Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.123008
Sirama Diarra, M. Samaké, A. Saye, Brehima Dembélé, Birama Traoré, S. Dembélé, Déssé Diarra, Y. Dianéssy, A. Guiré, B. Kamaté
{"title":"Epidemiological, Diagnostic and Therapeutic Aspects of Breast Cancer in the Gynecology and Obstetrics Department of the CHU Gabriel Touré from 2020 to 2022","authors":"Sirama Diarra, M. Samaké, A. Saye, Brehima Dembélé, Birama Traoré, S. Dembélé, Déssé Diarra, Y. Dianéssy, A. Guiré, B. Kamaté","doi":"10.4236/abcr.2023.123008","DOIUrl":"https://doi.org/10.4236/abcr.2023.123008","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.124010
Michael Godfrey, P. Godfrey
{"title":"Breast Thermography: A 20-Year Retrospective Review of Infra-Red Breast Thermal Imaging in New Zealand and Its Potential Role in Breast Health Management","authors":"Michael Godfrey, P. Godfrey","doi":"10.4236/abcr.2023.124010","DOIUrl":"https://doi.org/10.4236/abcr.2023.124010","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.113013
Xian P. Jiang, C. Baucom, Toby Jiang, R. Elliott
Purpose: HLA-G binds to the inhibitory receptors of uterine NK cells and plays an important role in protection of fetal cells from maternal NK lysis. HLA-G also mediates tumor escape, but the immunosuppressive role is often neglected. These studies have focused on the examination of HLA-G expression in human breast and ovarian carcinoma and HLA-G immunosuppressive role in NK cytolysis. Methods: We examined HLA-G expression in breast and ovarian carcinoma cell lines by real time PCR, ELISA and immunofluorescent staining, and in frozen breast and ovarian carcinoma tissues by immunohistochemistry (IHC). We treated the breast cancer cell lines with anti-human HLA-G antibody or progesterone. Then, NK cytolysis was measured by using MTT assay. Results: We find breast and ovarian cancer cell lines increase the expression of HLA-G mRNA and protein, compared to normal cells. IHC shows that 100% of frozen breast and ovarian carcinoma tissues overexpress HLA-G protein. HLA-G IHC scores of breast and ovarian carcinoma are significantly higher than normal breast and ovarian tissues, respectively (both p < 0.01). Blocking HLA-G of the breast cancer cells by the antibody increases NK cytolysis. Progesterone upregulates HLA-G mRNA and protein of human breast cancer cell lines. The increased HLA-G expression by progesterone suppresses the NK cytolysis. Conclusion: Human breast and ovarian carcinoma overexpress HLA-G immunosuppressive molecules. Blocking HLA-G protein by antibody improves the cytolysis of NK cells against human breast cancer cell lines. In contrast, upregulation of HLA-G expression by progesterone impairs NK cytolytic function. Thus, HLA-G is a new immune checkpoint protein and potential cancer immunotherapeutic target.
