Chemical Communications最新文献

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A novel directed evolution platform for engineering chemically gated protein switches. 一个新的定向进化平台，用于工程化学门控蛋白开关。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d5cc06861d

Luis A Vázquez-Rivera, Jiaqi Shen, Gwendolyn Shingles, Guanwei Zhou, Wenjing Wang

Chemically gated protein switches have broad applications in regulating cellular activities. In this study, we introduce DuoSelect, a yeast surface selection platform for selecting protein switches based on signal-to-background ratios by combining both negative and positive selections in a single round of sorting. We demonstrate this platform's utility by selecting for two chemical-dependent protein switches and showcase the protein switch's application in cellular assays.

化学门控蛋白开关在调节细胞活动方面有着广泛的应用。在这项研究中，我们介绍了DuoSelect，这是一个酵母表面选择平台，通过在单轮分类中结合阴性和阳性选择，根据信号与背景比选择蛋白质开关。我们通过选择两个化学依赖的蛋白质开关来展示该平台的实用性，并展示蛋白质开关在细胞分析中的应用。

引用次数: 0

Non-thermal plasma restructuring of electrocatalyst surfaces for efficient hydrogen and oxygen reactions. 高效氢、氧反应电催化剂表面的非热等离子体重组。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d5cc06818e

Chu Qin, Zhenglong Tao, Xuanhao Wu, Zhongqing Jiang

Electrocatalysts for water electrolysis, fuel cells, and metal-air batteries are largely governed by processes occurring within the outermost few nanometres of their surface. Low-temperature plasmas provide an effective means to tailor this region, using energetic electrons and reactive species to enable rapid, surface-confined modification while preserving the underlying scaffold. In this Feature Article, we review plasma engineering strategies for HER, OER and ORR electrocatalysts, including examples from zinc-air batteries and direct methanol fuel cells. We classify plasma effects into five generic design modes: phase transformation and plasma-assisted derivation; defect and vacancy engineering; plasma-induced doping; plasma-enabled deposition and interface construction; and single-atom anchoring with strong metal-support interactions. We also propose simple design rules that connect controllable plasma parameters to targeted active sites and device-level performance.

水电解、燃料电池和金属-空气电池的电催化剂在很大程度上是由发生在其表面最外层几纳米内的过程控制的。低温等离子体提供了定制该区域的有效手段，利用高能电子和活性物质实现快速、表面受限的修饰，同时保留底层支架。在这篇专题文章中，我们回顾了HER、OER和ORR电催化剂的等离子体工程策略，包括锌空气电池和直接甲醇燃料电池的例子。我们将等离子体效应分为五种一般设计模式：相变和等离子体辅助衍生；缺陷与空缺工程；plasma-induced掺杂;等离子体沉积和界面构建；单原子锚定与强金属支撑相互作用。我们还提出了简单的设计规则，将可控等离子体参数与目标活性位点和设备级性能联系起来。

引用次数: 0

Beyond Apoptosis: Platinum Phototherapeutics Overcome Resistance by Triggering Diverse Cell Death Pathways 超越凋亡：铂光疗通过触发多种细胞死亡途径克服耐药性

IF 4.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc00284f

Shu Chen, Zhigang Wang, Guangyu Zhu

Platinum(Pt)-based drugs remain the cornerstone of malignant tumor treatment, but are severely constrained by drug resistance. Conventional Pt agents primarily induce apoptosis, yet resistant cancer cells can bypass this pathway, leading to treatment failure. In contrast, phototherapeutic Pt complexes, leveraging photodynamic therapy and photoactivated chemotherapy, represent a novel approach to overcoming resistance by either enhancing apoptosis or activating alternative programmed cell death (PCD) pathways. This review provides a comprehensive overview of Pt-based photosensitizers and photoactivated agents that trigger diverse PCD pathways, including apoptosis, autophagy, ferroptosis, pyroptosis, and immunogenic cell death, to combat resistance. We elucidate the unique features and mechanistic underpinnings of each pathway, providing in-depth analyses of representative complexes to illustrate their PCD induction strategies and effectiveness in reducing resistance. Additionally, we present critical insights and forward-looking perspectives on the development of next-generation Pt phototherapeutics that leverage diverse PCD pathways. Overall, this review highlights the significance of multimodal PCD induction, proposing that targeting these pathways offers a novel strategic opportunity for Pt-based anticancer agents to overcome drug resistance.

