Objective: Discussion and analysis of the effect of the early application of Tirofiban on acute ischemic stroke (AIS) after intravenous thrombolysis with urokinase. Method: The subjects of this study are 40 patients with AIS admitted at the Yibin Fourth People’s Hospital, of which were computer-randomized into a control group (20 cases, with regular urokinase intravenous thrombolysis therapy) and a research group (20 cases, combined with early Tirofiban treatment) from January 2018 to December 2022. The intervention outcomes between these two groups were compared and analyzed. Result: The blood platelet-related parameters before treatment had no statistical difference between the two groups (P > 0.05), but the research group was higher than that of the control group after treatment (P < 0.05). The Barthel index before treatment in both groups had no statistical difference (P > 0.05), but the research group was higher than that of the control group after treatment (P < 0.05). Conclusion: Early Tirofiban treatment for patients with AIS after intravenous thrombolysis with urokinase could effectively regulate the blood platelet-related parameters, hence improving treatment benefits and living capacity for patients, with definite clinical benefits.
{"title":"The Effect of the Early Application of Tirofiban on Acute Ischemic Stroke (AIS) after Intravenous Thrombolysis with Urokinase","authors":"Mingfen Li","doi":"10.26689/jcnr.v7i4.5123","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5123","url":null,"abstract":"Objective: Discussion and analysis of the effect of the early application of Tirofiban on acute ischemic stroke (AIS) after intravenous thrombolysis with urokinase. Method: The subjects of this study are 40 patients with AIS admitted at the Yibin Fourth People’s Hospital, of which were computer-randomized into a control group (20 cases, with regular urokinase intravenous thrombolysis therapy) and a research group (20 cases, combined with early Tirofiban treatment) from January 2018 to December 2022. The intervention outcomes between these two groups were compared and analyzed. Result: The blood platelet-related parameters before treatment had no statistical difference between the two groups (P > 0.05), but the research group was higher than that of the control group after treatment (P < 0.05). The Barthel index before treatment in both groups had no statistical difference (P > 0.05), but the research group was higher than that of the control group after treatment (P < 0.05). Conclusion: Early Tirofiban treatment for patients with AIS after intravenous thrombolysis with urokinase could effectively regulate the blood platelet-related parameters, hence improving treatment benefits and living capacity for patients, with definite clinical benefits.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45892800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: A meta-analysis was conducted to systematically evaluate the effect of the escape room teaching method on nursing education. Methods: We searched PubMed, Medline, Web of Science, CNKI, VIP, and Wanfang databases, with a search time frame from the first day of database establishment to October 2022. Two researchers evaluated the quality of the obtained literature and extracted the data. The RevMan5.4 software was used for meta-analysis. Results: A total of 7 studies involving 1487 nursing students were included. Compared with the control group, the escape room teaching method improved the professional performance of nursing students [standardized mean difference (SMD) = 0.98, 95% confidence interval (CI; 0.38,1.59), P < 0.0001]. The critical thinking ability of nursing students was enhanced [mean difference (MD) = 12.64, 95% CI (7.91,17.37), P < 0.0001], and the investment level of nursing students in learning was improved [MD = 4.18, 95% CI (1.74,6.62), P < 0.0001]. Conclusion: The escape room teaching method can improve nursing students’ professional performance, critical thinking ability, and learning engagement level. There is no significant difference in the impact of nursing teaching satisfaction, and there is still a lack of data support. This paper is limited by the quality and quantity of included literature, and more high-quality studies are still needed to further demonstrate the above conclusions.
