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Effects of the use of hyaluronic acid in arthroscopic discopexy with resorbable pins: A comparative study 透明质酸在关节镜下可吸收针内固定术中的应用:一项比较研究。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.jcms.2025.11.021
Diana Marcela Bernal Bermúdez , Simona Barone , Carlota Mazo Amorós , Alejandro Encinas Bascones , Alejandrina Millón-Cruz , Rafael Martin-Granizo
The aim of this study was to evaluate whether using hyaluronic acid (HA) after arthroscopic discopexy with resorbable pins offers additional benefits compared to the same technique without HA infiltration.
A retrospective study was performed, including 29 patients who underwent arthroscopic discopexy with HA infiltration and 31 patients who underwent the procedure without any additional substance between 2009 and 2017.
The evaluated parameters were: maximum interincisal opening (MIO), lateral movements (LM), protrusive movement (PM), joint pain (VAS scale), joint locking, and clicking. All patients were followed up at 1, 3, 6, and 12 months.
MIO improved in both groups, with an average improvement of 7.4 mm for the HA group and 8.03 mm for the control group at the 1-year follow-up. Pain scores (VAS) decreased from moderate to mild in both groups with a p-value <0.000, showing better scores for the HA group (11.88 ± 16.17) after one year. Protrusive movement improved significantly in both groups. Joint noise improved in both groups; the HA group saw a reduction from 56.3 % to 17.24 % (p-value = 0.001) at the 1-year follow-up, whereas the control group persisted at 12.9 % from the 55.6 % reported before the intervention. The HA group had better outcomes regarding joint locking, with no blocking events up to 6 months, compared to two patients in the control group experiencing blocking at the 1-year follow-up.
In conclusion, HA infiltration showed a beneficial trend in joint locking and pain scores, although the difference in joint locking was not statistically significant. However, improvements in MIO, protrusive movement, lateral movement, and joint noise in both groups are attributed to the positive effects of arthroscopic discopexy.
本研究的目的是评估关节镜下关节内固定术后使用透明质酸(HA)是否比不使用透明质酸浸润的相同技术有更多的好处。进行了一项回顾性研究,其中包括2009年至2017年期间29例接受骨凝血酶浸润的关节镜内固定术患者和31例接受无任何额外物质手术的患者。评估参数为:最大内径开口(MIO)、横向运动(LM)、突出运动(PM)、关节疼痛(VAS评分)、关节锁定和咔嚓声。随访时间分别为1、3、6、12个月。两组的MIO均有改善,1年随访时,HA组平均改善7.4 mm,对照组平均改善8.03 mm。两组疼痛评分(VAS)均由中度降至轻度,并有p值
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引用次数: 0
Surgeon- and parent-reported outcome after surgery for craniosynostosis 外科医生和家长报告颅缝闭锁手术后的结果
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.jcms.2025.104427
Subhas Konar , Joel John , Dhaval Shukla , Neil Manjunath Salian , Dwarakanath Srivinias , Girish Rao
While previous studies have focused on quantitative assessments and surgeon-reported surgical outcomes, limited research exists on parent-reported outcomes following surgical correction of craniosynostosis. Our study assessed both surgeon-assessed and parent-reported outcomes in children who underwent craniosynostosis correction surgery. A retrospective observational study analyzed the outcomes of 103 children who underwent craniosynostosis surgery between January 2009 and June 2022. First the surgeon assessed the outcome using the Sloan outcome classification system, which ranks cosmetic results on a six-point ordinal scale ranging from excellent correction (Class 1) to compromised correction requiring revision surgery (Class 7). Second, a non-structured patient-reported outcome measurement (PROM) evaluating subjective postoperative changes in cosmetic appearance, vision, oropharyngeal symptoms, scholastic performance, and quality of life (QOL) for both the child and parent was carried out. PROM responses were categorized as A (worsened), B (unchanged), C (moderately improved), or D (significantly improved). Fifty-eight children (56.3 %) achieved a Sloan Class 1 outcome, indicating excellent correction with no visible or palpable deformity. Children with metopic suture synostosis showed the highest improvement (85.7 %). Subjective outcome assessment using PROM revealed statistically significant differences between syndromic (S) and nonsyndromic (NS) craniosynostosis groups across multiple domains. There was a strong correlation between surgeon-reported outcomes and PROM domains of cosmesis, as well as parent and child quality of life. Our study highlights the importance of incorporating both objective and subjective measures in assessing outcomes of craniosynostosis surgery.
