Pub Date : 2022-01-01DOI: 10.4236/ojrd.2022.122005
K. Ouattara, B. Baya, D. Soumaré, T. Kanouté, Mohamed Tolofodie, Kafui Komla Gaglo Koudemon, Salifou Koné, B. Diarra, Y. Sarro, Y. Toloba, M. Maiga
Introduction: Mycobacteria pulmonary diseases are chronic illnesses with various impacts on patients’ health status, and wellbeing. These diseases currently represent a global health issue due to increasing burdens and the lack of new development on therapeutic options. Policies based on the quality of life may help to improve the management of this chronic respiratory disease; this study was designed to assess the quality of life of patients treated for the pulmonary mycobacterial disease. Materials and Methods: Participants diagnosed with a mycobacterial pulmonary disease were selected from the University Clinical Research Centers’ (UCRC) 2019 mycobacterial cohort database. A telephone interview was conducted using the Medical Outcome Study Short Form (SF-36) which has 36 items evaluating physical and mental wellbeing. Scores range from 0 - 100, with higher scores indicating greater Health-related quality of life (HRQOL). Statistical analysis was performed with SPSS 23.0 and the Fisher test was used to compare percentages. A p-value less than 0.05 was considered significant. Results: A hemoglobin was 11.8 ± 2.2 g/dl. The mean SF-36 score was 75.1 ± 16.6, and impairment was mainly related to mental problems in 59.6%. The mean total score was significantly lower with age more than 42 years than age less than 42 years. But HIV positive and BMI less than 18.5 do not lead to a significant change of mean total score. Conclusion: Patients with mycobacterial pulmonary diseases have more psychological problems than physical ones. Hence the importance of psychological support in their management to improve their quality of life. A large sample size with a deep interview component would be necessary to address limitations in this design.
{"title":"Assessment of the Quality of Life of Patients with Mycobacterial Pulmonary Diseases","authors":"K. Ouattara, B. Baya, D. Soumaré, T. Kanouté, Mohamed Tolofodie, Kafui Komla Gaglo Koudemon, Salifou Koné, B. Diarra, Y. Sarro, Y. Toloba, M. Maiga","doi":"10.4236/ojrd.2022.122005","DOIUrl":"https://doi.org/10.4236/ojrd.2022.122005","url":null,"abstract":"Introduction: Mycobacteria pulmonary diseases are chronic illnesses with various impacts on patients’ health status, and wellbeing. These diseases currently represent a global health issue due to increasing burdens and the lack of new development on therapeutic options. Policies based on the quality of life may help to improve the management of this chronic respiratory disease; this study was designed to assess the quality of life of patients treated for the pulmonary mycobacterial disease. Materials and Methods: Participants diagnosed with a mycobacterial pulmonary disease were selected from the University Clinical Research Centers’ (UCRC) 2019 mycobacterial cohort database. A telephone interview was conducted using the Medical Outcome Study Short Form (SF-36) which has 36 items evaluating physical and mental wellbeing. Scores range from 0 - 100, with higher scores indicating greater Health-related quality of life (HRQOL). Statistical analysis was performed with SPSS 23.0 and the Fisher test was used to compare percentages. A p-value less than 0.05 was considered significant. Results: A hemoglobin was 11.8 ± 2.2 g/dl. The mean SF-36 score was 75.1 ± 16.6, and impairment was mainly related to mental problems in 59.6%. The mean total score was significantly lower with age more than 42 years than age less than 42 years. But HIV positive and BMI less than 18.5 do not lead to a significant change of mean total score. Conclusion: Patients with mycobacterial pulmonary diseases have more psychological problems than physical ones. Hence the importance of psychological support in their management to improve their quality of life. A large sample size with a deep interview component would be necessary to address limitations in this design.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70584423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojrd.2022.122004
Y. Y. Camgoz, F. Y. Inal, Öznur Şen
{"title":"Ventilator Associated Pneumonia in an Intensive Care Unit","authors":"Y. Y. Camgoz, F. Y. Inal, Öznur Şen","doi":"10.4236/ojrd.2022.122004","DOIUrl":"https://doi.org/10.4236/ojrd.2022.122004","url":null,"abstract":"","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70584371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-28DOI: 10.4236/ojrd.2021.114011
M. Bautista, J. Vossoughi, A. Johnson, M. Keszler
Sixty-four pediatric patients with asthma exacerbation were studied. The children were subjected to respiratory resistance evaluation using the Airflow Perturbation Device (APD) and spirometry evaluation. They were then administered albuterol and 15 minutes later the APD and spirometry evaluations were repeated. Eleven of the children could not perform spirometry. The APD results demonstrated that respiratory resistance of the patients decreased by about 20%, indicating that the APD could detect the expected response to bronchodilator. However, no similar conclusion could be made with the spirometry parameters (FVC, FEV1, FEV1/FVC, and FEF25% - 75%) performed on the same patients. The differences on the spirometry parameters did not change significantly before and after bronchodilator administration. Furthermore, these differences were negligibly increased or decreased for some with no consistency between the FVC, FEV1, FEV1/FVC, and FEF25% - 75%. Even though all the children were clinically improved after albuterol administration and discharged home, this could not be demonstrated by spirometry data. This study validates previous reports that spirometry is not a reliable pulmonary diagnostic tool for young children, as spirometry is highly effort-dependent and requires a substantial degree of patient cooperation. APD on the other hand is a reliable, simple, effortless diagnostic tool that can be utilized in evaluation and management of children with asthma symptoms and exacerbation.
