Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie最新文献

BackgroundGuidelines for treatment-resistant schizophrenia (TRS) advocate for a trial of clozapine monotherapy before the consideration of antipsychotic augmentation. Commonly cited justifications for augmentation include inadequate response to clozapine monotherapy and the potential to lower the necessary clozapine dose or serum concentration, thereby reducing dose-dependent adverse effects. Nonetheless, the degree to which these outcomes are realized in routine clinical practice, particularly among individuals with concurrent disorders, remains uncertain. This study aimed to explore the extent to which clozapine monotherapy is utilized before the initiation of antipsychotic augmentation strategies, and to assess the effects of antipsychotic augmentation on clozapine serum concentrations and the incidence of related adverse effects.MethodsWe retrospectively analyzed clinical and drug monitoring data from 80 adults with TRS and substance use disorder (SUD) comorbidity at a provincial inpatient centre for concurrent disorders. Antipsychotic augmentation was quantified using Defined Daily Dose (DDD). Generalized and linear mixed models compared the impact of monotherapy vs. augmentation on clozapine serum levels and adverse effects, adjusting for covariates.ResultsMost patients receiving antipsychotic augmentation (78%) did not have an adequate trial of clozapine monotherapy. Analysis revealed that clozapine with antipsychotic augmentation was modestly and negatively associated (B = -0.039; 95% CI = -0.078 - -0.001) with clozapine serum concentrations, particularly at higher DDD (≥2). Clozapine with antipsychotic augmentation was not associated with reduced incidence of dose-dependent adverse events (tachycardia, constipation, or overall anticholinergic medication use).ConclusionFindings from this study indicate that commonly cited rationales for combining clozapine with antipsychotic augmentation - namely, enhancing tolerability through clozapine dose reduction or mitigating inadequate response to monotherapy - are not consistently supported by real-world outcomes. These results underscore the necessity for clinical guidelines to incorporate context-sensitive recommendations that address the complexities inherent in managing individuals with TRS and comorbid SUDs, while integrating real-world considerations and the perspectives of those with lived experience.

BackgroundDespite well-known benefits of family involvement and interventions, gaps remain in their implementation in early intervention for psychosis. Guidelines have been developed for early psychosis services to bridge evidence-implementation gaps. Little attention has been paid to their nature, quality and recommendations regarding family involvement and interventions. We aimed to identify, describe, and appraise family-focused recommendations in Canadian early psychosis guidelines.MethodsWe conducted a systematic review (PROSPERO#CR042020208974), including Canadian guidelines/standards for first-episode psychosis/early intervention in psychosis, or for psychosis/schizophrenia with a section on first-episode psychosis/early intervention for psychosis. The search was conducted in Google and Google Advanced of 58 websites (April 2024). From each document, bibliographic information and family-focused recommendations were extracted. All family-focused recommendations were subject to content analysis and mapped against a patient and family engagement framework. All guidelines were appraised using Appraisal of Guidelines Research & Evaluation-Recommendation EXcellence (AGREE-REX), assessing rigor and implementability. Family-focused recommendations were rated on three AGREE-REX items. Findings were narratively synthesized.ResultsSeven documents were included, with five provincial early psychosis guidelines and two Canada-wide schizophrenia-spectrum guidelines. 96 family-focused recommendations were extracted covering 21 themes (19 appeared in ≤4 guidelines; two (family psychoeducation; involving families in treatment-planning) in five guidelines). No guidelines had recommendations regarding families in inpatient care; only two guidelines had recommendations for navigating consent vis-à-vis family involvement. 77.4% of recommendations were about direct care; 22.5% about involving families in organizational design/governance; and none about policymaking involvement. AGREE-REX ratings for relevant outcomes and local applicability were lower for family-focused recommendations than overall guidelines. Most guidelines fared poorly in eliciting families' values/preferences.ConclusionFew family-focused recommendations featured consistently across early psychosis guidelines. There was little guidance on navigating barriers to family involvement. Our analysis revealed critical gaps, including in viewing families as partners in treatment decision-making and services/policy design. Future guidelines must integrate stakeholders' values/preferences and guidance on real-world implementation.

Objective: To identify sociodemographic, lifestyle, and psychological correlates of flourishing mental health (i.e., feeling good and functioning well) in a population-based sample of young adults.

Method: Data for this cross-sectional study were drawn from the ongoing Nicotine Dependance in Teens study, Québec, Canada. Of 799 participants in cycle 23, 792 (mean (SD) age = 30.6 (1.0) years) provided data on positive mental health using the Mental Health Continuum - Short Form (MHC-SF) and were retained for analysis. Each potential correlate was studied in an unadjusted model, a model adjusted for age and sex, and a model adjusted for age, sex and other covariates related to the specific correlate of interest.

