Obesity is a condition triggered by many risk factors, but the main one is due to high calorie intake and low physical activity. Various studies have explored the relationship between obesity and metabolic complications, namely chronic degenerative disorders. In the condition of obesity, there are biochemical changes including chronic inflammation. This condition mainly occurs due to the load on the metabolic tissue due to weight gain and fat tissue dysfunction. These changes result in changes in the distribution of leukocytes, lymphocyte activity, and in general the immune defense system. The changes that occur include the occurrence of a chronic inflammatory process. Among the various inflammatory mediators, there are three mediators that play an important role in the regulation of the immune system due to obesity, namely TNF-α, IL-6, and adiponectin. In addition, the accumulation of free fatty acids in obesity can activate a cascade of a series of pro-inflammatory kinases, such as IkB kinase and c-Jun N-terminal kinase, which triggers fatty tissue to release IL-6. Other effects include activation of the inflammasome, and hyperleptinemia. Leptin is then associated with cell survival, cytokine release, and chemotaxis. In addition, leptin can also be related to the proliferation of T cells.
肥胖是一种由许多危险因素引发的疾病，但主要原因是高热量摄入和低体力活动。各种研究探索了肥胖与代谢并发症，即慢性退行性疾病之间的关系。在肥胖的情况下，存在包括慢性炎症在内的生化变化。这种情况主要是由于体重增加和脂肪组织功能障碍导致代谢组织负荷增加而发生的。这些变化导致白细胞分布、淋巴细胞活性以及总体免疫防御系统的变化。所发生的变化包括慢性炎症过程的发生。在各种炎症介质中，有三种介质在调节肥胖引起的免疫系统中发挥重要作用，即TNF-α、IL-6和脂联素。此外，肥胖中游离脂肪酸的积累可以激活一系列促炎激酶的级联反应，如IkB激酶和c-Jun n -末端激酶，从而触发脂肪组织释放IL-6。其他影响包括炎性体的激活和高瘦素血症。瘦素与细胞存活、细胞因子释放和趋化性有关。此外，瘦素还可能与T细胞的增殖有关。
{"title":"Immune regulation in obesity: a narrative review","authors":"I. Manuaba, D. A. Sindhughosa","doi":"10.15562/ijbs.v17i1.459","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.459","url":null,"abstract":"Obesity is a condition triggered by many risk factors, but the main one is due to high calorie intake and low physical activity. Various studies have explored the relationship between obesity and metabolic complications, namely chronic degenerative disorders. In the condition of obesity, there are biochemical changes including chronic inflammation. This condition mainly occurs due to the load on the metabolic tissue due to weight gain and fat tissue dysfunction. These changes result in changes in the distribution of leukocytes, lymphocyte activity, and in general the immune defense system. The changes that occur include the occurrence of a chronic inflammatory process. Among the various inflammatory mediators, there are three mediators that play an important role in the regulation of the immune system due to obesity, namely TNF-α, IL-6, and adiponectin. In addition, the accumulation of free fatty acids in obesity can activate a cascade of a series of pro-inflammatory kinases, such as IkB kinase and c-Jun N-terminal kinase, which triggers fatty tissue to release IL-6. Other effects include activation of the inflammasome, and hyperleptinemia. Leptin is then associated with cell survival, cytokine release, and chemotaxis. In addition, leptin can also be related to the proliferation of T cells.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90779405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Pinatih, D. Wihandani, A. E. Darwinata, Gede Setula Narayana, I Putu Gede Septiawan Saputra, I Gede Putu Supadmanaba
Background: Low-grade chronic inflammation may contribute to the development of atherosclerosis as well as hypertension by inducing the production of pro-inflammatory cytokines. Several studies have revealed a relationship between the microbiota living in the gut and the incidence of hypertension. Two of several gut microbiota that contributed, in this case, are Escherichia coli (E. coli) and Roseburia intestinalis (R. intestinalis). Therefore this study aimed to identify and quantify gut microbes namely R. intestinalis and E.coli in hypertensive patients in Bali, especially in Denpasar City. Methods: This research is a cross-sectional study located at South Denpasar Health Center I, Bali, and the Integrated Biomedical Laboratory, Faculty of Medicine, Universitas Udayana. The sample in this study were hypertensive patients who had been registered at South Denpasar Health Center I and who met the inclusion criteria and did not meet the exclusion criteria. The E. coli and R. intestinalis concentrations were assessed by conducting DNA isolation and RT-qPCR. Statistical analysis using univariate analysis, bivariate analysis using the Independent T-Test; Mann-Whitney Test; Chi-Square, and ROC analysis Results: There were 70 subjects included in this study. Thirty-one subjects were hypertensive patients and the other 39 patients were not hypertensive. The age of the subjects between the two groups was found statistically significant (p=0.007). We also found that comorbid were found mostly in hypertensive patients (p=0.009). Most of the comorbid experienced among them were cardiovascular diseases and diabetes mellitus. Hypertensive subjects had more E. coli concentration in their gut compared with non-hypertensive subjects (p=0.048), while R. intestinalis concentrations were similar in both groups (p>0.05). From the multivariate analysis, it was found that hypertensive patients tended to have a higher concentration of E. coli than non-hypertensive patients (p=0.012; 95% CI:0.055–0.417). Conclusion: E. coli concentration in the gut is independently associated with the incidence of hypertension, while R. intestinalis concentration is not.
