Clinical Neuropsychologist最新文献

Objective: The analysis of risk of bias in systematic reviews (SR) and meta-analyses (MA) is a fundamental task to ensure the correct synthesis of results. To carry out this task, specific tools must be used for each research design of the studies analyzed. The choice of an appropriate tool is currently a challenge for researchers developing SR and MA in the area of symptom and performance validity because the research designs used have been created specifically for this field. Although these designs can be integrated within the classic classifications, they present a number of particular characteristics that are not reflected in any of the current risk of bias analysis tools. The aim of this study is to design a checklist specifically for systematic review/meta-analysis focused on validity tests. Methods: The checklist was developed through objective review of the existing evidence, development of checklist items, and refinement by external feedback and performance analysis. Results: The checklist is composed of four sections: Clinical comparison group selection, sources of bias in either simulation or criterion group designs, and overall assessment of the study. Inter-rater reliability was assessed with a sample of 20 studies, resulting in good to excellent intraclass correlation coefficients for most items. Conclusions: The checklist seeks to fill an important gap in the literature by serving as an assessment tool that improves the reliability of evidence synthesis in symptom and performance validity studies. This instrument facilitates the development of SR and MA that meet international standards, improving methodological rigor and reliability in the forensic setting.

Objective: People with functional seizures (FS) have frequent and disabling cognitive dysfunction and mental health symptoms, with low quality of life. However, interrelationships among these constructs are poorly understood. In this meta-analysis, we examined associations between objective (i.e. performance-based) cognitive testing and self-reported (i) mental health, (ii) cognition, and (iii) quality of life in FS. Method: We searched MEDLINE, Embase, PsycINFO, and Web of Science, with the final search on June 10, 2024. Inclusion criteria were studies documenting relationships between objective cognitive test scores and self-reported (i.e. subjective) mental health, cognition, and/or quality of life in adults with FS. Exclusion criteria were mixed FS/epilepsy samples. A modified Newcastle-Ottawa Scale evaluated risk of bias. This project is registered as CRD42023392385 in PROSPERO. Results: Initially, 4,054 unique reports were identified, with the final sample including 24 articles of 1,173 people with FS. Mean age was 35.9 (SD = 3.9), mean education was 12.6 (SD = 1.3), and proportion of women was 73.9%. Risk of bias was moderate, due in part to inconsistent reporting of confounding demographic variables. Significant relationships were found between global objective cognition and global self-reported mental health (k = 21, Z = -0.23 [0.04], 95% CI = -0.30, -0.16), depression (k = 11, Z = -0.13 [0.05], 95% CI = -0.21, -0.04), cognition (k = 5, Z = -0.16 [0.05], 95% CI = -0.26, -0.06), and quality of life (k = 5, Z = -0.17 [0.05], 95% CI = -0.24, -0.10). Exploratory analyses showed associations between select cognitive and mental health constructs. Conclusions: Objective cognition is reliably associated with self-reported mental health, cognition, and quality of life in people with FS. Scientific and clinical implications are discussed.

Objective: Older adults with cognitive impairment are at risk of medication-taking errors. This study assessed the impact of providing medication adherence feedback to cognitively impaired older adults. Methods: Forty participants with mild cognitive impairment or mild dementia had their medication adherence electronically monitored for 8 weeks. They were provided with verbal and visual feedback about their adherence results. Initial participant reactions were elicited using a Motivational Interviewing approach, and self-reported behavior changes were assessed during a follow-up interview. Quantitative analyses assessed relationships among electronically monitored and self-rated adherence, initial reactions to adherence feedback, and subsequently reported medication self-management changes. Thematic analysis determined facilitators and barriers to making self-management changes. Results: Although self-rated adherence was high, electronic monitoring revealed that 20% of the sample had suboptimal adherence (took the recommended dose on <80% of monitored days). Fifty-three percent of the sample reported feeling surprised by their adherence results, and 45% endorsed initial motivation to change self-management behaviors. Motivated participants demonstrated worse electronically monitored adherence than unmotivated peers, and those who were surprised by their medication-taking errors expressed greater initial motivation to change. At follow-up, 50% reported having made changes, and 82.4% of them indicated that this study played a role. Facilitators of making changes included awareness of medication-taking errors and cognitive impairment, whereas barriers included lack of perceived difficulty/need. Conclusions: Adherence monitoring with feedback is feasible and impactful in cognitively impaired older adults. Increasing awareness of medication-taking errors fosters motivation to improve medication self-management and results in participant-reported behavior change.