Results: Of 792 participants retained for analysis, 39.4% (39.9% of females; 38.8% of males) reported flourishing mental health. Variables associated with higher odds of flourishing included attended university (OR: 1.44 [1.05, 1.99]), being in a relationship (OR: 1.64 [1.22, 2.21], being employed (OR: 1.97 [1.27, 3.11]), high sleep quality (OR: 3.45 [2.53, 4.73]), meeting leisure screen time guidelines (OR: 2.12 [1.59, 2.85]), and relatively high levels of coping ability (OR: 3.11 [2.58, 3.80]). Variables associated with lower odds of flourishing included living alone (OR: 0.58 [0.38, 0.86]), relatively low household income (OR: 0.37 [0.20, 0.64]), and high depressive (OR: 0.05 [0.01, 0.15]) and anxiety (0.17 [0.09, 0.29]) symptoms.

Conclusions: Sociodemographic (education, relationship status, employment status, and income), lifestyle (sleep, screen time), and psychological (coping ability, depressive and anxiety symptoms) factors are correlates of flourishing mental health in this population-based sample of young adults. Results provide a foundation for future research to inform the development of effective programs targeting specific subgroups to promote positive mental health in young adults.

ObjectivesEarly psychosis intervention (EPI) programs play a crucial role in detecting and treating psychosis early, yet disparities in access persist. This study aimed to assess the spatial accessibility of EPI programs in Toronto, Canada, and to explore the association between access and indicators of neighbourhood-level marginalization.MethodsWe conducted a geospatial analysis using floating catchment area and two-step floating catchment area methods, examining EPI program locations, census population estimates for the 158 Toronto neighbourhoods, and area-level marginalization data. Spatial regression models were used to estimate the association between marginalization factors and spatial accessibility.ResultsOn average, the closest EPI program is 4 km away from the centre of any given neighbourhood (range 0.8-11 km), with variability across the city. Clustering is observed in some neighbourhoods, indicating better spatial accessibility, whereas other neighbourhoods face lower access. A full spatial regression model showed increasing levels of housing and dwelling marginalization, as well as material resource marginalization, to be associated with better access.ConclusionWe identified neighbourhoods that have poorer spatial accessibility to EPI services. Some neighbourhood-level marginalization indicators previously found to be associated with psychosis risk are also associated with better spatial accessibility. It is notable that EPI services in Toronto may be located where they are most needed the most. The study underscores the importance of geospatial analyses to identify and address geographic distance as a potential source of disparity in access.

Background: Suicide is a leading cause of mortality among youth globally. Evidence suggests that individuals with physical illness, mental illness, or neurodevelopmental disorders are at increased risk of suicide. However, few studies have estimated the prevalence of suicidal ideation and suicide attempts among youth with compounding health burdens. The purpose of this study is to estimate the prevalence of suicidal ideation and suicide attempts and their associations across morbidity status among youth in Canada.

Methods: Data come from 6,915 youth aged 15-17 years (49% female) enrolled in the 2019 Canadian Health Survey on Children and Youth. The person most knowledgeable or the youth themselves provided responses regarding sociodemographic characteristics, morbidity status, and indicators of suicide. The prevalence of suicidal ideation (past year) and suicide attempts (lifetime) were compared across morbidities (none, physical illness only, mental illness only, neurodevelopmental disorder only, and multimorbidity). Logistic regression models estimated adjusted associations between morbidity status and suicidal behaviour.

Results: Suicidal ideation and suicide attempts were most commonly reported by youth with mental illness only (32%, 18%) and multimorbidity (28%, 19%). While all morbidities were associated with indicators of suicide, the strongest association was found between multimorbidity and suicide attempts odds ratio = 5.2 (3.4, 8.0).

Conclusions: These contemporary estimates of youth in Canada suggest that suicidal ideation and suicide attempts are common and reinforce the need for integrated physical and mental health services for youth with multimorbidity to reduce the incidence. Research investigating causal mechanisms of the intersections between physical illness, mental illness, neurodevelopmental disorders, and suicide is needed.Plain Language Summary Title:Morbidity, suicidal ideation and suicide attempts among youth in Canada.

