In this paper, we want to consider what would be involved in calculating the R2 relaxation of amide protons in a protein caused by dipolar interactions with nearby protons, for which there are many. NMR textbooks give analytical equations and sometimes derivations for solution NMR relaxation due to dipolar interactions between two spins. There are also closed equations for dipolar interactions between three spins, which include relaxation interference, also known as cross-correlated cross-relaxation. We here derive an expression for interference between four spins. For larger systems, such as amide protons in a protein, we develop a local-field methodology, from which solution relaxation interference can be computed for a basically limitless number of interacting spins.
{"title":"Multispin Cross-Correlated Transverse Dipolar NMR Relaxation in Solution","authors":"E. Zuiderweg","doi":"10.1155/2022/1617848","DOIUrl":"https://doi.org/10.1155/2022/1617848","url":null,"abstract":"In this paper, we want to consider what would be involved in calculating the R2 relaxation of amide protons in a protein caused by dipolar interactions with nearby protons, for which there are many. NMR textbooks give analytical equations and sometimes derivations for solution NMR relaxation due to dipolar interactions between two spins. There are also closed equations for dipolar interactions between three spins, which include relaxation interference, also known as cross-correlated cross-relaxation. We here derive an expression for interference between four spins. For larger systems, such as amide protons in a protein, we develop a local-field methodology, from which solution relaxation interference can be computed for a basically limitless number of interacting spins.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"41 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88949429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mulugeta Markos, A. Saka, L. Jule, N. Nagaprasad, K. Ramaswamy
Vertical electrical sounding and magnetic methods were carried out to assess groundwater potential in Adilo catchment, Kembata Tembaro Zone, South Nations, Nationalities and Peoples Regional Government, Main Ethiopian Rift. The data were acquired from eight VES points using Schlumberger electrode arrays with maximum half current electrode spacing ( AB / 2 = 500 ) and 253 magnetic data points were analyzed. The qualitative analysis of VES data was accomplished by using curves, apparent resistivity, and pseudodepths, and the quantitative interpretations of the VES data were constructed by the VES data using IPI-Res3, IPI2Win, and surfer software and constructing geoelectric section along with profiles and lithological information from the borehole and Geosoft interpretation was used for magnetic data. The VES results of the data revealed five geoelectric layers which differ in degree of fracturing, weathering, and formation. The upward continued magnetic field map anomaly to 560 m illustrated northwestern to the southwest; areas have a low magnetic anomaly. Examining the potential aquifer of profile one’s geoelectric section, the horizons of layer four were better potential aquifers as the highly fractured and weathered ignimbrite zone of layer five of VES13 was 219 m deeper than the depths of the other VES points, and along with profile two geoelectric sections, the horizon of layer four VES23 layer five has the lowest resistivity with large thickness at a depth of 253 m. Thus, the low resistivity and the large thickness of these formations are an indication of the high yield of groundwater potential in the study area.
{"title":"Groundwater Potential Assessment Using Vertical Electrical Sounding and Magnetic Methods: A Case of Adilo Catchment, South Nations, Nationalities and Peoples Regional Government, Ethiopia","authors":"Mulugeta Markos, A. Saka, L. Jule, N. Nagaprasad, K. Ramaswamy","doi":"10.1155/2021/5424865","DOIUrl":"https://doi.org/10.1155/2021/5424865","url":null,"abstract":"Vertical electrical sounding and magnetic methods were carried out to assess groundwater potential in Adilo catchment, Kembata Tembaro Zone, South Nations, Nationalities and Peoples Regional Government, Main Ethiopian Rift. The data were acquired from eight VES points using Schlumberger electrode arrays with maximum half current electrode spacing (\u0000 \u0000 \u0000 AB\u0000 \u0000 /\u0000 2\u0000 =\u0000 500\u0000 \u0000 ) and 253 magnetic data points were analyzed. The qualitative analysis of VES data was accomplished by using curves, apparent resistivity, and pseudodepths, and the quantitative interpretations of the VES data were constructed by the VES data using IPI-Res3, IPI2Win, and surfer software and constructing geoelectric section along with profiles and lithological information from the borehole and Geosoft interpretation was used for magnetic data. The VES results of the data revealed five geoelectric layers which differ in degree of fracturing, weathering, and formation. The upward continued magnetic field map anomaly to 560 m illustrated northwestern to the southwest; areas have a low magnetic anomaly. Examining the potential aquifer of profile one’s geoelectric section, the horizons of layer four were better potential aquifers as the highly fractured and weathered ignimbrite zone of layer five of VES13 was 219 m deeper than the depths of the other VES points, and along with profile two geoelectric sections, the horizon of layer four VES23 layer five has the lowest resistivity with large thickness at a depth of 253 m. Thus, the low resistivity and the large thickness of these formations are an indication of the high yield of groundwater potential in the study area.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"27 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90189612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stretched hydrogels make uniformly anisotropic environments for quadrupolar nuclei such as 2H, 23Na, and 133Cs. Such surroundings cause the partial alignment of nuclear spin bearing ions and molecules that is sufficiently pronounced to alter the nuclear magnetic resonance spectra of the guest species. In most cases, resonance splittings are directly related to the spin quantum number I. The relative intensities of the components of the resonance multiplets can be inferred from basic quantum mechanics.