{"title":"Identification and quantification of Roseburia intestinalis and Escherichia coli in hypertensive patients in Denpasar","authors":"K. Pinatih, D. Wihandani, A. E. Darwinata, Gede Setula Narayana, I Putu Gede Septiawan Saputra, I Gede Putu Supadmanaba","doi":"10.15562/ijbs.v17i1.457","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.457","url":null,"abstract":"Background: Low-grade chronic inflammation may contribute to the development of atherosclerosis as well as hypertension by inducing the production of pro-inflammatory cytokines. Several studies have revealed a relationship between the microbiota living in the gut and the incidence of hypertension. Two of several gut microbiota that contributed, in this case, are Escherichia coli (E. coli) and Roseburia intestinalis (R. intestinalis). Therefore this study aimed to identify and quantify gut microbes namely R. intestinalis and E.coli in hypertensive patients in Bali, especially in Denpasar City.\u0000Methods: This research is a cross-sectional study located at South Denpasar Health Center I, Bali, and the Integrated Biomedical Laboratory, Faculty of Medicine, Universitas Udayana. The sample in this study were hypertensive patients who had been registered at South Denpasar Health Center I and who met the inclusion criteria and did not meet the exclusion criteria. The E. coli and R. intestinalis concentrations were assessed by conducting DNA isolation and RT-qPCR. Statistical analysis using univariate analysis, bivariate analysis using the Independent T-Test; Mann-Whitney Test; Chi-Square, and ROC analysis\u0000Results: There were 70 subjects included in this study. Thirty-one subjects were hypertensive patients and the other 39 patients were not hypertensive. The age of the subjects between the two groups was found statistically significant (p=0.007). We also found that comorbid were found mostly in hypertensive patients (p=0.009). Most of the comorbid experienced among them were cardiovascular diseases and diabetes mellitus. Hypertensive subjects had more E. coli concentration in their gut compared with non-hypertensive subjects (p=0.048), while R. intestinalis concentrations were similar in both groups (p>0.05). From the multivariate analysis, it was found that hypertensive patients tended to have a higher concentration of E. coli than non-hypertensive patients (p=0.012; 95% CI:0.055–0.417).\u0000Conclusion: E. coli concentration in the gut is independently associated with the incidence of hypertension, while R. intestinalis concentration is not.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81078049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Ketut Puspa Sari, N. Mulyantari, S. Herawati, A. A. Lestari, Ni Nyoman Mahartini, I. Wande
Background: ABO and Rhesus blood groups are clinically important, especially in blood transfusion. Blood groups are determined by the antigens found on the erythrocyte membrane. In patients with hematologic malignancies, especially from the myeloid lineage, changes in blood group can occur in the ABO system mainly due to weakness or loss of some ABO antigens. Case Description: A nine-year-old girl was admitted to the hospital with a chief complaint of high fever three days before admission. The patient had been diagnosed with acute non-lymphoblastic leukemia three months ago. From medical history, the patient had undergone chemotherapy and received 22 bags of PRC transfusion with blood group O (+) from February 27th until May 28th 2018. On July 21st 2018, the transfusion procedure was repeated, and the blood group showed B (+). The procedure was repeated using a new sample but the result remained the same. The crossmatch was performed with five blood groups O (+) and two blood groups B (+) showed mayor: negative, minor:+weak, AC:+weak, mayor: negative, minor:+weak, AC:+weak, respectively. Conclusion: Changes in blood group antigens in hematologic malignancies that experience ABO antigen alternation and return to the original blood group reflect the remission from the disease. The expression of H antigen in blood groups A and B may revert to normal with an improvement from the underlying disease.