虽然以前的研究主要集中在定量评估和外科医生报告的手术结果,但关于颅缝闭锁手术矫正后父母报告的结果的研究有限。我们的研究评估了接受颅缝闭合矫正手术的儿童的外科医生评估和家长报告的结果。一项回顾性观察性研究分析了2009年1月至2022年6月期间接受颅缝闭锁手术的103名儿童的结果。首先,外科医生使用斯隆结果分类系统评估结果,该系统将美容结果按6分制进行排序,从良好的矫正(1级)到需要翻修手术的受损矫正(7级)。其次,进行非结构化的患者报告结果测量(PROM),评估儿童和父母在美容外观、视力、口咽症状、学习成绩和生活质量(QOL)方面的主观术后变化。PROM反应分为A(恶化)、B(不变)、C(中度改善)或D(显著改善)。58名儿童(56.3%)达到斯隆1级结果,表明良好的矫正,没有可见或可触及的畸形。异位缝合性滑膜闭锁患儿的改善程度最高(85.7%)。使用PROM进行的主观结果评估显示,综合征(S)和非综合征(NS)颅缝闭锁组在多个领域之间存在统计学上的显著差异。外科医生报告的结果与化妆的胎膜早破领域以及父母和孩子的生活质量之间存在很强的相关性。我们的研究强调了在评估颅缝闭锁手术结果时结合客观和主观措施的重要性。
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引用次数: 0
Clinical outcomes of gingivoperiosteoplasty performed in early childhood in patients with bilateral cleft lip and palate 儿童早期双侧唇腭裂患者龈周成形术的临床效果。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.jcms.2025.12.002
Yuki Arimura , Tadashi Yamanishi , Takahiro Nishio , Setsuko Uematsu , Aiko Hyodo , Katsuhiko Amano , Seiji Iida , Juntaro Nishio
This study aims to investigate the postoperative maxillofacial growth and bone formation after gingivoperiosteoplasty (GPP) performed in early childhood for patients with bilateral cleft lip and palate (BCLP). Thirty non-syndromic patients with complete BCLP who underwent a two-stage palatoplasty protocol were enrolled. Their alveolar cleft sides were categorized into two groups based on whether GPP was applied at the timing of hard palate closure (GPP group, n = 33) or not (non-GPP group, n = 27). Computed tomography (CT) and lateral cephalograms both taken at 8 years of age were analysed. Bone bridge formation was significantly higher in the GPP group (93.9 %) compared to the non-GPP group (11.1 %). However, the mean proportion of the bone created within the alveolar cleft site measured at multiple vertical levels in the GPP group was 54.4 %. Lateral cephalometric analysis revealed that the GPP group showed both anteroposterior length of the maxilla (GPP: 46.5 ± 3.0 mm, non-GPP: 50.2 ± 2.3 mm) and ANB (GPP: 3.4 ± 3.0°, non-GPP: 6.6 ± 2.5°) significantly smaller than the non-GPP group. These results demonstrated that GPP, performed at 1.5 years of age for BCLP, resulted in insufficient new bone formation and negatively impacted maxillary development. Based on these findings, we have discontinued our GPP protocol for patients with BCLP.
