Seminars in Colon and Rectal Surgery最新文献

The shift from open to endoscopic surgeries, including laparoscopic and robot-assisted surgeries, has enabled the storage of a large number of high-quality intraoperative videos. Endoscopic surgery is highly compatible with artificial intelligence (AI), especially deep-learning-based computer vision, as it provides easy access to videos that form the basis of image analysis. Following the self-learning process, wherein surgeons gain an understanding of surgery by repeatedly watching intraoperative videos, numerous efforts have been made to build AI models for surgery using AI input and analyzing a vast amount of information from intraoperative videos. However, whether AI's understanding of surgery increases sufficiently and becomes useful in daily surgical practice remains unclear. Therefore, this review aims to discuss the current status and future challenges of using AI in surgery, particularly in laparoscopic colorectal surgery, and to explore aspects such as surgical phase or step recognition, navigation and surgical automation, and surgical skill assessment.

Recent advancements in artificial intelligence (AI) have had a profound impact on the field of gastrointestinal endoscopy, particularly in the realm of colonoscopy. Recent studies have shown excellent performance of AI models in both computer-aided detection (CADe) and computer-aided diagnosis (CADx) of polyps. Moreover, AI has shown promising results in other aspects of colonoscopy such as prediction of depth of tumor invasion, colonoscopy quality assurance, and AI applications in inflammatory bowel disease.

In this review, we summarize the recent literature on the application of AI in colonoscopy, and review the limitations and challenges of existing AI technologies and future directions for this field.

The incidence of colorectal anastomotic leaks is approximately 5–19 % of cases, posing a threat to intestinal continuity, particularly if the leak arises after a low or ultra-low colorectal anastomosis. A Turnbull–Cutait procedure can be a salvage option for such patients and they may be eligible if they are adequate redo pelvic surgery candidates, who are motivated to regain intestinal continuity, and who have good continence and anal function at baseline. The first stage of the procedure is colonic mobilization and pull-through after perineal division at the top of the anorectal complex and mucosectomy. A diverting loop ileostomy is utilized. The second stage is amputation of the excess colon and creation of a hand-sewn colo-anal anastomosis, typically performed 7 days later. Outcomes after a Turnbull–Cutait procedure are reasonable based on a series from specialized centers with 80–90 % of patients having a complete Turnbull–Cutait and reversal of the diverting ileostomy. Low anterior resection syndrome is common. In the long-term, studies show that just over half of patients will remain stoma free at 5 years; fecal incontinence is the main reason for failure and return to a stoma. The prospect of a Turnbull–Cutait can be kept in mind when addressing an anastomotic leak in appropriate patients; this may allow for surgical decision-making that makes it feasible to utilize a Turnbull–Cutait in the future.

Advancements in the surgical and medical care of anorectal malformation (ARMs) have led to greater life expectancy and improved quality of life. Patients with ARM frequently experience fecal incontinence (17–77 %), constipation (23–87 %), and rectal prolapse (4–60 %). Upper urinary tract abnormalities occur in 40-83 %, leading to end-stage renal disease in 5–18 % and kidney transplantation in 2–8 %. Urinary incontinence occurs in 0–41 % of patients. Mullerian anomalies occur in up to 60 % of patients, and 36–41 % present with hematometra, which may impact fertility. Cryptorchidism is seen in 19 % and may lead to reduced paternity rates. Sexual dysfunction impacts 6–66 % of patients and coital debut is delayed, often due to fear of flatus or soiling. While fertility rates vary, childbirth is still possible. However, pregnancies carry a higher risk of miscarriage and premature delivery, and delivery via Cesarean section is recommended. Malignancy is uncommon, but patient anatomy is imperative to consider when assessing cancer risk, screening needs, and the impact of cancer treatment. Depression and anxiety occur in 80 %, with up to 15 % reporting suicidal ideation, yet only 12–40 % receive treatment. The high prevalence of ongoing complications highlights the need for continued multidisciplinary care after index ARM repair.

