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Nomogram for Predicting Efficacy and Prognosis After Chemotherapy for Advanced NSCLC 预测晚期 NSCLC 化疗后疗效和预后的提名图
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-08-08 DOI: 10.1111/crj.13815
Jiaying Gao, Yandong Nan, Gang Liu, Shihong Zhao, Huanqing Xiong, Yifeng Wang, Faguang Jin

Purpose

One major issue is the therapeutic effect following chemotherapy for non–small cell lung cancer (NSCLC). Although numerous risk factors have been identified and novel therapies have been developed, improving patient overall survival (OS) remains a crucial postoperative issue. This study aimed to develop a nomogram for accurately predicting the OS of patients with Stage III–IV NSCLC treated with chemotherapy.

Methods

The Department of Respiration at Tangdu Hospital, Air Force Medical University, prospectively collected data on 321 patients between January 2018 and December 2023. A week before treatment, the platelet-to-lymphocyte ratio (PLR), the neutrophil-to-lymphocyte ratio (NLR), and seven autoantibodies were measured using Youden's index, which was obtained using the ROC curve. The formula was used to compute the values of PLR and NLR. After using multifactor Cox regression analysis to identify risk factors, a nomogram was produced regarding the therapeutic effect following chemotherapy. The performance of the nomogram was assessed using a bootstrapped-concordance index and calibration plots.

Result

It was determined that NLR, sex-determining region Y-box 2 (SOX2), adenosine triphosphate binding RNA deconjugase 4–5 (GBU4-5), and MAGE family member A1 (MAGEA1) were significantly associated factors that could be combined to accurately predict the therapeutic effect following chemotherapy. Utilizing these risk indicators, we were able to develop a nomogram that predicted the patients' survival at 1, 3, and 5 years. At 3 years, the area under the curve representing the expected survival probability was 0.762 (95% confidence interval 0.66–0.87). With a bootstrapped-concordance index of 0.762, the nomogram demonstrated good calibration.

Conclusions

Our nomogram proved to be a valuable instrument in accurately predicting the overall survival of patients.

目的:一个主要问题是非小细胞肺癌(NSCLC)化疗后的治疗效果。虽然已经发现了许多风险因素,并开发出了新型疗法,但提高患者的总生存率(OS)仍是术后的一个关键问题。本研究旨在开发一种提名图,用于准确预测接受化疗的III-IV期NSCLC患者的OS:空军军医大学唐都医院呼吸科前瞻性地收集了2018年1月至2023年12月期间321名患者的数据。治疗前一周,采用尤登指数(Youden's index)测定血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)以及七种自身抗体,利用ROC曲线得出。该公式用于计算 PLR 和 NLR 的值。在使用多因素考克斯回归分析确定风险因素后,生成了化疗后疗效的提名图。使用自引导一致性指数和校准图评估了提名图的性能:结果:NLR、性别决定区Y-盒2(SOX2)、三磷酸腺苷结合RNA解拮抗剂4-5(GBU4-5)和MAGE家族成员A1(MAGEA1)被确定为显著相关的因素,这些因素结合在一起可准确预测化疗后的疗效。利用这些风险指标,我们绘制出了预测患者 1 年、3 年和 5 年生存率的提名图。在 3 年时,代表预期生存概率的曲线下面积为 0.762(95% 置信区间为 0.66-0.87)。自引导一致性指数为 0.762,表明提名图具有良好的校准性:我们的提名图被证明是准确预测患者总生存期的重要工具。
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引用次数: 0
Circ_0028826 Promotes Growth and Metastasis of NSCLC via Acting as a Sponge of miR-758-3p to Derepress IDH2 Expression Circ_0028826 通过充当 miR-758-3p 的海绵来抑制 IDH2 的表达,从而促进 NSCLC 的生长和转移。
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-08-07 DOI: 10.1111/crj.13802
Lihong Guo, Xueqin Liu, Jie Zhang, Zhuixing Liu, Bohao Zhang, Yang Sun, Dandan Cui, Jinpeng Liu

Background

Non–small cell lung cancer (NSCLC) is one of the cancers with the highest mortality and morbidity in the world. Circular RNAs (circRNAs) are newly identified players in carcinogenesis and development of various cancers. This study is aimed at exploring the functional effects and mechanism of circ_0028826 in the development of NSCLC.

Methods

Real-time quantitative PCR (RT-qPCR) was used to detect the expression levels of circ_0028826, IDH2 mRNA, and miR-758-3p. IDH2, Bcl2, Bax, and E-cadherin protein levels were detected using a western blot. Cell Counting Kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), flow cytometry, wound healing, and transwell assays were used to assess the capacities of proliferation, apoptosis, migration, and invasion. Interaction between miR-758-3p and circ_0028826 or IDH2 was validated using a dual-luciferase reporter assay. The role of circ_0028826 in vivo was checked based on a xenograft tumor model.