ObjectivesDelayed sleep-wake phase disorder (DSWPD) most commonly affects young individuals (adolescents and young adults), but it is often undetected in clinical practice. Despite several reports suggesting a link between DSWPD and depression, no systematic review has investigated this association. The aim of this systematic review was to determine whether DSWPD is associated with depression among young individuals.MethodsMEDLINE, EMBASE, PsycINFO, and CINAHL Plus were searched up to 29 July 2024. Primary studies investigating DSWPD and depression among young individuals were eligible. Methodological quality and risk of bias was assessed with the National Institute of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Common-effect models were conducted to examine the relationship between DSWPD status (categorical variable: yes or no) and depression severity (continuous variable). PROSPERO ID: CRD42023458889.ResultsSixteen studies were included with 766 participants being evaluated against the diagnostic criteria for DSWPD from the International Classification of Sleep Disorders. Thirteen out of 15 studies demonstrated that young individuals with DSWPD had a significantly greater severity of depressive symptoms than young individuals without DSWPD. NIH quality assessment scores ranged between 5 and 9 (out of a total of 11). DSWPD status had a significantly large effect on depression severity in the common-effect model (N: 16 estimates, 693 participants, Cohen's d = 0.92, 95% confidence interval (95% CI) [0.76-1.08]). The subgroup analysis also demonstrated significant findings with the common-effect model that only utilized data from studies that controlled for psychiatric disorders (N: 12 estimates, 535 participants, Cohen's d = 0.88, 95% CI [0.70-1.06]).ConclusionsDSWPD is associated with a greater severity of depressive symptoms among young individuals. Although more research is required to understand this association, it may be useful to consider the presence of DSWPD when managing young individuals who present with persistent sleep disturbances (e.g., sleep-onset insomnia) and depressive symptoms.

Aim: This paper provides a detailed account of the process and outcomes involved in adapting a psychosocial intervention - the Optimal Health Program (OHP) - for young individuals who are at clinical high risk (CHR) for psychosis. This adaptation process included the active participation of youth with lived experience of psychosis spectrum disorder (CHR and first episode psychosis). Methods: A six-member advisory group consisting of youth with lived experience was established. The group convened weekly to review the OHP workbook in detail. This initiative was supported by a dedicated research assistant. Adherence to established guidelines for engaging with youth was maintained throughout. Following the completion of the adaptation, a review session was conducted to gather feedback. Results: The primary adaptations made to the intervention can be categorized as follows: 1) modification of language; 2) tailoring to the CHR population; 3) incorporation of personal stories; 4) emphasis on personalized recovery; 5) inclusion of 'guiding and supportive activities'; 6) enhancement of graphic design. Suggestions for a digital application were not integrated due to their scope extending beyond the aims of the current project. An assessment of the engagement process revealed that the involvement of youth was meaningful and impactful. Conclusions: Through sustained and meaningful engagement with youth with lived experience, the present project adapted OHP for CHR individuals. The resulting intervention materials are anticipated to be closely aligned with the distinct needs and priorities of young CHR individuals. Subsequent endeavours in developing appropriate interventions that aim to improve outcomes for this population should involve engaging and collaborating with individuals with lived experience. We are currently in the process of evaluating the feasibility, acceptability, and preliminary efficacy of delivering OHP to individuals with CHR in a clinical trial.

ObjectiveThe effectiveness of current treatment options for depressive symptoms has been widely investigated with acknowledgment that some patients were either not adequately responding to treatment, finding the existing treatment intolerable, or otherwise prefer alternative options. There is increasing interest in microbiota modulation as an alternate form of depression treatment, with a growing number of trials and reviews on the subject published in the last five years. This systematic review aimed to analyze all completed randomized control trials (RCTs) that assessed depression symptoms in adults not using antidepressants, before and after oral methods of microbiota manipulation.MethodAll completed parallel-arm RCTs that assessed depression symptoms in adult participants before and after oral methods of microbiota manipulation were retrieved from four databases, MEDLINE, Embase, PsycINFO, and Cochrane Central Register of Controlled Trials. Data on study and intervention characteristics as well as RCT conclusions were collected independently and in duplicate, and each study's findings were summarized individually. Risk of bias was completed.ResultsWe included 66 RCTs in our review, 34 of which concluded significant differences between the intervention and control group in depressive symptom using different interventions and measures. Of the 66 trials, 54 used probiotic interventions, seven used prebiotic, eight used synbiotic and two used oral fecal microbiota transplantation. Wide variation was observed in studies' design, intervention composition and consumption methods across all 66 RCTs. No statistical synthesis or meta-analyses were possible due to the wide variety of interventions, measures and outcomes.ConclusionsThe heterogeneity of the existing RCTs did not allow for concrete conclusions on whether oral microbiota manipulation interventions are viable alternative treatment options for adults experiencing depression symptoms. We encourage the development of standardized guidelines for the design and reporting of microbiota studies in depression for the possibility of future intervention efficacy testing.