{"title":"Change of ABO blood group in a patient with Acute Myelocytic Leukemia (AML): a case report","authors":"Ni Ketut Puspa Sari, N. Mulyantari, S. Herawati, A. A. Lestari, Ni Nyoman Mahartini, I. Wande","doi":"10.15562/ijbs.v17i1.428","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.428","url":null,"abstract":"Background: ABO and Rhesus blood groups are clinically important, especially in blood transfusion. Blood groups are determined by the antigens found on the erythrocyte membrane. In patients with hematologic malignancies, especially from the myeloid lineage, changes in blood group can occur in the ABO system mainly due to weakness or loss of some ABO antigens.\u0000Case Description: A nine-year-old girl was admitted to the hospital with a chief complaint of high fever three days before admission. The patient had been diagnosed with acute non-lymphoblastic leukemia three months ago. From medical history, the patient had undergone chemotherapy and received 22 bags of PRC transfusion with blood group O (+) from February 27th until May 28th 2018. On July 21st 2018, the transfusion procedure was repeated, and the blood group showed B (+). The procedure was repeated using a new sample but the result remained the same. The crossmatch was performed with five blood groups O (+) and two blood groups B (+) showed mayor: negative, minor:+weak, AC:+weak, mayor: negative, minor:+weak, AC:+weak, respectively.\u0000Conclusion: Changes in blood group antigens in hematologic malignancies that experience ABO antigen alternation and return to the original blood group reflect the remission from the disease. The expression of H antigen in blood groups A and B may revert to normal with an improvement from the underlying disease.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78355811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart failure remain as major health problem worldwide, causing severe morbidity and high mortality. Strong relationship between cardiac disorders and kidney disorders that affect the patient's prognosis. Cardiorenal syndrome (CRS) is a group of symptoms due to acute or chronic damage to one of the organs, including the heart or kidneys, which will affect the function of other organs. The heart and kidney each play a role as a regulator of the body's hemodynamic balance. The kidneys produce urine based on that produced by glomerular filtration which depends on the level of renal perfusion and arteriolar blood pressure. CRS classified into five. The classification is based on the primary and secondary damage from CRS occurs in the heart, kidney or outside the heart and/or kidney. Understanding the pathophysiology of CRS benefit to comprehensively manage patients with such condition.
{"title":"Cardiorenal Syndrome: revisiting its pathophysiology and classification","authors":"I. M. F. Wikananda, I. Widiana, D. A. Sindhughosa","doi":"10.15562/ijbs.v17i1.441","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.441","url":null,"abstract":"Heart failure remain as major health problem worldwide, causing severe morbidity and high mortality. Strong relationship between cardiac disorders and kidney disorders that affect the patient's prognosis. Cardiorenal syndrome (CRS) is a group of symptoms due to acute or chronic damage to one of the organs, including the heart or kidneys, which will affect the function of other organs. The heart and kidney each play a role as a regulator of the body's hemodynamic balance. The kidneys produce urine based on that produced by glomerular filtration which depends on the level of renal perfusion and arteriolar blood pressure. CRS classified into five. The classification is based on the primary and secondary damage from CRS occurs in the heart, kidney or outside the heart and/or kidney. Understanding the pathophysiology of CRS benefit to comprehensively manage patients with such condition.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84187652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agung B S Satyarsa, D. P. W. Wardhana, I. B. Y. Brahmantya, Rohadi Muhammad Rosyid, S. Maliawan
Introduction: Traumatic brain injury (TBI) is the disease that causes the most common disability globally. The cisternostomy as adjuvant management of TBI lacks documentation. We aim to prove the effectiveness and safety of cisternostomy and decompressive craniectomy in managing traumatic brain injury. Methods: The search for published scientific articles using the Preferred Reporting, Items for Systematic Reviews, and Meta-Analysis (PRISMA) method. The search was conducted using the PubMed, Cochrane library, and Medline databases published in English for the last ten years until June 2022, evaluating the effectiveness and safety of cisternostomy and decompressive craniectomy in managing traumatic brain injury. The Oxford Center for Evidence-based medicine assessed the evidence levels of each study. Data analysis with RevMan version 5.3. Results: Four studies were included in this meta-analysis, two RCTs, and two observational studies. We find a total of 1000 patients with; 596 cisternostomies and 404 decompressive craniectomies. These primary points show that mean GOS at six weeks is 0.93 (I2:52%; 95%CI: 0.70 to 1.17; p<0,01), decrease in intracranial pressure post-operation is -3.20 mmHg (I2:97%; 95%CI: -3.84 to -2.56; p<0,01), duration of ICU stay is -2.37 days (I2:37%; 95%CI: -4.54 to -0.21; p<0,03), and mortality is 0.51 (I2:21%; 95%CI: 0.42 to 0.63; p<0,01). Conclusion: Cisternostomy is a beneficial procedure in TBI, leading to survival benefits and better clinical outcomes. Hopefully, more studies will examine its role in TBI patients critically in the future.