{"title":"What Are the Relative Intensities of the Components of NMR Spectral Multiplets from Quadrupolar Nuclei in Uniformly Anisotropic Media?","authors":"S. Elliott, P. Kuchel","doi":"10.1155/2021/8890478","DOIUrl":"https://doi.org/10.1155/2021/8890478","url":null,"abstract":"Stretched hydrogels make uniformly anisotropic environments for quadrupolar nuclei such as 2H, 23Na, and 133Cs. Such surroundings cause the partial alignment of nuclear spin bearing ions and molecules that is sufficiently pronounced to alter the nuclear magnetic resonance spectra of the guest species. In most cases, resonance splittings are directly related to the spin quantum number I. The relative intensities of the components of the resonance multiplets can be inferred from basic quantum mechanics.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"57-58 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73432325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In MRI, at ultrahigh field, the use of parallel transmit radiofrequency (RF) arrays is very beneficial to better control spin excitation spatially. In that framework, the so-called “universal pulse” technique, proposed recently for head imaging at 7 tesla, gives access to “plug-and-play” nonadiabatic solutions exhibiting good robustness against intersubject variations in the resonant transmit fields. This new type of solution has been defined so far as the result of numerical pulse optimizations performed across a collection of RF field maps acquired on a small population sample (pulse design database). In this work, we investigate an alternative universal pulse design approach in the linear small tip angle regime whereby the database of RF field maps is first transformed into a second-order statistical model and which then exploits a statistical robust design formalism for the optimization of the RF and magnetic field gradient waveforms. Experimental validation with an eightfold transmit RF coil for 7 tesla brain imaging shows that this new approach brings some benefit in terms of computational efficiency. Hence, for a design database composed of 35 maps, the computation time initially of 50 min could be reduced down to 3 min. The proposed statistical approach thus enables integration of large databases, presumably necessary to ensure robust solutions. Finally, it provides means to compute flip angle statistics and, along with it, simple performance metrics for quality assurance (RF pulse performance) or guidance in the optimization of TX array architectures.
{"title":"A Statistical Robust Approach to Design Parallel Transmit Radiofrequency Excitations in MRI","authors":"V. Gras, F. Mauconduit, N. Boulant","doi":"10.1155/2020/6018107","DOIUrl":"https://doi.org/10.1155/2020/6018107","url":null,"abstract":"In MRI, at ultrahigh field, the use of parallel transmit radiofrequency (RF) arrays is very beneficial to better control spin excitation spatially. In that framework, the so-called “universal pulse” technique, proposed recently for head imaging at 7 tesla, gives access to “plug-and-play” nonadiabatic solutions exhibiting good robustness against intersubject variations in the resonant transmit fields. This new type of solution has been defined so far as the result of numerical pulse optimizations performed across a collection of RF field maps acquired on a small population sample (pulse design database). In this work, we investigate an alternative universal pulse design approach in the linear small tip angle regime whereby the database of RF field maps is first transformed into a second-order statistical model and which then exploits a statistical robust design formalism for the optimization of the RF and magnetic field gradient waveforms. Experimental validation with an eightfold transmit RF coil for 7 tesla brain imaging shows that this new approach brings some benefit in terms of computational efficiency. Hence, for a design database composed of 35 maps, the computation time initially of 50 min could be reduced down to 3 min. The proposed statistical approach thus enables integration of large databases, presumably necessary to ensure robust solutions. Finally, it provides means to compute flip angle statistics and, along with it, simple performance metrics for quality assurance (RF pulse performance) or guidance in the optimization of TX array architectures.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"29 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81348387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The magnetization differential equations of Bloch are integrated using a matrix diagonalization method. The solution describes several limiting cases and leads to compact expressions of wide validity for a spin ensemble initially at equilibrium.