铂基药物仍然是恶性肿瘤治疗的基石，但受到耐药性的严重限制。传统的铂类药物主要诱导细胞凋亡，但耐药的癌细胞可以绕过这一途径，导致治疗失败。相比之下，光疗Pt复合物，利用光动力疗法和光激活化疗，代表了一种通过增强细胞凋亡或激活选择性程序性细胞死亡（PCD）途径来克服耐药性的新方法。本文综述了基于PCD的光敏剂和光激活剂的研究进展，这些光敏剂和光激活剂可触发多种PCD途径，包括细胞凋亡、自噬、铁坏死、焦亡和免疫原性细胞死亡，以对抗耐药性。我们阐明了每个途径的独特特征和机制基础，并对代表性复合物进行了深入分析，以说明它们的PCD诱导策略和降低耐药性的有效性。此外，我们还提出了利用不同PCD途径的下一代Pt光疗的关键见解和前瞻性观点。总之，这篇综述强调了多模式PCD诱导的重要性，提出靶向这些途径为基于pt的抗癌药物克服耐药性提供了新的战略机会。

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引用次数: 0

A modification-free nanochannel platform for monitoring cerebral β-amyloid peptides based on the dispersion of stimuli-responsive polymer-modified gold nanoparticles. 基于刺激反应聚合物修饰金纳米颗粒分散的无修饰纳米通道平台监测大脑β-淀粉样肽。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d5cc06579h

Jiaqi Ji, Bin Liu, Haoting Qiu, Mingdi Yu, Yanlong Huang, Changman Guo, Xiaoyan Dang, Congyu Zhang, Ding-Yi Fu, Shushu Ding

We have developed a modification-free glass nanochannel for sensitive and selective detection of Aβ monomers, which operates through a dispersion-dominated recognition mechanism based on stimuli-responsive polymer-functionalized gold nanoparticles. This platform was successfully applied to monitor Aβ monomers in live mouse brains in Alzheimer's disease combined with in vivo microdialysis.

我们开发了一种无修饰的玻璃纳米通道，用于敏感和选择性地检测a β单体，该通道通过基于刺激响应聚合物功能化金纳米颗粒的分散主导识别机制运作。该平台结合体内微透析成功应用于阿尔茨海默病小鼠活体脑内Aβ单体的监测。

引用次数: 0

A dual-gated polymersome nanoreactor. 双门控聚合体纳米反应器。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc01021k

Ping Wei, Dongjing Guo, Jinghua Chen

We devised a simple method to regulate the membrane permeability of polymersomes. The key concept of our method is to use stimuli-responsive block copolymers as gate-generating components. Such copolymers have been adopted to prepare 'smart nanoreactors' that respond to changes in temperature or solution pH.

我们设计了一种简单的方法来调节聚合体的膜通透性。我们方法的关键概念是使用刺激响应嵌段共聚物作为门生成组件。这种共聚物已被用于制备“智能纳米反应器”，可以对温度或溶液pH值的变化做出反应。

引用次数: 0

A COF-decorated nanocellulose separator affording modulated ion transport for advanced Zn metal batteries. 为高级锌金属电池提供调制离子传输的cof修饰纳米纤维素分离器。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc00608f

Chunhui Huang, Meng Tian, Ge Jin, Yuhan Zou, Yuyuan Wang, Jiyun Hu, Yang He, Ya-Yun Li, Jingyu Sun

A novel covalent organic framework (COF)-decorated nanocellulose separator is customized. Benefiting from the distinctive zincophilic motifs, such a separator helps homogenize the ionic flux, enhance the ion-transport kinetics, and facilitate desolvation of hydrated Zn²⁺, thereby improving the reversibility of Zn plating/stripping toward advanced Zn metal batteries.

研制了一种新型的共价有机框架修饰纳米纤维素分离器。得益于独特的亲锌基元，这种分离器有助于离子通量均匀化，增强离子传输动力学，促进水合Zn2+的脱溶，从而提高锌电镀/剥离的可逆性，从而实现先进的锌金属电池。

引用次数: 0

Dual-Acceptor-Clamped Diketopyrrolopyrrole for High Performance monopolar n-Type Transistors 高性能单极n型晶体管双受体箝位双酮吡咯咯

IF 4.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc00082g

Zhiwei Yang, Shihong Zhou, Haijun Long, Yanlin Chen, Jing Li, Tianwen Chen, Xiaodi Gong, Zitong Liu, Luxi Tan

A diketopyrrolopyrrole (DPP) semiconductor incorporating fluorinated naphthobisthiadiazole (FNTz) end units in an A2–A1–A2 architecture, DNTDPP, is synthesized to stabilize electron transport. The molecule exhibits a low LUMO level (−3.89 eV), strong solid state aggregation, and excellent thermal stability. Top gate bottom contact OTFTs deliver monopolar n type behavior with electron mobility up to 1.18 cm² V⁻¹ s⁻¹.

