{"title":"Factors associated with disease activity of rheumatoid arthritis patients based on Disease Activity Score 28 (DAS28) at Sanglah Central General Hospital, Bali, Indonesia","authors":"P. Kurniari, G. Kambayana, I. P. F. Sukmajaya P","doi":"10.15562/ijbs.v15i2.311","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.311","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77826697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie Wijayanti, D. Wihandani, A. E. Darwinata, I Gede Putu Supadmanaba
Introduction: Breast cancer is the most common cancer found in women and is one of the diseases associated with aging. Previos studies have found a significant association between the BsmI vitamin D receptor and breast cancer. This study aims to prove the relationship between BsmI vitamin D receptor polymorphisms with clinicopathological features of breast cancer at Sanglah Hospital, Denpasar Bali. Methods: This research is an analytic study with cross sectional method. The samples used in this study were 50 stored biological materials in the form of DNA from breast cancer patients in 2016- 2018 which is in the Biochemistry Laboratory of the Udayana Faculty of Medicine. To determine the polymorphism of the BsmI vitamin D receptor gene, DNA samples from breast cancer patients were amplified by polymerase chain reaction (PCR) method, then identified by sequencing method. The results obtained were then analyzed statistically using bivariate and multivariate analysis by using spss 25.sav. Results: 45 people (90.0%) were found with heterozygous polymorphism G/A and 5 people (10.0%) with homozygous wildtype GG. There was a statistically significant relationship between BsmI vitamin D receptor polymorphism and breast cancer stage at Sanglah Hospital Denpasar Bali (p=0.048). There was no significant relationship between age and history of contraceptive use and clinicopathology of breast cancer, but menstrual status was significant with the stage of breast cancer patients (p=0.037). Conclusion: There is a significant relationship between BsmI vitamin D receptor polymorphism and breast cancer stage at Sanglah Hospital Denpasar Bali.
{"title":"The Relationship of BsmI Vitamin D Receptor Gene Polymorphism with Clinicopathological Picture of Breast Cancer Patients at Sanglah Hospital Denpasar Bali","authors":"Stephanie Wijayanti, D. Wihandani, A. E. Darwinata, I Gede Putu Supadmanaba","doi":"10.15562/ijbs.v15i2.334","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.334","url":null,"abstract":"Introduction: Breast cancer is the most common cancer found in women and is one of the diseases associated with aging. Previos studies have found a significant association between the BsmI vitamin D receptor and breast cancer. This study aims to prove the relationship between BsmI vitamin D receptor polymorphisms with clinicopathological features of breast cancer at Sanglah Hospital, Denpasar Bali.\u0000Methods: This research is an analytic study with cross sectional method. The samples used in this study were 50 stored biological materials in the form of DNA from breast cancer patients in 2016- 2018 which is in the Biochemistry Laboratory of the Udayana Faculty of Medicine. To determine the polymorphism of the BsmI vitamin D receptor gene, DNA samples from breast cancer patients were amplified by polymerase chain reaction (PCR) method, then identified by sequencing method. The results obtained were then analyzed statistically using bivariate and multivariate analysis by using spss 25.sav.\u0000Results: 45 people (90.0%) were found with heterozygous polymorphism G/A and 5 people (10.0%) with homozygous wildtype GG. There was a statistically significant relationship between BsmI vitamin D receptor polymorphism and breast cancer stage at Sanglah Hospital Denpasar Bali (p=0.048). There was no significant relationship between age and history of contraceptive use and clinicopathology of breast cancer, but menstrual status was significant with the stage of breast cancer patients (p=0.037).\u0000Conclusion: There is a significant relationship between BsmI vitamin D receptor polymorphism and breast cancer stage at Sanglah Hospital Denpasar Bali.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78561710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of tuberculous epididymal-orchitis: a literature review","authors":"H. Hadiansyah, I. Wahyudi, N. Rasyid","doi":"10.15562/ijbs.v15i2.341","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.341","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75384449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dana Daniati, D. Wihandani, A. E. Darwinata, I Gede Putu Supadmanaba
Introduction: Cancer is one of the diseases associated with aging. Breast cancer is one of the most common cancers in women. There are many studies linking vitamin D receptor expression with breast cancer. Many previous studies have shown a significant association between the Apa1 vitamin D receptor and the clinicopathological characteristics of breast cancer. This study aims to prove the association between the Apa1 vitamin D receptor polymorphism and the clinicopathological characteristics of breast cancer at Sanglah Hospital, Denpasar Bali. Methods: This research is an analytic study with cross sectional method. The research was conducted at the Integrated Biomedical Laboratory Unit of the Faculty of Medicine, Udayana University from February to May 2021. The samples in this study were 38 stored biological materials in the form of DNA from breast cancer patients in the Biochemistry Laboratory of the Udayana Faculty of Medicine. To determine the polymorphism of the Apa1 vitamin D receptor, DNA samples from breast cancer patients were amplified by polymerase chain reaction (PCR) method, then identified by sequencing method. Statistical analysis used bivariate and multivariate analysis to determine the association between Apa1 vitamin D receptor polymorphism and clinicopathological characteristics of breast cancer. Result: From the sequencing results, it was found that there were 14 people (36.8%) with homozygous Wildtype CC, 7 people (18.4%) with heterozygous AC, and 17 people (44.7%) with homozygous polymorphism AA. There was no significant association between age, menopausal status, and history of contraception with breast cancer clinicopathology, but menopausal status was significant with the stage of breast cancer patients (p=0.046). There was no significant association between the Apa1 vitamin D receptor polymorphism with the clinicopathological characteristics of breast cancer where the p value> 0.05. Conclusion: There was no significant association between the Apa1 vitamin D receptor polymorphism with the clinicopathological characteristics of breast cancer at Sanglah Hospital, Denpasar Bali.
