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Rectus sheath nerve block for analgesia & incarcerated hernia reduction in the emergency department. 在急诊科使用直肠鞘神经阻滞术进行镇痛和嵌顿疝缩小术。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-14 DOI: 10.1016/j.ajem.2024.10.021
Sofia Portuondo Quirch, Veronica Abello, Olga Chamberlain, Nicole Lynn Warren, Michael Shalaby

Background: Patients who present to the emergency department (ED) with incarcerated or strangulated ventral hernias are often in significant pain. Furthermore, even with procedural sedation, reduction itself also causes substantial pain. Hernias that cannot be reduced at the bedside with intravenous opioids or procedural sedation will require emergent surgery, which contributes to morbidity and mortality, especially in high-risk populations.

Case report: We present the case of a 94-year-old man with an incarcerated ventral hernia that was reduced in the ED with the aid of a rectus sheath block, ultimately avoiding the need for emergent surgical intervention.

Implications: Ultrasound can visualize and diagnose an incarcerated hernia, and a bilateral rectus sheath block can be performed in the ED to anesthetize the peritoneal wall, paralyze abdominal musculature, and achieve nearly painless hernia reduction.

背景:急诊科(ED)收治的腹股沟嵌顿或绞窄性疝气患者通常会感到剧烈疼痛。此外,即使在手术过程中使用镇静剂,缩小术本身也会引起剧烈疼痛。如果无法在床边使用静脉注射阿片类药物或手术镇静剂来缓解疝气,则需要进行急诊手术,这将导致发病率和死亡率上升,尤其是在高危人群中:我们介绍了一例患有腹股沟嵌顿疝的 94 岁老人的病例,该患者在急诊室接受了直肠鞘阻滞治疗,最终避免了紧急手术干预:意义:超声波可显示并诊断嵌顿疝,在急诊室进行双侧直肠鞘膜阻滞可麻醉腹膜壁,麻痹腹部肌肉组织,实现近乎无痛的疝气缩小术。
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引用次数: 0
Trends and hospital practice variation for analgesia for children with sickle cell disease with vaso-occlusive pain episodes: An 11-year analysis 镰状细胞病患儿血管闭塞性疼痛发作时的镇痛趋势和医院做法差异:11 年分析。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-13 DOI: 10.1016/j.ajem.2024.10.028
Mohamed Eltorki MBChB, MSc , Matt Hall PhD , Sriram Ramgopal MD , Pradip P. Chaudhari MD , Oluwakemi Badaki-Makun MD, PhD , Chris A. Rees MD, MPH , Kelly R. Bergmann DO , Daniel J. Shapiro MD , Frank Gonzalez MD , Timothy Phamduy DO , Mark I. Neuman MD, MPH
<div><div>This cross-sectional analysis of 86,111 visits for sickle cell disease and vaso-occlusive episodes (VOE) in U.S. pediatric emergency departments between 2013 and 2023 shows increased use of NSAIDs, ketamine, and acetaminophen, with unchanged opioid use. Hospitals with a higher volume of VOE visits more frequently administered opioids.</div></div><div><h3>Background</h3><div>Vaso-occlusive episodes (VOEs) are a hallmark of sickle cell disease (SCD), leading to frequent emergency department (ED) visits. Effective pain management is crucial, with guidelines recommending routine use of non-steroidal anti-inflammatory drugs (NSAIDs) with opioids, and emerging evidence supporting ketamine use. However, these recommendations are based on low-certainty evidence, and the impact of these guidelines on analgesia use over time remains unclear.</div></div><div><h3>Objective</h3><div>This study aimed to analyze trends in analgesia use over an 11-year period in pediatric SCD patients presenting to U.S. EDs with VOE and assess variations in treatment across hospitals.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted using data from the Pediatric Health Information System covering 34 U.S. children's hospitals from January 1, 2013, to December 31, 2023. The primary outcomes were the proportions of visits where opioids, NSAIDs, acetaminophen, and/or ketamine were administered on the first calendar day of the initial visit. Secondary outcomes included the co-administration of NSAIDs with opioids. Logistic and linear regression models were used to assess trends and hospital-level variations.