Purpose: To comprehensively integrate qualitative findings on the reasons of late diagnosis in HIV/AIDS patients and to encourage timely clinic consultations for advisory purposes.
Methods: A qualitative systematic review utilizing a meta-aggregation approach. Extensive searches were conducted across PubMed, Embase, Cochrane Library, Web of Science, CINAHL, ProQuest, Scopus, Medline, CNKI, VIP, Chinese Biomedical, and Wanfang databases. The search was completed on December 10th, 2024. Studies were screened according to predefined inclusion and exclusion criteria. Quality assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research. The review adhered to PRISMA 2021 guidelines.
Results: A total of 13 articles were included, 113 original findings were extracted and categorized into 13 new categories, which were further synthesized into three integrated findings: (1) lack of proper knowledge about HIV; (2) complex psychological distress and (3) inadequate medical resources and limited services.
Conclusion: This meta-synthesis of qualitative research focused on the reasons for late diagnosis in people living with HIV(PLWH). It is based on an in-depth exploration of patients' personal feelings and experiences, as well as insights into their genuine desires. Patients' lack of disease knowledge may amplify fears, leading to anxiety, depression, and other adverse psychological conditions that reduce willingness to seek medical care and contribute to late HIV diagnosis. Furthermore, this reduced healthcare-seeking behavior contributes to underutilization of healthcare resources and impairs system efficiency. Consequently, the risk of late-stage consultation for serious conditions such as AIDS increases. Given these diagnostic challenges, enhancing early detection among PLWH is critical to reducing viral transmission and improving the quality of life of those infected.
Clinical trial registration: As it was based entirely on previously published studies, this study protocol had registered on the PROSPERO website (CRD42025631287).
Purpose: Lung cancer has a profound impact on the whole family, particularly patients and family caregivers. This research adopted a dyadic method to examine the dyadic effect of family function on quality of life (QoL), and the mediating role of financial toxicity in lung cancer patient-caregiver dyads.
Methods: This was cross-sectional research that included 218 pairs of participants. Family function, financial toxicity, and QoL were assessed by Family Assessment Device, Comprehensive scores for financial toxicity based on patient-reported outcome measures and The European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire, respectively. SPSS 24.0 and AMOS 23.0 statistical software were used for statistical analysis.
Results: The actor-partner interdependence mediation model analysis demonstrated good model fit (χ2/df =2.333, RMSEA=0.078, NFI=0.995, TLI=0.992, CFI=0.997, SRMR =0.004). Results revealed significant dyadic interdependence, showing that both patients' and family caregivers' QoL was associated with their own and their partner's family function and financial toxicity. Notably, family function exerted both actor effects (individual's family function influencing their own QoL) and partner effects (individual's family function influencing their partner's QoL). Mediation analysis further indicated that these effects operated through both direct pathways and indirect pathways mediated by financial toxicity - where one's family function could impact either their own or their partner's QoL via their own or their partner's financial toxicity.
Conclusions: The findings highlight the need for integrated interventions targeting both family dynamics and financial distress to enhance well-being in cancer care dyads. Adopting this dyadic approach may significantly improve QoL for patients and caregivers, particularly in oncological settings where financial toxicity intensifies disease-related challenges.
Purpose: This study aimed to investigate the effects of climate change anxiety and environmental sustainability attitudes on pro-environmental behaviors among nursing students. As the core workforce of future nursing, nursing students must adapt to all nursing environments affected by climate change and be empowered to address its risks and impacts. They can play a crucial role in contributing to a healthy environment by enhancing their capacity to respond to climate change and practicing pro-environmental behaviors.
Methods: Data were collected from April 15 to 22, 2024, through an online survey distributed to junior and senior nursing students with clinical experience. Responses from 334 participants were analyzed using multiple regression analysis to examine the relationships between climate change anxiety, environmental sustainability attitudes, and pro-environmental behaviors.
Results: Multiple regression analysis revealed environmental sustainability attitudes, cognitive impairment (a subfactor of climate change anxiety), academic year, and gender (in decreasing order of effect size) to be significant predictors of pro-environmental behaviors. The regression model explained 15% of the variance in pro-environmental behaviors.
Conclusions: Higher environmental sustainability attitudes and lower levels of cognitive anxiety are associated with an increase in pro-environmental behaviors. To boost such behaviors among nursing students, enhancing environmental sustainability attitudes and effectively managing climate change anxiety, specifically cognitive impairment, are essential.