{"title":"Assessment of Bronchodilator Response in Children with Asthma Exacerbation Using the Respiratory Resistance Values","authors":"M. Bautista, J. Vossoughi, A. Johnson, M. Keszler","doi":"10.4236/ojrd.2021.114011","DOIUrl":"https://doi.org/10.4236/ojrd.2021.114011","url":null,"abstract":"Sixty-four pediatric patients \u0000with asthma exacerbation were studied. The children \u0000were subjected to respiratory resistance evaluation using the Airflow \u0000Perturbation Device (APD) and spirometry evaluation. They were then administered albuterol and 15 minutes later the APD and \u0000spirometry evaluations were repeated. Eleven of the children could not \u0000perform spirometry. The APD results \u0000demonstrated that respiratory resistance of the patients decreased by about \u000020%, indicating that the APD could detect the expected response to \u0000bronchodilator. However, no similar conclusion could be made with the \u0000spirometry parameters (FVC, FEV1, FEV1/FVC, and FEF25% - \u000075%) performed on the same patients. The differences on the spirometry \u0000parameters did not change significantly \u0000before and after bronchodilator administration. Furthermore, these \u0000differences were negligibly increased or decreased for some with no consistency \u0000between the FVC, FEV1, FEV1/FVC, and FEF25% - 75%. Even though all the children \u0000were clinically improved after albuterol administration and discharged home, \u0000this could not be demonstrated by spirometry data. This study validates \u0000previous reports that spirometry is not a reliable pulmonary diagnostic tool \u0000for young children, as spirometry is highly effort-dependent and requires a \u0000substantial degree of patient cooperation. APD on the other hand is a reliable, \u0000simple, effortless diagnostic tool that can be utilized in evaluation and \u0000management of children with asthma symptoms and exacerbation.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46696660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-24DOI: 10.4236/ojrd.2021.113009
Billy Peng, Matthew Miller, Mark Slootsky, Ravi Patel, A. Baydur
Background: Tidal expiratory flow limitation (tEFL) is defined as absence of increase in air flow during forced expiration compared to tidal breathing and is related to dyspnea at rest and minimal exertion in patients with chronic airflow limitation (CAL). Tidal EFL has not been expressed as a continuous variable (0% - 100%) in previous analyses. Objective: To relate the magnitude of tEFL to spirometric values and Modified Medical Research Council (MMRC) score and Asthma Control Test (ACT). Methods: Tidal EFL was computed as percent of the tidal volume (0% - 100%) spanned (intersected) by the forced expiratory-volume curve. Results: Of 353 patients screened, 192 (114 M, 78 F) patients (136 with COPD, 56 with asthma) had CAL. Overall characteristics: (mean ± SD) age 59 ± 11 years, BMI 28 ± 7, FVC (% pred) 85 ± 20, FEV1 (% pred) 66 ± 21, FEV1/FVC 55% ± 10%, RV (% pred) 147 ± 42. Tidal EFL in patients with tEFL was 53% ± 39%. Using univariate analysis, strongest correlations were between tEFL and FVC and between tEFL and RV in patients with BMI 2. In patients with nonreversible CAL, tEFL was positively associated with increasing MMRC, negatively with spirometric measurements, and positively with RV/TLC. In asthmatics, ACT scores were higher in patients with mean BMI ≥ 28 kg/m2 (p 40% (p Conclusions: Dyspnea is strongly associated with tEFL and lung function, particularly in patients with nonreversible CAL. Air trapping and BMI contribute to tEFL.
