{"title":"Front Matter: Volume 11070","authors":"T. Hasan","doi":"10.1117/12.2549385","DOIUrl":"https://doi.org/10.1117/12.2549385","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89439558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Zhu, Michele M. Kim, Y. Ong, A. Dimofte, S. Singhal, K. Cengel
Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. We have developed an improved model for direct light calculation that accounts for the anisotropy of the light from the light sources. A comprehensive analysis of the distribution of light fluence during HPPH and Photofrin PDT is presented in clinical cases and the improvements between the two protocol are discussed.
{"title":"Light distribution monitoring using an IR navigation system for pleural PDT (Conference Presentation)","authors":"T. Zhu, Michele M. Kim, Y. Ong, A. Dimofte, S. Singhal, K. Cengel","doi":"10.1117/12.2527789","DOIUrl":"https://doi.org/10.1117/12.2527789","url":null,"abstract":"Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. We have developed an improved model for direct light calculation that accounts for the anisotropy of the light from the light sources. A comprehensive analysis of the distribution of light fluence during HPPH and Photofrin PDT is presented in clinical cases and the improvements between the two protocol are discussed.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81501713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tom Dougherty and the FDA approval of PDT photosensitizers (Conference Presentation)","authors":"S. Marcus","doi":"10.1117/12.2541578","DOIUrl":"https://doi.org/10.1117/12.2541578","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76525817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Much more than an impactful cancer scientist: Tom Dougherty as a graduate student advisor, mentor, advocate, and friend (Conference Presentation)","authors":"C. Gomer","doi":"10.1117/12.2536232","DOIUrl":"https://doi.org/10.1117/12.2536232","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88236097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We will discuss product target profiles that photosensitizers for PDT should met to satisfy the requirements of clinical PDT. Next, we will review the spectroscopy and photochemistry of the main families of photosensitizers with an impact in clinical PDT. We will critically examine the factors that made such photosensitizers appealing for PDT and their shortcomings. Finally, an overview of opportunities ahead will be presented. Topics addressed – The phototherapeutic window – Electronic spectroscopy of porphyrin derivatives, phthalocyanines and BODIPYs – Photochemistry and ROS – Factors contributing to the performance of PDT sensitizers
{"title":"Photosensitizers and photochemistry (Conference Presentation)","authors":"L. Arnaut","doi":"10.1117/12.2536227","DOIUrl":"https://doi.org/10.1117/12.2536227","url":null,"abstract":"We will discuss product target profiles that photosensitizers for PDT should met to satisfy the requirements of clinical PDT. Next, we will review the spectroscopy and photochemistry of the main families of photosensitizers with an impact in clinical PDT. We will critically examine the factors that made such photosensitizers appealing for PDT and their shortcomings. Finally, an overview of opportunities ahead will be presented.\u0000 \u0000Topics addressed\u0000 – The phototherapeutic window\u0000 – Electronic spectroscopy of porphyrin derivatives, phthalocyanines and BODIPYs\u0000 – Photochemistry and ROS\u0000 – Factors contributing to the performance of PDT sensitizers","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73597899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraoperative photodynamic therapy of glioblastoma: the Japanese experience (Conference Presentation)","authors":"Y. Muragaki","doi":"10.1117/12.2536242","DOIUrl":"https://doi.org/10.1117/12.2536242","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86475042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To understand the origin of life on Earth, and to evaluate the potential for life on exoplanets, we must understand the pathways that lead from chemistry to biology. Recent experiments suggest that a chemically rich environment that provides the building blocks of membranes, nucleic acids and peptides, along with sources of chemical energy, could result in the emergence of replicating, evolving cells. Diverse photochemical processes are thought to have been important for the origin of life, from photochemical steps in prebiotic synthetic pathways, to the generation of useful forms of chemical energy, to the selection of the canonical nucleotides based on their photostability. I will discuss the many ways in which UV light may have influenced the origin of life.
{"title":"Photochemistry and the origin of life (Conference Presentation)","authors":"J. Szostak","doi":"10.1117/12.2534140","DOIUrl":"https://doi.org/10.1117/12.2534140","url":null,"abstract":"To understand the origin of life on Earth, and to evaluate the potential for life on exoplanets, we must understand the pathways that lead from chemistry to biology. Recent experiments suggest that a chemically rich environment that provides the building blocks of membranes, nucleic acids and peptides, along with sources of chemical energy, could result in the emergence of replicating, evolving cells. Diverse photochemical processes are thought to have been important for the origin of life, from photochemical steps in prebiotic synthetic pathways, to the generation of useful forms of chemical energy, to the selection of the canonical nucleotides based on their photostability. I will discuss the many ways in which UV light may have influenced the origin of life.","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73290259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-invasive skin evaluation for assessing treatment efficacy of port-wine stains (Conference Presentation)","authors":"Xian-Zhou Jiang","doi":"10.1117/12.2525292","DOIUrl":"https://doi.org/10.1117/12.2525292","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74596240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Azaïs, M. Baydoun, C. Rebahi, O. Moralès, C. Frochot, L. Colombeau, B. Leroux, E. Thecua, N. Delhem, P. Collinet, S. Mordon
{"title":"Treatment of peritoneal carcinomatosis of various origins by photodynamic therapy: state of the art (Conference Presentation)","authors":"H. Azaïs, M. Baydoun, C. Rebahi, O. Moralès, C. Frochot, L. Colombeau, B. Leroux, E. Thecua, N. Delhem, P. Collinet, S. Mordon","doi":"10.1117/12.2526638","DOIUrl":"https://doi.org/10.1117/12.2526638","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74885571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunology and PDT: how a fantastic mentor encouraged expansion of PDT (Conference Presentation)","authors":"S. Gollnick","doi":"10.1117/12.2525740","DOIUrl":"https://doi.org/10.1117/12.2525740","url":null,"abstract":"","PeriodicalId":6365,"journal":{"name":"17th International Photodynamic Association World Congress","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80206166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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