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Psychoneuroimmunological Markers of Psychological Intervention in Pediatric Cancer: A Systematic Review and New Integrative Model 儿童癌症心理干预的心理神经免疫学标志物:系统综述和新的综合模型
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-08-01 DOI: 10.1016/j.anr.2023.07.001
Idyatul Hasanah , Nursalam Nursalam , Ilya Krisnana , Wawan F. Ramdani , Zikrul Haikal , Tita Rohita

Purpose

Pediatric cancer is a serious problem and still becomes a global challenge today. Various complex stressors due to diagnosis, disease symptoms, and various side-effects from the treatment that children with cancer undergo will cause problems in the child's psychoneuroimmunological aspects. Psychological interventions designed to modulate the stress response include psychoneuroimmunological markers. Unfortunately, there is little evidence to support the effect of psychological interventions on psychoneuroimmunological markers. This systematic review aims to assess the effectiveness of psychological interventions on psychoneuroimmunological markers in children with cancer and to provide a new integrative model for further research.

Methods

This systematic review uses four main databases (Scopus, PubMed, ScienceDirect, and ProQuest). The guideline used Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Selecting articles used the Rayyan application. The quality study was conducted using Joanna Briggs Institute (JBI)'s critical appraisal tools. The data were analyzed using the population, intervention, comparison, outcome, and study design (PICO) Synthesis based on similarities and differences in study characteristics to interpret the results.

Results

The search results in this systematic review found 1653 articles, 21 of which matched the predetermined inclusion and exclusion criteria. Most of the designs used were randomized controlled trials (57.1%). Massage therapy was the most common type of psychological intervention (14.2%). Almost half of the studies measured psychological responses (38.0%), and psycho-physiological responses (42.9%), and only a small proportion assessed the effectiveness of psychological interventions on neuroimmunological markers in pediatric cancer.

Conclusions

We recommend the use of psychological interventions as an additional intervention in managing psychoneuroimmunological markers of pediatric cancer. This study offers a new integrative model demonstrating the interaction between stress and psychological intervention involving neuroendocrine and immune mechanisms. However, future researchers need to test all domains of these new integrative models. This will reveal the complex interactions among these components and understand their relevance to health outcomes.

目的儿童癌症是一个严重的问题,今天仍然是一个全球性的挑战。癌症儿童因诊断、疾病症状和治疗产生的各种副作用而产生的各种复杂压力将导致儿童心理神经免疫学方面的问题。旨在调节应激反应的心理干预措施包括心理神经免疫标志物。不幸的是,几乎没有证据支持心理干预对心理神经免疫标志物的影响。本系统综述旨在评估心理干预对癌症儿童心理神经免疫标志物的有效性,并为进一步研究提供一个新的综合模型。方法本系统综述使用了四个主要数据库(Scopus、PubMed、ScienceDirect和ProQuest)。该指南使用了系统评价和荟萃分析(PRISMA)的首选报告项目。选择使用Rayyan应用程序的文章。质量研究是使用乔安娜·布里格斯研究所(JBI)的关键评估工具进行的。基于研究特征的相似性和差异性,使用人群、干预、比较、结果和研究设计(PICO)综合来分析数据,以解释结果。结果本次系统综述的检索结果共发现1653篇文章,其中21篇符合预定的纳入和排除标准。使用的大多数设计是随机对照试验(57.1%)。按摩疗法是最常见的心理干预类型(14.2%)。几乎一半的研究测量了心理反应(38.0%)和心理生理反应(42.9%),只有一小部分研究评估了心理干预对癌症儿童神经免疫标志物的有效性。结论我们建议使用心理干预作为管理儿童癌症心理神经免疫标志物的额外干预。这项研究提供了一个新的综合模型,证明了压力和心理干预之间的相互作用,包括神经内分泌和免疫机制。然而,未来的研究人员需要测试这些新的综合模型的所有领域。这将揭示这些组成部分之间的复杂相互作用,并了解它们与健康结果的相关性。
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引用次数: 1
Increased Parasympathetic Activity as a Fall Risk Factor Beyond Conventional Factors in Institutionalized Older Adults with Mild Cognitive Impairment 在有轻度认知障碍的制度化老年人中,副交感神经活动增加是一个比传统因素更危险的跌倒因素
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-08-01 DOI: 10.1016/j.anr.2023.05.001
Minhee Suh

Purpose

This study aimed to investigate autonomic nervous function during the orthostatic challenge and its relationship with depression and fall, and to elucidate fall-associated factors, including autonomic function, executive function, and depression among institutionalized older adults with mild cognitive impairment (MCI).

Methods

This study employed a descriptive cross-sectional design. Fall experiences in the current institutions were researched. Heart rate variability (HRV) during the orthostatic challenge was measured. Executive function was evaluated using the semantic verbal fluency test and clock drawing test. Depression was assessed using the Geriatric Depression Scale.