Objective: Obstructive sleep apnea (OSA) has been associated with structural and functional brain changes and cognitive impairment in sleep clinic samples. Persons with traumatic brain injury (TBI) are at increased risk of OSA compared to community samples, and many experience chronic cognitive disability. However, the impact of OSA on cognitive outcome after TBI is unknown. The purpose of this study was to examine the relationship between polysomnographic sleep parameters on neuropsychological performance 2 years following TBI. We hypothesized that oxygen desaturation, sleep fragmentation, and sleep depth would predict neuropsychological performance. Method: Participants (N = 123) were persons with moderate-to-severe TBI who underwent Type 1 Polysomnography during acute neurorehabilitation. At 2 years post-TBI, participants completed telephone-based neuropsychological testing (the Brief Test of Adult Cognition by Telephone). General linear models were fit to investigate the relationship between sleep parameters and neuropsychological performance, controlling for demographics and posttraumatic amnesia. Results: When controlling for demographics, injury characteristics, and other sleep parameters, greater percent of Stage 1 sleep time predicted poorer cognitive performance (Overall BTACT composite, p = 0.0078, η_p2 = 6.6%; Verbal Memory composite, p = 0.0407, η_p2 = 3.9%; Executive Function composite, p = 0.0215, η_p2 = 4.9%). Oxygen desaturation, cortical arousals, Stage 3 sleep, and the obstructive apnea-hypopnea index were not significantly associated with cognitive outcome. Conclusions: Reduced sleep depth was associated with cognitive outcome in persons with TBI; these findings require replication. Future research should examine whether improving sleep (e.g. increasing deep sleep) during acute recovery can improve cognitive recovery following TBI.

Objective: Despite significant progress in understanding the factors influencing cognitive function in Parkinson's disease (PD), there is a notable gap in data representation for the Latinx population. This study aims to evaluate the contributors to and disparities in cognitive performance among Latinx patients with PD. Methods: A retrospective analysis was conducted based on cross-sectional data encompassing demographic, environmental, motor, and non-motor disease characteristics from the Latin American Research Consortium on the Genetics of PD (LARGE-PD) and the Parkinson's Progression Markers Initiative (PPMI) cohorts. Linear regression multivariable models were applied to identify variables affecting Montreal Cognitive Assessment (MoCA) scores, accounting for age, sex, and years of education. Results: The analysis comprised of 3,054 PD patients (2,041 from LARGE-PD and 1,013 from PPMI) and 1,303 Latinx-controls. Latinx-PD patients (mean age 63.0 ± 11.8, 56.8% male) exhibited a significantly lower average MoCA score (p < .001) compared to white Non-Hispanic PD patients from PPMI (mean age 67.5 ± 9.9, 61.7% male). This difference persisted when comparing the Latinx-PD to the Latinx-controls (mean age 58.7 ± 9.3, 33.2% male; p < .001). Factors significantly associated with better MoCA scores in Latinx-PD included unilateral symptom onset (p = .009), and higher educational attainment (p < .001). Conversely, those associated with worse scores included the use of dopamine agonists (p = .01), previous tobacco use (p = .01), older age (p < .001), and a higher Hoehn and Yahr scale score (p < .001). Conclusions: Latinx-PD patients demonstrated significantly lower cognitive scores compared to their white non-Hispanic PD counterparts and Latinx-controls. These results highlight the importance of interpreting MoCA scores in a nuanced manner within diverse populations.

Objective: Few performance validity tests exist for youth undergoing baseline testing for the management of sport-related concussion. This study provides an initial validation of a reliable span calculation from the Wechsler Intelligence Scale for Children-Fourth Edition Letter-Number Sequencing (LNS) subtest as a performance validity indicator for youth baseline testing (Reliable Letter-Number Span; RLNS). Method: Youth athletes (n = 173) underwent baseline concussion testing for the management of sport-related concussion. We classified participants as valid (n = 153) or invalid performance (n = 20) based on several well-established performance validity tests. We calculated RLNS by summing the spans of alphanumeric characters across two items within the Letter-Number Sequencing subtest, similar to the Reliable Digit Span. To better determine the utility of RLNS, we also examined other novel reliable span metrics and established summary scores from the Letter-Number Sequencing as potential validity indicators. Results: Analyses revealed excellent classification accuracy for RLNS, with an area under the curve of .88 (95% CI [.81, .96]). The optimal cutoff for RLNS (≤6) yielded .55 sensitivity and .95 specificity. Results showed similar but slightly lower classification accuracy statistics (areas under the curve of .77-.86) for the other LNS validity indicators. Conclusion: Initial findings support the criterion validity of RLNS as an embedded validity indicator. This measure is among the few extant performance validity tests that may be appropriate for youth baseline concussion testing. RLNS may also be appropriate for other types of pediatric evaluations. However, additional support is necessary before neuropsychologists can use RLNS clinically.