目的：采用荟萃分析方法，系统评价逃生室教学法在护理教育中的效果。方法：检索PubMed、Medline、Web of Science、CNKI、VIP和万方数据库，检索时间为数据库建立第一天至2022年10月。两名研究人员评估了获得的文献的质量，并提取了数据。采用RevMan5.4软件进行荟萃分析。结果：共纳入7项研究，涉及1487名护生。与对照组相比，逃生室教学法提高了护生的专业表现[标准化平均差（SMD）=0.98，95%置信区间（CI；0.38,1.59），P<0.001]。护生的批判性思维能力增强[平均差（MD）=12.64，95%CI（7.91,17.37），P<0.0001]，并提高了护生的学习投入水平[MD=4.18，95%CI（1.74,6.62），P<0.0001]。结论：逃生室教学法能提高护生的专业表现、批判性思维能力和学习参与水平。对护理教学满意度的影响没有显著差异，仍缺乏数据支持。本文受限于收录文献的质量和数量，还需要更多高质量的研究来进一步论证上述结论。
{"title":"Meta-Analysis of the Effect of the Escape Room Teaching Method on Nursing Education","authors":"Xing Yang, Yuying Hao, Shanhong Fan, Lina Zhang, Rui Song, Jie Liu, Mei-juan Bian","doi":"10.26689/jcnr.v7i4.4172","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.4172","url":null,"abstract":"Objectives: A meta-analysis was conducted to systematically evaluate the effect of the escape room teaching method on nursing education. Methods: We searched PubMed, Medline, Web of Science, CNKI, VIP, and Wanfang databases, with a search time frame from the first day of database establishment to October 2022. Two researchers evaluated the quality of the obtained literature and extracted the data. The RevMan5.4 software was used for meta-analysis. Results: A total of 7 studies involving 1487 nursing students were included. Compared with the control group, the escape room teaching method improved the professional performance of nursing students [standardized mean difference (SMD) = 0.98, 95% confidence interval (CI; 0.38,1.59), P < 0.0001]. The critical thinking ability of nursing students was enhanced [mean difference (MD) = 12.64, 95% CI (7.91,17.37), P < 0.0001], and the investment level of nursing students in learning was improved [MD = 4.18, 95% CI (1.74,6.62), P < 0.0001]. Conclusion: The escape room teaching method can improve nursing students’ professional performance, critical thinking ability, and learning engagement level. There is no significant difference in the impact of nursing teaching satisfaction, and there is still a lack of data support. This paper is limited by the quality and quantity of included literature, and more high-quality studies are still needed to further demonstrate the above conclusions.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45403177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the clinical efficacy of acupuncture combined with emotional intervention in patients with post-stroke depression (PSD). Methods: A total of 100 patients with PSD who met the inclusion criteria were randomly divided into an experimental group (50 cases) and a control group (50 cases) using the random number table method, and the enrollment was in order of admission time. The control group used conventional treatment of oral antidepressant Deanxit tablets (0.5 mg flupenthixol + 10 mg melitracen) with the dose appropriately adjusted according to the patient’s medication effect, and modern rehabilitation treatment given selectively according to the patient’s condition. The experimental group had similar treatment as the control group with the addition of traditional Chinese medicine (TCM) acupuncture combined with emotional intervention. The application effects of both groups before and after treatment were verified using the Hamilton Depression Rating Scale (Ham-D), National Institutes of Health Stroke Scale (NIHSS), and Activities of Daily Living (ADL), serotonin levels were measured, and statistical analyses were carried out. Results: The total effective rate of patients in the experimental group was significantly higher than that in the control group, and the Ham-D score, NIHSS score, ADL score, and serotonin level after treatment were significantly higher than those in the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusion: For patients with PSD, adding TCM acupuncture with emotional intervention on top of conventional treatment significantly improve the clinical efficacy and better improve the daily life ability of patients.