{"title":"Expiratory Flow Limitation and Its Relation to Dyspnea and Lung Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease: Analysis Using the Forced Expiratory Flow-Volume Curve and Critique","authors":"Billy Peng, Matthew Miller, Mark Slootsky, Ravi Patel, A. Baydur","doi":"10.4236/ojrd.2021.113009","DOIUrl":"https://doi.org/10.4236/ojrd.2021.113009","url":null,"abstract":"Background: Tidal expiratory flow limitation (tEFL) is defined as absence of \u0000increase in air flow during forced expiration compared to tidal breathing and \u0000is related to dyspnea at rest and minimal exertion in patients with chronic \u0000airflow limitation (CAL). Tidal EFL has not been expressed as a continuous \u0000variable (0% - 100%) in previous analyses. Objective: To relate the \u0000magnitude of tEFL to spirometric values and Modified Medical Research Council \u0000(MMRC) score and Asthma Control Test (ACT). Methods: Tidal EFL was computed as percent of the tidal \u0000volume (0% - 100%) spanned (intersected) by the forced expiratory-volume curve. Results: Of 353 patients \u0000screened, 192 (114 M, 78 F) patients (136 with COPD, 56 with asthma) had CAL. \u0000Overall characteristics: (mean ± SD) age 59 ± 11 years, BMI 28 ± 7, FVC (% \u0000pred) 85 ± 20, FEV1 (% pred) 66 ± 21, FEV1/FVC 55% ± 10%, RV (% pred) 147 ± 42. \u0000Tidal EFL in patients with tEFL was 53% ± 39%. Using univariate analysis, \u0000strongest correlations were between tEFL and FVC and between tEFL and RV in \u0000patients with BMI 2. In patients with nonreversible CAL, \u0000tEFL was positively associated with increasing MMRC, negatively with \u0000spirometric measurements, and positively with RV/TLC. In asthmatics, ACT scores \u0000were higher in patients with mean BMI ≥ 28 kg/m2 (p 40% (p Conclusions: Dyspnea is strongly associated with tEFL and \u0000lung function, particularly in patients with nonreversible CAL. Air trapping \u0000and BMI contribute to tEFL.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41417097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-24DOI: 10.4236/ojrd.2021.113010
Xin Wang, Di Wu, Yanmei Wu, Hongyan Liu, Wang Ying, Chunmei Yun, D. Sun, Gao Xiaoyu
Chronic obstructive pulmonary disease (COPD) is a major chronic respiratory disease worldwide. Inflammatory cells reflect the inflammatory situation both in peripheral blood and induced sputum. Their correlation has not been reported. The correlation between neutrophils (Neu), eosinophils (Eos), and lymphocyte (Lym) in induced sputum and that in peripheral blood of COPD patients was evaluated to explore the consistency of inflammatory cells in peripheral blood and induced sputum. Peripheral blood and induced sputum were collected from 437 patients with acute exacerbation of COPD (AECOPD) who were hospitalized in the Department of respiratory and critical care medicine, Inner Mongolia People’s Hospital. The correlation analysis was performed by Spearman correlation analysis. The ratios of Neu, Eos, and Lym in induced sputum were (79.15 ± 22.60)%, (5.23 ± 12.74)%, and (1.69 ± 2.66)%. The ratios of Neu, Eos, and Lym in peripheral blood were (63.29 ± 11.44)%, (2.99 ± 3.60)%, and (25.16 ± 10.19)%. The results showed that the ratios of Neu and Eos in induced sputum were significantly correlated with the proportion of corresponding cells in peripheral blood (P There was no correlation between the ratio of Lym and Leu in induced sputum and corresponding cells in peripheral blood (P > 0.05). In patients with AECOPD, the tendency of Neu and Eos in induced sputum was consistent with the corresponding cells in peripheral blood. Neu and Eos in induced sputum and peripheral blood reflected the degree of inflammation to guide the individualized medication of patients.