Results

Circ_0028826 was elevated in NSCLC, and its absence inhibited NSCLC cell proliferation, migration, invasion, and induced apoptosis. In terms of mechanism, circ_0028826 increased IDH2 expression by targeting miR-758-3p. In addition, circ_0028826 knockdown also regulated IDH2 by targeting miR-758-3p to inhibit tumor growth in vivo.

Conclusion

Circ_0028826 promoted the development of NSCLC via regulation of the miR-758-3p/IDH2 axis, providing a new strategy for NSCLC treatment.

背景:非小细胞肺癌(NSCLC非小细胞肺癌(NSCLC)是世界上死亡率和发病率最高的癌症之一。环状 RNA(circRNA)是新发现的在各种癌症的发生和发展中起作用的因子。本研究旨在探讨 circ_0028826 在 NSCLC 发病过程中的功能作用和机制:方法:采用实时定量 PCR(RT-qPCR)技术检测 circ_0028826、IDH2 mRNA 和 miR-758-3p 的表达水平。用 Western 印迹法检测 IDH2、Bcl2、Bax 和 E-cadherin 蛋白水平。细胞计数试剂盒-8(CCK-8)、5-乙炔基-2'-脱氧尿苷(EdU)、流式细胞术、伤口愈合和透孔试验被用来评估细胞的增殖、凋亡、迁移和侵袭能力。使用双荧光素酶报告实验验证了 miR-758-3p 与 circ_0028826 或 IDH2 之间的相互作用。通过异种移植肿瘤模型检验了circ_0028826在体内的作用:结果:Circ_0028826在NSCLC中升高,其缺失可抑制NSCLC细胞的增殖、迁移和侵袭,并诱导细胞凋亡。在机制方面,circ_0028826通过靶向miR-758-3p增加了IDH2的表达。此外,circ_0028826敲除后还能通过靶向miR-758-3p调节IDH2,从而抑制体内肿瘤的生长:Circ_0028826通过调控miR-758-3p/IDH2轴促进了NSCLC的发展,为NSCLC的治疗提供了一种新策略。
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引用次数: 0
A Nomogram for Predicting Cancer-Specific Survival in Young Patients With Advanced Lung Cancer Based on Competing Risk Model 基于竞争风险模型预测年轻晚期肺癌患者癌症特异性生存期的提名图
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-08-07 DOI: 10.1111/crj.13800
Jiaxin Li, Bolin Pan, Qiying Huang, Chulan Zhan, Tong Lin, Yangzhi Qiu, Honglang Zhang, Xiaohong Xie, Xinqin Lin, Ming Liu, Liqiang Wang, Chengzhi Zhou

Background

Young lung cancer is a rare subgroup accounting for 5% of lung cancer. The aim of this study was to compare the causes of death (COD) among lung cancer patients of different age groups and construct a nomogram to predict cancer-specific survival (CSS) in young patients with advanced stage.

Methods

Lung cancer patients diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and stratified into the young (18–45 years) and old (> 45 years) groups to compare their COD. Young patients diagnosed with advanced stage (IVa and IVb) from 2010 to 2015 were reselected and divided into training and validation cohorts (7:3). Independent prognostic factors were identified through the Fine-Gray's test and further integrated to the competing risk model. The area under the receiver operating characteristic curve (AUC), consistency index (C-index), and calibration curve were applied for validation.

Results

The proportion of cancer-specific death (CSD) in young patients was higher than that in old patients with early-stage lung cancer (p < 0.001), while there was no difference in the advanced stage (p = 0.999). Through univariate and multivariate analysis, 10 variables were identified as independent prognostic factors for CSS. The AUC of the 1-, 3-, and 5-year prediction of CSS was 0.688, 0.706, and 0.791 in the training cohort and 0.747, 0.752, and 0.719 in the validation cohort. The calibration curves demonstrated great accuracy. The C-index of the competing risk model was 0.692 (95% CI: 0.636–0.747) in the young patient cohort.

Conclusion

Young lung cancer is a distinct entity with a different spectrum of competing risk events. The construction of our nomogram can provide new insights into the management of young patients with lung cancer.

背景:年轻肺癌是一个罕见的亚组,占肺癌的5%。本研究旨在比较不同年龄组肺癌患者的死亡原因(COD),并构建一个提名图来预测晚期年轻患者的癌症特异性生存率(CSS):从监测、流行病学和最终结果(SEER)数据库中提取了2004年至2015年间确诊的肺癌患者,并将其分为年轻组(18-45岁)和年长组(大于45岁),以比较他们的死因。重新选择了2010年至2015年诊断为晚期(IVa和IVb)的年轻患者,并将其分为训练组和验证组(7:3)。通过Fine-Gray检验确定了独立的预后因素,并进一步整合到竞争风险模型中。应用接收者操作特征曲线下面积(AUC)、一致性指数(C-index)和校准曲线进行验证:结果:年轻肺癌患者的癌症特异性死亡(CSD)比例高于老年早期肺癌患者(P 结论:年轻肺癌是一个独特的实体,其癌症特异性死亡比例高于老年早期肺癌患者:年轻肺癌是一个独特的实体,具有不同的竞争风险事件谱。我们构建的提名图可以为年轻肺癌患者的治疗提供新的见解。
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引用次数: 0
Primary Pulmonary Angiosarcoma Found Incidentally in a Complicated Patient: A Rare Case Report 并发症患者偶然发现的原发性肺血管肉瘤:罕见病例报告
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-08-06 DOI: 10.1111/crj.13818
Reza Basiri, Alireza Ziaei Moghaddam, Arezoo Rikhtegar, Amir Hossein Jafarian