{"title":"Breast and Ovarian Carcinoma Overexpress HLA-G, a Neglected Cancer Immunosuppressive Protein","authors":"Xian P. Jiang, C. Baucom, Toby Jiang, R. Elliott","doi":"10.4236/abcr.2022.113013","DOIUrl":"https://doi.org/10.4236/abcr.2022.113013","url":null,"abstract":"Purpose: HLA-G binds to the inhibitory receptors of uterine NK cells and plays an important role in protection of fetal cells from maternal NK lysis. HLA-G also mediates tumor escape, but the immunosuppressive role is often neglected. These studies have focused on the examination of HLA-G expression in human breast and ovarian carcinoma and HLA-G immunosuppressive role in NK cytolysis. Methods: We examined HLA-G expression in breast and ovarian carcinoma cell lines by real time PCR, ELISA and immunofluorescent staining, and in frozen breast and ovarian carcinoma tissues by immunohistochemistry (IHC). We treated the breast cancer cell lines with anti-human HLA-G antibody or progesterone. Then, NK cytolysis was measured by using MTT assay. Results: We find breast and ovarian cancer cell lines increase the expression of HLA-G mRNA and protein, compared to normal cells. IHC shows that 100% of frozen breast and ovarian carcinoma tissues overexpress HLA-G protein. HLA-G IHC scores of breast and ovarian carcinoma are significantly higher than normal breast and ovarian tissues, respectively (both p < 0.01). Blocking HLA-G of the breast cancer cells by the antibody increases NK cytolysis. Progesterone upregulates HLA-G mRNA and protein of human breast cancer cell lines. The increased HLA-G expression by progesterone suppresses the NK cytolysis. Conclusion: Human breast and ovarian carcinoma overexpress HLA-G immunosuppressive molecules. Blocking HLA-G protein by antibody improves the cytolysis of NK cells against human breast cancer cell lines. In contrast, upregulation of HLA-G expression by progesterone impairs NK cytolytic function. Thus, HLA-G is a new immune checkpoint protein and potential cancer immunotherapeutic target.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.114015
Bambara Augustin Tozoula, Ouedraogo Nina-Astrid, A. Etienne, K. Bernard, Akanni Fayçal, Sama Alice Cynthia, O. Diallo
{"title":"Evaluation of Clinical and Radiological Tumour Response during Neo-Adjuvant Breast Cancer Chemotherapy at Yalgado Ouedraogo University Hospital","authors":"Bambara Augustin Tozoula, Ouedraogo Nina-Astrid, A. Etienne, K. Bernard, Akanni Fayçal, Sama Alice Cynthia, O. Diallo","doi":"10.4236/abcr.2022.114015","DOIUrl":"https://doi.org/10.4236/abcr.2022.114015","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.111005
Sidy Ka, M. Guèye, M. Dieng, S. Baldé, Samuel Kobinama, J. Thiam, A. Dem
{"title":"Cystic Breast Cancer. A Confusing Entity. Study of 8 Cases at Dakar University Surgical Oncology Unit","authors":"Sidy Ka, M. Guèye, M. Dieng, S. Baldé, Samuel Kobinama, J. Thiam, A. Dem","doi":"10.4236/abcr.2022.111005","DOIUrl":"https://doi.org/10.4236/abcr.2022.111005","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.112006
S. Zawawy, G. Khedr
Non metastatic patients (n=108) had median follow up duration of 3.5 years. 21.3% patients developed relapse with median time to relapse of 11 months. 78.3% of relapsed patients had visceral (88.3% lung) metastasis, 13% bone metastasis, 21.7% brain metastasis and 13% LRR. Predictor for relapse: Significantly high risk of relapse in patients with large tumor size [T4: 66.75%, T3: 22.9%, T2:16.7%, T1: 0% (p= 0.002)], positive LNs [N3: 100%, N2: 37.9%, N1: 15.1%, N0: 4.3% (p <0.001)] and Ki67 [> 20: 31.6% versus 10.8% for Ki67≤ 20 (P =0.007)]. Multivariate analysis revealed only T4 and N2-3 were significantly associated with high probability for relapse (P = 0.022 & 0.038, respectively). Tumor grade I 1(0.9) 0 1(0.8) II 41(38.0) 7(35.0) 48(37.5) III 66(61.1) 13(65.0) 79(61.7) histopathology IDC 94(87.1) 13(65.0) 107(83.6) ILC 8(7.4) 1(5.0) 9(7.0) Others 6(5.5) 6(30.0) 12(9.4) surgery MRM 71(65.7) 0 BCS 37(34.3) 0 ALND 100(92.6) 0 SLN 8(7.4) 0 Neo adjuvant chemotherapy 34/108 (31.5%) CR 6(17.6%) PR 24(70.6%) No response 4(11.8%) Types of chemotherapy FAC 14(12.9%) 14 (11%) AC and Taxol 94(87%) 20 (100%) 114 (89%) Platinum/Gem 0(0%) 20(100%) 20(15.6%) Taxotere 0(0%) 12(60%) Xeloda 0(0%) 6(30%) Adjuvant XRT NO 10(9.3%) 20 (100%) 30(23.4%) conventional 56(51.8%) 0 56(43.8%) hypofractionation 42(38.9%) 0 42(32.8%) K. M Curve for DFS among non metastatic TNBC.