Development of enterocutaneous fistula (ECF) remains a challenging complication of gastrointestinal surgery and fistulizing disease processes. Successful management of ECF is dependent on timely diagnosis, effective treatment of resulting intra-abdominal sepsis, wound/nutrition management, and supporting the patient though the perioperative optimization period. When approached in multi-disciplinary setting with teams specializing in ECF/intestinal failure, care is optimized and can allow for patients to have greater independence even with complex wounds. While resolution of the ECF remains the overarching goal, a methodical and stepwise approach to management remains paramount both before and after surgical intervention. This chapter outlines ECF management from initial diagnosis to intra-operative decision making after a patient is deemed a candidate for surgery. Further, it highlights patient-specific considerations that can be overlooked in the big picture view of ECF management. While ECF treatment is challenging, the chance to cure a patient of their fistula is a rewarding experience for the patient and ECF/intestinal failure team members alike.

Anorectal mucosal melanoma accounts for less than 1 % of all anorectal malignant tumors and a tendency for delayed diagnosis leads to advanced disease at presentation.^1,2 Due to the rarity of the disease, there are limited prospective trials exploring the optimal treatment strategies. Generally, tumors are surgically excised, with a preference for conservative management with wide local excision. In the past decade, there have been advances with immunotherapy and other targeted therapies. Multiple clinical trials continue exploring neoadjuvant/adjuvant combination treatments in the setting of advanced or unresectable disease.

The indications for colorectal surgery in cirrhotic patients have recently been broadened, mostly due to a better understanding and multidisciplinary management of cirrhosis. However, anesthesia and colorectal surgery may both exacerbate deteriorations in liver function in a patient with chronic liver disease such that careful preoperative patient selection remains mandatory. Four scores (i.e., Child-Turcotte-Pugh, the Model for End-Stage Liver Disease, Mayo Risk Score, and (VOCAL)-Penn cirrhosis surgical risk score) are currently available to assess the severity of cirrhosis, determine the risk of decompensation, and to estimate postoperative mortality. For colorectal resection to be safely performed electively in patients with compensated liver disease, optimization of the patient is mandatory in the preoperative setting. Preoperative transjugular intrahepatic portosystemic shunt (TIPS) is a promising strategy in patients with portal hypertension, but it requires further evaluation. Similarly, further studies are needed to validate both the feasibility and safety of the laparoscopic approach to colorectal surgery in cirrhotic patients. In summary, preoperative identification and optimization combined with meticulous postoperative care are essential for optimum outcomes in patients with chronic liver disease undergoing colorectal surgery.

Disease recurrence after surgery for ileocolic Crohn's is common, and repeat surgery is necessary for approximately one-third of patients within ten years. This recurrence rate is influenced by many factors, some of which relate to the disease phenotype. Others may be influenced by the patient (i.e., smoking) or the gastroenterologist with careful disease monitoring and the judicious use of adjuvant medication. The surgeon may also be able to reduce recurrence in the both preoperative preparation of the patient, the timing of surgery, and the intra-operative surgical technique. Evidence of how the surgeon can influence recurrence is discussed in this manuscript, considering current definitions, pathophysiology, and risk factors for recurrence.

Colorectal cancer is associated with distant metastases in 19–26% of patients at initial presentation. Local tumor complications such as obstruction, perforation, and hemorrhage may be identified at initial presentation or may develop during treatment for those that were initially asymptomatic. Optimal management in these situations is dependent on rapid recognition and assessment of the patient's clinical condition, a thorough understanding of oncologic principles, and a multidisciplinary approach to treatment. Given the the reliance on systemic therapy for the management of metastatic disease, it is essential to minimize potential morbidity and mortality to avoid unnecessary treatment delays in this subset of patients. This review highlights the most common local tumor complications seen in the setting of stage IV colorectal cancer and approaches to each.