Introduction

Primary pulmonary angiosarcoma (PPA) is a highly aggressive and rare malignancy originating from the endothelial cells of blood vessels in the lungs. PPA is an extremely rare subtype, with less than 30 cases reported to date. PPA is not only challenging to diagnose but also has a poor prognosis, often resulting in a high mortality rate within a year of diagnosis, regardless of the treatment approach.

Method

We present the case of a 33-year-old woman with no significant past medical history who presented with abdominal pain and was incidentally found to have a right hilar mass with pleural effusion and empyema. After undergoing surgery for a perforated gastric ulcer, her pulmonary lesions were further worked up. Despite an extensive diagnostic evaluation, including imaging, bronchoscopy, and thoracotomy, establishing a diagnosis was challenging. Ultimately, PPA was diagnosed on surgical lung biopsy, and the patient was started on pazopanib and paclitaxel chemotherapy but expired after 1 month due to multiple complications.

Conclusion

This case highlights the difficulty in diagnosing this rare tumor and its poor prognosis regardless of therapy. Greater awareness of PPA and more research are needed to improve early detection and treatment options for this deadly disease.

简介原发性肺血管肉瘤(PPA)是一种源自肺部血管内皮细胞的高度侵袭性罕见恶性肿瘤。PPA 是一种极为罕见的亚型,迄今报道的病例不到 30 例。PPA 不仅诊断困难,而且预后较差,无论采用何种治疗方法,通常在确诊后一年内死亡率较高:我们介绍了一例 33 岁女性的病例,她既往无重大病史,因腹痛就诊,偶然发现右侧腹股沟肿块,伴有胸腔积液和肺水肿。在接受胃溃疡穿孔手术后,她的肺部病变得到了进一步检查。尽管进行了广泛的诊断评估,包括影像学检查、支气管镜检查和胸腔切开术,但确诊仍很困难。最终,手术肺活检确诊为 PPA,患者开始接受帕唑帕尼和紫杉醇化疗,但 1 个月后因多种并发症去世:本病例凸显了诊断这种罕见肿瘤的难度,以及无论采用何种治疗方法,其预后都很差。我们需要提高对PPA的认识并开展更多研究,以改善这种致命疾病的早期发现和治疗方案。
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引用次数: 0
Unplanned Perioperative Reoperation Following Pulmonary Resection in Lung Cancer Patients: A Report of a Single-Center Experience 肺癌患者肺切除术后非计划围手术期再次手术:单中心经验报告
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-08-06 DOI: 10.1111/crj.13810
Hongxiang Feng, Yue Zhao, Chaoyang Liang, Yuhui Shi, Deruo Liu, Jin Zhang, Zhenrong Zhang

Background

Pulmonary resection is an important part of comprehensive treatment of lung cancer. Despite the progress in recent thoracic surgery, reoperation is occasionally inevitable for managing severe perioperative complications. This study aimed to investigate the incidence and causes of perioperative reoperation in lung cancer patients.

Methods

We retrospectively collected patients who underwent reoperation following pulmonary resection from January 2010 to February 2021 in China-Japan Friendship Hospital.

Results

Among the 5032 lung cancer patients who received primary pulmonary resection in our institute, 37 patients underwent perioperative reoperation with the rate being 0.74%. Lobectomy was the most frequently executed procedure (56.8%). The mean duration of the primary surgery was 143.6 ± 65.1 min. About half of the cases received secondary surgery within 24 h of the primary surgery, whereas only one case underwent secondary surgery 30 days after the primary surgery (due to chylous leakage). The major causes of the reoperation were bleeding (73.0%), chylous leakage (13.5%), lobar torsion (5.4%), air leakage (2.7%), atelectasis (2.9%), and cardiac herniation (2.7%).

Conclusion

The most prevalent reasons for unplanned reoperation following pulmonary resection in lung cancer patients include bleeding, chylous leakage, and lobar torsion. The strict control of the surgical indications and standardization of surgical procedures are fundamental to reduce unplanned secondary operations after pulmonary resections. Timely identification of the need to secondary surgery is also important to ensure patients' safety.