{"title":"Solution of the Bloch Equations including Relaxation","authors":"E. Johnston","doi":"10.1155/2020/8819956","DOIUrl":"https://doi.org/10.1155/2020/8819956","url":null,"abstract":"The magnetization differential equations of Bloch are integrated using a matrix diagonalization method. The solution describes several limiting cases and leads to compact expressions of wide validity for a spin ensemble initially at equilibrium.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"20 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2020-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78780660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Ziener, M. Uhrig, T. Kampf, V. Sturm, F. Kurz, S. Heiland, M. Bendszus, M. Pham, P. Jakob, H. Schlemmer, L. Buschle
Magnetic resonance imaging based on steady-state free precision (SSFP) sequences is a fast method to acquire , , and - weighted images. In inhomogeneous tissues such as lung tissue or blood vessel networks, however, microscopic field inhomogeneities cause a nonexponential free induction decay and a non-Lorentzian lineshape. In this work, the SSFP signal is analyzed for different prominent tissue models. Neglecting the effect of non-Lorentzian lineshapes can easily result in large errors of the determined relaxation times. Moreover, sequence parameters of SSFP measurements can be optimized for the nonexponential signal decay in many tissue structures.
{"title":"Lineshape of Magnetic Resonance and its Effects on Free Induction Decay and Steady-State Free Precession Signal Formation","authors":"C. Ziener, M. Uhrig, T. Kampf, V. Sturm, F. Kurz, S. Heiland, M. Bendszus, M. Pham, P. Jakob, H. Schlemmer, L. Buschle","doi":"10.1155/2020/5057386","DOIUrl":"https://doi.org/10.1155/2020/5057386","url":null,"abstract":"Magnetic resonance imaging based on steady-state free precision (SSFP) sequences is a fast method to acquire , , and - weighted images. In inhomogeneous tissues such as lung tissue or blood vessel networks, however, microscopic field inhomogeneities cause a nonexponential free induction decay and a non-Lorentzian lineshape. In this work, the SSFP signal is analyzed for different prominent tissue models. Neglecting the effect of non-Lorentzian lineshapes can easily result in large errors of the determined relaxation times. Moreover, sequence parameters of SSFP measurements can be optimized for the nonexponential signal decay in many tissue structures.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"35 1","pages":"1-17"},"PeriodicalIF":0.6,"publicationDate":"2020-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90601204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, H. M. Sonawat
Cerebral malaria causes several deaths every year. Global metabolic alteration, specifically hypoglycemia and lactic acidosis are hallmarks of severe malaria. Glucose being the major fuel source for the brain, it is important to understand cerebral glucose utilization in the host during cerebral complications of the disease that may have a significant role in cerebral pathogenesis. We have used 13C NMR spectroscopy to understand glucose utilization in the brain and liver of mice with cerebral malaria (CM), noncerebral malaria (NCM), and in control mice. Animals were challenged with intravenous glucose bolus followed by metabolic profiling of brain and liver extracts. Our result suggests a differential glucose utilization in the malaria group with respect to that of controls, while no difference between CM and NCM.