{"title":"Clinical Study of Acupuncture Combined with Emotional Intervention in Patients with Post-Stroke Depression","authors":"Fajin Wang, Yanyan Huang, Zhidan Zhang, Yan-hua Yang, Huikai Wang, Hao Han, Yongsheng Zhang, Yuxiang Jiao, Jianyong Gao","doi":"10.26689/jcnr.v7i4.5124","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5124","url":null,"abstract":"Objective: To investigate the clinical efficacy of acupuncture combined with emotional intervention in patients with post-stroke depression (PSD). Methods: A total of 100 patients with PSD who met the inclusion criteria were randomly divided into an experimental group (50 cases) and a control group (50 cases) using the random number table method, and the enrollment was in order of admission time. The control group used conventional treatment of oral antidepressant Deanxit tablets (0.5 mg flupenthixol + 10 mg melitracen) with the dose appropriately adjusted according to the patient’s medication effect, and modern rehabilitation treatment given selectively according to the patient’s condition. The experimental group had similar treatment as the control group with the addition of traditional Chinese medicine (TCM) acupuncture combined with emotional intervention. The application effects of both groups before and after treatment were verified using the Hamilton Depression Rating Scale (Ham-D), National Institutes of Health Stroke Scale (NIHSS), and Activities of Daily Living (ADL), serotonin levels were measured, and statistical analyses were carried out. Results: The total effective rate of patients in the experimental group was significantly higher than that in the control group, and the Ham-D score, NIHSS score, ADL score, and serotonin level after treatment were significantly higher than those in the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusion: For patients with PSD, adding TCM acupuncture with emotional intervention on top of conventional treatment significantly improve the clinical efficacy and better improve the daily life ability of patients.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44355968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yajie Huo, Yu Mao, F. Luo, Fengjiao Zhang, Lifang Xie, Xiaoke Zhang, Kai Liu, Ling Sun, Hongmei Liu, Lige Song, Huanhuan Wang, Zhiqiang Kang
Objective: To explore the mechanism of circRNA-vgll3 in osteogenic differentiation of human bone marrow mesenchymal stem cells. Methods: BMSCs cells were transfected with circRNA-vgll3, and divided into circRNA-vgll3 high-level group, circRNA-vgll3 low-level group, and negative control group (circRNA-vgll3 not transfected) according to the amount of transfection. The proliferation and apoptosis of BMSCs osteoblasts in each group were analyzed, and the alkaline phosphatase (ALP) activity, type I collagen gray value, bone morphogenetic protein 2 (BMP-2), Runx2 protein, and mRNA expression levels were detected. Results: The circRNA-vgll3 low-level group had a significant inhibitory effect on the proliferation of BMSCs osteoblasts, and the apoptosis rate of the circRNA-vgll3 low-level group was significantly higher than that of the circRNA-vgll3 high-level group ( P < 0.05 ); ALP activity, type I collagen gray value, BMP-2, Runx2 protein, and mRNA expression levels in the high-level circRNA-vgll3 group were significantly higher than those in the low-level circRNA-vgll3 group, and the difference was statistically significant (P < 0.05). Conclusion: Overexpression of circRNA-vgll3 can promote the osteogenic differentiation ability of BMSCs, while low expression of circRNA-vgll3 can inhibit the osteogenic differentiation ability of BMSCs. The main mechanism of action is that circRNA-vgll3 can affect osteogenic differentiation by regulating the Runx2 protein.
{"title":"Exploring the Mechanism of Circ-vgll3 in Osteogenically Differentiated Human Bone Marrow Mesenchymal Stem Cells","authors":"Yajie Huo, Yu Mao, F. Luo, Fengjiao Zhang, Lifang Xie, Xiaoke Zhang, Kai Liu, Ling Sun, Hongmei Liu, Lige Song, Huanhuan Wang, Zhiqiang Kang","doi":"10.26689/jcnr.v7i4.5139","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5139","url":null,"abstract":"Objective: To explore the mechanism of circRNA-vgll3 in osteogenic differentiation of human bone marrow mesenchymal stem cells. Methods: BMSCs cells were transfected with circRNA-vgll3, and divided into circRNA-vgll3 high-level group, circRNA-vgll3 low-level group, and negative control group (circRNA-vgll3 not transfected) according to the amount of transfection. The proliferation and apoptosis of BMSCs osteoblasts in each group were analyzed, and the alkaline phosphatase (ALP) activity, type I collagen gray value, bone morphogenetic protein 2 (BMP-2), Runx2 protein, and mRNA expression levels were detected. Results: The circRNA-vgll3 low-level group had a significant inhibitory effect on the proliferation of BMSCs osteoblasts, and the apoptosis rate of the circRNA-vgll3 low-level group was significantly higher than that of the circRNA-vgll3 high-level group ( P < 0.05 ); ALP activity, type I collagen gray value, BMP-2, Runx2 protein, and mRNA expression levels in the high-level circRNA-vgll3 group were significantly higher than those in the low-level circRNA-vgll3 group, and the difference was statistically significant (P < 0.05). Conclusion: Overexpression of circRNA-vgll3 can promote the osteogenic differentiation ability of BMSCs, while low expression of circRNA-vgll3 can inhibit the osteogenic differentiation ability of BMSCs. The main mechanism of action is that circRNA-vgll3 can affect osteogenic differentiation by regulating the Runx2 protein.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43614838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The rejected specimens from the Emergency Department of the Center of Clinical Laboratory from January 1, 2022 to January 1, 2023 were analyzed to reduce the specimen rejection rates and to improve the quality of inspection. The results showed that there were 1488 samples of rejected specimens and the non-conforming rate was 0.58%. The departments involved were mainly the Emergency Department, the Hematology Department, the Cardiology Department, the Intensive Care Department, and the Brain Surgery Department. Among the reasons for rejection, blood hemolysis accounted for 43.15%, blood coagulation accounted for 26.61%, and the rate of insufficient specimens was 17.14%. Among them, the sample rejection rate for arterial blood gas analysis was the highest, which accounted for 1.74%; followed by specimens for coagulation test, which was 1.18%. These results indicate the main reason for producing rejected specimens is mainly due to not following the standard operating procedure. Specimen rejection can largely be avoided if the standards for specimen collection are strictly followed.