本研究旨在探讨儿童早期双侧唇腭裂(BCLP)患者龈周成形术(GPP)后颌面生长和骨形成情况。30例无综合征的完全性BCLP患者接受了两期腭成形术。根据在硬腭闭合时是否应用GPP (GPP组,n = 33)和是否应用GPP(非GPP组,n = 27)将其牙槽侧裂分为两组。分析了8岁时的计算机断层扫描(CT)和侧位脑电图。GPP组的骨桥形成率(93.9%)明显高于非GPP组(11.1%)。然而,GPP组在多个垂直水平测量的牙槽骨裂位置内产生的骨的平均比例为54.4%。侧位头位测量分析显示,GPP组的上颌骨前后位长度(GPP: 46.5±3.0 mm,非GPP: 50.2±2.3 mm)和ANB (GPP: 3.4±3.0°,非GPP: 6.6±2.5°)均明显小于非GPP组。这些结果表明,在1.5岁时为BCLP进行GPP会导致新骨形成不足,并对上颌发育产生负面影响。基于这些发现,我们已经停止了BCLP患者的GPP方案。
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引用次数: 0
Pathologic assessment Reveals limited efficacy of immunotherapy in recurrent high-grade salivary gland carcinomas: A clinicopathologic and genomic study 病理评估显示免疫治疗对复发性高级别唾液腺癌的有限疗效:一项临床病理和基因组研究。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.jcms.2025.11.018
Zhen Zhu , Junhui Yuan , Xu Zhang , Liyuan Dai , Wei Du , Xiaoli Liu
Recurrent high-grade salivary gland carcinomas (SGCs) have limited treatment options, and immunotherapy's role remains unclear. This study evaluated radiologic and pathologic responses to immunotherapy in resectable recurrent high-grade SGCs. We retrospectively analyzed 108 patients from a tertiary center: 41 received neoadjuvant immunotherapy, while 67 underwent upfront surgery. Radiologic response (RECIST 1.1) and pathologic response (immune-related criteria) were discordant—34.1 % showed partial radiologic responses, but only 9.8 % achieved partial pathologic responses, with no complete responses. PD-L1 amplification correlated with response (25 % vs. 8.1 % in non-responders, p = 0.042), whereas B2M loss (29.3 % post-treatment, p = 0.032) and TP53/PIK3CA co-mutations (37.8 % in non-responders) were linked to resistance. Survival did not differ between groups (3-year event-free survival: 19.5 % vs. 23.9 %, p = 0.447; overall survival: 26.8 % vs. 31.3 %, p = 0.593). These findings highlight immunotherapy's limited pathologic efficacy in recurrent high-grade SGCs, with response rates lower on pathologic than radiologic assessment. PD-L1 and B2M alterations underscore the need for biomarker-driven strategies. This study provides a foundation for improving outcomes in this aggressive disease.
复发性高级别唾液腺癌(SGCs)的治疗选择有限,免疫治疗的作用尚不清楚。本研究评估了可切除复发的高级别SGCs的放射学和病理反应。我们回顾性分析了来自三级中心的108例患者:41例接受了新辅助免疫治疗,67例接受了前期手术。放射反应(RECIST 1.1)和病理反应(免疫相关标准)不一致- 34.1%显示部分放射反应,但只有9.8%达到部分病理反应,没有完全反应。PD-L1扩增与应答相关(25% vs. 8.1%,无应答者,p = 0.042),而B2M丢失(治疗后29.3%,p = 0.032)和TP53/PIK3CA共突变(无应答者,37.8%)与耐药性相关。两组间生存率无差异(3年无事件生存率:19.5% vs. 23.9%, p = 0.447;总生存率:26.8% vs. 31.3%, p = 0.593)。这些发现强调了免疫疗法对复发性高级别SGCs的有限病理疗效,病理评估的反应率低于放射评估。PD-L1和B2M的改变强调了生物标志物驱动策略的必要性。本研究为改善这种侵袭性疾病的预后提供了基础。
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引用次数: 0
Evaluation of mandibular morphology in untreated growing patients with hemifacial Microsomia: a 3D computed tomography study 未经治疗的生长中的半面小畸形患者下颌形态的评估:一项3D计算机断层扫描研究。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.jcms.2025.11.019
Roberto Uomo , Wanda Maldonato , Alessandra Putrino , Luca Borro , Marta Cecchitelli , Lucilla Ravà , Aurelio Secinaro , Angela Galeotti
Hemifacial Microsomia (HFM) is the second most common craniofacial malformation after clefts and it is characterized by mandibular hypoplasia and facial asymmetry.
This retrospective study aimed to evaluate mandibular morphology in growing HFM patients using three-dimensional (3D) computed tomography (CBCT), focusing on volumetric asymmetries.
A total of 26 patients aged 5–13 years with unilateral HFM were analyzed. They were stratified into two age groups (5–8 and 9–13 years) and classified according to Pruzansky-Kaban system in two severity categories (mild/severe deformity). CBCT data were processed to reconstruct 3D mandibular models, segmenting the condylar, coronoid and gonion regions. Volumetric differences between affected and unaffected sides were compared across age and severity subgroups.
Results showed that all the three functional units were significantly smaller on the affected side, especially in severe HFM cases. However, no statistically significant differences were found between the two age groups, suggesting that mandibular asymmetry remains substantively unchanged over the two consecutive time points examined. Multivariable regression confirmed that HFM severity was strongly associated with condylar and gonial volume discrepancies.