{"title":"The effectivity and safety of cisternostomy and decompressive craniectomy as management of brain trauma: a systematic review and meta-analysis","authors":"Agung B S Satyarsa, D. P. W. Wardhana, I. B. Y. Brahmantya, Rohadi Muhammad Rosyid, S. Maliawan","doi":"10.15562/ijbs.v17i1.448","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.448","url":null,"abstract":"Introduction: Traumatic brain injury (TBI) is the disease that causes the most common disability globally. The cisternostomy as adjuvant management of TBI lacks documentation. We aim to prove the effectiveness and safety of cisternostomy and decompressive craniectomy in managing traumatic brain injury.\u0000Methods: The search for published scientific articles using the Preferred Reporting, Items for Systematic Reviews, and Meta-Analysis (PRISMA) method. The search was conducted using the PubMed, Cochrane library, and Medline databases published in English for the last ten years until June 2022, evaluating the effectiveness and safety of cisternostomy and decompressive craniectomy in managing traumatic brain injury. The Oxford Center for Evidence-based medicine assessed the evidence levels of each study. Data analysis with RevMan version 5.3.\u0000Results: Four studies were included in this meta-analysis, two RCTs, and two observational studies. We find a total of 1000 patients with; 596 cisternostomies and 404 decompressive craniectomies. These primary points show that mean GOS at six weeks is 0.93 (I2:52%; 95%CI: 0.70 to 1.17; p<0,01), decrease in intracranial pressure post-operation is -3.20 mmHg (I2:97%; 95%CI: -3.84 to -2.56; p<0,01), duration of ICU stay is -2.37 days (I2:37%; 95%CI: -4.54 to -0.21; p<0,03), and mortality is 0.51 (I2:21%; 95%CI: 0.42 to 0.63; p<0,01).\u0000Conclusion: Cisternostomy is a beneficial procedure in TBI, leading to survival benefits and better clinical outcomes. Hopefully, more studies will examine its role in TBI patients critically in the future.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85332026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Septian, Nyoman Srie Laksminingsih, M. Asih, I. Widiana, I. K. Mariadi
Background: Chronic viral hepatitis B causes chronic inflammatory process, hepatocyte damage, progressive fibrosis, and irreversible liver damage, leading to high morbidity. There are two methods of diagnosing liver fibrosis, invasive (biopsy) and non-invasive, including radiological examination using the elastography method and hematological examination. This study aims to determine the relationship between the elasticity of liver parenchyma using the Shear Wave Elastography (SWE) method and fibrosis index in chronic viral hepatitis B patients. Methods: This research is a cross-sectional study using 68 samples that met the inclusion criteria. The 2D-SWE examination was blindly performed by two observers using a convex transducer probe with frequencies ranging from 1.2 to 6 MHz. Data were analyzed using SPSS version 20.0 for Windows. Results: In our study, there was a significant moderate positive correlation between the elasticity of liver parenchyma and the fibrosis index performed by both observers (r=0.52; p < 0.001). After controlling confounding variables, a higher correction was obtained (r=0.61), suggesting a change from moderate to strong correlation (p<0.05). Conclusion: There was a positive and significant correlation between the elasticity of liver parenchyma and fibrosis index.