Results

Of the 115 older adults, 17 (14.8%) experienced falls in the current institution. None of the HRV indices during the orthostatic challenge showed any significant changes except for the standard deviation of normal RR intervals (p = .037) in the institutionalized older adults with MCI. None of the HRV indices was significantly related to the depressive symptoms. Multivariate logistic regression analysis showed that normalized high frequency on lying was independently associated with falls (OR = 1.027, p = .049) after adjusting for other conventional fall risk factors although executive function and depressive symptoms were not significant factors for falls.

Conclusions

Institutionalized older adults with MCI were vulnerable to autonomic nervous modulation, especially to sympathetic modulation, during the orthostatic challenge, which was not associated with depressive symptoms. As increased resting parasympathetic activity seemed to play a key role in association with falls, autonomic nervous function assessment should be considered for fall risk evaluation.

目的本研究旨在探讨直立挑战过程中的自主神经功能及其与抑郁和跌倒的关系,并阐明轻度认知障碍(MCI)住院老年人跌倒的相关因素,包括自主神经功能、执行功能和抑郁。对当前机构的秋季经历进行了研究。测量直立挑战期间的心率变异性(HRV)。采用语义-语言流利性测试和时钟绘制测试对执行功能进行评估。使用老年抑郁症量表评估抑郁症。结果在115名老年人中,有17人(14.8%)在目前的机构中经历过跌倒。在患有MCI的住院老年人中,除了正常RR间期的标准差(p=.037)外,直立挑战期间的HRV指数均未显示任何显著变化。HRV指标均与抑郁症状无显著相关性。多变量逻辑回归分析显示,在调整了其他常规跌倒风险因素后,标准化的高躺着频率与跌倒独立相关(OR=1.027,p=0.049),尽管执行功能和抑郁症状不是跌倒的显著因素。结论患有MCI的住院老年人在直立挑战过程中易受自主神经调节,尤其是交感神经调节的影响,这与抑郁症状无关。由于静息副交感神经活动的增加似乎在跌倒中起着关键作用,因此跌倒风险评估应考虑自主神经功能评估。
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引用次数: 0
A Theory-Based, Technology-Assisted Intervention in a Hybrid Cardiac Rehabilitation Program for Patients with Coronary Heart Disease: A Feasibility Study 基于理论、技术辅助干预冠心病患者混合心脏康复计划的可行性研究
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-08-01 DOI: 10.1016/j.anr.2023.06.004
Mei Sin Chong , Janet Wing Hung Sit , Kai Chow Choi , Anwar Suhaimi , Sek Ying Chair

Purpose

To assess the feasibility of a technology-assisted intervention in a hybrid cardiac rehabilitation program among patients with coronary heart disease.

Methods

This study was a two-arm parallel randomized controlled trial. Twenty-eight patients with coronary heart disease were randomly assigned to either the intervention group, receiving a 12-week technology-assisted intervention (n = 14), or the control group (n = 14), receiving usual care. Guided by the Health Belief Model, the intervention group received three center-based, supervised exercise training sessions, a fitness watch that served as a cue to action, six educational videos, and a weekly video call. The Self-efficacy for Exercise, exercise capacity, and Health Promoting Lifestyle Profile II were assessed at baseline and immediately post-intervention (12-weeks).

Results

Among the 28 patients who participated in this study, 85.7% completed the program, with a relatively low attrition rate (14.3%). The number of exercise training sessions accomplished by the participants in the intervention group was 51.27 ± 19.41 out of 60 sessions (85.5%) compared to 36.46 ± 23.05 (60.8%) in the control group. No cardiac adverse events or hospitalizations were reported throughout the study. Participants in the intervention group showed greater improvement in health-promoting behaviors when compared with the control group at 12 weeks. Within-group effects demonstrated improvement in exercise self-efficacy and exercise capacity among participants in the intervention group. A participant satisfaction survey conducted immediately post-intervention revealed that participants were “very satisfied” (23.1%) and “satisfied” (76.9%) with the technology-assisted intervention.

Conclusions

The findings demonstrated that technology-assisted intervention in a hybrid cardiac rehabilitation program was feasible and suggested to be beneficial in improving exercise self-efficacy, exercise capacity, and health promoting behavior among patients with coronary heart disease. A full-scale study is needed to determine its effectiveness in the long term.

Trial and protocol registration

ClinicalTrials.gov NCT04862351.

https://clinicaltrials.gov/ct2/show/NCT04862351.