This study highlights the value of CBCT-based 3D reconstruction for precise assessment of mandibular morphology and supports its role in individualized diagnosis and treatment planning for HFM patients.
半面小畸形(HFM)是继唇裂之后第二常见的颅面畸形,其特征是下颌发育不全和面部不对称。本回顾性研究旨在利用三维(3D)计算机断层扫描(CBCT)评估生长中的HFM患者的下颌形态,重点关注体积不对称。对26例5 ~ 13岁单侧HFM患者进行分析。患者分为5-8岁和9-13岁两组,并根据Pruzansky-Kaban系统分为轻度/重度畸形两种严重程度。对CBCT数据进行处理,重建三维下颌模型,分割髁突、冠状和阴离子区域。在不同年龄和严重程度亚组中比较受影响侧和未受影响侧的体积差异。结果显示,患侧的三个功能单位均明显变小,特别是在严重的HFM病例中。然而,在两个年龄组之间没有发现统计学上的显著差异,这表明下颌不对称在两个连续的时间点上基本保持不变。多变量回归证实HFM的严重程度与髁突和性腺体积差异密切相关。本研究强调了基于cbct的下颌三维重建在精确评估下颌形态方面的价值,并支持其在HFM患者的个体化诊断和治疗计划中的作用。
{"title":"Evaluation of mandibular morphology in untreated growing patients with hemifacial Microsomia: a 3D computed tomography study","authors":"Roberto Uomo ,&nbsp;Wanda Maldonato ,&nbsp;Alessandra Putrino ,&nbsp;Luca Borro ,&nbsp;Marta Cecchitelli ,&nbsp;Lucilla Ravà ,&nbsp;Aurelio Secinaro ,&nbsp;Angela Galeotti","doi":"10.1016/j.jcms.2025.11.019","DOIUrl":"10.1016/j.jcms.2025.11.019","url":null,"abstract":"<div><div>Hemifacial Microsomia (HFM) is the second most common craniofacial malformation after clefts and it is characterized by mandibular hypoplasia and facial asymmetry.</div><div>This retrospective study aimed to evaluate mandibular morphology in growing HFM patients using three-dimensional (3D) computed tomography (CBCT), focusing on volumetric asymmetries.</div><div>A total of 26 patients aged 5–13 years with unilateral HFM were analyzed. They were stratified into two age groups (5–8 and 9–13 years) and classified according to Pruzansky-Kaban system in two severity categories (mild/severe deformity). CBCT data were processed to reconstruct 3D mandibular models, segmenting the condylar, coronoid and gonion regions. Volumetric differences between affected and unaffected sides were compared across age and severity subgroups.</div><div>Results showed that all the three functional units were significantly smaller on the affected side, especially in severe HFM cases. However, no statistically significant differences were found between the two age groups, suggesting that mandibular asymmetry remains substantively unchanged over the two consecutive time points examined. Multivariable regression confirmed that HFM severity was strongly associated with condylar and gonial volume discrepancies.</div><div>This study highlights the value of CBCT-based 3D reconstruction for precise assessment of mandibular morphology and supports its role in individualized diagnosis and treatment planning for HFM patients.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"54 2","pages":"Article 104416"},"PeriodicalIF":2.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential of minimally invasive sagittal split ramus osteotomy to transform patient outcomes: A randomized, double-blind, controlled, split-mouth study 探索微创矢状分叉支截骨术改变患者预后的潜力:一项随机、双盲、对照、裂口研究
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-18 DOI: 10.1016/j.jcms.2025.104426
Ahmet Emin Demirbaş , Yusuf Nuri Kaba , İbrahim Mert Erkan , Gökhan Çoban
Sagittal split ramus osteotomy is a widely used procedure in orthognathic surgery; however, conventional techniques are associated with notable morbidity, including bleeding, edema, and pain. Recently, minimally invasive techniques have been described to reduce surgery-related morbidities and improve patients’ outcomes. This randomized, double-blind, controlled, split-mouth trial aimed to compare the conventional approach with a minimally invasive sagittal split osteotomy (MISSRO) in terms of surgical efficiency and postoperative outcomes. In each of the thirty-six patients included in the study, a conventional sagittal split osteotomy (SSRO) was performed on one side of the mandible, and a MISSRO was performed on the contralateral side. The MISSRO technique was characterized by a short mucosal incision, minimal soft-tissue dissection, and a low and short osteotomy. Operative time and bleeding were statistically significantly lower on the minimally invasive side (p < 0.001). Postoperative edema measurements on days 1, 7, 14, and 30 were also statistically significantly reduced (p < 0.001). Pain scores were statistically significantly lower at the first postoperative hour (p = 0.002) on the minimally invasive side, with no differences at later time points. The findings suggest that MISSRO is a safe and effective alternative to the conventional method, enhancing recovery by reducing tissue trauma and improving perioperative outcomes.