Objective: The aim of this study was to create demographically-adjusted norms for Rey-Osterrieth Complex Figure Test (RCFT) for Sri Lankan adults. Method: Four-hundred and twenty-two healthy, adult participants (age: 19-83 years, education: 5-23 years, 202 men) underwent the RCFT copy, 3-min and 30-minute-recall trials. Age- and education-stratified percentile-based norms and demographically-adjusted regression-based norms were created for copy-trial scores and recall trial scores, respectively. Results: There was a ceiling effect of the copy scores where the maximum possible score (i.e. 36) reached between 25th and 90th percentile depending of the age and the education band. Age, years of education and sex accounted for 25.0% of the variance of the RCFT 3-min-recall scores (adjusted R² = 0.25, p < .0001). The age and years of education explained 25.1% of the variance of the 30-minute recall score (adjusted R² = 0.251, p < .0001). Age accounted for 7%-8% and years of education accounted for 10%-11% of the variances of the recall trial scores. Sex only affected the 3-min recall scores and accounted for only about 1% of the variance. No significant differences in RCFT scores were observed among different ethnic groups. Conclusions: These RCFT norms for Sri Lankan adults fill a hiatus in neuropsychological assessment of visuospatial construction and visual memory. The percentile tables and accompanying software-based calculator with embedded regression equations help clinicians more readily interpret individual test results and account for the RCFT performance variability introduced by demographic variables.

Objective: While it is generally assumed that common neurobehavioral assessments, such as the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV), function similarly in clinical and non-clinical populations, this has not been validated in adults with congenital heart disease (CHD). In this study, we examined the latent factor structure of the WAIS-IV in adults with d-transposition of the great arteries (d-TGA) who participated in the Boston Circulatory Arrest Study. Method: The WAIS-IV was administered as part of a larger assessment battery. Confirmatory factor analysis was used to fit one-, two-, and four-factor models of general cognitive ability, as well as a second order Full Scale IQ factor, as published in the WAIS-IV manual. Results: Eighty-seven adults with d-TGA were assessed. The four-factor model and second-order models both fit the data well, with all subtests loading significantly and in expected directions onto four latent factors (Verbal Comprehension, Perceptual Reasoning, Working Memory, Processing Speed), similar to the normative population. Conclusions: Among adults with d-TGA, the latent factor structure of the WAIS-IV is similar to the normative sample, suggesting that the WAIS-IV is an appropriate tool to use in adults with d-TGA and, potentially, in other CHD subgroups.

Objective: The Rey Auditory Verbal Learning Test (RAVLT) is a classic test used to assess episodic verbal memory in research and clinical practice. We aimed to adapt the RAVLT materials into Russian, provide performance norms across the adult lifespan for the Russian adaptation, and develop a mobile application for automated RAVLT administration across languages. Method: We created three psycholinguistically matched alternative versions of the RAVLT materials in Russian and incorporated them into a new RAVLT World tablet application. We tested 354 neurologically healthy 21-to-89-year-old Russian speakers, modeled their performance using multivariate multiple regression, and calculated demographically adjusted norms. We also tested the equivalence of performance across the three alternative Russian versions and between the pen-and-paper and digital form. Results: Performance across three alternative versions and between the pen-and-paper and digital form was equivalent, although test-retest reliability measured via intraclass correlation coefficients was limited. Older age, male gender and fewer years of education were associated with lower performance on both raw trial scores (R² = .515) and composite scores (R² = .961). Demographically adjusted norms are now available in a paper form and as part of the RAVLT World application. Conclusions: The new RAVLT adaptation can be used to assess verbal memory in Russian-speaking adults, serving their clinical needs and diversifying research on verbal memory. The equivalent alternative versions can serve for repeated testing in longitudinal designs. The RAVLT World tablet application, with automated administration and scoring, makes the test more accessible to patients and allows to incorporate multiple language versions.