{"title":"Correlation of Inflammatory Cells in Induced Sputum and Peripheral Blood of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease","authors":"Xin Wang, Di Wu, Yanmei Wu, Hongyan Liu, Wang Ying, Chunmei Yun, D. Sun, Gao Xiaoyu","doi":"10.4236/ojrd.2021.113010","DOIUrl":"https://doi.org/10.4236/ojrd.2021.113010","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a major chronic respiratory disease worldwide. Inflammatory \u0000cells reflect the inflammatory situation both in \u0000peripheral blood and induced sputum. Their correlation has not been reported. The correlation between \u0000neutrophils (Neu), eosinophils (Eos), and lymphocyte (Lym) in induced sputum \u0000and that in peripheral blood of COPD patients \u0000was evaluated to explore \u0000the consistency of inflammatory cells in peripheral blood \u0000and induced sputum. Peripheral blood and induced sputum were collected from 437 patients \u0000with acute exacerbation of COPD (AECOPD) who \u0000were hospitalized in the Department of respiratory and critical care medicine, \u0000Inner Mongolia People’s Hospital. The correlation \u0000analysis was performed by Spearman correlation analysis. The \u0000ratios of Neu, \u0000Eos, and Lym in induced sputum were (79.15 ± 22.60)%, (5.23 ± 12.74)%, and \u0000(1.69 ± 2.66)%. The ratios of Neu, Eos, and Lym in peripheral blood were (63.29 ± 11.44)%, (2.99 ± 3.60)%, and (25.16 ± 10.19)%. The results \u0000showed that the ratios of Neu and Eos in induced sputum were significantly \u0000correlated with the proportion of corresponding cells in peripheral blood (P There was no correlation between the ratio of \u0000Lym and Leu in induced sputum and corresponding cells in peripheral \u0000blood (P > 0.05). In patients with AECOPD, the \u0000tendency of Neu and Eos in induced sputum was consistent with the \u0000corresponding cells in peripheral blood. Neu and Eos in induced \u0000sputum and peripheral blood reflected the degree of inflammation to \u0000guide the individualized medication of patients.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43023617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-03DOI: 10.4236/ojrd.2020.102004
P. Houngbégnon, H. Lawin, M. Kedote, Affoussatou Amadou, E. Atindégla, B. Fayomi, S. Dossou-Gbété, V. Agueh
Objective: Air pollution is becoming one of the public concerns requiring urgent feasible response per local context. Defining accurately the level of exposure of outdoor air pollution effect on health of venders working along main roads and roundabouts with high traffic is important. This study was conducted to assess respiratory health risks on venders associated with different geographical positions in Cotonou. Methods: A cross-sectional study was conducted along the main road with high traffic including three roundabouts in Cotonou. The 194 study participants from all shops, one respondent per shop, were given a unique GPS data associated to indicate the shop’s geographical position. The study employed validated questionnaire on respiratory symptoms. Results: Study participants had mean age of 36.26 (±11.65) years with sex ratio of (M/F) 1.8. Majority (72.7%) of study participates reported to have at least one respiratory symptom and 69% of them were working in non-ventilated rooms. The proportion of having at least one respiratory symptom was significantly different (p < 0.001) between the subpopulations at roundabouts (96.15%) and apart from the roundabouts (64.08%). The most reported symptoms were cough (47.94%) and itchy nose (42.27%). The risk of cough (OR = 5.15; 95% CI = [2.21 - 12.04]; p < 0.001) and itchy nose symptoms (OR = 3.44; 95% CI = [1.55 - 7.63]; p = 0.002) were higher in individuals working at the roundabouts compared to those working along the main road. Conclusion: Working in roundabout is associated with more respiratory symptoms than working in shops along main road. Air pollution mitigation efforts should focus in such settings, taking into account the sub-population of workers in resource limited countries.