{"title":"Statistical Analysis and Countermeasures for Specimen Rejection in the Emergency Department","authors":"Yinhua Fan, Bo-cheng Zhao","doi":"10.26689/jcnr.v7i4.5137","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5137","url":null,"abstract":"The rejected specimens from the Emergency Department of the Center of Clinical Laboratory from January 1, 2022 to January 1, 2023 were analyzed to reduce the specimen rejection rates and to improve the quality of inspection. The results showed that there were 1488 samples of rejected specimens and the non-conforming rate was 0.58%. The departments involved were mainly the Emergency Department, the Hematology Department, the Cardiology Department, the Intensive Care Department, and the Brain Surgery Department. Among the reasons for rejection, blood hemolysis accounted for 43.15%, blood coagulation accounted for 26.61%, and the rate of insufficient specimens was 17.14%. Among them, the sample rejection rate for arterial blood gas analysis was the highest, which accounted for 1.74%; followed by specimens for coagulation test, which was 1.18%. These results indicate the main reason for producing rejected specimens is mainly due to not following the standard operating procedure. Specimen rejection can largely be avoided if the standards for specimen collection are strictly followed.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41897071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore and analyze the effect of hormone therapy combined with hydroxychloroquine in the treatment of IgA nephropathy. Methods: 30 patients with IgA nephropathy who were admitted to the Urology Department of Jiuquan hospital from August 2021 to May 2023 were selected as the research subjects, and they divided into an observation group and control group by drawing lots, with 15 cases in each group. The observation group underwent hydroxychloroquine treatment in addition of hormone therapy, and the control group underwent conventional treatment and hormone therapy. The rate of effectiveness of treatment, serum index, and renal function of both groups were compared. Results: The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P < 0.05). There was no significant difference in serum creatinine and serum albumin (P > 0.05) between the groups before treatment; after treatment, the serum creatinine and serum albumin in the steroid group were significantly better than those in the reference group (P < 0.05). Besides, there was no significant difference in urine protein quantification and glomerular filtration rate between the groups before treatment (P > 0.05); after treatment, the hormone group’s urine protein quantification and glomerular filtration rate were significantly better than those in the reference group (P < 0.05). The rate of effectiveness of the hormone group was significantly higher than that of the reference group (P < 0.05). Conclusion: Hormone therapy combined with hydroxychloroquine in the treatment of IgA nephropathy is more effective than hormone therapy alone, thus this treatment plan is worthy of promotion and application.
