、植骨皮质和松质的应力分布，以研究其生物力学特征。在三种不同的固定方式下，植骨的位移以及钢板和螺钉的变形均无明显差异。重叠式固定和齐平式固定分别显示出最低和最高的应力。三种固定方式均能满足力学要求，且无 MFC 植骨断裂和大位移的风险。这些结果为 MFC 骨移植的最佳固定方法提供了启示，为临床应用提供了宝贵的指导和参考。

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引用次数: 0

Comparative analysis of postoperative complications and outcomes in outpatient versus inpatient orthognathic surgery: A retrospective cohort study. 门诊与住院正颌外科手术术后并发症和疗效的比较分析：回顾性队列研究。

IF 3.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-09-07 DOI: 10.1016/j.jcms.2024.09.003

Samanta Buchholzer,Romain Aymon,Benno Rehberg-Klug,Paolo Scolozzi

The purpose of this study was to assess and compare the complication rates of single-jaw orthognathic surgery between outpatients and inpatients, and to examine their impact on the outcome of care setting. A retrospective cohort study was performed of patients who underwent single-jaw orthognathic procedures. Outpatients between 2008 and 2023 were selected as the study group, while inpatients between 1997 and 2023 were enrolled as the control group. The predictor variable was the patient care setting. The primary outcome variable was the occurrence of overall complications. Secondary outcomes included surgery-, anesthesia-, and patient-related complications. Other study variables included age, sex, surgery, and anesthetic procedures. Descriptive, bivariate, and multiple logistic regression statistics were computed and the significance level was set at p ≤ 0.05. The sample included 307 patients with a mean age of 23.1 years ±9.5 years, of whom 55% were female. The outpatient and inpatient groups consisted of 123 (40.1%) and 184 (59.9%) patients, respectively. Of the 123 outpatients, 104 (85.5%) were discharged on the day of surgery. Age (p = 0.012) and ketamine administration (p = 0.022) were significantly associated with complications among outpatients. Outpatient setting and age were significantly associated with overall complications (OR 2.48; 95% confidence interval [CI] 1.34-4.66, p = 0.003 and OR 0.94, 95% CI 0.88-0.98, p = 0.021, respectively) and anesthetic-related complications (OR 4.43, 95% CI 2.03-10.5, p = 0.0003 and OR 0.92, 95% CI 0.83-0.98, p = 0.041, respectively). The study demonstrated that outpatient orthognathic surgery had a high success rate but also identified a higher rate of anesthetic-related complications among outpatients, particularly in younger patients and in those receiving ketamine.

本研究旨在评估和比较门诊病人和住院病人单颌正颚手术的并发症发生率，并研究其对护理环境结果的影响。本研究对接受单颌正颚手术的患者进行了回顾性队列研究。研究选取 2008 年至 2023 年的门诊患者作为研究组，1997 年至 2023 年的住院患者作为对照组。预测变量为患者护理环境。主要结果变量是总体并发症的发生率。次要结果包括手术、麻醉和患者相关并发症。其他研究变量包括年龄、性别、手术和麻醉程序。研究计算了描述性、双变量和多元逻辑回归统计，显著性水平设定为 p≤ 0.05。样本包括 307 名患者，平均年龄为 23.1 岁 ±9.5 岁，其中 55% 为女性。门诊组和住院组分别有 123 名（40.1%）和 184 名（59.9%）患者。在 123 名门诊患者中，104 人（85.5%）在手术当天出院。年龄（p = 0.012）和氯胺酮用量（p = 0.022）与门诊患者的并发症显著相关。门诊环境和年龄分别与总体并发症（OR 2.48；95% 置信区间 [CI] 1.34-4.66，p = 0.003 和 OR 0.94，95% CI 0.88-0.98，p = 0.021）和麻醉相关并发症（OR 4.43，95% CI 2.03-10.5，p = 0.0003 和 OR 0.92，95% CI 0.83-0.98，p = 0.041）显著相关。该研究表明，门诊正颌手术的成功率很高，但也发现门诊患者中麻醉相关并发症的发生率较高，尤其是年轻患者和使用氯胺酮的患者。

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引用次数: 0

Investigation of nasal cavity alterations in individuals with neurofibromatosis type 1 using CBCT. 利用 CBCT 研究 1 型神经纤维瘤病患者的鼻腔改变。

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery

Pub Date : 2024-09-07 DOI: 10.1016/j.jcms.2024.09.002

Ingrid Cristina Pinto da Costa, Bruna Caroline Tomé Barreto, Luísa Schubach da Costa Barreto, Karin Soares Cunha, Andréa de Castro Domingos Vieira, Margareth Maria Gomes de Souza

Objectives: This study aimed to investigate nasal septum deviation (NSD), nasal bone length (NBL), and the morphology of the middle nasal conchae (MNC) and inferior nasal conchae (INC), as well as their correlations.

Materials and methods: The sample included 56 cone-beam computed tomography scans divided into two groups: a study group (SG; individuals with NF1; n = 28) and a control group (CG; individuals without NF1; n = 28). NSD, NBL, MNC, and INC classifications were assessed. MNC images were classified as normal, bullous, paradoxical, secondary, and accessory. INC images were classified as normal, lamellar, compact, combined, and bullous. Intra- and interobserver reliability were evaluated.

Results: SG had a mean NSD of 11.6° (±4.5°) compared with 9.6° (±3.2°) for the CG, showing moderate deviations with no significant difference between groups. SG had a mean NBL of 22.4 mm (±3.4 mm) compared with 22.1 mm (±3.2 mm) for the CG, with a statistically significant difference. Both groups exhibited normal, bullosa, and accessory MNC classifications. SG INC were normal, lamellar, and combined, whereas CG INC were normal and lamellar. There was a weak correlation between NSD and NBL across groups.

Conclusion: Individuals with NF1 showed longer NBL. The weak correlation between NSD and NBL suggested multifactorial influences on these variations. These findings advance our understanding of craniofacial development in NF1 and highlight the need for further research into nasal cavity involvement in this complex genetic disorder.

研究目的本研究旨在调查鼻中隔偏曲（NSD）、鼻骨长度（NBL）、中鼻小锥体（MNC）和下鼻小锥体（INC）的形态及其相关性：样本包括 56 个锥形束计算机断层扫描，分为两组：研究组（SG；NF1 患者；n = 28）和对照组（CG；无 NF1 患者；n = 28）。对 NSD、NBL、MNC 和 INC 分类进行了评估。MNC 图像分为正常、牛皮状、矛盾、继发性和附属性。INC 图像分为正常、片状、紧密、合并和大泡。对观察者内部和观察者之间的可靠性进行了评估：SG的平均NSD为11.6°（±4.5°），而CG为9.6°（±3.2°），显示出中等偏差，组间无显著差异。SG 的平均 NBL 为 22.4 毫米（±3.4 毫米），而 CG 为 22.1 毫米（±3.2 毫米），差异有统计学意义。两组的 MNC 分为正常、牛皮癣和附属 MNC。SG INC 为正常、片状和合并，而 CG INC 为正常和片状。各组的 NSD 和 NBL 之间存在微弱的相关性：结论：NF1患者的NBL较长。结论：NF1 患者的 NBL 较长，而 NSD 和 NBL 之间的相关性较弱，这表明这些变异受到多种因素的影响。这些发现加深了我们对 NF1 颅面发育的了解，并强调了进一步研究鼻腔参与这种复杂遗传疾病的必要性。

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引用次数: 0