矢状分叉支截骨术是一种广泛应用于正颌手术的方法;然而,传统技术与显著的发病率相关,包括出血、水肿和疼痛。最近,微创技术已被描述为减少手术相关的发病率和改善患者的结果。这项随机、双盲、对照、裂口试验旨在比较传统入路与微创矢状劈开截骨术(MISSRO)在手术效率和术后结果方面的差异。在研究中包括的36例患者中,每个患者在一侧下颌骨进行常规矢状劈开截骨术(SSRO),并在对侧进行misro。misro技术的特点是短的粘膜切口,最小的软组织剥离,低而短的截骨。微创侧手术时间和出血量显著低于微创侧(p < 0.001)。术后第1、7、14和30天的水肿测量值也有统计学意义上的显著降低(p < 0.001)。微创侧患者术后1小时疼痛评分差异有统计学意义(p = 0.002),后续时间点差异无统计学意义。研究结果表明,misro是一种安全有效的替代传统方法,通过减少组织创伤和改善围手术期预后来促进恢复。
{"title":"Exploring the potential of minimally invasive sagittal split ramus osteotomy to transform patient outcomes: A randomized, double-blind, controlled, split-mouth study","authors":"Ahmet Emin Demirbaş ,&nbsp;Yusuf Nuri Kaba ,&nbsp;İbrahim Mert Erkan ,&nbsp;Gökhan Çoban","doi":"10.1016/j.jcms.2025.104426","DOIUrl":"10.1016/j.jcms.2025.104426","url":null,"abstract":"<div><div>Sagittal split ramus osteotomy is a widely used procedure in orthognathic surgery; however, conventional techniques are associated with notable morbidity, including bleeding, edema, and pain. Recently, minimally invasive techniques have been described to reduce surgery-related morbidities and improve patients’ outcomes. This randomized, double-blind, controlled, split-mouth trial aimed to compare the conventional approach with a minimally invasive sagittal split osteotomy (MISSRO) in terms of surgical efficiency and postoperative outcomes. In each of the thirty-six patients included in the study, a conventional sagittal split osteotomy (SSRO) was performed on one side of the mandible, and a MISSRO was performed on the contralateral side. The MISSRO technique was characterized by a short mucosal incision, minimal soft-tissue dissection, and a low and short osteotomy. Operative time and bleeding were statistically significantly lower on the minimally invasive side (<em>p</em> &lt; 0.001). Postoperative edema measurements on days 1, 7, 14, and 30 were also statistically significantly reduced (<em>p</em> &lt; 0.001). Pain scores were statistically significantly lower at the first postoperative hour (<em>p</em> = 0.002) on the minimally invasive side, with no differences at later time points. The findings suggest that MISSRO is a safe and effective alternative to the conventional method, enhancing recovery by reducing tissue trauma and improving perioperative outcomes.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"54 1","pages":"Article 104426"},"PeriodicalIF":2.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145771991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of bite force recovery in patients with maxillofacial fracture 评估颌面部骨折患者咬合力的恢复情况。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.jcms.2021.02.017
Hamed Gheibollahi , Ehsan Aliabadi , Mohammad Saleh Khaghaninejad , Sona Mousavi , Ali Peyravi , Amirhossein Babaei
The aim of this study was to measure the maximum voluntary bite force and recovery time in patients treated for different types of the maxillofacial fracture.
Patients aged between 18 and 60 years, who received surgical treatment for a single isolated fracture of the maxillofacial structure, were included in this study. Healthy individuals without any maxillofacial abnormality were selected as the control group. Bite force (in kg) was measured at the first incisor tooth, bilaterally, prior to surgery and 2 weeks, 6 weeks, 3 months, and 6 months after surgery.