{"title":"Association between shear wave liver elastography and fibrosis index in chronic viral hepatitis B patients","authors":"H. Septian, Nyoman Srie Laksminingsih, M. Asih, I. Widiana, I. K. Mariadi","doi":"10.15562/ijbs.v17i1.415","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.415","url":null,"abstract":"Background: Chronic viral hepatitis B causes chronic inflammatory process, hepatocyte damage, progressive fibrosis, and irreversible liver damage, leading to high morbidity. There are two methods of diagnosing liver fibrosis, invasive (biopsy) and non-invasive, including radiological examination using the elastography method and hematological examination. This study aims to determine the relationship between the elasticity of liver parenchyma using the Shear Wave Elastography (SWE) method and fibrosis index in chronic viral hepatitis B patients.\u0000Methods: This research is a cross-sectional study using 68 samples that met the inclusion criteria. The 2D-SWE examination was blindly performed by two observers using a convex transducer probe with frequencies ranging from 1.2 to 6 MHz. Data were analyzed using SPSS version 20.0 for Windows.\u0000Results: In our study, there was a significant moderate positive correlation between the elasticity of liver parenchyma and the fibrosis index performed by both observers (r=0.52; p < 0.001). After controlling confounding variables, a higher correction was obtained (r=0.61), suggesting a change from moderate to strong correlation (p<0.05).\u0000Conclusion: There was a positive and significant correlation between the elasticity of liver parenchyma and fibrosis index.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88797427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Abdominal mass is one of the common pediatric tumors that can manifest as abdominal pain or a distended abdomen, and it requires immediate management. Some of them can often be incidentally discovered by parents, during routine pediatric examination in an outpatient clinic, or detected on imaging multimodalities. This study is aimed to evaluate the prevalence of pediatric abdominal mass and to demonstrate tumor characteristics by radiology imaging findings in Prof. I G. N. G. Ngoerah Hospital Denpasar. Methods: We conducted a descriptive, cross-sectional study of patients with abdominal masses discovered by Abdominal CT scan in the Radiology Department of Prof. I G. N. G. Ngoerah Hospital from January 2018 to December 2020. Medical record review and data analysis were done retrospectively. Results: We identified 143 pediatric patients diagnosed with abdominal masses discovered by a CT scan in the Radiology Department of Prof. I G. N. G. Ngoerah Hospital from January 2018 to December 2020. Female patients were found more than male patients (77 vs. 66 patients). Out of all patients, the majority of age were 1 to 9 years old (65 patients, 45%), while the second were 10 to 18 years old (52 patients, 35%), and the rest were one month – 11 months (17 patients, 12%) and <1 month (5 patients, 4%) respectively. The average age was 7.44 years old. Conclusion: The abdominal imaging and histopathological findings help evaluate abdominal mass in children. An accurate diagnosis is essential for proper management.
简介:腹部肿块是儿科常见的肿瘤之一，可表现为腹痛或腹胀，需要立即治疗。其中一些通常会被父母偶然发现，在门诊的常规儿科检查中，或在多模式成像中发现。本研究旨在评估儿童腹部肿块的患病率，并通过登巴萨教授I g.n. g.n goerah医院的放射成像结果来证明肿瘤的特征。方法:我们对2018年1月至2020年12月在I G. N. G. Ngoerah医院教授放射科通过腹部CT扫描发现腹部肿块的患者进行了描述性横断面研究。病历回顾和资料分析回顾性进行。结果:我们确定了2018年1月至2020年12月在I G. N. G. Ngoerah医院教授放射科通过CT扫描发现腹部肿块的143例儿科患者。女性患者多于男性患者(77例对66例)。在所有患者中，年龄以1 ~ 9岁居多(65例，45%)，其次为10 ~ 18岁(52例，35%)，其余分别为1 ~ 11个月(17例，12%)和<1个月(5例，4%)。平均年龄为7.44岁。结论:腹部影像学和组织病理学检查有助于评估儿童腹部肿块。准确的诊断对适当的治疗至关重要。
{"title":"Prevalence and Characteristics of Pediatric Abdominal Mass in Radiology Department Prof. Ngoerah General Hospital Bali, From January 2018 to December 2020","authors":"Ni Nyoman Margiani","doi":"10.15562/ijbs.v17i1.440","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.440","url":null,"abstract":"Introduction: Abdominal mass is one of the common pediatric tumors that can manifest as abdominal pain or a distended abdomen, and it requires immediate management. Some of them can often be incidentally discovered by parents, during routine pediatric examination in an outpatient clinic, or detected on imaging multimodalities. This study is aimed to evaluate the prevalence of pediatric abdominal mass and to demonstrate tumor characteristics by radiology imaging findings in Prof. I G. N. G. Ngoerah Hospital Denpasar.\u0000Methods: We conducted a descriptive, cross-sectional study of patients with abdominal masses\u0000discovered by Abdominal CT scan in the Radiology Department of Prof. I G. N. G. Ngoerah Hospital from January 2018 to December 2020. Medical record review and data analysis were done retrospectively.\u0000Results: We identified 143 pediatric patients diagnosed with abdominal masses discovered by a CT scan in the Radiology Department of Prof. I G. N. G. Ngoerah Hospital from January 2018 to December 2020. Female patients were found more than male patients (77 vs. 66 patients). Out of all patients, the majority of age were 1 to 9 years old (65 patients, 45%), while the second were 10 to 18 years old (52 patients, 35%), and the rest were one month – 11 months (17 patients, 12%) and <1 month (5 patients, 4%) respectively. The average age was 7.44 years old.\u0000Conclusion: The abdominal imaging and histopathological findings help evaluate abdominal mass in children. An accurate diagnosis is essential for proper management.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78926708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rahayu, E. Setiawan, I. K. Sumerjana, Ida Bagus Made Suryatika, I. W. G. A. E. Putra, Ketut Tadeus Max Nurcahya Pinatih, Idola Pratiwi, I. M. N. Arthana, I. G. A. S. Widiantari