背景:肺切除术是肺癌综合治疗的重要组成部分。尽管近年来胸外科手术取得了很大进展,但为了处理严重的围手术期并发症,再次手术有时仍不可避免。本研究旨在调查肺癌患者围手术期再次手术的发生率和原因:我们回顾性收集了 2010 年 1 月至 2021 年 2 月期间在中日友好医院接受肺切除术后再次手术的患者:结果:在我院接受原发性肺切除术的5032例肺癌患者中,有37例患者进行了围手术期再手术,再手术率为0.74%。肺叶切除术是最常见的手术(56.8%)。初次手术的平均时间为(143.6 ± 65.1)分钟。约半数病例在初次手术后24小时内接受了二次手术,只有一例在初次手术后30天接受了二次手术(由于乳糜漏)。再次手术的主要原因是出血(73.0%)、乳糜漏(13.5%)、肺叶扭转(5.4%)、漏气(2.7%)、肺不张(2.9%)和心脏疝(2.7%):结论:肺癌患者肺切除术后最常见的非计划再手术原因包括出血、乳糜漏和肺叶扭转。严格控制手术适应症和规范手术流程是减少肺切除术后意外二次手术的根本。及时发现是否需要二次手术对于确保患者的安全也很重要。
{"title":"Unplanned Perioperative Reoperation Following Pulmonary Resection in Lung Cancer Patients: A Report of a Single-Center Experience","authors":"Hongxiang Feng,&nbsp;Yue Zhao,&nbsp;Chaoyang Liang,&nbsp;Yuhui Shi,&nbsp;Deruo Liu,&nbsp;Jin Zhang,&nbsp;Zhenrong Zhang","doi":"10.1111/crj.13810","DOIUrl":"10.1111/crj.13810","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pulmonary resection is an important part of comprehensive treatment of lung cancer. Despite the progress in recent thoracic surgery, reoperation is occasionally inevitable for managing severe perioperative complications. This study aimed to investigate the incidence and causes of perioperative reoperation in lung cancer patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively collected patients who underwent reoperation following pulmonary resection from January 2010 to February 2021 in China-Japan Friendship Hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 5032 lung cancer patients who received primary pulmonary resection in our institute, 37 patients underwent perioperative reoperation with the rate being 0.74%. Lobectomy was the most frequently executed procedure (56.8%). The mean duration of the primary surgery was 143.6 ± 65.1 min. About half of the cases received secondary surgery within 24 h of the primary surgery, whereas only one case underwent secondary surgery 30 days after the primary surgery (due to chylous leakage). The major causes of the reoperation were bleeding (73.0%), chylous leakage (13.5%), lobar torsion (5.4%), air leakage (2.7%), atelectasis (2.9%), and cardiac herniation (2.7%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The most prevalent reasons for unplanned reoperation following pulmonary resection in lung cancer patients include bleeding, chylous leakage, and lobar torsion. The strict control of the surgical indications and standardization of surgical procedures are fundamental to reduce unplanned secondary operations after pulmonary resections. Timely identification of the need to secondary surgery is also important to ensure patients' safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"18 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Biomarkers for Lung Adenocarcinoma With Qi Deficiency and Phlegm Dampness 气虚痰湿型肺腺癌生物标志物的鉴定
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-08-06 DOI: 10.1111/crj.13812
Jiabin Chen, Sheng Wang, Qiaolei Yang, Yongjun Zhang, Jianfei Shen, Kequn Chai

Background

Qi deficiency and phlegm dampness (QPD) is one of the most common traditional Chinese medicine (TCM) syndromes in lung adenocarcinoma (LUAD). This study aimed to identify syndrome-specific biomarkers for LUAD with QPD syndrome.

Methods

Peripheral blood mononuclear cells (PBMCs) from LUAD patients with QPD, LUAD patients with non-QPD (N-QPD), and healthy control (H) were collected and analyzed with RNA-seq to identify differentially expressed genes (DEGs). The area under the receiver operator characteristic curve (AUC) of each DEG was calculated, and the top 10 highest AUC DEGs were validated by qRT-PCR. Logistic regression analysis was used to develop a diagnostic model evaluated with AUC.

Results

A total of 135 individuals were enrolled in this study (training set: 15 QPD, 15 N-QPD, 15 H; validation set: 30 QPD, 30 N-QPD, 30 H). A total of 1480 DEGs were identified between QPD and N-QPD. The qRT-PCR results showed that the expression of DDR2 was downregulated, and PPARG was upregulated, which was in line with the finding of the training set. We developed a diagnostic model with these two genes. The AUC of the diagnostic model in the training cohort and validation cohort was 0.891 and 0.777, respectively.

Conclusions

We identified the two genes (DDR2 and PPARG) as syndrome-specific biomarkers for LUAD with QPD syndrome and developed a novel diagnostic model, which may help to improve the accuracy and sensibility of clinical diagnosis and provide a new target for natural drug treatment of LUAD.

