Hongyu Wu, Shuhan Lin, Xiangcun Zuo, Weishi Hua, Tao Sun, Guoqing Shao, Fang Li, Dongming Zhao, Zhixin Feng, Dan Zhu, Lianhui Wang
An RAA-CRISPR-HCR (RCH) cascade amplification system was developed, which generates an ultrasensitive colorimetric response to low concentrations of African Swine Fever Virus (ASFV) DNA with a detection limit of 1 copy/µL. It demonstrates excellent accuracy and specificity in real samples, facilitating efficient on-site visual early detection of ASFV.
{"title":"RAA-CRISPR-HCR cascade amplification for ultrasensitive visual detection of African Swine Fever Virus DNA","authors":"Hongyu Wu, Shuhan Lin, Xiangcun Zuo, Weishi Hua, Tao Sun, Guoqing Shao, Fang Li, Dongming Zhao, Zhixin Feng, Dan Zhu, Lianhui Wang","doi":"10.1039/d5cc06815k","DOIUrl":"https://doi.org/10.1039/d5cc06815k","url":null,"abstract":"An RAA-CRISPR-HCR (RCH) cascade amplification system was developed, which generates an ultrasensitive colorimetric response to low concentrations of African Swine Fever Virus (ASFV) DNA with a detection limit of 1 copy/µL. It demonstrates excellent accuracy and specificity in real samples, facilitating efficient on-site visual early detection of ASFV.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"84 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antibiotic resistance represents an emerging global health threat.In this contribution we report all-atom molecular dynamics simulations of a bacterial protein in Acinetobacter baumanii. By using enhanced sampling we show the favorable internalization of the antibiotic via the CarO porin. This results correlates with the knockout or the mutation of the porin as a resistance mechanism.
{"title":"Internalization of Antibiotics by the Multi-Resistant Bacteria Acinetobacter baumannii through the CarO Outer Membrane Porin. †","authors":"Antonio Monari, Florent Barbault","doi":"10.1039/d5cc06876b","DOIUrl":"https://doi.org/10.1039/d5cc06876b","url":null,"abstract":"Antibiotic resistance represents an emerging global health threat.In this contribution we report all-atom molecular dynamics simulations of a bacterial protein in Acinetobacter baumanii. By using enhanced sampling we show the favorable internalization of the antibiotic via the CarO porin. This results correlates with the knockout or the mutation of the porin as a resistance mechanism.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"7 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arunabha Thakur, Brendan L Murphy, You Jiang, Nattamai Bhuvanesh, François P. Gabbaï
As part of our interest in anion binding platforms, we now report the synthesis and structure of a neutral distibora[1.1]ferrocenophane, which behaves as a bidentate Lewis acid as demonstrated by its ability to chelate fluoride ion. Coordination of the anion between the two antimony(V) centers is associated with a considerable fluoride ion affinity of 346 kJ∙mol-1.
{"title":"Fluoride ion chelation via pnictogen bonding using a distibora[1.1]ferrocenophane","authors":"Arunabha Thakur, Brendan L Murphy, You Jiang, Nattamai Bhuvanesh, François P. Gabbaï","doi":"10.1039/d5cc06492a","DOIUrl":"https://doi.org/10.1039/d5cc06492a","url":null,"abstract":"As part of our interest in anion binding platforms, we now report the synthesis and structure of a neutral distibora[1.1]ferrocenophane, which behaves as a bidentate Lewis acid as demonstrated by its ability to chelate fluoride ion. Coordination of the anion between the two antimony(V) centers is associated with a considerable fluoride ion affinity of 346 kJ∙mol-1.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"17 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The field of high-energy-density materials continues to face the long-standing challenge of achieving an optimal balance between energy and stability, two inherently conflicting parameters. While monocyclic energetic compounds often struggle to achieve this balance, emerging strategies that integrate multiple explosophoric units within a single molecular framework have shown remarkable promise. Among these, the N-methylene-C bridging strategy stands out for enabling precise modulation of performance and safety through rational selection of ring systems and functional groups. This feature article highlights synthetic methodologies for achieving N-methylene-C linked HEDMs and provides critical insights into their structure-property relationships.
{"title":"N-Methylene-C linkages: a versatile tool for engineering unsymmetrical energetic materials with an energy-stability balance.","authors":"Prachi Bhatia,Dheeraj Kumar","doi":"10.1039/d5cc06482a","DOIUrl":"https://doi.org/10.1039/d5cc06482a","url":null,"abstract":"The field of high-energy-density materials continues to face the long-standing challenge of achieving an optimal balance between energy and stability, two inherently conflicting parameters. While monocyclic energetic compounds often struggle to achieve this balance, emerging strategies that integrate multiple explosophoric units within a single molecular framework have shown remarkable promise. Among these, the N-methylene-C bridging strategy stands out for enabling precise modulation of performance and safety through rational selection of ring systems and functional groups. This feature article highlights synthetic methodologies for achieving N-methylene-C linked HEDMs and provides critical insights into their structure-property relationships.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"3 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Direct seawater electrolysis has recently emerged as a sustainable approach for green hydrogen production by harnessing abundant marine resources. However, its industrial deployment faces significant challenges due to the complex composition of seawater enriched in diverse ions and microorganisms which can induce severe chemical and physical degradation of electrolysis systems. Despite significant advances in the field, a comprehensive overview and analysis of seawater electrolysis remain relatively limited, particularly regarding electrochemical fundamentals, materials development and technological innovation. In this review, we provide a systematic overview of recent advances in electrocatalytic seawater electrolysis and offer insights into the major barriers to achieving stable hydrogen production. We discuss key aspects such as catalyst and electrode design, electrolyzer optimization, etc., to establish a roadmap for the commercialization of efficient, cost-effective and sustainable seawater electrolysis technology.
