{"title":"EGFR-targeted photosensitizer-peptide conjugates (Conference Presentation)","authors":"M. Vicente","doi":"10.1117/12.2528197","DOIUrl":"https://doi.org/10.1117/12.2528197","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82188727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How important are the contact-dependent reactions to the outcome of PDT? (Conference Presentation)","authors":"M. Baptista, Thiago T Tasso","doi":"10.1117/12.2526157","DOIUrl":"https://doi.org/10.1117/12.2526157","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85074551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global opportunities for PDT (Conference Presentation)","authors":"C. Hopper","doi":"10.1117/12.2525579","DOIUrl":"https://doi.org/10.1117/12.2525579","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90375649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. LaRochelle, Alberto J. Ruiz, R. E. LeBlanc, E. Maytin, T. Hasan, M. Chapman, B. Pogue
{"title":"Weather forecast and light-tissue model based dose planning for daylight PpIX-photodynamic therapy of skin (Conference Presentation)","authors":"E. LaRochelle, Alberto J. Ruiz, R. E. LeBlanc, E. Maytin, T. Hasan, M. Chapman, B. Pogue","doi":"10.1117/12.2525434","DOIUrl":"https://doi.org/10.1117/12.2525434","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81402947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The potential of phytotherapeutic compounds available on the market as a new photosensitizers for dental antimicrobial PDT: a photochemical and photobiological in vitro study (Conference Presentation)","authors":"A. Garcez, E. Nardini, R. Cardoso, M. Ribeiro","doi":"10.1117/12.2525257","DOIUrl":"https://doi.org/10.1117/12.2525257","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76687879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas A. Shell, Jennifer R. Shell, Colter G. Sheveland, Dillon C. Zites
{"title":"Near infrared light-mediated delivery of anticancer agents (Conference Presentation)","authors":"Thomas A. Shell, Jennifer R. Shell, Colter G. Sheveland, Dillon C. Zites","doi":"10.1117/12.2528271","DOIUrl":"https://doi.org/10.1117/12.2528271","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"302 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79680128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Berg, A. S. Fremstedal, Anette Weyergang, J. Gołąb, O. Norum
{"title":"Photochemical internalization (PCI) of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity (Conference Presentation)","authors":"K. Berg, A. S. Fremstedal, Anette Weyergang, J. Gołąb, O. Norum","doi":"10.1117/12.2526088","DOIUrl":"https://doi.org/10.1117/12.2526088","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72737517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Lilge, C. McFadden, K. Ramadan, Zhangcheng Zheng, Fynn Schwiegelshohn, Vaughn Betz, M. Cypel
While the prevalence of central bronchial tumours is declining, that of peripheral lung tumours is increasing. Peripheral lung tumours present either as individual index lesion or as field cancerization, requiring for the former targeting of particular confined volumes of lung tissue versus a therapy for an entire lung or particular lobes thereof. Using FullMonte, a Monte Carlo code; the ability to achieve a tumour selective PDT by transbronchial light source placement was simulated for 525, 665 and 808 nm wavelength. Simulations were executed utilizing in silica models with up to 10 generations of the bronchial tree, tissue photosensitizer concentrations taken from literature or measure in preclinical model systems and tissue optical properties measured with alive ex vivo pig and human lungs perfused with either blood or a transparent low cellular (STEEN) fluid. The measured effective attenuation coefficients [cm-1] at the three wavelengths for ventilated lungs with either blood 1.26±1.07, 1.93±0.534, 1.09±0.93 or STEEN fluid 1.01±0.873, 0.901±0.318, 0.641±0.31 used as perfusate. When modelling the PDT dose distribution in the lung’s the bronchial air ducts up to the eight generations perturb the fluence considerably. In all simulations, a dose sufficient to cause necrosis in 98% of the target volume placement of 3 source fibres albeit with various extent of normal lung tumour damage. Full coverage of an entire lung lobe with only three source fibres placed does not provide for effective coverage of the diffuse disease unless a very high selective uptake of the photosensitizer in malignant tissues can be achieved.