Background: Tinnitus is the perception of sound heard by a person without an external stimulus. About 10-14.5% of the world's population experience tinnitus, with the most common age group being 40-60. The management of tinnitus is still a challenge for researchers. Until now, there has been no effective management of tinnitus. The last therapy available is to make artificial sounds that imitate the tinnitus sound so that it can mask the actual tinnitus sound. In addition, music therapy is expected to reduce the stress level of tinnitus patients. Methods: This research is a follow-up study from previous research with 26 subjects. After getting the frequency and amplitude of tinnitus, a sound stimulus is made by combining tone variations and good generators obtained from audiometric masking. Tone variations are made using a basic tone that matches the patient's tinnitus frequency. After that, the patient will assess the results of the merger. Then all the participants will listen to dan evaluate the mixing song. Results: Of all subjective tinnitus sound generators, 3-5% have frequencies below 20 Hz and above 20,000 Hz. Songs made by recording in a soundproof room also have a frequency of 20 Hz and above 20,000 Hz, about 5 – 7%, where the song has an unnecessary frequency. The subjective tinnitus sound generator with the created song has an amplitude of < 85dB so that it can be adjusted with the volume control on the speaker. Conclusion: Tinnitus songs were made with the addition of Piano and Violin and Flute music, and Guitar, Bass and Balinese gamelan had a frequency of 20 – 20,000 Hz with an amplitude of < 85 dB, which can be adjusted with the volume so that it is safe and comfortable for tinnitus sufferers.
{"title":"Making tinnitus songs according to the frequency and amplitude of the sound of tinnitus sufferers that are safe and comfortable for sufferers","authors":"M. Rahayu, E. Setiawan, I. K. Sumerjana, Ida Bagus Made Suryatika, I. W. G. A. E. Putra, Ketut Tadeus Max Nurcahya Pinatih, Idola Pratiwi, I. M. N. Arthana, I. G. A. S. Widiantari","doi":"10.15562/ijbs.v17i1.422","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.422","url":null,"abstract":"Background: Tinnitus is the perception of sound heard by a person without an external stimulus. About 10-14.5% of the world's population experience tinnitus, with the most common age group being 40-60. The management of tinnitus is still a challenge for researchers. Until now, there has been no effective management of tinnitus. The last therapy available is to make artificial sounds that imitate the tinnitus sound so that it can mask the actual tinnitus sound. In addition, music therapy is expected to reduce the stress level of tinnitus patients.\u0000Methods: This research is a follow-up study from previous research with 26 subjects. After getting the frequency and amplitude of tinnitus, a sound stimulus is made by combining tone variations and good generators obtained from audiometric masking. Tone variations are made using a basic tone that matches the patient's tinnitus frequency. After that, the patient will assess the results of the merger. Then all the participants will listen to dan evaluate the mixing song.\u0000Results: Of all subjective tinnitus sound generators, 3-5% have frequencies below 20 Hz and above 20,000 Hz. Songs made by recording in a soundproof room also have a frequency of 20 Hz and above 20,000 Hz, about 5 – 7%, where the song has an unnecessary frequency. The subjective tinnitus sound generator with the created song has an amplitude of < 85dB so that it can be adjusted with the volume control on the speaker.\u0000Conclusion: Tinnitus songs were made with the addition of Piano and Violin and Flute music, and Guitar, Bass and Balinese gamelan had a frequency of 20 – 20,000 Hz with an amplitude of < 85 dB, which can be adjusted with the volume so that it is safe and comfortable for tinnitus sufferers.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79656196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: perinatal asphyxia is the second-highest cause of neonatal death in Indonesia. According to the World Health Organization (WHO), perinatal asphyxia is when a baby experiences spontaneous and regular breathing failure immediately after birth. Various risk factors may cause perinatal asphyxia, including maternal, fetal, and placental factors. This study aims to identify the risk factors associated with the incidence of perinatal asphyxia at the Sanjiwani Regional General Hospital, Gianyar. Methods: This research was an observational analytic study with a case-control design involving 114 samples of newborns from January 1 to December 31, 2022, at the Sanjiwani Gianyar Hospital. The case group was selected using a total sampling technique, and the control group using a simple random sampling technique. Data were extracted from the medical records and analyzed using univariate, bivariate, and multivariate methods. Bivariate analysis used Chi-square or Fisher's exact tests, while multivariate analysis used logistic regression. The P-value of <0.05 is considered significant. Results: A total of 57 cases and 57 controls were included in this study. The bivariate analysis found the factors associated with perinatal asphyxia were meconium-stained amniotic fluid (p=0.021; OR=2.742; 95%CI=1.150-6.539), mode of delivery (p=0.003; OR=3.203; 95%CI=1.484-6.913), low birth weight (p=0.002; OR=4.595; 95%CI=1.681-12.561), and prematurity (p=0.006; OR=4.732; 95%CI=1.462-15.322). In multivariate analysis, it was found that meconium-stained amniotic fluid has the strongest association with perinatal asphyxia. Conclusion: There is a significant relationship between meconium-stained amniotic fluid, method of delivery, low birth weight, and prematurity with the incidence of perinatal asphyxia.