{"title":"Analysis of the Effect of Hormone Therapy Combined with Hydroxychloroquine in the Treatment of IgA Nephropathy","authors":"Guo-liang Liu","doi":"10.26689/jcnr.v7i4.5150","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5150","url":null,"abstract":"Objective: To explore and analyze the effect of hormone therapy combined with hydroxychloroquine in the treatment of IgA nephropathy. Methods: 30 patients with IgA nephropathy who were admitted to the Urology Department of Jiuquan hospital from August 2021 to May 2023 were selected as the research subjects, and they divided into an observation group and control group by drawing lots, with 15 cases in each group. The observation group underwent hydroxychloroquine treatment in addition of hormone therapy, and the control group underwent conventional treatment and hormone therapy. The rate of effectiveness of treatment, serum index, and renal function of both groups were compared. Results: The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P < 0.05). There was no significant difference in serum creatinine and serum albumin (P > 0.05) between the groups before treatment; after treatment, the serum creatinine and serum albumin in the steroid group were significantly better than those in the reference group (P < 0.05). Besides, there was no significant difference in urine protein quantification and glomerular filtration rate between the groups before treatment (P > 0.05); after treatment, the hormone group’s urine protein quantification and glomerular filtration rate were significantly better than those in the reference group (P < 0.05). The rate of effectiveness of the hormone group was significantly higher than that of the reference group (P < 0.05). Conclusion: Hormone therapy combined with hydroxychloroquine in the treatment of IgA nephropathy is more effective than hormone therapy alone, thus this treatment plan is worthy of promotion and application.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41503402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Given the global trends in population aging, the prevalence of vascular dementia (VD) is increasing year by year. VD has become the second most common type of dementia and can seriously threaten the quality of life of patients. Since VD is preventable, it is important to study VD clinically in order to improve the prognosis of patients. In recent years, a large number of studies have been carried out at home and abroad, focusing on the pathogenesis, rehabilitation assessment, and treatment of VD. This article is a concise overview of these studies.
{"title":"Pathogenesis, Rehabilitation Assessment, Treatment Status, and Research Progress of Vascular Dementia","authors":"Yaxi Zhao","doi":"10.26689/jcnr.v7i4.5116","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5116","url":null,"abstract":"Given the global trends in population aging, the prevalence of vascular dementia (VD) is increasing year by year. VD has become the second most common type of dementia and can seriously threaten the quality of life of patients. Since VD is preventable, it is important to study VD clinically in order to improve the prognosis of patients. In recent years, a large number of studies have been carried out at home and abroad, focusing on the pathogenesis, rehabilitation assessment, and treatment of VD. This article is a concise overview of these studies.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45027938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To study the predictive value of serum pregenomic RNA (pgRNA) on HBeAg clearance in patients with chronic hepatitis B with low HBeAg levels during pegylated interferon therapy. Methods: Twenty chronic hepatitis B patients with HBeAg positive and quantitative <50S/CO were selected for this study. The subjects underwent pegylated interferon therapy for 48–96 weeks and were followed up in the outpatient clinic after treatment. The patients were then divided into groups based on whether their HbeAg turned negative. The predictive ability of each indicator for HBeAg negative conversion was evaluated in the HBeAg negative group and the HBeAg positive group. Results: The results of logistic regression analysis suggested that pgRNA and HBcrAg were better indicators for predicting the clearance of HBeAg after treatment. Conclusion: For patients with chronic hepatitis B with low HBeAg levels, pgRNA is a good indicator in predicting HBeAg clearance during pegylated interferon therapy.
{"title":"Predictive Value of Serum pgRNA on HBeAg Clearance in Patients with Chronic Hepatitis B with Low HBeAg Levels Treated with Pegylated Interferon","authors":"Y. Li, Yifei Lyu, F. Xi, Ying Gao","doi":"10.26689/jcnr.v7i4.4906","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.4906","url":null,"abstract":" Objective: To study the predictive value of serum pregenomic RNA (pgRNA) on HBeAg clearance in patients with chronic hepatitis B with low HBeAg levels during pegylated interferon therapy. Methods: Twenty chronic hepatitis B patients with HBeAg positive and quantitative <50S/CO were selected for this study. The subjects underwent pegylated interferon therapy for 48–96 weeks and were followed up in the outpatient clinic after treatment. The patients were then divided into groups based on whether their HbeAg turned negative. The predictive ability of each indicator for HBeAg negative conversion was evaluated in the HBeAg negative group and the HBeAg positive group. Results: The results of logistic regression analysis suggested that pgRNA and HBcrAg were better indicators for predicting the clearance of HBeAg after treatment. Conclusion: For patients with chronic hepatitis B with low HBeAg levels, pgRNA is a good indicator in predicting HBeAg clearance during pegylated interferon therapy.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43673589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the advantages of continuous nursing based on the Omaha system for patients with oral cancer surgery. Methods: 120 cases patients who were treated surgically for oral cancer from January 2020 to June 2022 were selected for this study; the ages of patients ranged from 26–78 years old. The patients were divided into a control group (60 patients) who would undergo routine nursing and an observation group who would undergo continuous nursing based on the Omaha. Statistical analysis was carried out on the clinical data. Results: After nursing, the quality of life, degree of understanding towards the disease, total satisfaction, and total rate of effectiveness of the observation group were significantly higher than those of the control group, and the negative emotion scores were significantly lower in the observation group (P < 0.05). Conclusion: Continuous nursing based on the Omaha system can not only improve the quality of life of oral cancer patients after surgery, but also alleviate the negative emotions of patients, expand the degree of understanding towards the disease, and improve their overall quality of life. Besides, high rates of nursing satisfaction and total effectiveness can promote the postoperative recovery of patients.