{"title":"Critical progress in direct seawater electrolysis for sustainable hydrogen production.","authors":"Peng Wang,Qiang Gao,Min-Rui Gao","doi":"10.1039/d5cc06592e","DOIUrl":"https://doi.org/10.1039/d5cc06592e","url":null,"abstract":"Direct seawater electrolysis has recently emerged as a sustainable approach for green hydrogen production by harnessing abundant marine resources. However, its industrial deployment faces significant challenges due to the complex composition of seawater enriched in diverse ions and microorganisms which can induce severe chemical and physical degradation of electrolysis systems. Despite significant advances in the field, a comprehensive overview and analysis of seawater electrolysis remain relatively limited, particularly regarding electrochemical fundamentals, materials development and technological innovation. In this review, we provide a systematic overview of recent advances in electrocatalytic seawater electrolysis and offer insights into the major barriers to achieving stable hydrogen production. We discuss key aspects such as catalyst and electrode design, electrolyzer optimization, etc., to establish a roadmap for the commercialization of efficient, cost-effective and sustainable seawater electrolysis technology.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"74 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing-Wang Cui, Shuai Ma, Yun-Rui Chen, Jia-Qi Pan, Bin Tan, Jie Zhang
A pyridinium-functionalized CP was ultrasonically transformed into nanoparticles, delivering a recyclable photocatalyst for selective alcohol oxidation. Notably, water addition triggers 1O2 generation via •O2− and H2O interactions, markedly boosting selectivity. This work presents the first exploration of pyridinium-bearing CPs functioning as nanocatalysts for controlled photooxidation.
{"title":"Controlled ROS generation in pyridinium-functionalized nanocatalysts for selective photooxidation","authors":"Jing-Wang Cui, Shuai Ma, Yun-Rui Chen, Jia-Qi Pan, Bin Tan, Jie Zhang","doi":"10.1039/d5cc06709j","DOIUrl":"https://doi.org/10.1039/d5cc06709j","url":null,"abstract":"A pyridinium-functionalized CP was ultrasonically transformed into nanoparticles, delivering a recyclable photocatalyst for selective alcohol oxidation. Notably, water addition triggers 1O2 generation via •O2− and H2O interactions, markedly boosting selectivity. This work presents the first exploration of pyridinium-bearing CPs functioning as nanocatalysts for controlled photooxidation.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"79 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magnesium-based organometallic complexes that facilitate redox-neutral catalysis represent an alternative to traditional transition-metal catalysis, enabling unprecedented functionalization of organic molecules. Moreover, its low toxicity and cost-effectiveness make it a key element in environmentally benign organic transformations. Accordingly, an extensive range of reactions, including substitution, addition, cyclization, and radical cross-coupling, has been achieved through magnesium-based catalysis, either under thermal or photo-irradiation conditions. Here, we delineated the valuable organic transformations accomplished recently via earth-abundant magnesium metal catalysis.
{"title":"Recent Advancements in Magnesium-Mediated Organic Transformations","authors":"Inder Kumar, Manisha ., Ritika Sharma, Upendra Sharma","doi":"10.1039/d5cc06257h","DOIUrl":"https://doi.org/10.1039/d5cc06257h","url":null,"abstract":"Magnesium-based organometallic complexes that facilitate redox-neutral catalysis represent an alternative to traditional transition-metal catalysis, enabling unprecedented functionalization of organic molecules. Moreover, its low toxicity and cost-effectiveness make it a key element in environmentally benign organic transformations. Accordingly, an extensive range of reactions, including substitution, addition, cyclization, and radical cross-coupling, has been achieved through magnesium-based catalysis, either under thermal or photo-irradiation conditions. Here, we delineated the valuable organic transformations accomplished recently via earth-abundant magnesium metal catalysis.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"244 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuefei Jing,Jen Suh,Joshua Maxwell,Karishma Patel,Alexander Norman,Xavier J Reid,Chandrika Deshpande,Jason K K Low,Richard J Payne,Toby Passioura,Joel P Mackay
The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design.