{"title":"Modelling novel PDT approaches to target peripheral lung cancers (Conference Presentation)","authors":"L. Lilge, C. McFadden, K. Ramadan, Zhangcheng Zheng, Fynn Schwiegelshohn, Vaughn Betz, M. Cypel","doi":"10.1117/12.2526056","DOIUrl":"https://doi.org/10.1117/12.2526056","url":null,"abstract":"While the prevalence of central bronchial tumours is declining, that of peripheral lung tumours is increasing. Peripheral lung tumours present either as individual index lesion or as field cancerization, requiring for the former targeting of particular confined volumes of lung tissue versus a therapy for an entire lung or particular lobes thereof. Using FullMonte, a Monte Carlo code; the ability to achieve a tumour selective PDT by transbronchial light source placement was simulated for 525, 665 and 808 nm wavelength. Simulations were executed utilizing in silica models with up to 10 generations of the bronchial tree, tissue photosensitizer concentrations taken from literature or measure in preclinical model systems and tissue optical properties measured with alive ex vivo pig and human lungs perfused with either blood or a transparent low cellular (STEEN) fluid. \u0000The measured effective attenuation coefficients [cm-1] at the three wavelengths for ventilated lungs with either blood 1.26±1.07, 1.93±0.534, 1.09±0.93 or STEEN fluid 1.01±0.873, 0.901±0.318, 0.641±0.31 used as perfusate. When modelling the PDT dose distribution in the lung’s the bronchial air ducts up to the eight generations perturb the fluence considerably. \u0000In all simulations, a dose sufficient to cause necrosis in 98% of the target volume placement of 3 source fibres albeit with various extent of normal lung tumour damage. Full coverage of an entire lung lobe with only three source fibres placed does not provide for effective coverage of the diffuse disease unless a very high selective uptake of the photosensitizer in malignant tissues can be achieved.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79522081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite tremendous progress in biomedical science, the number of reported food-borne diseases continues to rise. Health experts estimate that every year food-borne illnesses in USA cost 86 billion dollars. Obviously, existing antibacterial technologies for microbial control of foods are not enough effective. Photosensitization is a treatment involving the interaction of the two non-toxic factors, photosensitizer and light, which in the presence of oxygen results in the destruction of the target cell without leakage of harmful by-products in the environment. According to our results, chlorophyllin (food additive E140) exhibits perfect photosensitizing properties. After excitation with light (405 nm) it inactivates food pathogens, their spores and biofilms, yeasts/microfungi. ROS-induced oxidative stress and following membrane damage was the main reason of photosensitization- based inactivation of microorganisms. Afterwards we applied photosensitization for microbial control of fresh produce. Obtained results indicate that this treatment significantly (2-3 log CFU/g) reduces microbial load on fruits (strawberries, apricots, plums), vegetables (cauliflower, cucumber, lettuce, basil) and sprouts without thermal effects on food matrix. Moreover, this treatment extended the shelf-life of treated produce by 2-4 days what is economically very important. No reduction of nutritional value (antioxidant activity, chlorophyll content) or organoleptic properties (color, texture, taste) of treated produce has been observed. In order to decontaminate fresh produce from Gram (+) and Gram (-) pathogens in uniform way, chlorophyllin was conjugated with chitosan. Obtained data reveal that such photoactivated conjugate is very effective against all pathogens and can be applied for coating of fresh produce. Therefore, a photosensitization phenomenon might open a new avenue for the development of non-thermal, effective and ecologically friendly antimicrobial technology for preservation of fresh produce.