目的评估技术辅助干预冠心病患者混合心脏康复计划的可行性。方法采用双臂平行随机对照试验。28名冠心病患者被随机分配到接受12周技术辅助干预的干预组(n=14)或接受常规护理的对照组(n=14)。在健康信念模型的指导下,干预组接受了三次以中心为基础的、有监督的运动训练课程、一次作为行动提示的健身手表、六个教育视频和一次每周视频通话。在基线和干预后(12周)立即评估运动的自我效能感、运动能力和促进健康的生活方式概况II。结果在参与本研究的28名患者中,85.7%的患者完成了该项目,干预组参与者完成的运动训练次数为51.27±19.41次(占60次训练的85.5%),而对照组为36.46±23.05次(60.8%)。在整个研究过程中,没有心脏不良事件或住院报告。与对照组相比,干预组的参与者在12周时表现出更大的健康促进行为改善。组内效应表明,干预组参与者的运动自我效能感和运动能力有所提高。干预后立即进行的参与者满意度调查显示,参与者对技术辅助干预“非常满意”(23.1%)和“满意”(76.9%)。结论技术辅助干预混合心脏康复计划是可行的,有利于提高冠心病患者的运动自我效能、运动能力和健康促进行为。需要进行全面的研究,以确定其长期有效性。试验和方案注册ClinicalTrials.gov NCT04862351。https://clinicaltrials.gov/ct2/show/NCT04862351.
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引用次数: 0
Validity and Reliability of the Korean Version of the Paternal Postnatal Attachment Scale 韩国版父亲产后依恋量表的效度与信度
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.03.003
Yookyung Choi, Suk-Sun Kim

Purpose

The study aimed to translate the Paternal Postnatal Attachment Scale (PPAS) into Korean and to evaluate the validity and reliability of the Korean version of the PPAS (K-PPAS).

Methods

The PPAS was translated, back-translated, and reviewed by 12 experts and 5 fathers following the World Health Organization's guideline. A convenience sample of 396 fathers with infants in their first 12 months participated in this study. For construct validity, an underlying factor structure and model fit was assessed with an exploratory and confirmatory factor analysis. Convergent and discriminant validity and reliability of the K-PPAS were evaluated.

Results

The construct validity of the K-PPAS with 11 items was identified by two-factor structures: healthy attachment relationship, and patience and tolerance. The final model fit was shown acceptable with the normed chi-square = 1.94, comparative fit index = .94, Tucker–Lewis index = .92, root mean square error of approximation = .07, and standardized root mean square residual = .06. This model had acceptable convergent and discriminant validity for each construct with the values of the composite reliability and heterotrait–monotrait ratio at a satisfactory level. Discriminant validity with known groups showed that fathers with no postnatal depression had significantly higher scores on the K-PPAS than those with postnatal depression. Cronbach's α and McDonald's omega coefficient of the K-PPAS was .84 and .83.

Conclusions

The K-PPAS would be beneficial to measure postnatal attachment among fathers with infants aged 12 months or younger in Korea. However, further studies are suggested to evaluate the applicability of the scale considering the various family structures, such as single or foster parents and multicultural families that exist within the Korean population.

目的本研究旨在将产后依恋量表(PPAS)翻译成韩语,并评估韩国版产后依恋量量表(K-PPAS)的有效性和可靠性。396名前12个月有婴儿的父亲参加了这项研究。对于结构有效性,通过探索性和验证性因素分析来评估潜在因素结构和模型拟合。评估了K-PPAS的收敛性和判别性的有效性和可靠性。结果K-PPAS的11个项目的结构有效性由两个因素结构确定:健康依恋关系、耐心和容忍。最终模型拟合被证明是可接受的,赋范卡方=1.94,比较拟合指数=.94,Tucker–Lewis指数=.92,近似均方根误差=.07,标准化均方根残差=.06。该模型对每个结构都具有可接受的收敛性和判别有效性,复合信度和异特异性-单性状比值均处于令人满意的水平。已知组的判别有效性表明,没有产后抑郁症的父亲在K-PPAS上的得分明显高于有产后抑郁症的爸爸。K-PPAS的Cronbachα和McDonald’s omega系数分别为.84和.83。结论K-PPAS有利于测量韩国12个月及以下婴儿父亲的产后依恋。然而,建议进行进一步的研究,以评估该量表的适用性,考虑到韩国人口中存在的各种家庭结构,如单亲或养父母以及多元文化家庭。
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引用次数: 1
Relationship Between Trunk Control Ability and Respiratory Function in Stroke Patients: A Scoping Review and Meta-Analysis 脑卒中患者躯干控制能力与呼吸功能的关系:一项范围回顾和meta分析
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.04.001
Hsiang-Chu Pai , Chia-Chi Li

Purpose

Hemiparesis in stroke survivors has been reported to affect respiratory function. The relationship between trunk control and respiratory function, however, is not well understood. We aimed to map the state of the association between the trunk and respiratory function as well as evaluate the effect of a respiratory function training intervention on trunk control for stroke survivors.

Methods

A scoping review and meta-analysis of observational and interventional studies were performed. Cochrane Library, CINAHL with Full Text (EBSCO), Medline (Ovid), and PubMed were searched using the terms stroke, respiratory, and trunk control. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist was used to examine the sections of each report.