{"title":"Respiratory Symptoms Associated with Workplaces Located along a Road with High-Traffic at Cotonou, Benin","authors":"P. Houngbégnon, H. Lawin, M. Kedote, Affoussatou Amadou, E. Atindégla, B. Fayomi, S. Dossou-Gbété, V. Agueh","doi":"10.4236/ojrd.2020.102004","DOIUrl":"https://doi.org/10.4236/ojrd.2020.102004","url":null,"abstract":"Objective: Air pollution is becoming one of the public concerns requiring urgent feasible response per local context. Defining accurately the level of exposure of outdoor air pollution effect on health of venders working along main roads and roundabouts with high traffic is important. This study was conducted to assess respiratory health risks on venders associated with different geographical positions in Cotonou. Methods: A cross-sectional study was conducted along the main road with high traffic including three roundabouts in Cotonou. The 194 study participants from all shops, one respondent per shop, were given a unique GPS data associated to indicate the shop’s geographical position. The study employed validated questionnaire on respiratory symptoms. Results: Study participants had mean age of 36.26 (±11.65) years with sex ratio of (M/F) 1.8. Majority (72.7%) of study participates reported to have at least one respiratory symptom and 69% of them were working in non-ventilated rooms. The proportion of having at least one respiratory symptom was significantly different (p < 0.001) between the subpopulations at roundabouts (96.15%) and apart from the roundabouts (64.08%). The most reported symptoms were cough (47.94%) and itchy nose (42.27%). The risk of cough (OR = 5.15; 95% CI = [2.21 - 12.04]; p < 0.001) and itchy nose symptoms (OR = 3.44; 95% CI = [1.55 - 7.63]; p = 0.002) were higher in individuals working at the roundabouts compared to those working along the main road. Conclusion: Working in roundabout is associated with more respiratory symptoms than working in shops along main road. Air pollution mitigation efforts should focus in such settings, taking into account the sub-population of workers in resource limited countries.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46364368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Abumossalam, T. Abdelgawad, Mohammed Abdelhalim Shendi, Mohammed Awadallah
Background: Smoking cessation has been long considered a sole precautionary mode of respiratory disability in both developed and developing countries. Aim of Work: our study aims to assess the impact of smoking cessation on clinical features as well as pulmonary functional measurement and exhaled CO level in ex-smokers. Patients and Methods: This observational cross sectional study was conducted on 306 subjects who were attending to outpatient pulmonology clinic in Center of medical services in Taibah University at Al-Medina Al-Munwara, Kingdom of Saudi. Subjects included in this study were selected as being ex-smoker for more than 6 months. They were classified according to the duration of smoking cessation into a) recent smoking quitter (stopped smoking ≤2 years) and; b) remote smoking quitter (stopped smoking >2 years). They were subjected to clinical evaluation, spirometry and exhaled CO level measurement in exhaled air. Results: All clinical features including cough, dyspnea, chest pain, hemoptysis, wheezes, hospitalization and relapse in both recent quitter and remote quitter subjects were statistically comparable but without statistical significant difference. There was statistical positive correlation between duration of smoking cessation and actual FEV1, actual FVC, actual PEFR, actual TLC, functional defect FEV1, functional defect of FVC, functional defect of PEFR and functional defect of TLC while statistical negative correlation was with CO exhaled level. Conclusion: Smoking cessation demonstrated an appreciated role in recovering patient clinical as well as pulmonary functional and gaseous characters towards healthy side.
{"title":"Recovery after Ordeal: Respiratory Alterations Linked to Quitting Smoking","authors":"A. Abumossalam, T. Abdelgawad, Mohammed Abdelhalim Shendi, Mohammed Awadallah","doi":"10.4236/ojrd.2019.94011","DOIUrl":"https://doi.org/10.4236/ojrd.2019.94011","url":null,"abstract":"Background: Smoking cessation has been long considered a sole precautionary mode of respiratory disability in both developed and developing countries. Aim of Work: our study aims to assess the impact of smoking cessation on clinical features as well as pulmonary functional measurement and exhaled CO level in ex-smokers. Patients and Methods: This observational cross sectional study was conducted on 306 subjects who were attending to outpatient pulmonology clinic in Center of medical services in Taibah University at Al-Medina Al-Munwara, Kingdom of Saudi. Subjects included in this study were selected as being ex-smoker for more than 6 months. They were