背景:气虚痰湿证(QPD)是肺腺癌(LUAD)最常见的中医证候之一。本研究旨在确定肺腺癌气虚痰湿证的特异性生物标志物:方法:收集患有 QPD 的 LUAD 患者、患有非 QPD 的 LUAD 患者(N-QPD)和健康对照(H)的外周血单核细胞(PBMCs),并进行 RNA-seq 分析,以确定差异表达基因(DEGs)。计算每个 DEG 的接收者操作特征曲线下面积(AUC),并通过 qRT-PCR 验证 AUC 最高的前 10 个 DEG。利用逻辑回归分析建立了一个用AUC评估的诊断模型:结果:共有 135 人参加了这项研究(训练集:15 个 QPD、15 个 N-QPD、15 个 N-QPD):结果:共有 135 人参加了这项研究(训练集:15 QPD、15 N-QPD、15 H;验证集:30 QPD、30 N-QPD、30 H):30个QPD、30个N-QPD、30个H)。在 QPD 和 N-QPD 之间共鉴定出 1480 个 DEGs。qRT-PCR 结果显示,DDR2 表达下调,PPARG 表达上调,这与训练集的结果一致。我们利用这两个基因建立了一个诊断模型。在训练组和验证组中,诊断模型的AUC分别为0.891和0.777:结论:我们发现了两个基因(DDR2和PPARG)是LUAD伴QPD综合征的综合征特异性生物标志物,并建立了一个新的诊断模型,这可能有助于提高临床诊断的准确性和敏感性,并为LUAD的天然药物治疗提供新的靶点。
{"title":"Identification of Biomarkers for Lung Adenocarcinoma With Qi Deficiency and Phlegm Dampness","authors":"Jiabin Chen,&nbsp;Sheng Wang,&nbsp;Qiaolei Yang,&nbsp;Yongjun Zhang,&nbsp;Jianfei Shen,&nbsp;Kequn Chai","doi":"10.1111/crj.13812","DOIUrl":"10.1111/crj.13812","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Qi deficiency and phlegm dampness (QPD) is one of the most common traditional Chinese medicine (TCM) syndromes in lung adenocarcinoma (LUAD). This study aimed to identify syndrome-specific biomarkers for LUAD with QPD syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Peripheral blood mononuclear cells (PBMCs) from LUAD patients with QPD, LUAD patients with non-QPD (N-QPD), and healthy control (H) were collected and analyzed with RNA-seq to identify differentially expressed genes (DEGs). The area under the receiver operator characteristic curve (AUC) of each DEG was calculated, and the top 10 highest AUC DEGs were validated by qRT-PCR. Logistic regression analysis was used to develop a diagnostic model evaluated with AUC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 135 individuals were enrolled in this study (training set: 15 QPD, 15 N-QPD, 15 H; validation set: 30 QPD, 30 N-QPD, 30 H). A total of 1480 DEGs were identified between QPD and N-QPD. The qRT-PCR results showed that the expression of DDR2 was downregulated, and PPARG was upregulated, which was in line with the finding of the training set. We developed a diagnostic model with these two genes. The AUC of the diagnostic model in the training cohort and validation cohort was 0.891 and 0.777, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We identified the two genes (DDR2 and PPARG) as syndrome-specific biomarkers for LUAD with QPD syndrome and developed a novel diagnostic model, which may help to improve the accuracy and sensibility of clinical diagnosis and provide a new target for natural drug treatment of LUAD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"18 8","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Which Is More Suitable for First-Line Treatment of Extensive-Stage Small Cell Lung Cancer, PD-L1 Inhibitors Versus PD-1 Inhibitors? A Systematic Review and Network Meta-Analysis PD-L1抑制剂与PD-1抑制剂哪个更适合广泛期小细胞肺癌的一线治疗?系统综述与网络荟萃分析》。
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-07-29 DOI: 10.1111/crj.13804
Wenjing Liu, Lulin Yu, Yuqian Feng, Siyu Huang, Yuxin Hua, Mingying Peng, Shanming Ruan, Kai Zhang

Background

In this network meta-analysis (NMA), the efficiency and safety of PD-1 inhibitors + chemotherapy and PD-L1 inhibitors + chemotherapy were compared in the first-line therapy of patients with extensive-stage small cell lung cancer (ES-SCLC).

Methods

We searched research databases, conference abstracts, and trial registries and subsequently chose relevant studies and extracted dates. The NMA was conducted to estimate the efficiency and safety of the PD-1 inhibitors + chemotherapy and PD-L1 inhibitors + chemotherapy on overall survival (OS), progression-free survival (PFS), overall remission rate (ORR), and adverse events (AEs). Studies were assessed for quality. Subgroup analyses were used to evaluate study heterogeneity.

Results

We included six randomized trials with a total of 3163 patients. Direct comparisons showed that patients who received either PD-1 inhibitors + chemotherapy (HR: 0.71, 95% CI: 0.57–0.87) or PD-L1 inhibitors + chemotherapy (HR: 0.74, 0.61–0.89) demonstrated significantly longer OS than those who received placebo + chemotherapy. The results of the NMA showed that no significant differences in OS (HR 0.96 95% CI: 0.72–1.3), PFS (HR 0.83, 95% CI: 0.51–1.4), and ORR (OR 1.3 95% CI: 0.66–2.5) were observed for PD-1 inhibitors + chemotherapy compared with PD-L1 inhibitors + chemotherapy, but the Bayesian ranking revealed that patients receiving PD-1 inhibitors + chemotherapy tended to have longer OS, PFS benefit, and better treatment response than patients receiving PD-L1 inhibitors + chemotherapy. In terms of safety, no significant difference was observed in their safety profiles.