Results

A total of 102 studies were identified, of which 12, published between 2011 and 2022, were included in the meta-analysis or narrative synthesis. Three studies were included in the meta-analysis of the correlation between trunk control and respiratory function parameters (forced vital capacity [FVC], forced expiratory volume during the first breath [FEV1], maximal inspiratory pressure [MIP], and maximal expiratory pressure [MEP]) with effect sizes (Fisher's z) for all outcomes, which ranged from small to intermediate (between 0.21 and 0.39). Furthermore, five studies were included in the meta-analysis of the effect of respiratory function training intervention on trunk control. An overall effect size (Cohen's d) of 1.47 corresponds to a large effect. We also found significant improvements in MIP and MEP but not in FVC and FEV1 for stroke survivors with the interventions.

Conclusions

Respiratory training, use of diaphragmatic resistance exercise or abdominal breathing, use of a pressure threshold-loading device, and the performance of functional strengthening exercises for the trunk muscles were found to increase patients’ trunk control and improve their respiratory muscle strength.

目的据报道,中风幸存者的偏瘫会影响呼吸功能。然而,躯干控制和呼吸功能之间的关系尚不清楚。我们旨在绘制躯干和呼吸功能之间的关联状态,并评估呼吸功能训练干预对中风幸存者躯干控制的影响。方法对观察性和介入性研究进行范围界定和荟萃分析。使用中风、呼吸和躯干控制等术语搜索Cochrane Library、CINAHL with Full Text(EBSCO)、Medline(Ovid)和PubMed。系统评价的首选报告项目和范围界定评价的荟萃分析扩展(PRISMA ScR)检查表用于检查每份报告的章节。结果共确定了102项研究,其中12项发表于2011年至2022年间,被纳入荟萃分析或叙事综合。三项研究纳入了躯干控制和呼吸功能参数(用力肺活量[FVC]、第一次呼吸时用力呼气量[FEV1]、最大吸气压力[MIP]和最大呼气压力[MEP])与所有结果的效应大小(Fisher’s z)之间相关性的荟萃分析,其范围从小到中等(0.21到0.39)。此外,呼吸功能训练干预对躯干控制影响的荟萃分析中包括了五项研究。1.47的总体效应大小(Cohen’s d)对应于大的效应。我们还发现,通过干预,中风幸存者的MIP和MEP有显著改善,但FVC和FEV1没有改善。结论呼吸训练、膈肌阻力运动或腹式呼吸、压力阈值加载装置的使用以及躯干肌肉功能强化运动的表现可以增强患者的躯干控制能力,提高呼吸肌肉力量。
{"title":"Relationship Between Trunk Control Ability and Respiratory Function in Stroke Patients: A Scoping Review and Meta-Analysis","authors":"Hsiang-Chu Pai ,&nbsp;Chia-Chi Li","doi":"10.1016/j.anr.2023.04.001","DOIUrl":"10.1016/j.anr.2023.04.001","url":null,"abstract":"<div><h3>Purpose</h3><p>Hemiparesis in stroke survivors has been reported to affect respiratory function. The relationship between trunk control and respiratory function, however, is not well understood. We aimed to map the state of the association between the trunk and respiratory function as well as evaluate the effect of a respiratory function training intervention on trunk control for stroke survivors.</p></div><div><h3>Methods</h3><p>A scoping review and meta-analysis of observational and interventional studies were performed. Cochrane Library, CINAHL with Full Text (EBSCO), Medline (Ovid), and PubMed were searched using the terms <em>stroke</em>, <em>respiratory</em>, and <em>trunk control</em>. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) checklist was used to examine the sections of each report.</p></div><div><h3>Results</h3><p>A total of 102 studies were identified, of which 12, published between 2011 and 2022, were included in the meta-analysis or narrative synthesis. Three studies were included in the meta-analysis of the correlation between trunk control and respiratory function parameters (forced vital capacity [FVC], forced expiratory volume during the first breath [FEV<sub>1</sub>], maximal inspiratory pressure [MIP], and maximal expiratory pressure [MEP]) with effect sizes (Fisher's <em>z</em>) for all outcomes, which ranged from small to intermediate (between 0.21 and 0.39). Furthermore, five studies were included in the meta-analysis of the effect of respiratory function training intervention on trunk control. An overall effect size (Cohen's <em>d</em>) of 1.47 corresponds to a large effect. We also found significant improvements in MIP and MEP but not in FVC and FEV<sub>1</sub> for stroke survivors with the interventions.</p></div><div><h3>Conclusions</h3><p>Respiratory training, use of diaphragmatic resistance exercise or abdominal breathing, use of a pressure threshold-loading device, and the performance of functional strengthening exercises for the trunk muscles were found to increase patients’ trunk control and improve their respiratory muscle strength.</p></div>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":"17 2","pages":"Pages 61-69"},"PeriodicalIF":2.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatigue and Quality of Life Among Patients with Diabetes and Non-diabetes Receiving Primary Percutaneous Coronary Interventions 原发性经皮冠状动脉介入治疗的糖尿病和非糖尿病患者的疲劳和生活质量
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.02.001
Shu-Fen Su , Wen-Ting Yeh

Purpose

Few studies have examined the effect of diabetes mellitus (DM) on patients with coronary artery disease. The relationships between quality of life (QoL), risk factors, and DM of patients receiving percutaneous coronary interventions (PCIs) are poorly understood. We investigated the influence of DM on fatigue and QoL over time among patients receiving PCIs.