classified according to the duration of smoking cessation into a) recent smoking quitter (stopped smoking ≤2 years) and; b) remote smoking quitter (stopped smoking >2 years). They were subjected to clinical evaluation, spirometry and exhaled CO level measurement in exhaled air. Results: All clinical features including cough, dyspnea, chest pain, hemoptysis, wheezes, hospitalization and relapse in both recent quitter and remote quitter subjects were statistically comparable but without statistical significant difference. There was statistical positive correlation between duration of smoking cessation and actual FEV1, actual FVC, actual PEFR, actual TLC, functional defect FEV1, functional defect of FVC, functional defect of PEFR and functional defect of TLC while statistical negative correlation was with CO exhaled level. Conclusion: Smoking cessation demonstrated an appreciated role in recovering patient clinical as well as pulmonary functional and gaseous characters towards healthy side.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46595644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Gharsalli, M. Attia, Sawssen Hantous-Zannad, I. Sahnoun, S. Maȃlej, L. Gharbi, H. Neji, K. B. Miled-M’rad
Introduction: The high resolution computed tomography (HRCT) is an important part in the diagnostic approach of interstitial lung disease (ILD) associated with connective tissue diseases (CTD) by providing detailed information on the elementary lesion and the radiological pattern of ILD. Aim: to point out the role of HRCT in the diagnosis of ILD associated with CTD (ILD-CTD). Methods: A Retrospective descriptive study was conducted between 2008 and 2017. Data of 24 patients presenting ILD-CTD were collected. A review of HRCT was performed by a radiologist without knowledge of the CTD. Results: Predominant elementary lesion of ILD associated with dermatomyositis (9 cases) was ground glass opacity (n = 9) followed by consolidation (n = 6). Non Specific Interstitial Pneumonia (NSIP) was the most reported pattern (5 cases). Ground glass opacity was also the predominant elementary lesion for the 2 cases of scleroderma and in Sjögren’s syndrome (4 cases/5). NSIP was the predominant radiological presentation in these two CTD. Lymphoid interstitial pneumonia revealed Sjögren’s syndrome in one case. In rheumatoid arthritis (6 cases), the elementary HRCT lesions were irregular interlobular septal thickening (n = 4) and honeycombing (n = 4) consistent with Usual Interstitial Pneumonia (UIP) in 2 cases. Similarly UIP has been described for the 2 patients with lupus and mixed connective tissue disease. Conclusion: HRCT plays an important role in the management of ILD-CTD. Description of the HRCT elementary lesions and the radiological pattern of ILD can be helpful for CTD’s diagnosis.
{"title":"Interstitial Lung Diseases Associated with Connective Tissue Pathologies: Radiologic Features","authors":"H. Gharsalli, M. Attia, Sawssen Hantous-Zannad, I. Sahnoun, S. Maȃlej, L. Gharbi, H. Neji, K. B. Miled-M’rad","doi":"10.4236/ojrd.2019.94010","DOIUrl":"https://doi.org/10.4236/ojrd.2019.94010","url":null,"abstract":"Introduction: The high resolution computed tomography (HRCT) is an important part in the diagnostic approach of interstitial lung disease (ILD) associated with connective tissue diseases (CTD) by providing detailed information on the elementary lesion and the radiological pattern of ILD. Aim: to point out the role of HRCT in the diagnosis of ILD associated with CTD (ILD-CTD). Methods: A Retrospective descriptive study was conducted between 2008 and 2017. Data of 24 patients presenting ILD-CTD were collected. A review of HRCT was performed by a radiologist without knowledge of the CTD. Results: Predominant elementary lesion of ILD associated with dermatomyositis (9 cases) was ground glass opacity (n = 9) followed by consolidation (n = 6). Non Specific Interstitial Pneumonia (NSIP) was the most reported pattern (5 cases). Ground glass opacity was also the predominant elementary lesion for the 2 cases of scleroderma and in Sjögren’s syndrome (4 cases/5). NSIP was the predominant radiological presentation in these two CTD. Lymphoid interstitial pneumonia revealed Sjögren’s syndrome in one case. In rheumatoid arthritis (6 cases), the elementary HRCT lesions were irregular interlobular septal thickening (n = 4) and honeycombing (n = 4) consistent with Usual Interstitial Pneumonia (UIP) in 2 cases. Similarly UIP has been described for the 2 patients with lupus and mixed connective tissue disease. Conclusion: HRCT plays an important role in the management of ILD-CTD. Description of the HRCT elementary lesions and the radiological pattern of ILD can be helpful for CTD’s diagnosis.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70583962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pattern of Acute Asthma Seen in Children Emergency Department of the River State University Teaching Hospital Portharcourt Nigeria