Conclusion

In comparison to placebo + chemotherapy, PD-L1 inhibitors + chemotherapy and PD-1 inhibitors + chemotherapy significantly improved survival for ES-SCLC. According to the available data, PD-L1 inhibitors + chemotherapy and PD-1 inhibitors + chemotherapy had equivalent efficacy and safety; however, the level of evidence of this type of comparison is limited.

研究背景在这项网络荟萃分析(NMA)中,比较了PD-1抑制剂+化疗和PD-L1抑制剂+化疗在广泛期小细胞肺癌(ES-SCLC)患者一线治疗中的有效性和安全性:我们检索了研究数据库、会议摘要和试验登记,随后选择了相关研究并提取了日期。NMA旨在估算PD-1抑制剂+化疗和PD-L1抑制剂+化疗对总生存期(OS)、无进展生存期(PFS)、总缓解率(ORR)和不良事件(AEs)的有效性和安全性。对研究进行了质量评估。亚组分析用于评估研究的异质性:我们纳入了六项随机试验,共3163名患者。直接比较显示,接受PD-1抑制剂+化疗(HR:0.71,95% CI:0.57-0.87)或PD-L1抑制剂+化疗(HR:0.74,0.61-0.89)的患者的OS明显长于接受安慰剂+化疗的患者。NMA结果显示,OS(HR 0.96 95% CI:0.72-1.3)、PFS(HR 0.83,95% CI:0.51-1.4)和ORR(OR 1.3 95% CI:0.66-2.5)与PD-1抑制剂+化疗(HR:0.74,95% CI:0.61-0.89)相比无明显差异。5),但贝叶斯排序显示,接受PD-1抑制剂+化疗的患者往往比接受PD-L1抑制剂+化疗的患者有更长的OS、PFS获益和更好的治疗反应。在安全性方面,两者的安全性无明显差异:结论:与安慰剂+化疗相比,PD-L1抑制剂+化疗和PD-1抑制剂+化疗能明显改善ES-SCLC的生存率。根据现有数据,PD-L1抑制剂+化疗和PD-1抑制剂+化疗具有同等的疗效和安全性;然而,这类比较的证据水平有限。
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引用次数: 0
Evaluation of the diagnostic role of radial probe endobronchial ultrasound for peripheral pulmonary lesions 评估径向探头支气管内超声波对周围肺部病变的诊断作用。
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-07-28 DOI: 10.1111/crj.13792
Wei Wang, Li Li, Qian Zhang, Yan Wang, Chun Hua Xu

Objective

To evaluate the predictive value of echo features of radial probe endobronchial ultrasound (RP-EBUS) in the differential diagnosis of malignant and benign 1esions.

Methods

The clinical data of 336 patients with peripheral pulmonary lesions (PPLs) undergoing RP-EBUS were analyzed in order to evaluate the predictive value of the three EBUS echo features including continuous margin, absence of a linear-discrete air bronchogram, and heterogeneous in pulmonary lesions. The sensitivity and specificity for each echoic feature or in combination in diagnosing malignancy or benignity were determined.

Results

336 cases of PPLs including 216 cases of malignant lesions and 120 cases of benign lesions. The sensitivity and specificity of the continuous margin to the diagnosis of malignant lesions were 86.11% and 17.50%. The sensitivity and specificity of the absence of a linear-discrete air bronchogram to the diagnosis of malignant lesions were 66.67% and 57.50%, and the positive predictive value was 73.85%. The sensitivity and specificity of heterogeneity to the diagnosis of malignant lesions were 65.28% and 72.50%, and the positive predictive value was 81.03%. The combination of heterogeneous and absence of a linear-discrete air bronchogram could improve the diagnostic specificity to 87.50%, and the positive predictive value to 80.77%.

Conclusion

The two EBUS echo features of heterogeneous and absence of a linear-discrete air bronchogram have predictive value for PPLs, especially in the presence of two features the pulmonary lesions should be highly suspected malignant tumors.