{"title":"Factors Associated with the incidence of perinatal asphyxia at Sanjiwani Regional General Hospital, Gianyar, Bali, Indonesia","authors":"Kadek Enny Pradnyaswari, Romy Windiyanto","doi":"10.15562/ijbs.v17i1.446","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.446","url":null,"abstract":"Background: perinatal asphyxia is the second-highest cause of neonatal death in Indonesia. According to the World Health Organization (WHO), perinatal asphyxia is when a baby experiences spontaneous and regular breathing failure immediately after birth. Various risk factors may cause perinatal asphyxia, including maternal, fetal, and placental factors. This study aims to identify the risk factors associated with the incidence of perinatal asphyxia at the Sanjiwani Regional General Hospital, Gianyar.\u0000Methods: This research was an observational analytic study with a case-control design involving 114 samples of newborns from January 1 to December 31, 2022, at the Sanjiwani Gianyar Hospital. The case group was selected using a total sampling technique, and the control group using a simple random sampling technique. Data were extracted from the medical records and analyzed using univariate, bivariate, and multivariate methods. Bivariate analysis used Chi-square or Fisher's exact tests, while multivariate analysis used logistic regression. The P-value of <0.05 is considered significant.\u0000Results: A total of 57 cases and 57 controls were included in this study. The bivariate analysis found the factors associated with perinatal asphyxia were meconium-stained amniotic fluid (p=0.021; OR=2.742; 95%CI=1.150-6.539), mode of delivery (p=0.003; OR=3.203; 95%CI=1.484-6.913), low birth weight (p=0.002; OR=4.595; 95%CI=1.681-12.561), and prematurity (p=0.006; OR=4.732; 95%CI=1.462-15.322). In multivariate analysis, it was found that meconium-stained amniotic fluid has the strongest association with perinatal asphyxia.\u0000Conclusion: There is a significant relationship between meconium-stained amniotic fluid, method of delivery, low birth weight, and prematurity with the incidence of perinatal asphyxia.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81914833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. K. Sutyawan, Maria Vinsensia Lie, Intan Ade Indraputri, Made Ayu Surasmiati, Ariani Andayani, Ni Made Ari Suryati
Introduction: Retinopathy of prematurity (ROP) is one of the important causes of blindness in children. ROP is characterized by abnormal retinal neovascularization of premature infants. Purpose: This study aimed to estimate the prevalence of ROP in preterm infants at Sanglah Hospital Bali from 2015-2017 and identify the risk factors predisposing them to ROP. Methods: This was a retrospective study, observational analysis on premature infants diagnosed as ROP at Sanglah Hospital Bali from January 2015 to December 2017, with a gestational age of 30 weeks or less at birth and a birth weight of 1500 grams or less. Infants whose gestational age was >30 weeks or whose birth weight was >1500 grams were also included. The ophthalmological examinations were initiated between the fourth and sixth weeks of chronological age or 34 weeks of corrected age, whichever was earlier, and were repeated weekly or biweekly as per Indonesian guidelines for ROP screening, until full vascularization of the retina reached zone 3. Results: Out of 31 infants diagnosed as ROP, 3 (9.7%) cases developed ROP in one eye, and 28 (90,3%) cases in both eyes. They were classified as 23 (74.2%) cases stage 1, and 8 (25,8%) cases stage 2. None of the studied infants presented ROP at stage 3, 4, or 5. The risk for ROP was not significantly associated with birth weight (OR 0.375; 95% CI 0.030 – 4.635), gestational age (OR 0.897; 95% CI 0.792 – 1.015), sepsis (OR 1.111; 95% CI 0.089 – 13.835), blood transfusion (OR 1.111; 95% CI 0.089 – 13.835), and HMD (OR 1.118; 95% CI 0.977 – 1.443). Conclusions: The data of this study showed that low gestational age, low birth weight, sepsis, oxygen therapy, and blood transfusion may be contribute to the development of ROP, but not significant statistically. Clinicians should be aware of the presence of the additional risk factors when monitoring preterm infants,especially when giving supplemental oxygen therapy.