{"title":"Brain and Hepatic Glucose Utilization in Malarial Infection Does Not Depend on Cerebral Symptoms of the Disease","authors":"Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, H. M. Sonawat","doi":"10.1155/2019/3542393","DOIUrl":"https://doi.org/10.1155/2019/3542393","url":null,"abstract":"Cerebral malaria causes several deaths every year. Global metabolic alteration, specifically hypoglycemia and lactic acidosis are hallmarks of severe malaria. Glucose being the major fuel source for the brain, it is important to understand cerebral glucose utilization in the host during cerebral complications of the disease that may have a significant role in cerebral pathogenesis. We have used 13C NMR spectroscopy to understand glucose utilization in the brain and liver of mice with cerebral malaria (CM), noncerebral malaria (NCM), and in control mice. Animals were challenged with intravenous glucose bolus followed by metabolic profiling of brain and liver extracts. Our result suggests a differential glucose utilization in the malaria group with respect to that of controls, while no difference between CM and NCM.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"18 1","pages":"1-7"},"PeriodicalIF":0.6,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81550818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In order to thoroughly comprehend and adequtely interpret NMR data, it is necessary to perceive the complex structure of spin Hamiltonian. Although NMR principles have been extensively discussed in a number of distinguished introductory publications, it still remains difficult to find illustrative graphical models revealing the tensorial nature of spin interaction. Exposure of the structure standing behind mathematical formulas can clarify intangible concepts and provide a coherent image of basic phenomena. This approach is essential when it comes to hard to manage, time-dependent processes such as Magic Angle Spinning (MAS), where the anisotropic character of the spin system interactions couple with experimentally introduced time evolution processes. The presented work concerns fundamental aspects of solid state NMR namely: the uniqueness of the tetrahedral angle and evolution of both dipolar D and chemical shield σ coupling tensors under MAS conditions.
{"title":"Magic Angle Spinning and Truncated Field Concept in NMR","authors":"J. Jenczyk","doi":"10.1155/2019/5895206","DOIUrl":"https://doi.org/10.1155/2019/5895206","url":null,"abstract":"In order to thoroughly comprehend and adequtely interpret NMR data, it is necessary to perceive the complex structure of spin Hamiltonian. Although NMR principles have been extensively discussed in a number of distinguished introductory publications, it still remains difficult to find illustrative graphical models revealing the tensorial nature of spin interaction. Exposure of the structure standing behind mathematical formulas can clarify intangible concepts and provide a coherent image of basic phenomena. This approach is essential when it comes to hard to manage, time-dependent processes such as Magic Angle Spinning (MAS), where the anisotropic character of the spin system interactions couple with experimentally introduced time evolution processes. The presented work concerns fundamental aspects of solid state NMR namely: the uniqueness of the tetrahedral angle and evolution of both dipolar D and chemical shield σ coupling tensors under MAS conditions.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"33 1","pages":"1-11"},"PeriodicalIF":0.6,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89193205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junghun Cho, Dong Zhou, Youngwook Kee, P. Spincemaille, Yi Wang
We modeled the magnetic field up to the quadrupole term to investigate not only the average susceptibility (dipole), but also the susceptibility distribution (quadrupole) contribution. Expanding the magnetic field up to the 2nd order provides the quadrupole (0th: monopole, 1st: dipole). Numerical simulations were performed to investigate the quadrupole contribution with subvoxel nonuniformity. Conventional dipole and our dipole + quadrupole models were compared in the simulation, the phantom and human brain. Furthermore, the quadrupole field was compared with the anisotropic susceptibility field in the dipole tensor model. In a nonuniformity case, numerical simulations showed a nonnegligible quadrupole field contribution. Our study showed a difference between the two methods in the susceptibility map at the edges; both the phantom and human studies showed sharper structural edges with the dipole + quadrupole model. Quadrupole moments showed contrast mainly at the structural boundaries. The quadrupole moment field contribution was smaller but nonnegligible compared to the anisotropic susceptibility contribution. Nonuniform and uniform source distributions can be separately considered by quadrupole expansion, which were mixed together in the dipole model. In the presence of nonuniformity, the susceptibility maps may be different between the two models. For a comprehensive field model, the quadrupole might need to be considered along with susceptibility anisotropy and microstructure effects.