尼日利亚Portharcourt河州立大学教学医院儿童急诊科急性哮喘的模式
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B. H. M. Ngahane, F. Kamdem, S. R. S. Njonnou, Nina Chebou, A. Dzudie, Serge Arnold Ebongue, B. Tengang, F. K. Lekpa, Yacouba Mapoure Njankouo, S. Mouliom, Henri Ngoté, H. L. Namme
Background: Venous thromboembolic (VTE) disease burden is increasing worldwide, representing a major cause of cardiovascular death and public health problem. Pulmonary embolism (PE) is the most serious clinical presentation of VTE. Epidemiological and clinical data on PE are still lacking in Africa, particularly in Cameroon. This study aimed at determining the clinical features as well as imaging presentation and outcome of pulmonary embolism. Methods: A cross-sectional study was carried out in three hospitals in Douala. We retrospectively reviewed patient records admitted for PE from January 2009 to May 2017. We collected data on epidemiology, clinical presentation, venous Doppler/pulmonary computed tomographic angiography (CTA), and outcome. Results: We included 103 patients (56 males) with PE. Their median age was 52 years. The main risk factors were obesity (49.5%), hypertension (35.0%), long trip (24.3%) and cancer (18.4%). The most frequent clinical presentations were dyspnoea (83.4%), chest pain (78.6%), and cough (40.8%). Additionally, pleural effusion (32.8%), atelectasis (25.7%) and pulmonary hyperlucency (20.0%) were the most frequent findings on chest X-ray. The main abnormalities found in electrocardiogram were sinus tachycardia (63.4%), S1Q3T3 aspect (37.6%) and right axial deviation (28.7%). Moreover, right cavities dilatation (26.0%), pulmonary artery hypertension (35.0%) and pulmonary artery dilatation (21.0%) were the main echocardiographic findings. Low-molecular-weight heparin (LMWH) was the initial anticoagulant in all cases. There were 19 (18.4%) in-hospital deaths, and the mean hospital stay was 8.5 ± 5 days. Conclusion: PE is not rare in our setting. Obesity, long trip and cancer are the main risk factors, while dyspnoea, chest pain and respiratory distress are the main clinical presentation for PE. LMWH remains the therapeutic agent of choice. Lastly, in-hospital mortality is very high.
{"title":"Epidemiology, Clinical and Paraclinical Presentations of Pulmonary Embolism: A Cross-Sectional Study in a Sub-Saharan Africa Setting","authors":"B. H. M. Ngahane, F. Kamdem, S. R. S. Njonnou, Nina Chebou, A. Dzudie, Serge Arnold Ebongue, B. Tengang, F. K. Lekpa, Yacouba Mapoure Njankouo, S. Mouliom, Henri Ngoté, H. L. Namme","doi":"10.4236/OJRD.2019.93008","DOIUrl":"https://doi.org/10.4236/OJRD.2019.93008","url":null,"abstract":"Background: Venous thromboembolic (VTE) disease burden is increasing worldwide, representing a major cause of cardiovascular death and public health problem. Pulmonary embolism (PE) is the most serious clinical presentation of VTE. Epidemiological and clinical data on PE are still lacking in Africa, particularly in Cameroon. This study aimed at determining the clinical features as well as imaging presentation and outcome of pulmonary embolism. Methods: A cross-sectional study was carried out in three hospitals in Douala. We retrospectively reviewed patient records admitted for PE from January 2009 to May 2017. We collected data on epidemiology, clinical presentation, venous Doppler/pulmonary computed tomographic angiography (CTA), and outcome. Results: We included 103 patients (56 males) with PE. Their median age was 52 years. The main risk factors were obesity (49.5%), hypertension (35.0%), long trip (24.3%) and cancer (18.4%). The most frequent clinical presentations were dyspnoea (83.4%), chest pain (78.6%), and cough (40.8%). Additionally, pleural effusion (32.8%), atelectasis (25.7%) and pulmonary hyperlucency (20.0%) were the most frequent findings on chest X-ray. The main abnormalities found in electrocardiogram were sinus tachycardia (63.4%), S1Q3T3 aspect (37.6%) and right axial deviation (28.7%). Moreover, right cavities dilatation (26.0%), pulmonary artery hypertension (35.0%) and pulmonary artery dilatation (21.0%) were the main echocardiographic findings. Low-molecular-weight heparin (LMWH) was the initial anticoagulant in all cases. There were 19 (18.4%) in-hospital deaths, and the mean hospital stay was 8.5 ± 5 days. Conclusion: PE is not rare in our setting. Obesity, long trip and cancer are the main risk factors, while dyspnoea, chest pain and respiratory distress are the main clinical presentation for PE. LMWH remains the therapeutic agent of choice. Lastly, in-hospital mortality is very high.","PeriodicalId":58512,"journal":{"name":"呼吸病期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43528430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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