目的评估径向探头支气管内超声(RP-EBUS)回声特征在恶性和良性病变鉴别诊断中的预测价值:分析336例接受RP-EBUS检查的肺外周病变(PPLs)患者的临床资料,以评估连续边缘、无线状离散空气支气管图和肺部病变异质性等三种EBUS回声特征的预测价值。确定了每个回声特征或其组合诊断恶性或良性病变的敏感性和特异性:336 例 PPL,包括 216 例恶性病变和 120 例良性病变。连续边缘对诊断恶性病变的敏感性和特异性分别为 86.11% 和 17.50%。无线状离散空气支气管造影对恶性病变诊断的敏感性和特异性分别为 66.67% 和 57.50%,阳性预测值为 73.85%。异质性对恶性病变诊断的敏感性和特异性分别为 65.28% 和 72.50%,阳性预测值为 81.03%。异型性和无线状离散空气支气管图的组合可将诊断特异性提高到 87.50%,阳性预测值提高到 80.77%:结论:异型性和无线状离散空气支气管图这两个 EBUS 回声特征对 PPL 具有预测价值,尤其是出现这两个特征的肺部病变应高度怀疑为恶性肿瘤。
{"title":"Evaluation of the diagnostic role of radial probe endobronchial ultrasound for peripheral pulmonary lesions","authors":"Wei Wang,&nbsp;Li Li,&nbsp;Qian Zhang,&nbsp;Yan Wang,&nbsp;Chun Hua Xu","doi":"10.1111/crj.13792","DOIUrl":"10.1111/crj.13792","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the predictive value of echo features of radial probe endobronchial ultrasound (RP-EBUS) in the differential diagnosis of malignant and benign 1esions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The clinical data of 336 patients with peripheral pulmonary lesions (PPLs) undergoing RP-EBUS were analyzed in order to evaluate the predictive value of the three EBUS echo features including continuous margin, absence of a linear-discrete air bronchogram, and heterogeneous in pulmonary lesions. The sensitivity and specificity for each echoic feature or in combination in diagnosing malignancy or benignity were determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>336 cases of PPLs including 216 cases of malignant lesions and 120 cases of benign lesions. The sensitivity and specificity of the continuous margin to the diagnosis of malignant lesions were 86.11% and 17.50%. The sensitivity and specificity of the absence of a linear-discrete air bronchogram to the diagnosis of malignant lesions were 66.67% and 57.50%, and the positive predictive value was 73.85%. The sensitivity and specificity of heterogeneity to the diagnosis of malignant lesions were 65.28% and 72.50%, and the positive predictive value was 81.03%. The combination of heterogeneous and absence of a linear-discrete air bronchogram could improve the diagnostic specificity to 87.50%, and the positive predictive value to 80.77%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The two EBUS echo features of heterogeneous and absence of a linear-discrete air bronchogram have predictive value for PPLs, especially in the presence of two features the pulmonary lesions should be highly suspected malignant tumors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"18 7","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11283883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Adherence and Health Status of Patients With COPD Under Treatment With Salmeterol/Fluticasone via the Elpenhaler® Device: The AHEAD Study 通过 Elpenhaler® 设备接受沙美特罗/氟替卡松治疗的慢性阻塞性肺病患者的治疗依从性和健康状况:AHEAD研究。
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-07-26 DOI: 10.1111/crj.13803
Konstantinos P. Exarchos, Georgios Hillas, Paschalis Steiropoulos, Polyanthi Papanastasiou, Athena Gogali, Konstantinos Kostikas
<div> <section> <h3> Background</h3> <p>Chronic obstructive pulmonary disease (COPD) is a heterogeneous progressive lung condition characterized by long-term respiratory symptoms and airflow limitation. Appropriate bronchodilation is the cornerstone of COPD treatment, leading to better health status as well as benefits in prognosis and mortality.</p> </section> <section> <h3> Methods</h3> <p>In the current open, noninterventional, observational study, 716 patients diagnosed with COPD of variable severity were administered a fixed-dose combination (FDC) of fluticasone propionate and salmeterol (500 + 50 mcg) through the Elpenhaler® device. The patients' adherence to treatment (based on the MMAS-8 [8-item Morisky Medication Adherence Scale]) and health status (based on the CCQ [Clinical COPD Questionnaire]) were assessed at the beginning of the study and at the end of the 3-month follow-up period.</p> </section> <section> <h3> Results</h3> <p>The mean ± SD MMAS-8 score at 1 and 3 months was 6.12 ± 1.89 and 6.45 ± 1.80, respectively, indicating medium adherence overall; however, there was a statistically significant increase of 0.33 units in the MMAS-8 score at the end of the follow-up (paired <i>t</i>-test <i>p</i> < 0.0001), suggestive of an improvement in adherence throughout the study. Higher adherence was associated with better health status at baseline, which further improved by the end of the follow-up. Moreover, we observed a statistically significant decrease of 1.07 points (<i>p</i> < 0.0001) in the mean CCQ total score from the baseline (CCQ score = 2.2 ± 1.00) until the end of the study follow-up (CCQ score = 1.13 ± 0.67). Similar conclusions were also drawn in the mean domain scores regarding symptoms (score equal to 1.36 ± 0.72, decrease by 1.18) as well as functional and mental state (scores equal to 0.86 ± 0.73 and 1.20 ± 0.88, decrease by 1.04 and 1.00, respectively, <i>p</i> < 0.0001). Similarly, when patients were stratified into subgroups with and without comorbidities, the former group showed an increase of 7% in the patients with medium to high adherence during the course of the study. In the same patient subgroup, there was a notable decrease in CCQ score by 1.18 points (<i>p</i> < 0.0001) during the study.</p> </section> <section> <h3> Conclusions</h3> <p>The administration of FDC of fluticasone propionate and salmeterol, (500 + 50 mcg) via the Elpenhaler® device for COPD, resulted in a well-maintained or slight increase in treatment adherence and a subsequent benefit in health status, which further persisted after
背景:慢性阻塞性肺疾病(COPD)是一种以长期呼吸道症状和气流受限为特征的异质性进行性肺部疾病。适当的支气管扩张是慢性阻塞性肺病治疗的基石,可改善患者的健康状况,改善预后,降低死亡率:在本项开放性、非干预性、观察性研究中,716 名严重程度不等的慢性阻塞性肺病患者通过 Elpenhaler® 设备接受了丙酸氟替卡松和沙美特罗(500 + 50 mcg)的固定剂量复合制剂(FDC)治疗。在研究开始时和 3 个月的随访期结束时,对患者的治疗依从性(基于 MMAS-8 [8 项莫里斯基用药依从性量表])和健康状况(基于 CCQ [临床慢性阻塞性肺病问卷])进行了评估:随访1个月和3个月时,MMAS-8评分的平均值(± SD)分别为6.12±1.89和6.45±1.80,表明总体依从性中等;但随访结束时,MMAS-8评分在统计学上显著增加了0.33个单位(配对t检验P 结论:氟丁胺口服溶液(FDC)的治疗效果显著:通过 Elpenhaler® 设备服用丙酸氟替卡松和沙美特罗(500 + 50 微克)的 FDC 治疗慢性阻塞性肺疾病,治疗依从性保持良好或略有提高,健康状况随之改善,并在治疗 3 个月后继续保持。
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引用次数: 0
A Randomized Controlled Clinical Trial Investigating the Weaning Process From Mechanical Ventilation in Elderly Patients With Dementia 研究老年痴呆症患者机械通气断奶过程的随机对照临床试验
IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2024-07-16 DOI: 10.1111/crj.13808
Jian-Feng Liang, Zhi-Yong Li, Hai-Shan Dong, Chang Xu, Chao-Qun Yin