Of 120 patients, 89 (74.17%) were male and 31 (25.83%) were female. Mean patient age (±SD) was 31.21 (±11.64) years. Bite forces relating to fractures of the zygomaticomaxillary complex (ZMC) with involvement of the arch and zygomaticofrontal suture reached normal levels after 6 weeks (from 3.89 (±1.11) to 10.82 (±1.29); p = 0.296 and from 4.20 (±0.93) to 10.70 (±1.70); p = 0.192, respectively). Bite force returned to normal after 3 months in fractures of the symphysis (from 2.05 (±0.97) to 12.18 (±0.77); p = 0.222), body (from 2.21 (±1.26) to 11.9 (±0.73); p = 0.750), angle (from 2.45 (±1.24) to 11.89 (±0.76); p = 0.769), condyle (from 2.45 (±1.27) to 11.25 (±0.82); p = 0.968), and ZMC with and without infraorbital rim involvement (from 3.83 (±0.93) to 11.92 (±0.84); p = 0.724 and from 3.7 (±1.21) to 12.03 (±0.82); p = 0.482, respectively).
Patients with ZMC fracture involving the arch and zygomaticofrontal suture require fewer follow-ups in comparison with those with other maxillofacial fractures. Measurement of maximal bite force can help to evaluate dentofacial deformities before and after surgical treatment.
本研究旨在测量不同类型颌面部骨折患者的最大自主咬合力和恢复时间。研究对象包括年龄在 18 至 60 岁之间、因颌面部结构单一孤立骨折而接受手术治疗的患者。没有任何颌面部异常的健康人被选作对照组。在手术前、手术后 2 周、6 周、3 个月和 6 个月,测量双侧第一颗门牙的咬合力(单位:千克)。在 120 名患者中,89 名(74.17%)为男性,31 名(25.83%)为女性。患者平均年龄(±SD)为 31.21(±11.64)岁。涉及牙弓和颧额缝的颧颌面复合体(ZMC)骨折的咬合力在 6 周后达到正常水平(分别从 3.89 (±1.11) 到 10.82 (±1.29); p = 0.296 和从 4.20 (±0.93) 到 10.70 (±1.70); p = 0.192)。干骺端骨折(从 2.05 (±0.97) 到 12.18 (±0.77); p = 0.222)、本体骨折(从 2.21 (±1.26) 到 11.9 (±0.73); p = 0.750)、角骨折(从 2.45 (±1.24) 到 11.89 (±0.76); p = 0.769)、髁突(从 2.45(±1.27)到 11.25(±0.82);p = 0.968)以及眶下缘受累和未受累的 ZMC(分别从 3.83(±0.93)到 11.92(±0.84);p = 0.724 和从 3.7(±1.21)到 12.03(±0.82);p = 0.482)。与其他颌面部骨折患者相比,涉及牙弓和颧额缝的 ZMC 骨折患者需要的随访次数较少。测量最大咬合力有助于评估手术治疗前后的颌面部畸形。
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引用次数: 0
Mechanistic insights into MRONJ from the role of type H vessels and bone density changes 从H型血管的作用和骨密度变化看MRONJ的机制。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.jcms.2025.11.004
Jiahui Shen , Yuzhu Wu , Xiaomin Zhao , Junxing Xu , Xiaoyuan Huang , Xiaolong Zang , Zhijian Xie , Yanhua Lan
This study investigated how ossification patterns influence type H vessel formation and bone mineral density in bisphosphonate (BIS)-treated bones, aiming to explain jawbones' heightened susceptibility to medication-related osteonecrosis (MRONJ).
A cross-sectional analysis of mandibular bone radiodensity was conducted using cone-beam computed tomography (CBCT) in 68 MRONJ patients and 71 controls. An early-stage MRONJ murine model was established through alendronate sodium administration. Mandibular and tibial samples were subjected to micro-CT analysis and immunohistochemical staining of type H vessels (CD31hi Endomucinhi) to evaluate osteogenic angiogenesis patterns.