{"title":"Chlorophyllin-based photosensitization for microbial control of fresh produce (Conference Presentation)","authors":"Ž. Lukšienė","doi":"10.1117/12.2525570","DOIUrl":"https://doi.org/10.1117/12.2525570","url":null,"abstract":"Despite tremendous progress in biomedical science, the number of reported food-borne diseases continues to rise. Health experts estimate that every year food-borne illnesses in USA cost 86 billion dollars. Obviously, existing antibacterial technologies for microbial control of foods are not enough effective.\u0000Photosensitization is a treatment involving the interaction of the two non-toxic factors, photosensitizer and light, which in the presence of oxygen results in the destruction of the target cell without leakage of harmful by-products in the environment. \u0000According to our results, chlorophyllin (food additive E140) exhibits perfect photosensitizing properties. After excitation with light (405 nm) it inactivates food pathogens, their spores and biofilms, yeasts/microfungi. ROS-induced oxidative stress and following membrane damage was the main reason of photosensitization- based inactivation of microorganisms. \u0000Afterwards we applied photosensitization for microbial control of fresh produce. Obtained results indicate that this treatment significantly (2-3 log CFU/g) reduces microbial load on fruits (strawberries, apricots, plums), vegetables (cauliflower, cucumber, lettuce, basil) and sprouts without thermal effects on food matrix. Moreover, this treatment extended the shelf-life of treated produce by 2-4 days what is economically very important. No reduction of nutritional value (antioxidant activity, chlorophyll content) or organoleptic properties (color, texture, taste) of treated produce has been observed.\u0000In order to decontaminate fresh produce from Gram (+) and Gram (-) pathogens in uniform way, chlorophyllin was conjugated with chitosan. Obtained data reveal that such photoactivated conjugate is very effective against all pathogens and can be applied for coating of fresh produce.\u0000Therefore, a photosensitization phenomenon might open a new avenue for the development of non-thermal, effective and ecologically friendly antimicrobial technology for preservation of fresh produce.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76492733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Banerjee, S. E. Sheikh, A. Malhotra, S. Mosse, S. Parker, N. Williams, S. Macrobert, R. Hamoudi, S. Bown, M. Keshtgar
Primary breast cancer while increasing in incidence has been successfully treated with a combination of surgery and adjuvant therapies in the majority of patients. Novel treatments for primary breast cancer need to show additional benefits to existing treatments with equivalent or improved efficacy for niche groups. Photodynamic therapy (PDT) is a potential novel treatment and a Phase I/IIA, open label, non-randomised, single site trial of photodynamic therapy for the treatment of primary breast cancer was conducted. The primary aim was to identify the light dose required for 12 mm of tumour necrosis (or a plateau of necrosis) assessed by histopathology. Post-dose MRI correlation with histopathology findings in treated tumours and in normal breast tissue was sought. In addition adverse events were recorded and comparison of outcome made with matched controls. Results of the first human clinical trial with 12 patients with median follow-up of 39 months showed PDT was well tolerated, with no adverse effects and comparable outcome to control populations. Tumour necrosis increased with incremental increases in light dose, however some patients showed a poor response even at the highest light dose. Analysis suggests that there may be predictive factors for good and poor response. PDT in primary breast cancer requires further investigation to identify which patients would most benefit from this therapy.
{"title":"Photodynamic therapy in primary breast cancer: the first human study (Conference Presentation)","authors":"S. Banerjee, S. E. Sheikh, A. Malhotra, S. Mosse, S. Parker, N. Williams, S. Macrobert, R. Hamoudi, S. Bown, M. Keshtgar","doi":"10.1117/12.2525480","DOIUrl":"https://doi.org/10.1117/12.2525480","url":null,"abstract":"Primary breast cancer while increasing in incidence has been successfully treated with a combination of surgery and adjuvant therapies in the majority of patients. Novel treatments for primary breast cancer need to show additional benefits to existing treatments with equivalent or improved efficacy for niche groups. Photodynamic therapy (PDT) is a potential novel treatment and a Phase I/IIA, open label, non-randomised, single site trial of photodynamic therapy for the treatment of primary breast cancer was conducted. The primary aim was to identify the light dose required for 12 mm of tumour necrosis (or a plateau of necrosis) assessed by histopathology. Post-dose MRI correlation with histopathology findings in treated tumours and in normal breast tissue was sought. In addition adverse events were recorded and comparison of outcome made with matched controls. Results of the first human clinical trial with 12 patients with median follow-up of 39 months showed PDT was well tolerated, with no adverse effects and comparable outcome to control populations. Tumour necrosis increased with incremental increases in light dose, however some patients showed a poor response even at the highest light dose. Analysis suggests that there may be predictive factors for good and poor response. PDT in primary breast cancer requires further investigation to identify which patients would most benefit from this therapy.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78287380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：