{"title":"Pattern of Failure and Treatment Results in Triple Negative Breast Cancer Patients","authors":"S. Zawawy, G. Khedr","doi":"10.4236/abcr.2022.112006","DOIUrl":"https://doi.org/10.4236/abcr.2022.112006","url":null,"abstract":"Non metastatic patients (n=108) had median follow up duration of 3.5 years. 21.3% patients developed relapse with median time to relapse of 11 months. 78.3% of relapsed patients had visceral (88.3% lung) metastasis, 13% bone metastasis, 21.7% brain metastasis and 13% LRR. Predictor for relapse: Significantly high risk of relapse in patients with large tumor size [T4: 66.75%, T3: 22.9%, T2:16.7%, T1: 0% (p= 0.002)], positive LNs [N3: 100%, N2: 37.9%, N1: 15.1%, N0: 4.3% (p <0.001)] and Ki67 [> 20: 31.6% versus 10.8% for Ki67≤ 20 (P =0.007)]. Multivariate analysis revealed only T4 and N2-3 were significantly associated with high probability for relapse (P = 0.022 & 0.038, respectively). Tumor grade I 1(0.9) 0 1(0.8) II 41(38.0) 7(35.0) 48(37.5) III 66(61.1) 13(65.0) 79(61.7) histopathology IDC 94(87.1) 13(65.0) 107(83.6) ILC 8(7.4) 1(5.0) 9(7.0) Others 6(5.5) 6(30.0) 12(9.4) surgery MRM 71(65.7) 0 BCS 37(34.3) 0 ALND 100(92.6) 0 SLN 8(7.4) 0 Neo adjuvant chemotherapy 34/108 (31.5%) CR 6(17.6%) PR 24(70.6%) No response 4(11.8%) Types of chemotherapy FAC 14(12.9%) 14 (11%) AC and Taxol 94(87%) 20 (100%) 114 (89%) Platinum/Gem 0(0%) 20(100%) 20(15.6%) Taxotere 0(0%) 12(60%) Xeloda 0(0%) 6(30%) Adjuvant XRT NO 10(9.3%) 20 (100%) 30(23.4%) conventional 56(51.8%) 0 56(43.8%) hypofractionation 42(38.9%) 0 42(32.8%) K. M Curve for DFS among non metastatic TNBC.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.112007
C. F. Ngatali, A. B. Liboko, Yves Mabiala, D. Moukassa, J. B. Nkoua-Mbon
{"title":"Epidemiological Clinical and Histological Aspects of Gynecological and Breast Cancer in Pointe Noire (Congo Brazzaville)","authors":"C. F. Ngatali, A. B. Liboko, Yves Mabiala, D. Moukassa, J. B. Nkoua-Mbon","doi":"10.4236/abcr.2022.112007","DOIUrl":"https://doi.org/10.4236/abcr.2022.112007","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.112011
Na Li, Wanwei Huang, Lijun Jiang, Lijun Zhang, Xiao-Li Lin, Haiting Wu, Yuting Huang, Yue Li
Purpose: To explore the effect of comprehensive intervention based on transition theory in enhancing the readiness for discharge of post-operative breast cancer patients. Method: In a non-simultaneous controlled study test, 99 post-operative breast cancer patients hospitalized between August 2019 and February 2020 were selected as the control group and 93 post-operative breast cancer patients hospitalized between March and August 2020 were selected as the test group at a Grade A tertiary tumor hospital. While the control group used the conventional care model, the test group added a comprehensive intervention based on transition theory to the routine nursing, which focused on stimulating patients’ awareness of health transitions, assisting patients to identify health critical events, strengthening social support and promoting self-management. The differences between the two groups were compared in terms of patient readiness for discharge and patient evaluation of the quality of discharge teaching. Result: The total score of readiness for discharge was higher in the test group than in the control group (171.7 ± 24.5 vs. 155.9 ± 28.9) and the scores for “Self-condition” (55.6 ± 8.2 vs. 50.8 ± 9.7), “Disease Knowledge” (64.7 ± 13.1 vs. 57.7 ± 13.8), “Coping Ability after Discharge” (24.6 ± 4.8 vs. 22.2 ± 5.6), “Expected Social Support after Discharge” (26.8 ± 4.5 vs. 25.2 ± 4.8) were higher than those of the control group, and all differences were statistically significant “Content that Patients Actually Acquired before Discharge” (51.2 ± 9.2 vs. 48.3 ± 11.3) and “Guiding Skills and Effects of Discharge for Nurses” (110.9 ± 12.6 vs. 104.3 ± 19.00) were also higher than those of the control group (p < 0.05). Conclusion: Comprehensive intervention based on transition theory for post-operative breast cancer patients is beneficial to improve the quality of discharge nursing guidance, thereby improving the readiness for discharge of patients and enhancing the sense of control and identity of patients after discharge.
