Pub Date : 2021-07-01DOI: 10.56042/ijca.v60i4.43196
Chinmoy Biswasa, A. Chatterjeea, Sreelekshmi Sreekumarb, M. KiranB., R. Ghosha
Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its two metal complexes [Cu(L)(OAc)] (1) and [ZnL(OAc)]2 (2) are reported. Between the two complexes 1 is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with 1. The IC50 value of the complex is measured as 0.72 M which is lower than that of cisplatin against A549.
{"title":"Synthesis and crystal structures of 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its metal complexes: Anticancer activity of [Cu(L)(OAc)]","authors":"Chinmoy Biswasa, A. Chatterjeea, Sreelekshmi Sreekumarb, M. KiranB., R. Ghosha","doi":"10.56042/ijca.v60i4.43196","DOIUrl":"https://doi.org/10.56042/ijca.v60i4.43196","url":null,"abstract":"Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its two metal complexes [Cu(L)(OAc)] (1) and [ZnL(OAc)]2 (2) are reported. Between the two complexes 1 is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with 1. The IC50 value of the complex is measured as 0.72 M which is lower than that of cisplatin against A549.","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"117 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74230344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.56042/ijca.v60i5.42321
{"title":"Synthesis of 4-{(E)-[(3-methyl-5-sulphanyl-4H-1,2,4-triazol-4-yl)imino]methyl} benzaldehyde and its complexes with Ag(I), Hg(II), Zn(II), Co(II), Ni(II) ions and its characterisation","authors":"","doi":"10.56042/ijca.v60i5.42321","DOIUrl":"https://doi.org/10.56042/ijca.v60i5.42321","url":null,"abstract":"","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"28 9 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72940476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.56042/ijca.v60i4.43960
{"title":"Synthesis and structure of a mixed ligand copper(II) compound based on a distorted {CuN2O3} square pyramid","authors":"","doi":"10.56042/ijca.v60i4.43960","DOIUrl":"https://doi.org/10.56042/ijca.v60i4.43960","url":null,"abstract":"","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"8 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85868777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-25DOI: 10.56042/ijca.v60i2.32300
{"title":"Effect of triton-X100 on ternary complexes of cobalt (II), nickel(II),copper (II) & zinc(II) with aspartic and citric acids","authors":"","doi":"10.56042/ijca.v60i2.32300","DOIUrl":"https://doi.org/10.56042/ijca.v60i2.32300","url":null,"abstract":"","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"58 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89060187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The polyaniline-coated magnetite/silica nanomaterials (Fe 3 O 4 @SiO 2 /PANI) have been synthesized and successfully applied as an effective sorbent for preconcentration of several typical organic acids from environmental water samples. The properties of Fe 3 O 4 @SiO 2 /PANI are characterized by FT-IR and XPS. These magnetic materials can enrich trace organic acids effectively by solid-phase extraction. Three kinds of organic acids, including benzoic acids, phthalic acids, and p -toluene sulfonic acids, are selected as target analytes for magnetic solid phase extraction (MSPE). Various experimental parameters of the MSPE were investigated and optimized. After the desorption process, the elution is detected by the UV-visible spectrophotometer. The spectroscopic data are analyzed through the partial least squares (PLS) method, which facilitate quantitation of mixture from complex data. The enrichment factor of benzoic acids, phthalic acids and p -toluene sulfonic acids reached 19.53, 20.31, and 16.89, respectively. A wide measurement range of 10 μg L -1 to 50 mg L -1 is obtained. The LOD is 0.8 μg L -1 . The spiked recoveries in the range of 94%-101% with RSD ( n =8) lower than 4%. The results illustrated that the combined approach of MSPE and PLS has great applied potential for a mixture of trace compounds in different fields of its high