Methods

An observational cohort study with a longitudinal, repeated-measures design was used to investigate fatigue and QoL among 161 Taiwanese patients with coronary artery disease with/without DM who received primary PCIs between February and December 2018. Participants provided demographic information and their Dutch Exertion Fatigue Scale and the 12-Item Short-Form Health Survey scores before the PCI and two weeks, three months, and six months post-discharge.

Results

Seventy-seven PCI patients were in the DM group (47.8%; mean age = 67.7 [SD = 10.4] years). The mean scores of fatigue, physical component scale (PCS), and mental component scale (MCS) were 7.88 (SD = 6.74), 40.74 (SD = 10.05), and 49.44 (SD = 10.57), respectively. DM did not affect the magnitude of change in fatigue or QoL over time. Patients with DM perceived similar fatigue as those without DM before PCI and two weeks, three and six months post-discharge. Patients with DM perceived lower psychological QoL than those without DM two weeks post-discharge. Compared to pre-surgery scores, patients without DM perceived lower fatigue at two weeks, three months, and six months post-discharge, and higher physical QoL at three- and six-months post-discharge.

Conclusions

Compared with DM patients, patients without DM had higher pre-intervention QoL and better psychological QoL two weeks post-discharge, and DM did not influence fatigue or QoL of patients receiving PCIs over six months. DM may affect patients in the long term; therefore, nurses should educate patients to regularly take medication, maintain proper habits, notice comorbidities, and follow rehabilitation regimes after PCIs to improve prognosis.

目的很少有研究检测糖尿病(DM)对冠状动脉疾病患者的影响。接受经皮冠状动脉介入治疗(PCI)的患者的生活质量(QoL)、危险因素和糖尿病之间的关系尚不清楚。我们研究了糖尿病对PCI患者疲劳和生活质量的影响。方法采用纵向重复测量设计的观察性队列研究,对2018年2月至12月期间接受原发PCI的161名患有/不患有糖尿病的台湾冠状动脉疾病患者的疲劳和生活水平进行了调查。参与者在PCI前和出院后两周、三个月和六个月提供了人口统计信息、荷兰运动疲劳量表和12项简式健康调查得分。结果共有7名PCI患者属于DM组(47.8%;平均年龄=67.7[SD=10.4]岁)。疲劳、身体成分量表和心理成分量表的平均得分分别为7.88(SD=6.74)、40.74(SD=10.05)和49.44(SD=10.57)。DM不影响疲劳或生活质量随时间变化的幅度。糖尿病患者在PCI前和出院后两周、三个月和六个月感觉到与无糖尿病患者相似的疲劳。出院两周后,糖尿病患者的心理生活质量低于无糖尿病患者。与术前评分相比,无DM患者在出院后两周、三个月和六个月的疲劳程度较低,出院后三个月、六个月身体生活质量较高。结论与DM患者相比,无糖尿病患者在干预前生活质量较高,出院后两周心理生活质量较好,DM对PCI患者6个月以上的疲劳和生活质量没有影响。DM可能会长期影响患者;因此,护士应教育患者定期服药,保持适当的习惯,注意合并症,并遵循PCI后的康复制度,以改善预后。
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引用次数: 0
Incidence and Risk Factors for Radiotherapy-Induced Oral Mucositis Among Patients With Nasopharyngeal Carcinoma: A Meta-Analysis 鼻咽癌患者放疗所致口腔黏膜炎的发病率及危险因素:一项荟萃分析
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.04.002
Juejin Li , Chuanmei Zhu , Yun Zhang , Chang Guan , Qi Wang , Yuxin Ding , Xiaolin Hu

Purpose

To evaluate the incidence and identify the risk factors for radiotherapy-induced oral mucositis among patients with nasopharyngeal carcinoma.

Methods

A meta-analysis was conducted. Eight electronic databases (Medline, Embase, Cochrane Library, CINAHL Plus with Full Text, Web of Science, China National Knowledge Infrastructure, Wanfang Database, and Chinese Scientific Journals Database) were systematically searched from inception to 4 March 2023 for relevant studies. Study selection and data extraction were conducted by two independent authors. The Newcastle‒Ottawa scale was used for quality assessment among the included studies. Data synthesis and analyses were performed in R software package version 4.1.3 and Review Manager Software 5.4. The pooled incidence was calculated using proportions with 95% confidence intervals (CIs), and the risk factors were evaluated using the odds ratio (OR) with 95% CIs. Sensitivity analysis and predesigned subgroup analyses were also conducted.