</div></div><div><h3>Results</h3><div>A total of 86,111 ED visits for VOE were analyzed. Opioids were administered in 82 % of encounters, NSAIDs in 72 %, acetaminophen in 17 %, and ketamine in 1 %. Co-administration of NSAIDs with opioids occurred in 59 % of the visits. Among discharged patients, there was a positive trend for NSAID use (slope: 1.68 %/year, 95 % CI: 0.91 %, 2.45 %) and NSAID-opioid co-administration (slope: 1.03 %/year, 95 % CI: 0.37 %, 1.69 %) over time. Acetaminophen use also increased over the study period (slope: 0.99 %/year, 95 % CI: 0.80 %, 1.17 %). In hospitalized patients, there was a significant upward trend for acetaminophen (slope: 1.29 %/year, 95 % CI: 0.69 %, 1.89 %) and ketamine (slope: 0.36 %/year, 95 % CI: 0.27 %, 0.45 %), while opioid use remained unchanged. Significant hospital-level variations were observed, with larger hospitals more likely to administer opioids but less likely to co-administer NSAIDs with opioids compared to medium-volume hospitals.</div></div><div><h3>Conclusion</h3><div>Over the past decade, the use of NSAIDs, acetaminophen, and ketamine has increased in the management of VOE in pediatric SCD patients, while opioid use remains consistent. The co-administration of NSAIDs and opioids has also increased, reflecting guideline adherence. Variations in analgesia practices across hospitals unders
这项对2013年至2023年间美国儿科急诊部门86111例镰状细胞病和血管闭塞性发作(VOE)就诊病例的横断面分析显示,非甾体抗炎药、氯胺酮和对乙酰氨基酚的使用有所增加,而阿片类药物的使用则保持不变。VOE就诊量较高的医院更频繁地使用阿片类药物:背景:血管闭塞发作(VOE)是镰状细胞病(SCD)的特征之一,导致急诊科(ED)就诊次数频繁。有效的疼痛治疗至关重要,指南建议常规使用非甾体抗炎药(NSAIDs)和阿片类药物,并有新证据支持使用氯胺酮。然而,这些建议都是基于确定性较低的证据,而且这些指南对镇痛药使用的长期影响仍不清楚:本研究旨在分析 11 年间因 VOE 而前往美国急诊室就诊的儿科 SCD 患者使用镇痛剂的趋势,并评估不同医院在治疗方面的差异:这项横断面研究使用了儿科健康信息系统(Pediatric Health Information System)的数据,涵盖了美国 34 家儿童医院,时间跨度为 2013 年 1 月 1 日至 2023 年 12 月 31 日。主要结果是在首次就诊的第一个日历日使用阿片类药物、非甾体抗炎药、对乙酰氨基酚和/或氯胺酮的就诊比例。次要结果包括非甾体抗炎药与阿片类药物的联合用药情况。采用逻辑和线性回归模型评估趋势和医院层面的差异:结果:共分析了86111例因VOE就诊的急诊患者。82%的就诊者使用了阿片类药物,72%使用了非甾体抗炎药,17%使用了对乙酰氨基酚,1%使用了氯胺酮。59%的就诊者在使用阿片类药物的同时使用了非甾体抗炎药。在出院患者中,非甾体抗炎药的使用(斜率:1.68 %/年,95 % CI:0.91 %,2.45 %)和非甾体抗炎药与阿片类药物的联合使用(斜率:1.03 %/年,95 % CI:0.37 %,1.69 %)随着时间的推移呈上升趋势。对乙酰氨基酚的使用在研究期间也有所增加(斜率:0.99%/年,95% CI:0.80%,1.17%)。在住院患者中,对乙酰氨基酚(斜率:1.29 %/年,95 % CI:0.69 %,1.89 %)和氯胺酮(斜率:0.36 %/年,95 % CI:0.27 %,0.45 %)的使用呈显著上升趋势,而阿片类药物的使用则保持不变。与中等规模的医院相比,规模较大的医院更有可能使用阿片类药物,但在使用阿片类药物的同时使用非甾体抗炎药的可能性较小:结论:在过去十年中,非甾体抗炎药、对乙酰氨基酚和氯胺酮在治疗小儿 SCD 患者 VOE 方面的使用有所增加,而阿片类药物的使用则保持一致。非甾体抗炎药和阿片类药物的联合用药也有所增加,这反映了对指南的遵守情况。各家医院镇痛方法的差异凸显了对这一人群实施标准化疼痛管理策略的必要性。
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引用次数: 0
Critical methodological considerations for opioid use disorder research in emergency departments. 急诊科阿片类药物使用障碍研究的关键方法学考虑因素。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-13 DOI: 10.1016/j.ajem.2024.10.025
Abid Rizvi, Almadhoun Yousuf
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引用次数: 0
Treatment of shoulder pain with ultrasound-guided interfascial plane block: A case series. 超声引导下筋膜间平面阻滞治疗肩痛:病例系列。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-13 DOI: 10.1016/j.ajem.2024.10.022
Samer Metri, Carlos Gonzalez-Cobos, Gabriel Rose

Background: Shoulder pain is a common presentation to the Emergency Department (ED). Despite an increasing volume of ED visits for shoulder pain, achieving adequate pain control can be challenging. Ultrasound-guided nerve blocks, such as the interscalene nerve block (ISB), are effective but can cause hemidiaphragmatic paresis and motor dysfunction. The interfascial plane block (IPB) is a simple and new regional anesthesia technique that spares the diaphragm, and most upper extremity motor function.