合成了聚苯胺包覆的磁铁矿/二氧化硅纳米材料(fe3o4 @ sio2 /PANI)，并成功地作为一种有效的吸附剂用于环境水样中几种典型有机酸的预富集。用FT-IR和XPS表征了fe3o4 @ sio2 /PANI的性能。这些磁性材料可以通过固相萃取有效富集微量有机酸。选择苯甲酸、邻苯二甲酸和对甲苯磺酸三种有机酸作为磁性固相萃取(MSPE)的目标分析物。对MSPE的各实验参数进行了研究和优化。解吸过程结束后，用紫外可见分光光度计检测洗脱。采用偏最小二乘(PLS)方法对光谱数据进行分析，便于从复杂数据中定量分析混合物。苯甲酸、邻苯二甲酸和对甲苯磺酸的富集系数分别为19.53、20.31和16.89。测量范围为10 μg L -1 ~ 50 mg L -1。LOD为0.8 μg L -1。加标回收率在94% ~ 101%之间，RSD (n =8) < 4%。结果表明，MSPE与PLS相结合的方法在不同领域的痕量化合物混合分析中具有很大的应用潜力
{"title":"Simultaneous spectroscopic determination of trace mixed organic acids in aqueous samples using magnetic solid phase extraction coupled with chemometrics method","authors":"Yugao Guo, Yuan Jiang, Pei Liu, Jianwei Yang, Qingyin Zhang, X. Bian","doi":"10.56042/ijca.v60i2.31885","DOIUrl":"https://doi.org/10.56042/ijca.v60i2.31885","url":null,"abstract":"The polyaniline-coated magnetite/silica nanomaterials (Fe 3 O 4 @SiO 2 /PANI) have been synthesized and successfully applied as an effective sorbent for preconcentration of several typical organic acids from environmental water samples. The properties of Fe 3 O 4 @SiO 2 /PANI are characterized by FT-IR and XPS. These magnetic materials can enrich trace organic acids effectively by solid-phase extraction. Three kinds of organic acids, including benzoic acids, phthalic acids, and p -toluene sulfonic acids, are selected as target analytes for magnetic solid phase extraction (MSPE). Various experimental parameters of the MSPE were investigated and optimized. After the desorption process, the elution is detected by the UV-visible spectrophotometer. The spectroscopic data are analyzed through the partial least squares (PLS) method, which facilitate quantitation of mixture from complex data. The enrichment factor of benzoic acids, phthalic acids and p -toluene sulfonic acids reached 19.53, 20.31, and 16.89, respectively. A wide measurement range of 10 μg L -1 to 50 mg L -1 is obtained. The LOD is 0.8 μg L -1 . The spiked recoveries in the range of 94%-101% with RSD ( n =8) lower than 4%. The results illustrated that the combined approach of MSPE and PLS has great applied potential for a mixture of trace compounds in different fields of its high","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"133 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86335493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-25DOI: 10.56042/ijca.v60i2.25520
Karuna Maheshwari, S. Saxena, Asha Jain
A new set of organic-inorganic hybrid complexes of lead(II) of sterically demanding heterocyclic β-diketones and flexible N-protected amino acids of composition Pb[RC(O)C:C(O)N(C 6 H 5 )N:CCH 3 ][C(O)C 6 H 4 C(O)NCHR'COO] (where R = C 6 H 5 , p-ClC 6 H 4 , CH 3 and R’ = CH(CH 3 )C 2 H 5, CH 2 CH(CH 3 ) 2 and CH(CH 3 ) 2 ) has been generated by the reactions of freshly prepared lead isopropoxide with sterically demanding heterocyclic β-diketones (LH) and flexible N-protected amino acids (AH) in 1:1:1 molar ratio in refluxing dry benzene . These lead(II) complexes of mixed organic ligands have been characterized on the basis of physico-chemical and spectroscopic studies.
