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Einleitung: Gold – ein besonderes Metall 引言:金,一个特殊的金属
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-7
B. Grewe
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引用次数: 0
Graphik 2: Die wichtigsten Goldförderländer 2017 图2:2017年主要金矿
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-130
B. Grewe
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引用次数: 0
Gold aus dem südafrikanischen Apartheidstaat und aus der Sowjetunion 南非种族隔离国家和苏联的黄金
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-96
B. Grewe
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引用次数: 0
Gold als Spekulationsobjekt: Der Preisrekord im Januar 1980 投机的黄金:1980年1月的价格记录
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-102
B. Grewe
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引用次数: 0
Goldene Götzen und göttliches Gold 纯金的偶像,和神圣的金子
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-18
B. Grewe
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引用次数: 0
Register 注册
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-126-1
B. Grewe
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引用次数: 1
Ökonomie und Gold in Frühgeschichte und Antike 古希腊和古代的经济学和黄金
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-21
B. Grewe
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引用次数: 0
Das Konfliktpotential des Goldes
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-58
B. Grewe
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引用次数: 0
Der große Schmuggel 大走私
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2019-01-01 DOI: 10.17104/9783406732133-98
B. Grewe
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引用次数: 0
Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system 一种新型热响应性水凝胶包覆金纳米棒作为药物递送系统的研制
IF 2.2 4区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2018-12-08 DOI: 10.1007/s13404-018-0248-x
Mehran Kurdtabar, Gazal Baghestani, Ghasem Rezanejade Bardajee

In this study, at first, gold nanorods (GNRs) were synthesized and then they were coated with a layer of hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) grafted onto carboxymethyl cellulose (CMC) as a backbone. The chemical structure of GNRs/PNIPAM-g-CMC hydrogel was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), atomic-force microscopy (AFM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The swelling properties of the obtained GNRs/PNIPAM-g-CMC hydrogel were studied at different times and temperatures. In addition, drug release from doxorubicin-loaded GNRs/PNIPAM-g-CMC hydrogel was examined at different temperatures during time. The drug release mechanism was studied by first-order, second-order, and Ritger–Peppas models. Finally, the GNRs/PNIPAM-g-CMC hydrogel biocompatibility was tested against L929 mouse fibroblast cells by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. Our study suggests that GNRs coated with low-cost hydrogels can be excellent candidate for drug delivery systems.

本研究首先合成了金纳米棒(GNRs),然后在其表面包裹一层以聚n -异丙基丙烯酰胺(PNIPAM)为骨架接枝的水凝胶。采用傅里叶变换红外(FT-IR)、热重分析(TGA)、原子力显微镜(AFM)、透射电子显微镜(TEM)和扫描电子显微镜(SEM)表征了GNRs/PNIPAM-g-CMC水凝胶的化学结构。研究了制备的GNRs/PNIPAM-g-CMC水凝胶在不同时间和温度下的溶胀性能。此外,在不同的温度和时间条件下,研究了负载阿霉素的GNRs/PNIPAM-g-CMC水凝胶的药物释放情况。采用一级、二级和Ritger-Peppas模型研究其释放机制。最后,采用3-[4,5-二甲基噻唑-2-基]-2,5二苯基溴化四唑(MTT)法检测GNRs/PNIPAM-g-CMC水凝胶对L929小鼠成纤维细胞的生物相容性。我们的研究表明,低成本水凝胶包裹的gnr可以成为药物输送系统的优秀候选者。
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引用次数: 14
期刊
Gold Bulletin
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