Case report: Three patients presented to the ED with acute shoulder pain refractory to oral analgesics and were treated successfully with an ultrasound-guided IPB in the ED.

Conclusion: The ultrasound-guided IPB is a simple, safe, and effective alternative approach to treating shoulder pain in the ED, especially in patients who may not tolerate ISB.

背景:肩痛是急诊科(ED)的常见病。尽管急诊科因肩部疼痛就诊的人数不断增加,但要实现充分的疼痛控制却很困难。超声引导下的神经阻滞,如肩胛间神经阻滞(ISB),效果显著,但可能导致半膈肌麻痹和运动功能障碍。筋膜间平面阻滞(IPB)是一种简单而新颖的区域麻醉技术,它可以保护膈肌和大部分上肢运动功能:病例报告:三位患者因口服止痛药难治的急性肩痛到急诊室就诊,在急诊室接受了超声引导下的 IPB 成功治疗:结论:超声引导 IPB 是急诊室治疗肩痛的一种简单、安全、有效的替代方法,尤其适用于不能耐受 ISB 的患者。
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引用次数: 0
Phospholipase A2 inhibitors: Potential treatment options for future snakebite envenomation! 磷脂酶 A2 抑制剂:未来被蛇咬伤后的潜在治疗方案!
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1016/j.ajem.2024.10.023
Chitta Ranjan Mohanty, Amiya Kumar Barik, Rakesh Vadakkethil Radhakrishnan, Srikant Behera, Gobinath Jayaraman
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引用次数: 0
The authors respond: Data units, population estimates, and comorbidities. 作者做出了回应:数据单位、人口估计数和合并症。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1016/j.ajem.2024.10.026
Sangil Lee, Leon Sun, J Priyanka Vakkalanka
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引用次数: 0
Comments on "The effect of intravenous ondansetron on QT interval in the emergency department". 关于 "急诊科静脉注射昂丹司琼对 QT 间期的影响 "的评论
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1016/j.ajem.2024.10.017
Uğur Durmuş
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引用次数: 0
High- versus low-dose ketamine for analgesia in older adults in the emergency department 急诊科为老年人提供高剂量氯胺酮镇痛与低剂量氯胺酮镇痛的比较。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1016/j.ajem.2024.10.015
Alexander D. Ginsburg M.D. , Heather A. Heaton M.D., M.S. , Aeryana Beaudrie-Nunn Pharm.D., R.Ph. , Lucas Oliveira J. e Silva M.D., Ph.D. , Elizabeth Canterbury Pharm.D., R.Ph. , Caitlin S. Brown Pharm.D., R.Ph. , Allyson K. Palmer M.D., Ph.D. , Kristin C. Cole M.S. , Erin D. Wieruszewski Pharm.D., R.Ph. , Fernanda Bellolio M.D., M.Sc.

Background and objectives

Ketamine is increasingly being utilized in the management of acute pain in the emergency department (ED), including for older adults, a population at increased risk of adverse effects from medications. We aimed to compare the safety and analgesic effects of high-dose (≥0.3 mg/kg) to low-dose (<0.3 mg/kg) intravenous (IV) ketamine among older ED patients.

Methods

Multi-center, retrospective cohort study of adults ≥60 years who received IV ketamine for pain between 2018 and 2021. The primary outcome was pain improvement as measured by the Numerical Rating Scale (NRS) pain score within 60 min after administration. Secondary outcomes included adverse effects (early discontinuation, nausea, rescue benzodiazepines and intubation) and the need for rescue analgesia. Linear regression was used to assess the association between the change in NRS pain scores and dose after adjusting for baseline pain, requiring an additional dose of ketamine, and receiving an opioid.

