Chemical Papers最新文献

This paper describes the development of a relatively feasible, economic, and safe method for the multigram-scale synthesis of BIIB068, an efficient reversible BTK inhibitor. The new process is highlighted by an economical construction of a 2-amino-4 substituted pyrimidine employing a simple nucleophilic substitution reaction and a green reduction of the cyano group. The developed process provided an overall yield of 32%, with an HPLC purity of 99%. The structure of BIIB068 was confirmed by MS, IR, ¹H-NMR, and ¹³C-NMR, and the structures of some intermediates were confirmed by MS and ¹H-NMR.

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Molecules containing multiple donor atoms such as nitrogen, oxygen and sulfur in their structure are more preferred as ionophores in the preparation of ion-selective electrodes. In this study, a new hydrazinecarbotioamide derivative molecule was synthesized as an ionophore and characterized using NMR, FT–IR and elemental analysis techniques. The potentiometric electrodes prepared with the synthesized new molecule (ionophore) exhibited selectivity towards lead(II) ions. This novel electrode had a low detection limit of 6.98 × 10^–7 M over a wide concentration range of 1.0 × 10^–6–1.0 × 10^–1 M. Obtained experimental data showed that the electrode has good repeatability, good selectivity and good stability. At the same time, it could work in a wide pH range without being affected by pH changes. The analytical applications of the developed electrode, whose potentiometric performance parameters were studied, were carried out in different water samples.

In this study, we examined the properties of conductive polymers and related composites that are typically used for EMI shielding owing of their magnetic and microwave properties. Ferrite/polymer (PANI) composites, which have magnetic properties, are a promising area of research for multifunctional materials. Specifically, we compared and contrasted the properties of PANI, gadolinium-substituted spinel ferrite, and their composites. In this research, we employed the sol–gel method to synthesize polyaniline and spinel ferrites. The nanocomposites were formed by combining the polyaniline and spinel ferrites. Various properties of these nanocomposites were analyzed using multiple characterization methods, including X-ray diffraction (XRD), a vibrating sample magnetometer (VSM), Direct current electrical resistivity and microwave. The X-ray diffraction pattern indicated the presence of a pure crystalline ferrite phase, with an average size of the crystallite approximately 40 nm. The ferromagnetic properties of the nanocomposites were demonstrated through the M-H loops. The microwave properties of materials, namely their capacity to reflect or deflect electromagnetic radiation in the appropriate frequency range, impact the effectiveness of EMI shielding for microwave applications.

This study established an analytical method based on manganese ferrite based magnetic dispersive solid phase extraction (MDSPE) before cold vapor generation–atomic absorption spectrometry (CVG-AAS) for the determination of cadmium at trace levels in lake water samples collected from Horseshoe Island, Antarctica. Manganese ferrite nanoparticles were synthesized to be used as an adsorbent in the MDSPE method. Different MDSPE and CVG parameters were fixed to their optimum values after univariate optimization approach. Under the optimum conditions, analytical performance of the developed MDSPE-CVG-AAS method was evaluated and its applicability/accuracy was determined by recovery experiments. Twelve different lake water samples collected from Horseshoe Island, Antarctica were analyzed. Matrix matching calibration strategy was used to eliminate possible matrix effects arising from the lake water samples. Good recovery results (93.2–112.5%) were obtained from the spiked samples that indicated the method suitability to real samples.

Hereby, in this paper, we have reported synthesis of uniform spherical-shaped nanoparticles of zinc oxide via green method, as well as their photocatalytic activity. The nanoparticles of zinc oxide were synthesized utilizing flower extract of Rhododendron arboreum where it performs the function of reducing as well as capping agent. The synthesized nanoparticles were characterized by numerous spectroscopic techniques such as UV–Vis and FT-IR. Scanning electron microscope analysis of product revealed spherical zinc oxide nanoparticles. Energy-dispersive spectral analysis indicated elemental composition, i.e., oxygen and zinc. The green synthesized zinc oxide nanoparticles have been employed as nanocatalyst for photocatalytic degradation of two cationic dyes, i.e., Fuchsin basic and Malachite green dye. In addition, various physicochemical parameters such as effect of the dye concentration, catalyst dosage and pH have also been optimized indicating better performance of these nanoparticles. Zinc oxide nanoparticles showed 99.18% degradation of Malachite green dye and 99.272% degradation of Fuchsin basic dye. These nanoparticles have great potential candidate as developing catalyst for selective degradation of cationic dyes.

Approaches to prevent document/product forgery using eco-friendly printing inks and security printing techniques on flexible substrates are two vital areas of research that demand coherent advancements. In this context, a new bithiophene-naphthalene chalcone (BTNP) was synthesized and characterized as a fluorescent pigment for use in security ink. BTNP exhibited good solid-state and solution phase fluorescence with intramolecular charge transfer confirmed using theoretical studies and emission spectra collected in THF/THF–hexane mixtures. The aggregation-induced emission of BTNP was established using solution phase studies in THF/THF–water mixtures. The strong solid-state yellow emission of BTNP prompted its use as a pigment in the preparation of an environment-friendly UV fluorescent formulation, devoid of any volatile organic compounds or hazardous air pollutants. The screen prints obtained on a UV dull paper substrate utilizing BTNP ink revealed good fluorescence, photostability, colorimetric, densitometric, and rub resistance characteristics, which showcase the potential applicability of the BTNP formulation in security printing. The low cytotoxic nature of the chalcone as observed in the MTT assay could also be exploited for the use of formulation in inkpads.

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