{"title":"Quantitative Susceptibility Mapping of Magnetic Quadrupole Moments","authors":"Junghun Cho, Dong Zhou, Youngwook Kee, P. Spincemaille, Yi Wang","doi":"10.1155/2019/7174937","DOIUrl":"https://doi.org/10.1155/2019/7174937","url":null,"abstract":"We modeled the magnetic field up to the quadrupole term to investigate not only the average susceptibility (dipole), but also the susceptibility distribution (quadrupole) contribution. Expanding the magnetic field up to the 2nd order provides the quadrupole (0th: monopole, 1st: dipole). Numerical simulations were performed to investigate the quadrupole contribution with subvoxel nonuniformity. Conventional dipole and our dipole + quadrupole models were compared in the simulation, the phantom and human brain. Furthermore, the quadrupole field was compared with the anisotropic susceptibility field in the dipole tensor model. In a nonuniformity case, numerical simulations showed a nonnegligible quadrupole field contribution. Our study showed a difference between the two methods in the susceptibility map at the edges; both the phantom and human studies showed sharper structural edges with the dipole + quadrupole model. Quadrupole moments showed contrast mainly at the structural boundaries. The quadrupole moment field contribution was smaller but nonnegligible compared to the anisotropic susceptibility contribution. Nonuniform and uniform source distributions can be separately considered by quadrupole expansion, which were mixed together in the dipole model. In the presence of nonuniformity, the susceptibility maps may be different between the two models. For a comprehensive field model, the quadrupole might need to be considered along with susceptibility anisotropy and microstructure effects.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"99 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80955796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arterial Spin Labeling (ASL) is a noninvasive MRI-based method to measure cerebral blood flow (CBF). Recently, the study of ASL as a functional tool has emerged once CBF fluctuation comes from capillaries in brain tissue, giving a more spatially specific response when compared to the standard functional MRI method, based on the blood oxygenation level-dependent (BOLD) contrast. Although the BOLD effect could be desirable to study brain function, if one aims to quantify CBF, such effect is considered contamination that can be more attenuated if short TE value is used in the image acquisition. An approach that provides both CBF and function information in a simultaneous acquisition is the use of a dual-echo ASL (DE-ASL) readout. Our purpose was to evaluate the information provided by DE-ASL regarding CBF quantification and functional connectivity with a motor task. Pseudocontinuous ASL of twenty healthy subjects (age: 32.4 ± 10.2 years, 13 male) was acquired at a 3T scanner. We analyzed the influence of TE on CBF values and brain connectivity provided by CBF and concurrent BOLD (cc-BOLD) time series. Brain networks were obtained by the general linear model and independent component analysis. Connectivity matrices were generated using a bivariate correlation (Fisher Z values). No effect of the sequence readout, but significant effect of the TE value, was observed on gray matter CBF values. Motor networks with reduced extension and more connections with important regions for brain integration were observed for CBF data acquired with short TE, proving its higher spatial specificity. Therefore, it was possible to use a dual-echo readout provided by a standard commercial ASL pulse sequence to obtain reliable quantitative CBF values and functional information simultaneously.
{"title":"Dual-Echo Arterial Spin Labeling for Brain Perfusion Quantification and Functional Analysis","authors":"A. Paschoal, F. F. Paiva, R. Leoni","doi":"10.1155/2019/5040465","DOIUrl":"https://doi.org/10.1155/2019/5040465","url":null,"abstract":"Arterial Spin Labeling (ASL) is a noninvasive MRI-based method to measure cerebral blood flow (CBF). Recently, the study of ASL as a functional tool has emerged once CBF fluctuation comes from capillaries in brain tissue, giving a more spatially specific response when compared to the standard functional MRI method, based on the blood oxygenation level-dependent (BOLD) contrast. Although the BOLD effect could be desirable to study brain function, if one aims to quantify CBF, such effect is considered contamination that can be more attenuated if short TE value is used in the image acquisition. An approach that provides both CBF and function information in a simultaneous acquisition is the use of a dual-echo ASL (DE-ASL) readout. Our purpose was to evaluate the information provided by DE-ASL regarding CBF quantification and functional connectivity with a motor task. Pseudocontinuous ASL of twenty healthy subjects (age: 32.4 ± 10.2 years, 13 male) was acquired at a 3T scanner. We analyzed the influence of TE on CBF values and brain connectivity provided by CBF and concurrent BOLD (cc-BOLD) time series. Brain networks were obtained by the general linear model and independent component analysis. Connectivity matrices were generated using a bivariate correlation (Fisher Z values). No effect of the sequence readout, but significant effect of the TE value, was observed on gray matter CBF values. Motor networks with reduced extension and more connections with important regions for brain integration were observed for CBF data acquired with short TE, proving its higher spatial specificity. Therefore, it was possible to use a dual-echo readout provided by a standard commercial ASL pulse sequence to obtain reliable quantitative CBF values and functional information simultaneously.","PeriodicalId":55216,"journal":{"name":"Concepts in Magnetic Resonance Part A","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91021215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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