Results

A total of 130 older adults received ketamine as an analgesic (37 high-dose, 93 low-dose). Median age was 69.2 years, 52 % were women, 40 % had a history of substance use disorder. Prior to ketamine, 76 % received alternate analgesics and 23 % antiemetics. Baseline mean pain score was lower in the high-dose group (6.7 vs. 8.3, difference −1.7 [95 % CI −2.6 to −0.7], p = 0.013). Change in NRS pain scores were similar between the high-dose and low-dose groups (−2.4 [95 % CI −3.6 to −1.3] vs −1.6 [95 % CI −2.2 to −0.9], p = 0.27). After adjustment for baseline pain score, the high-dose group had a larger reduction in pain scores (−1.3 [95 % CI −2.6 to −0.1], p = 0.042) and percent change of pain (−23.8 % [95 % CI −42.1 % to −5.4 %], p = 0.012). There was no significant difference in rates of rescue analgesia (35.1 % vs. 44.1 %, p = 0.35) or early discontinuation (29.7 % vs. 32.3 %, p = 0.78). Rates of adverse effects were similar.

Conclusion

High-dose and low-dose ketamine reduced pain scores in older adults. High-dose ketamine led to a greater reduction in pain scores, and there was no observed difference in adverse effects or the need for rescue analgesia. One-third needed discontinuation of ketamine in both groups.
背景和目的:氯胺酮正越来越多地被用于急诊科(ED)急性疼痛的治疗,包括老年人,因为老年人因药物不良反应而增加的风险更大。我们的目的是比较大剂量(≥0.3 毫克/千克)和小剂量(方法:多中心回顾性研究)氯胺酮的安全性和镇痛效果:多中心、回顾性队列研究,对象为 2018 年至 2021 年间接受静脉注射氯胺酮治疗疼痛的≥60 岁成人。主要结果为用药后 60 分钟内通过数字评分量表(NRS)疼痛评分衡量的疼痛改善情况。次要结果包括不良反应(提前停药、恶心、苯二氮卓类药物抢救和插管)以及对抢救性镇痛的需求。在对基线疼痛、需要额外剂量氯胺酮和接受阿片类药物进行调整后,采用线性回归评估 NRS 疼痛评分变化与剂量之间的关系:共有 130 名老年人接受了氯胺酮镇痛(37 名高剂量,93 名低剂量)。中位年龄为 69.2 岁,52% 为女性,40% 有药物使用障碍史。在使用氯胺酮之前,76%的患者接受了替代镇痛药,23%的患者接受了止吐药。大剂量组的基线平均疼痛评分较低(6.7 对 8.3,差异-1.7 [95 % CI -2.6 to -0.7],P = 0.013)。高剂量组和低剂量组的 NRS 疼痛评分变化相似(-2.4 [95 % CI -3.6 to -1.3] vs -1.6 [95 % CI -2.2 to -0.9],p = 0.27)。对基线疼痛评分进行调整后,大剂量组的疼痛评分(-1.3 [95 % CI -2.6 to -0.1],p = 0.042)和疼痛变化百分比(-23.8 % [95 % CI -42.1 % to -5.4%],p = 0.012)降低幅度更大。抢救性镇痛率(35.1% 对 44.1%,p = 0.35)和提前停药率(29.7% 对 32.3%,p = 0.78)没有明显差异。不良反应发生率相似:结论:大剂量和小剂量氯胺酮都能降低老年人的疼痛评分。大剂量氯胺酮能更大程度地降低疼痛评分,而在不良反应或镇痛抢救需求方面没有观察到差异。两组中都有三分之一的人需要停用氯胺酮。
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引用次数: 0
Comment on "Depression after traumatic brain injury: A systematic review and meta-analysis". 评论 "创伤性脑损伤后的抑郁症:系统回顾和荟萃分析 "发表评论。
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1016/j.ajem.2024.10.018
Akshat Kumar, Muhammed Shabil, Sanjit Sah
{"title":"Comment on \"Depression after traumatic brain injury: A systematic review and meta-analysis\".","authors":"Akshat Kumar, Muhammed Shabil, Sanjit Sah","doi":"10.1016/j.ajem.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.ajem.2024.10.018","url":null,"abstract":"","PeriodicalId":55536,"journal":{"name":"American Journal of Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of comprehensive documentation of snakebite envenoming: Is "the 'devil' in the details" or in their deficiency? 全面记录毒蛇咬伤的重要性:是 "细节决定成败 "还是 "细节决定成败"?
IF 2.7 3区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1016/j.ajem.2024.10.024
Ahmad Khaldun Ismail, Scott A Weinstein, David A Warrell
{"title":"The importance of comprehensive documentation of snakebite envenoming: Is \"the 'devil' in the details\" or in their deficiency?","authors":"Ahmad Khaldun Ismail, Scott A Weinstein, David A Warrell","doi":"10.1016/j.ajem.2024.10.024","DOIUrl":"https://doi.org/10.1016/j.ajem.2024.10.024","url":null,"abstract":"","PeriodicalId":55536,"journal":{"name":"American Journal of Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
American Journal of Emergency Medicine
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