Results

A total of 22 studies published from 2005 to 2023 were included. The results of the meta-analysis showed that the incidence of radiotherapy-induced oral mucositis was 99.0% among nasopharyngeal carcinoma patients, and the incidence of severe radiotherapy-induced oral mucositis was 52.0%. Poor oral hygiene, overweight before radiotherapy, oral pH < 7.0, the use of oral mucosal protective agents, smoking, drinking, combined chemotherapy, and the use of antibiotics at early treatment stage are risk factors for severe radiotherapy-induced oral mucositis. Sensitivity analysis and subgroup analyses also revealed that our results are stable and reliable.

Conclusions

Almost all patients with nasopharyngeal carcinoma have suffered from radiotherapy-induced oral mucositis, and more than half of patients have experienced severe oral mucositis. Facilitating oral health might be the key focus of reducing the incidence and severity of radiotherapy-induced oral mucositis among nasopharyngeal carcinoma patients.

Registration number

CRD42022322035.

目的评估鼻咽癌患者放疗诱发口腔粘膜炎的发生率并确定危险因素。方法进行荟萃分析。从成立到2023年3月4日,系统检索了8个电子数据库(Medline、Embase、Cochrane Library、CINAHL Plus with Full Text、Web of Science、中国国家知识基础设施、万方数据库和中国科学期刊数据库)进行相关研究。研究选择和数据提取由两位独立作者进行。纽卡斯尔-渥太华量表用于纳入研究的质量评估。数据合成和分析在R软件包版本4.1.3和Review Manager软件5.4中进行。合并发病率使用95%置信区间(CI)的比例进行计算,风险因素使用95%CI的比值比(OR)进行评估。还进行了敏感性分析和预先设计的亚组分析。结果纳入2005年至2023年发表的22项研究。荟萃分析结果显示,鼻咽癌患者放疗诱发口腔粘膜炎的发生率为99.0%,严重放疗诱发口腔黏膜炎的发生率52.0%;7.0、使用口腔黏膜保护剂、吸烟、饮酒、联合化疗以及在早期治疗阶段使用抗生素是严重放疗诱导的口腔粘膜炎的危险因素。敏感性分析和亚组分析也表明我们的结果是稳定可靠的。结论鼻咽癌患者大多有放疗引起的口腔粘膜炎,超过一半的患者有严重口腔粘膜炎。促进口腔健康可能是降低鼻咽癌患者放疗诱发口腔粘膜炎发生率和严重程度的关键。注册号CRD42022322035。
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引用次数: 0
What Frequency of Ankle Pump Exercise is Optimal to Improve Lower Limb Hemodynamics? A Systematic Review and Network Meta-analysis 踝关节泵运动的频率对改善下肢血流动力学是最佳的?系统回顾与网络元分析
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.03.001
Xin Wang , Rongsong Tang , Heli Zhang , Fan Li , Jing Wang , Baohua Li

Purpose

Ankle pump exercises (APE) have been widely used in clinical practice. However, best practices for APE have not been established. Recognize the most effective frequency of APE for improving lower extremity hemodynamics and establish recommendations in clinical practice.

Methods

Therefore, a systematic review and network meta-analysis (NMA) was performed according to PRISMA-NMA. Six English databases (Pubmed, Medline, CINAHL, Embase, the Cochrane library and ProQuest) and four Chinese databases (CNKI, Wanfang, VIP and Sinomed) were searched. Randomized controlled trials (RCTs) and quasi-experimental studies investigating the effects of different frequencies of APE on lower limb hemodynamics published before July 2022 were included. The reference list was also searched. Seven studies (one RCTs and six quasi-experimental studies) were included in the systematic review and five studies (one RCTs and four quasi-experimental studies) were included in the NMA. The risk of bias was assessed using the Cochrane and Joanna Briggs Institute tools. The NMA was performed using the R software (version 4.2.1) and OpenBUGS (version 3.2.3).

Results

The results of the NMA showed that a frequency of every 3–4 s the most effective in improving lower extremity hemodynamics (P =.85), followed by every 1–2 s (P = .81), every 5–6 s (P=.32) and less than every 10 s (P =.02). Subgroup analysis failed to find a difference between healthy participants and those with unilateral total hip arthroplasty or fracture (MD = −0.23, 95% CI-5.92 to 4.61).

Conclusions

Consequencely, for adult patients, with or without lower extremity disease, a frequency of every 3–4 s can be recommended as the optimal frequency of APE in clinical care practice.

Registered number on PROSPERO

CRD42022349365. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=349365.