{"title":"Analysis of the Effect of the Omaha-System-Based Continuous Nursing on Quality of Life of Patients with Oral Cancer","authors":"Chun Tian, Gaiping Huang, Li-jie Wang, Li Li","doi":"10.26689/jcnr.v7i4.5130","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5130","url":null,"abstract":"Objective: To explore the advantages of continuous nursing based on the Omaha system for patients with oral cancer surgery. Methods: 120 cases patients who were treated surgically for oral cancer from January 2020 to June 2022 were selected for this study; the ages of patients ranged from 26–78 years old. The patients were divided into a control group (60 patients) who would undergo routine nursing and an observation group who would undergo continuous nursing based on the Omaha. Statistical analysis was carried out on the clinical data. Results: After nursing, the quality of life, degree of understanding towards the disease, total satisfaction, and total rate of effectiveness of the observation group were significantly higher than those of the control group, and the negative emotion scores were significantly lower in the observation group (P < 0.05). Conclusion: Continuous nursing based on the Omaha system can not only improve the quality of life of oral cancer patients after surgery, but also alleviate the negative emotions of patients, expand the degree of understanding towards the disease, and improve their overall quality of life. Besides, high rates of nursing satisfaction and total effectiveness can promote the postoperative recovery of patients.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47407166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the effect of allocating case managers for gestational diabetes patients. Methods: 200 patients with gestational diabetes mellitus from December 2021 to December 2022 were included in this study, and the collection period. They were divided into groups according to the interventions received. Each patient in the observation group was managed by a case manager, while the control group were managed with conventional methods without the supervision of a case manager. There were 100 cases in each group, and the curative effects of the two groups were compared. Results: The fasting blood glucose and 2-hour postprandial blood glucose in the observation group were significantly lower than those of the control group (P < 0.05). The re-admission rate of patients due to poor blood sugar control in the observation group was lower than that in the control group (P < 0.05). The pregnancy outcome of the observation group was better than that of the control group (P < 0.05). Conclusion: Case management of gestational diabetes can not only control the blood glucose of pregnant women, but also improve pregnancy outcomes.
{"title":"Effect of Case Management for Patients with Gestational Diabetes","authors":"Meirong Wang","doi":"10.26689/jcnr.v7i4.5186","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5186","url":null,"abstract":"Objective: To explore the effect of allocating case managers for gestational diabetes patients. Methods: 200 patients with gestational diabetes mellitus from December 2021 to December 2022 were included in this study, and the collection period. They were divided into groups according to the interventions received. Each patient in the observation group was managed by a case manager, while the control group were managed with conventional methods without the supervision of a case manager. There were 100 cases in each group, and the curative effects of the two groups were compared. Results: The fasting blood glucose and 2-hour postprandial blood glucose in the observation group were significantly lower than those of the control group (P < 0.05). The re-admission rate of patients due to poor blood sugar control in the observation group was lower than that in the control group (P < 0.05). The pregnancy outcome of the observation group was better than that of the control group (P < 0.05). Conclusion: Case management of gestational diabetes can not only control the blood glucose of pregnant women, but also improve pregnancy outcomes.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49412589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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