MRONJ patients exhibited elevated alveolar (RDa: 591.79 ± 266.67 vs. 396.62 ± 196.64 HU) and mandibular body (RDb: 435.624 ± 329.64 vs. 207.97 ± 165.12 HU) radiodensities compared to controls, while condylar radiodensity remained comparable (RDc: 314.81 ± 140.38 vs. 353.77 ± 144.26 HU). The RDa/RDc ratio demonstrated a over two-fold increase in MRONJ cases (2.37 ± 1.83 vs. 1.32 ± 0.97). BIS treatment preserved type H vessel density in intramembranous ossification-derived alveolar bone but increased it in endochondral ossification-originating condyles and tibias.
The RDa/RDc ratio may serve as a diagnostic biomarker for BIS-related mandibular changes. Differential MRONJ risk correlates with embryological ossification patterns and type H vessel responses to BIS.
本研究探讨了骨化模式如何影响双膦酸盐(BIS)处理骨的H型血管形成和骨矿物质密度,旨在解释颌骨对药物相关性骨坏死(MRONJ)的高易感。使用锥形束计算机断层扫描(CBCT)对68例MRONJ患者和71例对照组进行了下颌骨放射密度的横断面分析。通过给药阿仑膦酸钠建立早期MRONJ小鼠模型。对下颌骨和胫骨标本进行显微ct分析和H型血管(CD31hi Endomucinhi)免疫组化染色,以评估成骨血管生成模式。MRONJ患者的牙槽(RDa: 591.79±266.67 vs. 396.62±196.64 HU)和下颌体(RDb: 435.624±329.64 vs. 207.97±165.12 HU)放射密度与对照组相比升高,而髁突放射密度保持相当(RDc: 314.81±140.38 vs. 353.77±144.26 HU)。MRONJ病例的RDa/RDc比增加了两倍多(2.37±1.83比1.32±0.97)。BIS治疗保留了膜内骨化源性牙槽骨的H型血管密度,但增加了软骨内骨化源性髁突和胫骨的H型血管密度。RDa/RDc比值可作为bis相关下颌病变的诊断性生物标志物。不同MRONJ风险与胚胎学骨化模式和H型血管对BIS的反应相关。
{"title":"Mechanistic insights into MRONJ from the role of type H vessels and bone density changes","authors":"Jiahui Shen ,&nbsp;Yuzhu Wu ,&nbsp;Xiaomin Zhao ,&nbsp;Junxing Xu ,&nbsp;Xiaoyuan Huang ,&nbsp;Xiaolong Zang ,&nbsp;Zhijian Xie ,&nbsp;Yanhua Lan","doi":"10.1016/j.jcms.2025.11.004","DOIUrl":"10.1016/j.jcms.2025.11.004","url":null,"abstract":"<div><div>This study investigated how ossification patterns influence type H vessel formation and bone mineral density in bisphosphonate (BIS)-treated bones, aiming to explain jawbones' heightened susceptibility to medication-related osteonecrosis (MRONJ).</div><div>A cross-sectional analysis of mandibular bone radiodensity was conducted using cone-beam computed tomography (CBCT) in 68 MRONJ patients and 71 controls. An early-stage MRONJ murine model was established through alendronate sodium administration. Mandibular and tibial samples were subjected to micro-CT analysis and immunohistochemical staining of type H vessels (CD31<sup>hi</sup> Endomucin<sup>hi</sup>) to evaluate osteogenic angiogenesis patterns.</div><div>MRONJ patients exhibited elevated alveolar (RDa: 591.79 ± 266.67 <em>vs.</em> 396.62 ± 196.64 HU) and mandibular body (RDb: 435.624 ± 329.64 <em>vs.</em> 207.97 ± 165.12 HU) radiodensities compared to controls, while condylar radiodensity remained comparable (RDc: 314.81 ± 140.38 <em>vs.</em> 353.77 ± 144.26 HU). The RDa/RDc ratio demonstrated a over two-fold increase in MRONJ cases (2.37 ± 1.83 <em>vs.</em> 1.32 ± 0.97). BIS treatment preserved type H vessel density in intramembranous ossification-derived alveolar bone but increased it in endochondral ossification-originating condyles and tibias.</div><div>The RDa/RDc ratio may serve as a diagnostic biomarker for BIS-related mandibular changes. Differential MRONJ risk correlates with embryological ossification patterns and type H vessel responses to BIS.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 12","pages":"Pages 2310-2319"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of Coronavirus Disease 2019 on maxillofacial surgery training in Portugal: The resident's perspective 2019冠状病毒病对葡萄牙颌面外科训练的影响:居民视角
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.jcms.2021.02.003
Pedro Gomes de Oliveira , Cátia Mateus , João Barros , Eduardo Ventura , José Soares , Helena Rodrigues , Paulo Valejo Coelho

Introduction

The COVID-19 pandemic has forced Portuguese healthcare institutions to adapt management protocols and prioritize resources. These adjustments had a significant impact, affecting both clinical care and also training programs. The aim of this study was to access the maxillofacial surgery resident's perspective on the pandemic's impact on specialty training.