目的踝关节泵运动(APE)在临床上得到了广泛的应用。然而,APE的最佳实践尚未确立。认识APE改善下肢血流动力学的最有效频率,并在临床实践中提出建议。方法根据PRISMA-NMA进行系统回顾和网络荟萃分析(NMA)。检索了6个英文数据库(Pubmed、Medline、CINAHL、Embase、Cochrane library和ProQuest)和4个中文数据库(CNKI、Wanfang、VIP和Sinomed)。包括2022年7月之前发表的随机对照试验(RCT)和准实验研究,研究不同频率的APE对下肢血流动力学的影响。还搜索了参考名单。系统综述中包括7项研究(1项随机对照试验和6项准实验研究),NMA中包括5项研究(一项随机对照研究和4项准实验性研究)。使用Cochrane和Joanna Briggs研究所的工具评估了偏倚的风险。使用R软件(4.2.1版)和OpenBUGS(3.2.3版)进行NMA。结果NMA的结果显示,每3-4秒的频率对改善下肢血流动力学最有效(P=.85),其次是每1-2秒(P=.81),每5-6秒(P=.32)和少于每10秒(P=.02)。亚组分析未能发现健康参与者与单侧全髋关节置换术或骨折参与者之间的差异(MD=-0.23,95%CI-5.92至4.61)。结论因此,对于患有或不患有下肢疾病的成年患者,在临床护理实践中,每3-4秒的频率可以被推荐为APE的最佳频率。PROSPEROCRD42022349365上的注册号。https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=349365.
{"title":"What Frequency of Ankle Pump Exercise is Optimal to Improve Lower Limb Hemodynamics? A Systematic Review and Network Meta-analysis","authors":"Xin Wang ,&nbsp;Rongsong Tang ,&nbsp;Heli Zhang ,&nbsp;Fan Li ,&nbsp;Jing Wang ,&nbsp;Baohua Li","doi":"10.1016/j.anr.2023.03.001","DOIUrl":"10.1016/j.anr.2023.03.001","url":null,"abstract":"<div><h3>Purpose</h3><p>Ankle pump exercises (APE) have been widely used in clinical practice. However, best practices for APE have not been established. Recognize the most effective frequency of APE for improving lower extremity hemodynamics and establish recommendations in clinical practice.</p></div><div><h3>Methods</h3><p>Therefore, a systematic review and network meta-analysis (NMA) was performed according to PRISMA-NMA. Six English databases (Pubmed, Medline, CINAHL, Embase, the Cochrane library and ProQuest) and four Chinese databases (CNKI, Wanfang, VIP and Sinomed) were searched. Randomized controlled trials (RCTs) and quasi-experimental studies investigating the effects of different frequencies of APE on lower limb hemodynamics published before July 2022 were included. The reference list was also searched. Seven studies (one RCTs and six quasi-experimental studies) were included in the systematic review and five studies (one RCTs and four quasi-experimental studies) were included in the NMA. The risk of bias was assessed using the Cochrane and Joanna Briggs Institute tools. The NMA was performed using the R software (version 4.2.1) and OpenBUGS (version 3.2.3).</p></div><div><h3>Results</h3><p>The results of the NMA showed that a frequency of every 3–4 s the most effective in improving lower extremity hemodynamics (P =.85), followed by every 1–2 s (P = .81), every 5–6 s (P=.32) and less than every 10 s (P =.02). Subgroup analysis failed to find a difference between healthy participants and those with unilateral total hip arthroplasty or fracture (MD = −0.23, 95% CI-5.92 to 4.61).</p></div><div><h3>Conclusions</h3><p>Consequencely, for adult patients, with or without lower extremity disease, a frequency of every 3–4 s can be recommended as the optimal frequency of APE in clinical care practice.</p></div><div><h3>Registered number on PROSPERO</h3><p>CRD42022349365. <span>https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=349365</span><svg><path></path></svg>.</p></div>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":"17 2","pages":"Pages 53-60"},"PeriodicalIF":2.2,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9588078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of Early Warning Scoring Systems Regarding Adverse Events of Unanticipated Clinical Deterioration in Complementary and Alternative Medicine Hospitals 补充和替代医学医院非预期临床恶化不良事件预警评分系统的性能
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.04.003
Jee-In Hwang , Jae-Woo Park , Jinsung Kim , Na-Yeon Ha

Purpose

This study aims to examine the performance of early warning scoring systems regarding adverse events of unanticipated clinical deterioration in complementary and alternative medicine hospitals.

Methods

A medical record review of 500 patients from 5-year patient data in two traditional Korean medicine hospitals was conducted. Unanticipated clinical deterioration events included unexpected in-hospital mortality, cardiac arrest, and unplanned transfers to acute-care conventional medicine hospitals. Scores of the Modified Early Warning Score (MEWS), National Early Warning Score (NEWS), and National Early Warning Score 2 (NEWS2) were calculated. Their performance was evaluated by calculating areas under the receiver-operating characteristic curve for the event occurrence. Multiple logistic regression analyses were performed to determine the factors associated with event occurrence.