前言:早产儿视网膜病变(ROP)是儿童致盲的重要原因之一。ROP以早产儿视网膜新生血管异常为特征。目的:本研究旨在估计2015-2017年巴厘岛Sanglah医院早产儿ROP的患病率，并确定易患ROP的危险因素。方法:对2015年1月至2017年12月在巴厘岛Sanglah医院诊断为ROP的早产儿进行回顾性研究和观察分析，这些早产儿出生时胎龄不超过30周，出生体重不超过1500克。孕周>30周或出生体重>1500克的婴儿也包括在内。在实足年龄的第4周至第6周或矫正年龄的34周(以较早者为准)之间开始眼科检查，并按照印度尼西亚ROP筛查指南每周或每两周重复一次，直到视网膜血管完全形成达到3区。结果:31例诊断为ROP的患儿中，单眼ROP 3例(9.7%)，双眼ROP 28例(90.3%)。1期23例(74.2%)，2期8例(25.8%)。研究中没有婴儿在第3,4或5期出现ROP。ROP风险与出生体重无显著相关性(OR 0.375;95% CI 0.030 - 4.635)，胎龄(OR 0.897;95% CI 0.792 - 1.015)，脓毒症(OR 1.111;95% CI 0.089 - 13.835)，输血(OR 1.111;95% CI 0.089 - 13.835)和HMD (OR 1.118;95% ci 0.977 - 1.443)。结论:本研究资料显示，低胎龄、低出生体重、败血症、氧疗、输血等因素均可能促进ROP的发生，但统计学意义不显著。临床医生在监测早产儿时应注意其他危险因素的存在，特别是在给予补充氧治疗时。
{"title":"Characteristic and risk factors of retinopathy of prematurity in Sanglah Hospital Denpasar: 3-years retrospective study","authors":"I. K. Sutyawan, Maria Vinsensia Lie, Intan Ade Indraputri, Made Ayu Surasmiati, Ariani Andayani, Ni Made Ari Suryati","doi":"10.15562/ijbs.v17i1.434","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.434","url":null,"abstract":"Introduction: Retinopathy of prematurity (ROP) is one of the important causes of blindness in children. ROP is characterized by abnormal retinal neovascularization of premature infants.\u0000Purpose: This study aimed to estimate the prevalence of ROP in preterm infants at Sanglah Hospital Bali from 2015-2017 and identify the risk factors predisposing them to ROP.\u0000Methods: This was a retrospective study, observational analysis on premature infants diagnosed as ROP at Sanglah Hospital Bali from January 2015 to December 2017, with a gestational age of 30 weeks or less at birth and a birth weight of 1500 grams or less. Infants whose gestational age was >30 weeks or whose birth weight was >1500 grams were also included. The ophthalmological examinations were initiated between the fourth and sixth weeks of chronological age or 34 weeks of corrected age, whichever was earlier, and were repeated weekly or biweekly as per Indonesian guidelines for ROP screening, until full vascularization of the retina reached zone 3.\u0000Results: Out of 31 infants diagnosed as ROP, 3 (9.7%) cases developed ROP in one eye, and 28 (90,3%) cases in both eyes. They were classified as 23 (74.2%) cases stage 1, and 8 (25,8%) cases stage 2. None of the studied infants presented ROP at stage 3, 4, or 5. The risk for ROP was not significantly associated with birth weight (OR 0.375; 95% CI 0.030 – 4.635), gestational age (OR 0.897; 95% CI 0.792 – 1.015), sepsis (OR 1.111; 95% CI 0.089 – 13.835), blood transfusion (OR 1.111; 95% CI 0.089 – 13.835), and HMD (OR 1.118; 95% CI 0.977 – 1.443).\u0000Conclusions: The data of this study showed that low gestational age, low birth weight, sepsis, oxygen therapy, and blood transfusion may be contribute to the development of ROP, but not significant statistically. Clinicians should be aware of the presence of the additional risk factors when monitoring preterm infants,especially when giving supplemental oxygen therapy.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83690853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：