Methods

We designed a nationwide questionnaire to evaluate surgical activity of maxillofacial surgery residents, the impact on surgical training and the perceived effect on their future.

Results

We collected results of all maxillofacial surgery residents currently in training. Three out of 32 reported a decline in surgical activity of 90–100%, 11 stated a reduction of 75%, 12 expressed a decrease of 50% and 6 described a decline of 25%.

Discussion

The majority of residents stated the need to consider an extension of training time. Alternative training tools such as virtual activities and simulation training should be considered as formal complements to residency programs.

Conclusion

We found a significant decrease in surgical activity among all trainees coupled with a unanimous concern regarding their training progression.
2019冠状病毒病大流行迫使葡萄牙医疗机构调整管理方案并优先考虑资源。这些调整对临床护理和培训项目都产生了重大影响。本研究的目的是了解颌面外科住院医生对大流行对专业培训影响的看法。方法在全国范围内设计问卷,评估颌面外科住院医师的手术活动、对手术培训的影响以及对其未来的感知影响。结果收集所有正在培训的颌面外科住院医师的结果。32人中有3人报告手术活动减少了90-100%,11人报告减少了75%,12人报告减少了50%,6人报告减少了25%。大多数住院医生表示需要考虑延长培训时间。替代培训工具,如虚拟活动和模拟培训应被视为正式补充住院医师计划。结论:我们发现所有受训者的手术活动明显减少,并且一致关注他们的培训进展。
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引用次数: 0
Lower face widening in mandibular osteotomies: Is the increase in osseous and cutaneous bigonial distance correlated with mandibular advancement? 下颌骨截骨术中下脸变宽:骨性和皮肤双颊距离的增加是否与下颌骨前进相关?
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 DOI: 10.1016/j.jcms.2025.09.016
Guillaume Santoni , Thomas Schouman , Jean-Baptiste Caruhel
Mandibular osteotomies are known to widen the mandibular angles by increasing the bigonial distance (BGD). Previous studies have highlighted the relationship between the extent of mandibular movement and the increase in BGD, both for cutaneous bigonial distance (CBGD) and osseous bigonial distance (OBGD). However, the relationship between changes in OBGD, CBGD and mandibular advancement remains to be fully established.
The aim of this study was to compare changes in OBGD and CBGD using adapted three-dimensional examination techniques in patients who underwent mandibular osteotomies. Preoperative and postoperative computed tomography scans and stereophotogrammetry were used to measure mandibular advancement, OBGD and CBGD before and after surgery.
Of the 77 patients included, 93.5 % underwent bilateral sagittal split osteotomy, and 79.2 % had received patient-specific guided surgery. Of these, 53 patients had mandibular advancement and 24 underwent mandibular setback. In all cases, a significant increase in both OBGD and CBGD was found after surgery. The extent of mandibular advancement was significantly associated with a greater increase in both OBGD and CBGD.
众所周知,下颌截骨术通过增加双侧距离(BGD)来扩大下颌角。先前的研究强调了下颌运动程度与BGD增加之间的关系,包括皮肤双牙距离(CBGD)和骨双牙距离(OBGD)。然而,OBGD、CBGD的变化与下颌前移之间的关系仍有待完全确定。本研究的目的是比较使用适应的三维检查技术在接受下颌截骨术的患者中OBGD和CBGD的变化。术前和术后采用计算机断层扫描和立体摄影测量术测量术前和术后下颌推进、OBGD和CBGD。在纳入的77例患者中,93.5%的患者接受了双侧矢状面劈开截骨术,79.2%的患者接受了特定的指导手术。其中,53例患者下颌骨前进,24例患者下颌骨后退。在所有病例中,手术后发现OBGD和CBGD均显著增加。下颌前移的程度与OBGD和CBGD的增加显著相关。
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引用次数: 0
期刊
Journal of Cranio-Maxillofacial Surgery
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