Results

The incidence of unanticipated clinical deterioration events was 1.1% (225/21101). The area under the curve of MEWS, NEWS, and NEWS2 was .68, .72, and .72 at 24 hours before the events, respectively. NEWS and NEWS2, with almost the same performance, were superior to MEWS (p = .009). After adjusting for other variables, patients at low-medium risk (OR = 3.28; 95% CI = 1.02–10.55) and those at medium and high risk (OR = 25.03; 95% CI = 2.78–225.46) on NEWS2 scores were more likely to experience unanticipated clinical deterioration than those at low risk. Other factors associated with the event occurrence included frailty risk scores, clinical worry scores, primary medical diagnosis, prescribed medicine administration, acupuncture treatment, and clinical department.

Conclusions

The three early warning scores demonstrated moderate-to-fair performance for clinical deterioration events. NEWS2 can be used for early identification of patients at high risk of deterioration in complementary and alternative medicine hospitals. Additionally, patient, care, and system factors need to be considered to improve patient safety.

目的本研究旨在检验补充医学医院和替代医学医院对非预期临床恶化不良事件的预警评分系统的性能。方法对两所韩国传统医学医院的500例5年住院患者的病历资料进行回顾性分析。意外的临床恶化事件包括意外的住院死亡率、心脏骤停和意外转移到急诊常规医学医院。计算修正预警分数(MEWS)、国家预警分数(NEWS)和国家预警分数2(NEWS2)的分数。通过计算事件发生时接收器工作特性曲线下的面积来评估它们的性能。进行多元逻辑回归分析,以确定与事件发生相关的因素。结果非预期临床恶化事件发生率为1.1%(225/21101)。在事件发生前24小时,MEWS、NEWS和NEWS2的曲线下面积分别为.68、.72和.72。NEWS和NEWS2表现几乎相同,优于MEWS(p=0.009)。在调整其他变量后,NEWS2评分中处于中低风险(OR=3.28;95%CI=1.02–10.55)和中高风险(OR=25.03;95%CI=2.78–225.46)的患者比处于低风险的患者更有可能出现意外的临床恶化。与事件发生相关的其他因素包括虚弱风险评分、临床担忧评分、初级医学诊断、处方药管理、针灸治疗和临床科室。结论三个早期预警评分对临床恶化事件表现为中度至中度。NEWS2可用于辅助和替代医学医院中病情恶化风险高的患者的早期识别。此外,需要考虑患者、护理和系统因素,以提高患者安全性。
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引用次数: 1
Advanced Practice Nurses' Organization Commitment: Impact of Job Environment, Job Satisfaction, and Person-Organization Fit 高级执业护士组织承诺:工作环境、工作满意度和个人与组织契合度的影响
IF 2.2 3区 医学 Q2 NURSING Pub Date : 2023-05-01 DOI: 10.1016/j.anr.2023.03.002
Yeon Hee Kim , Soo Il Shin , Hye-Kyung Kim , Myunghee Jun , Michael Wreen

Purpose

The demand for advanced practice nurses (APNs) has increased globally due to a shortage of physicians and an increased demand for high-quality healthcare. Research is needed on the enhancement of advanced practice nurses' organization commitment. Organization commitment (OC) directly impacts the retention of APNs. This study aims to identify the key factors affecting the OC of advanced practice nurses.

Method

A cross-sectional survey was conducted at the largest hospital in South Korea. A total of 189 APNs answered survey questions. A partial least squares-structural equation modeling method was employed to analyze the survey responses.

Results

A pay scale of APNs is positively associated with person-organization fit (POF). However, the effect of job location and computer self-efficacy on POF is not significant. Job satisfaction plays a salient direct role in supervision and POF. Job satisfaction is also a significant moderator in the relationship between supervision and POF. POF is significantly associated with both OC and supervision. Supervision has a positive effect on organization commitment.

Conclusions

Pay scale, job satisfaction, supervision, and POF are significant factors affecting organization commitment. Establishing an intra-organization entity, such as APN steering committee, to ensure mutual consensus and transparent communication between administrators and APNs would enhance POF, the rating of supervision, and organization commitment.

目的由于医生短缺和对高质量医疗保健的需求增加,全球对高级执业护士(APN)的需求增加。需要研究如何增强高级实习护士的组织承诺。组织承诺(OC)直接影响APN的保留。本研究旨在找出影响高级实习护士OC的关键因素。方法在韩国最大的医院进行横断面调查。共有189个APN回答了调查问题。采用偏最小二乘结构方程建模方法对调查响应进行分析。结果APN的薪酬水平与人-组织匹配度呈正相关。然而,工作地点和计算机自我效能感对POF的影响并不显著。工作满意度在监督和POF中起着显著的直接作用。工作满意度也是监督和POF之间关系的重要调节因素。POF与OC和监督密切相关。监督对组织承诺有积极影响。结论支付量表、工作满意度、监督和POF是影响组织承诺的重要因素。建立一个组织内实体,如APN指导委员会,以确保管理员和APN之间的相互共识和透明沟通,将增强POF、监督评级和组织承诺。
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引用次数: 5
期刊
Asian Nursing Research
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