{"title":"Association of Apa1 Vitamin D Receptor Polymorphism and Clinicopthological Characteristics of Breast Cancer at Sanglah Hospital Denpasar Bali","authors":"Dana Daniati, D. Wihandani, A. E. Darwinata, I Gede Putu Supadmanaba","doi":"10.15562/ijbs.v15i2.348","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.348","url":null,"abstract":"Introduction: Cancer is one of the diseases associated with aging. Breast cancer is one of the most common cancers in women. There are many studies linking vitamin D receptor expression with breast cancer. Many previous studies have shown a significant association between the Apa1 vitamin D receptor and the clinicopathological characteristics of breast cancer. This study aims to prove the association between the Apa1 vitamin D receptor polymorphism and the clinicopathological characteristics of breast cancer at Sanglah Hospital, Denpasar Bali.\u0000Methods: This research is an analytic study with cross sectional method. The research was conducted at the Integrated Biomedical Laboratory Unit of the Faculty of Medicine, Udayana University from February to May 2021. The samples in this study were 38 stored biological materials in the form of DNA from breast cancer patients in the Biochemistry Laboratory of the Udayana Faculty of Medicine. To determine the polymorphism of the Apa1 vitamin D receptor, DNA samples from breast cancer patients were amplified by polymerase chain reaction (PCR) method, then identified by sequencing method. Statistical analysis used bivariate and multivariate analysis to determine the association between Apa1 vitamin D receptor polymorphism and clinicopathological characteristics of breast cancer. \u0000Result: From the sequencing results, it was found that there were 14 people (36.8%) with homozygous Wildtype CC, 7 people (18.4%) with heterozygous AC, and 17 people (44.7%) with homozygous polymorphism AA. There was no significant association between age, menopausal status, and history of contraception with breast cancer clinicopathology, but menopausal status was significant with the stage of breast cancer patients (p=0.046). There was no significant association between the Apa1 vitamin D receptor polymorphism with the clinicopathological characteristics of breast cancer where the p value> 0.05.\u0000Conclusion: There was no significant association between the Apa1 vitamin D receptor polymorphism with the clinicopathological characteristics of breast cancer at Sanglah Hospital, Denpasar Bali.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"163 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75975537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Kadek Eka Widiadnyani, P. R. K. Giri, I. F. N. Sidiartha, I. Tunas
{"title":"In-vitro anti-bacterial effectiveness test of 2% chlorhexidine digluconate and ethanol extract of green meniran leaves (Phyllanthus niruri Linn) on the growth of Enterococcus faecalis bacterial colony","authors":"Ni Kadek Eka Widiadnyani, P. R. K. Giri, I. F. N. Sidiartha, I. Tunas","doi":"10.15562/ijbs.v15i2.352","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.352","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82569039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kurniawan Adi Prabowo, Anak Agung Ayu Yuli Gayatri, N. M. Sukmawati, M. Utama, Ketut Agus Somia, K. Merati
Introduction: Toxoplasma encephalitis (TE) is the most commonly found in HIV patients who have no cotrimoxazole prophylaxis, especially when the CD count is <100 / µL. Therapy is often based on a presumptive diagnosis because definitive diagnosis is difficult, and TE can be life threatening. Aim of this study is to provide a characteristic description of TE in HIV patients who admitted at Sanglah Hospital. Methods: This is a retrospective descriptive study of 43 adult patients admitted with diagnosis TE at the Sanglah Hospital, Indonesia between January 1st 2018 to December 31th 2018. Results: Most patients were male (69.8%), with the predominant age ranged 31-40 years old (39.5%). Among all patients; 14% on cotrimoxazole prophylaxis, and 23.3% on antiretroviral therapy. The most common clinical manifestation was headache (58.1%). Oral candidiasis was found in 67.4% of patients. CD4 levels <100 cells / µL were found in 62.8% of patients, absolute lymphocytes <500 / µL in 32.6% of patients. Anemia was found in 37.2% of patients. Multiple ring enhancement was the most common feature found on head CT scan, with the profound location was parietal lobe (46.5%). Pyrimethamine + clindamycin is used in 72.1% of cases. The TE mortality rate in HIV patients in this study was 11.6%. Conclusion: TE in HIV patients was more common on male, younger age and who are not receiving appropriate prophylaxis and/or without antiretroviral therapy. Laboratory study predominantly showed severe immunodeficiency. The most patients making a full recovery with pyrimethamine and clindamycin treatment.