{"title":"A Study on the Effect of Comprehensive Intervention Based on Transition Theory on the Readiness for Discharge of Post-Operative Breast Cancer Patients","authors":"Na Li, Wanwei Huang, Lijun Jiang, Lijun Zhang, Xiao-Li Lin, Haiting Wu, Yuting Huang, Yue Li","doi":"10.4236/abcr.2022.112011","DOIUrl":"https://doi.org/10.4236/abcr.2022.112011","url":null,"abstract":"Purpose: To explore the effect of comprehensive intervention based on transition theory in enhancing the readiness for discharge of post-operative breast cancer patients. Method: In a non-simultaneous controlled study test, 99 post-operative breast cancer patients hospitalized between August 2019 and February 2020 were selected as the control group and 93 post-operative breast cancer patients hospitalized between March and August 2020 were selected as the test group at a Grade A tertiary tumor hospital. While the control group used the conventional care model, the test group added a comprehensive intervention based on transition theory to the routine nursing, which focused on stimulating patients’ awareness of health transitions, assisting patients to identify health critical events, strengthening social support and promoting self-management. The differences between the two groups were compared in terms of patient readiness for discharge and patient evaluation of the quality of discharge teaching. Result: The total score of readiness for discharge was higher in the test group than in the control group (171.7 ± 24.5 vs. 155.9 ± 28.9) and the scores for “Self-condition” (55.6 ± 8.2 vs. 50.8 ± 9.7), “Disease Knowledge” (64.7 ± 13.1 vs. 57.7 ± 13.8), “Coping Ability after Discharge” (24.6 ± 4.8 vs. 22.2 ± 5.6), “Expected Social Support after Discharge” (26.8 ± 4.5 vs. 25.2 ± 4.8) were higher than those of the control group, and all differences were statistically significant “Content that Patients Actually Acquired before Discharge” (51.2 ± 9.2 vs. 48.3 ± 11.3) and “Guiding Skills and Effects of Discharge for Nurses” (110.9 ± 12.6 vs. 104.3 ± 19.00) were also higher than those of the control group (p < 0.05). Conclusion: Comprehensive intervention based on transition theory for post-operative breast cancer patients is beneficial to improve the quality of discharge nursing guidance, thereby improving the readiness for discharge of patients and enhancing the sense of control and identity of patients after discharge.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/abcr.2022.114016
Sèdjro Raoul Atadé, Patrice Dangbemey, Roger Klipezo, Donald Adjagba, David Lionel Togbenon, K. Salifou, B. Hounkpatin, J. Denakpo
{"title":"Epidemiological, Diagnostic and Therapeutic Aspects of Locally Advanced and/or Metastatic Breast Cancers at the Chu-Mel of Cotonou","authors":"Sèdjro Raoul Atadé, Patrice Dangbemey, Roger Klipezo, Donald Adjagba, David Lionel Togbenon, K. Salifou, B. Hounkpatin, J. Denakpo","doi":"10.4236/abcr.2022.114016","DOIUrl":"https://doi.org/10.4236/abcr.2022.114016","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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