以A2-A1-A2结构的氟化萘双噻二唑（FNTz）为末端单元，合成了一种稳定电子传递的二酮吡咯（DPP）半导体。该分子具有低LUMO能级（−3.89 eV）、强固态聚集和优异的热稳定性。上栅极下接触otft提供单极n型行为，电子迁移率高达1.18 cm²V（⁻¹s）。

引用次数: 0

Direct Carbonylative Amidation of Benzylic Alcohols with Alkylamines via Palladium Catalyzed C-O Bond Activation 钯催化C-O键活化苯基醇与烷基胺直接羰基化酰胺化反应

IF 4.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc01058j

Zhiping Yin, Heng Li, Xiaowen Qin, Mengyang Liu, Chang-Sheng Wang, Xiao-Feng Wu

A palladium-catalyzed direct carbonylative amidation that enables the efficient coupling of benzylic alcohols with alkylamines under mild conditions has been developed. Key to the success is the use of pentafluoropyridine as a activating group, which facilitates selective alcohol activation and suppresses undesired side reactions.Amide bond formation stands as a cornerstone-and a persistent challenge-in synthetic chemistry, particularly in the context of modern atom-and step-economical synthesis. 1 This is especially relevant for medicinally privileged structures such as the benzylamide motifs found in widely prescribed Z-drugs like zolpidem and alpidem, where efficient and modular access to this scaffold is highly desirable (Scheme 1, a). 2 While classical condensation methods relying on pre-activated carboxylic derivatives remain indispensable in both academic and industrial settings, their dependence on stoichiometric coupling agents and the concomitant generation of chemical waste imposes clear limitations in terms of sustainability and operational simplicity. Following the pioneering work on transition-metal-catalyzed carbonylative coupling by R. F. Heck, catalytic carbonylation has emerged as a powerful synthetic platform. 3 Among its most notable advances is the threecomponent coupling of aryl (pseudo)halides, carbon monoxide, and amines, which offers an efficient and direct route to amide bonds. 4 Despite substantial progress, these methods universally require pre-functionalized electrophilic partners, which introduces additional synthetic steps and constrains the modularity of the approach.

研究了一种钯催化的直接羰基化酰胺化反应，使苯醇和烷基胺在温和条件下有效偶联。成功的关键是使用五氟吡啶作为激活基团，促进选择性醇激活和抑制不希望的副反应。酰胺键的形成是合成化学的基石，也是一个持续的挑战，特别是在现代原子和步骤经济合成的背景下。这尤其适用于医用特权结构，如在广泛处方的z -药物如唑吡坦和阿吡坦中发现的苯酰胺基序，其中高效和模块化地获得这种支架是非常可取的（方案1，a）。2而依赖于预活化羧基衍生物的经典缩合方法在学术和工业环境中仍然不可或缺。它们对化学计量偶联剂的依赖以及由此产生的化学废物在可持续性和操作简单性方面造成了明显的限制。继r.f. Heck在过渡金属催化羰基化偶联方面的开创性工作之后，催化羰基化已经成为一个强大的合成平台。其最显著的进展是芳基（伪）卤化物、一氧化碳和胺的三组分偶联，这为酰胺键提供了有效和直接的途径。尽管取得了实质性进展，但这些方法普遍需要预功能化的亲电性伙伴，这引入了额外的合成步骤并限制了方法的模块化。

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引用次数: 0

Slime Mold-Bioinspired MXene Membrane for Efficient Uranium Immobilization 黏菌- MXene膜高效固定化铀

IF 4.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc00676k

Yujie Shao, Yan Liu, Zhirong Liu, Ruiming Zhang, Changfu Wang, Yun Wang, Dingzhong Yuan, Fengtao Yu, Hao Jiang

Inspired by cellular slime molds, a biomimetic self-supporting MXene membrane is fabricated. This design integrates covalent cross-linking for stability with phosphate groups for specific uranium capture. The membrane achieves a high extraction capacity of 3,768 mg/g under an applied voltage, demonstrating a promising strategy for advanced nuclear wastewater treatment.

受细胞黏菌的启发，制作了一种仿生自支撑MXene膜。这种设计结合了共价交联的稳定性与磷酸基团特定的铀捕获。在外加电压作用下，该膜的萃取能力高达3768 mg/g，为核废水的高级处理提供了一种有前景的策略。

引用次数: 0

Carbon dots-based covalent organic frameworks with high water dispersibility for photodynamic cancer therapy 具有高水分散性的碳点共价有机框架用于光动力癌症治疗

IF 4.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications

Pub Date : 2026-03-17 DOI: 10.1039/d6cc00125d

Binyu Zhao, Sitong Zhou, Jie Gao, Ke Chen, Fengshou Wu

A facile and effective strategy was developed to construct highly dispersed carbon dots-based COFs. The resulting CDs-COF exhibited good crystallinity, superior water dispersibility, pH-responsive degradation behavior, and high photodynamic therapy activity. This study provides a promising strategy to fabricate water‐dispersed COFs for highly efficient tumor ablation.

提出了一种简单有效的方法来构建高度分散的碳点基COFs。所制得的CDs-COF具有良好的结晶度、优异的水分散性、ph响应降解行为和光动力治疗活性。该研究提供了一种有前途的策略来制造水分散的COFs，用于高效的肿瘤消融。

引用次数: 0

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