{"title":"Organic-Inorganic Hybrid Complexes of Lead (II) of Sterically Demanding Heterocyclic β-diketones and Flexible N-Protected Amino Acids","authors":"Karuna Maheshwari, S. Saxena, Asha Jain","doi":"10.56042/ijca.v60i2.25520","DOIUrl":"https://doi.org/10.56042/ijca.v60i2.25520","url":null,"abstract":"A new set of organic-inorganic hybrid complexes of lead(II) of sterically demanding heterocyclic β-diketones and flexible N-protected amino acids of composition Pb[RC(O)C:C(O)N(C 6 H 5 )N:CCH 3 ][C(O)C 6 H 4 C(O)NCHR'COO] (where R = C 6 H 5 , p-ClC 6 H 4 , CH 3 and R’ = CH(CH 3 )C 2 H 5, CH 2 CH(CH 3 ) 2 and CH(CH 3 ) 2 ) has been generated by the reactions of freshly prepared lead isopropoxide with sterically demanding heterocyclic β-diketones (LH) and flexible N-protected amino acids (AH) in 1:1:1 molar ratio in refluxing dry benzene . These lead(II) complexes of mixed organic ligands have been characterized on the basis of physico-chemical and spectroscopic studies.","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"102 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74877084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-25DOI: 10.56042/ijca.v60i2.41671
Averi Guha, E. Zangrando, A. Chandra
Four new mononuclear manganese(III) complexes namely 1, 2, 3 and 4 of salen-type ligands H2L 1-H2L 4 (ligands were obtained in situ via Schiff-base condensation of 2-formyl-6-hydroxymethyl-4-methylphenol and amines cyclohexane-1,2diamine, 2-methylpropane-1,2-diamine, propane-1,2-diamine and ethane-1,2-diamine, respectively) have been synthesised and characterised by routine physicochemical techniques. 1 is further characterised by X-ray single crystal structure analysis. Catalytic efficiencies of the complexes as epoxidation catalysts (substrates: styrene and (E)-stilbene; terminal oxidants: PhIO/NaOCl; solvent: MeCN /dicholorometane) and as catalysts for oxidation of catachol (substrates: 3,5-di-tertbutylcatechol (3,5-DTBC); solvent: methanol) have been evaluated. In both cases the catalytic efficiency increases on going from 4-1 although the actual mechanisms in those two catalytic reactions are completely different. However, the observations have been rationalized on the basis of steric and electronic factors exerted by the alkyl substituents present on the imine back-bone of the salen-type ligands. This study also verifies that there is at least another active epoxidizing species, [Cl–O–Mn(III)(salen)X] in addition to the discrete Mn(V)=O(salen) species in epoxidation of olefins depending upon the terminal oxidants employed.
{"title":"Epoxidation and catechol oxidation catalytic processes promoted by manganese(III) complexes of salen-type ligands","authors":"Averi Guha, E. Zangrando, A. Chandra","doi":"10.56042/ijca.v60i2.41671","DOIUrl":"https://doi.org/10.56042/ijca.v60i2.41671","url":null,"abstract":"Four new mononuclear manganese(III) complexes namely 1, 2, 3 and 4 of salen-type ligands H2L 1-H2L 4 (ligands were obtained in situ via Schiff-base condensation of 2-formyl-6-hydroxymethyl-4-methylphenol and amines cyclohexane-1,2diamine, 2-methylpropane-1,2-diamine, propane-1,2-diamine and ethane-1,2-diamine, respectively) have been synthesised and characterised by routine physicochemical techniques. 1 is further characterised by X-ray single crystal structure analysis. Catalytic efficiencies of the complexes as epoxidation catalysts (substrates: styrene and (E)-stilbene; terminal oxidants: PhIO/NaOCl; solvent: MeCN /dicholorometane) and as catalysts for oxidation of catachol (substrates: 3,5-di-tertbutylcatechol (3,5-DTBC); solvent: methanol) have been evaluated. In both cases the catalytic efficiency increases on going from 4-1 although the actual mechanisms in those two catalytic reactions are completely different. However, the observations have been rationalized on the basis of steric and electronic factors exerted by the alkyl substituents present on the imine back-bone of the salen-type ligands. This study also verifies that there is at least another active epoxidizing species, [Cl–O–Mn(III)(salen)X] in addition to the discrete Mn(V)=O(salen) species in epoxidation of olefins depending upon the terminal oxidants employed.","PeriodicalId":54992,"journal":{"name":"Indian Journal of Chemistry Section A-Inorganic Bio-Inorganic Physical Theoretical & Analytical Chemistry","volume":"25 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86071447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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