{"title":"The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides.","authors":"Xuefei Jing,Jen Suh,Joshua Maxwell,Karishma Patel,Alexander Norman,Xavier J Reid,Chandrika Deshpande,Jason K K Low,Richard J Payne,Toby Passioura,Joel P Mackay","doi":"10.1039/d5cc06167a","DOIUrl":"https://doi.org/10.1039/d5cc06167a","url":null,"abstract":"The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"42 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obtaining crystalline materials possessing any one of these three properties—second-harmonic generation (SHG) switchable behavior, ultra-wide bandgap (deep-ultraviolet transparency), or strong nonlinear optical (NLO) effects—is highly challenging. Here, we report a fully inorganic NLO material RbHSeO4, which simultaneously exhibits all the three properties. It features an ultra-wide bandgap (6.56 eV), a large room-temperature SHG effect (about 5.8 times that of KH2PO4), and reversible SHG switching behavior over a wide temperature range near room temperature. Variable-temperature experimental dynamic charge density analysis and ab initio molecular dynamics (AIMD) jointly confirm the proton hopping between O atoms at specific lattice sites during heating and the resulting phase transition. Theoretical calculations suggest that the strong SHG effect and SHG switching property may mainly originate from the ordered arrangement of [(HSeO4)−]∞ chains involving hydrogen bonds and the disruption of this order by lattice thermal vibrations, respectively.
{"title":"Strong Second-Harmonic Generation and Wide Temperature Range Switching Behavior Coexisting in An Ultrawide-Bandgap Selenate","authors":"Chi Yang, Mei-Ling Xin","doi":"10.1039/d5cc06860f","DOIUrl":"https://doi.org/10.1039/d5cc06860f","url":null,"abstract":"Obtaining crystalline materials possessing any one of these three properties—second-harmonic generation (SHG) switchable behavior, ultra-wide bandgap (deep-ultraviolet transparency), or strong nonlinear optical (NLO) effects—is highly challenging. Here, we report a fully inorganic NLO material RbHSeO4, which simultaneously exhibits all the three properties. It features an ultra-wide bandgap (6.56 eV), a large room-temperature SHG effect (about 5.8 times that of KH2PO4), and reversible SHG switching behavior over a wide temperature range near room temperature. Variable-temperature experimental dynamic charge density analysis and ab initio molecular dynamics (AIMD) jointly confirm the proton hopping between O atoms at specific lattice sites during heating and the resulting phase transition. Theoretical calculations suggest that the strong SHG effect and SHG switching property may mainly originate from the ordered arrangement of [(HSeO4)−]∞ chains involving hydrogen bonds and the disruption of this order by lattice thermal vibrations, respectively.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"84 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huifeng Wang, Wenjing Ma, Lei Deng, Genting Huang, Sisi Gong, Xiuling Chen, Shi-Yong Liu
A novel, additive-free method has been developed for synthesizing 2,4-disubstituted oxazoles via thiourea-mediated cyclization of substituted 2-oxo-2-phenylethyl acetates. This approach utilizes readily available thiourea and α-acyloxy ketones under mild conditions with simple operation, offering a reliable and versatile route to diverse substituted oxazole derivatives.Substituted-oxazoles heterocycles often exhibit interesting bioactive properties, these structural motifs are important building blocks inhennoxazole, mirabegron, ritonavir, and dasatinib pharmacologically relevant molecules. [1][2][3][4] Beyond their biological relevance, substitutedoxazoles have wide application in agrochemicals, and materials science, and exhibit versatile utility as key components in fluorescent dyes and organic light-emitting diodes (OLEDs), effective ligands in transition-metal catalysis, functional polymers, corrosion inhibitors, chemical sensors, and highly adaptable building blocks in organic synthesi. [5][6] Recently, substantial research efforts have been devoted toward efficient synthetic routes to substituted oxazoles.
{"title":"Metal and additive-free synthesis of 2,4-disubstituted oxazoles via thiourea-mediated cyclization reaction","authors":"Huifeng Wang, Wenjing Ma, Lei Deng, Genting Huang, Sisi Gong, Xiuling Chen, Shi-Yong Liu","doi":"10.1039/d5cc07183f","DOIUrl":"https://doi.org/10.1039/d5cc07183f","url":null,"abstract":"A novel, additive-free method has been developed for synthesizing 2,4-disubstituted oxazoles via thiourea-mediated cyclization of substituted 2-oxo-2-phenylethyl acetates. This approach utilizes readily available thiourea and α-acyloxy ketones under mild conditions with simple operation, offering a reliable and versatile route to diverse substituted oxazole derivatives.Substituted-oxazoles heterocycles often exhibit interesting bioactive properties, these structural motifs are important building blocks inhennoxazole, mirabegron, ritonavir, and dasatinib pharmacologically relevant molecules. [1][2][3][4] Beyond their biological relevance, substitutedoxazoles have wide application in agrochemicals, and materials science, and exhibit versatile utility as key components in fluorescent dyes and organic light-emitting diodes (OLEDs), effective ligands in transition-metal catalysis, functional polymers, corrosion inhibitors, chemical sensors, and highly adaptable building blocks in organic synthesi. [5][6] Recently, substantial research efforts have been devoted toward efficient synthetic routes to substituted oxazoles.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"80 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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