Background

Limited data is available regarding the weaning techniques employed for mechanical ventilation (MV) in elderly patients with dementia in China.

Objective

The primary objective of this study is to investigate diverse weaning methods in relation to the prognostic outcomes of elderly patients with dementia undergoing MV in the intensive care unit (ICU). Specifically, we seek to compare the prognosis, likelihood of successful withdrawal from MV, and the length of stay (LOS) in the ICU.

Methods

The study was conducted as a randomized controlled trial, encompassing a group of 169 elderly patients aged ≥ 65 years with dementia who underwent MV. Three distinct weaning methods were used for MV cessation, namely, the tapering parameter, spontaneous breathing trial (SBT), and SmartCare (Dräger, Germany).

Results

In the tapering parameter group, the LOS in the ICU was notably prolonged compared to both the SBT and SmartCare groups. However, no statistically significant differences were observed among the groups with respect to demographic characteristics, such as age and sex, as well as factors including the rationale for ICU admission, cause of MV, MV mode, oxygenation index, hemoglobin levels, albumin levels, ejection fraction, sedation and analgesia practices, tracheotomy, duration of MV, successful extubation, successful weaning, incidences of ventilator-associated pneumonia, and overall prognosis.

Conclusions

Both the SBT and SmartCare withdrawal methods demonstrated a reduction in the duration of MV and LOS in the ICU when compared to the tapering parameter method.

Trial Registration

Chinese Clinical Trial Registry: ChiCTR1900028449

背景关于中国老年痴呆症患者机械通气(MV)断流技术的数据有限:本研究的主要目的是调查在重症监护室(ICU)接受机械通气治疗的老年痴呆症患者的不同断流方法与预后结果的关系。具体而言,我们试图比较预后、成功退出 MV 的可能性以及在重症监护室的住院时间(LOS):研究以随机对照试验的形式进行,169 名年龄≥ 65 岁的老年痴呆症患者接受了 MV 治疗。研究采用了三种不同的停用中压方法,即渐减参数、自主呼吸试验(SBT)和 SmartCare(德国 Dräger):结果:与 SBT 组和 SmartCare 组相比,减量参数组患者在重症监护室的住院时间明显延长。然而,在人口统计学特征(如年龄和性别)、入住 ICU 的原因、中风原因、中风模式、氧合作用指数、血红蛋白水平、白蛋白水平、射血分数、镇静和镇痛方法、气管切开术、中风持续时间、成功拔管、成功断奶、呼吸机相关肺炎发病率和总体预后等因素方面,各组间未观察到明显差异:结论:与减量参数法相比,SBT 和 SmartCare 拔管法均可缩短中压持续时间和重症监护室的住院时间:中国临床试验注册中心ChiCTR1900028449。
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引用次数: 0
期刊
Clinical Respiratory Journal
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