{"title":"HIV-related toxoplasma encephalitis: a tertiary care experience","authors":"Kurniawan Adi Prabowo, Anak Agung Ayu Yuli Gayatri, N. M. Sukmawati, M. Utama, Ketut Agus Somia, K. Merati","doi":"10.15562/ijbs.v15i2.331","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.331","url":null,"abstract":"Introduction: Toxoplasma encephalitis (TE) is the most commonly found in HIV patients who have no cotrimoxazole prophylaxis, especially when the CD count is <100 / µL. Therapy is often based on a presumptive diagnosis because definitive diagnosis is difficult, and TE can be life threatening. Aim of this study is to provide a characteristic description of TE in HIV patients who admitted at Sanglah Hospital.\u0000Methods: This is a retrospective descriptive study of 43 adult patients admitted with diagnosis TE at the Sanglah Hospital, Indonesia between January 1st 2018 to December 31th 2018. \u0000Results: Most patients were male (69.8%), with the predominant age ranged 31-40 years old (39.5%). Among all patients; 14% on cotrimoxazole prophylaxis, and 23.3% on antiretroviral therapy. The most common clinical manifestation was headache (58.1%). Oral candidiasis was found in 67.4% of patients. CD4 levels <100 cells / µL were found in 62.8% of patients, absolute lymphocytes <500 / µL in 32.6% of patients. Anemia was found in 37.2% of patients. Multiple ring enhancement was the most common feature found on head CT scan, with the profound location was parietal lobe (46.5%). Pyrimethamine + clindamycin is used in 72.1% of cases. The TE mortality rate in HIV patients in this study was 11.6%.\u0000Conclusion: TE in HIV patients was more common on male, younger age and who are not receiving appropriate prophylaxis and/or without antiretroviral therapy. Laboratory study predominantly showed severe immunodeficiency. The most patients making a full recovery with pyrimethamine and clindamycin treatment. ","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"150 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80383908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mylda Pratiwi Ahmadwirawan, H. Cangara, A. Santoso, Marhaen Hardjo, Endy Adnan, F. Hamid
{"title":"Analysis of Interleukin-6 level in Serum and Histopathology Changes of Cardiovascular Tissue on Male Wistar Rat with Nonalcoholic Fatty Liver Disease (NAFLD)","authors":"Mylda Pratiwi Ahmadwirawan, H. Cangara, A. Santoso, Marhaen Hardjo, Endy Adnan, F. Hamid","doi":"10.15562/ijbs.v15i2.321","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.321","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"50 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82441045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florensia Orisa Ponnio Angriawan, N. Sriwidyani, N. N. A. Dewi
{"title":"Administration of Caffeine Cream Increased Apoptotic Cells and Decreased Phosphorylated ATR (Thr 1989) Expression in Ultraviolet B Exposed Skin Mice (Mus musculus)","authors":"Florensia Orisa Ponnio Angriawan, N. Sriwidyani, N. N. A. Dewi","doi":"10.15562/ijbs.v15i2.320","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.320","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73084155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-hyperurisemic Activity of Combination of Beetroot Powder (Beta vulgaris L.) And Allopurinol in Potassium Oxonate-Induced White Rats","authors":"Anggraini Wulandari, P. Dirgahayu, B. Wiboworini","doi":"10.15562/ijbs.v15i2.319","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.319","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85216872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Puspita, Purwadi Sujalmo, Rizki Puji Agustin, Nesti Desi Ari
{"title":"Clinical findings, laboratory, and imaging features of COVID-19 patients at Universitas Gadjah Mada (UGM) Academic Hospital, Yogyakarta, Indonesia","authors":"R. Puspita, Purwadi Sujalmo, Rizki Puji Agustin, Nesti Desi Ari","doi":"10.15562/ijbs.v15i2.347","DOIUrl":"https://doi.org/10.15562/ijbs.v15i2.347","url":null,"abstract":"","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"600 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77242530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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