Pub Date : 2025-09-01DOI: 10.3760/cma.j.cn112138-20240927-00610
J P Chen, S Q Feng, Y Li
{"title":"[Progress in targeted therapies for type Ⅰ interferon pathway in systemic lupus erythematosus].","authors":"J P Chen, S Q Feng, Y Li","doi":"10.3760/cma.j.cn112138-20240927-00610","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240927-00610","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 9","pages":"891-899"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20250117-00046
X R Li, J X Xie
{"title":"[Advances in anti-interleukin-5 therapy for severe eosinophilic asthma].","authors":"X R Li, J X Xie","doi":"10.3760/cma.j.cn112138-20250117-00046","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250117-00046","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"793-800"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20250216-00087
G Y Dai, B Xu, Y F Tu, L M Wei, Z Y Liu, Y Q Bai, Z H Ai, Y Q Bao, H Y Yu
{"title":"[A case of localized Leydig cell tumor diagnosed by bilateral ovarian vein sampling].","authors":"G Y Dai, B Xu, Y F Tu, L M Wei, Z Y Liu, Y Q Bai, Z H Ai, Y Q Bao, H Y Yu","doi":"10.3760/cma.j.cn112138-20250216-00087","DOIUrl":"10.3760/cma.j.cn112138-20250216-00087","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"766-769"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20250428-00246
Y Y Chen, A Song, X P Xing, O Wang
{"title":"[Advances in preoperative diagnostic approaches for parathyroid carcinoma].","authors":"Y Y Chen, A Song, X P Xing, O Wang","doi":"10.3760/cma.j.cn112138-20250428-00246","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250428-00246","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"786-792"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20241225-00855
L H Zheng, C C Guo, Y Han
{"title":"[IgG<sub>4</sub>-related diseases of the gastrointestinal tract].","authors":"L H Zheng, C C Guo, Y Han","doi":"10.3760/cma.j.cn112138-20241225-00855","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241225-00855","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"782-785"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20241015-00690
L Liu, Z P Zhao, X H Shen, Y W Wang, C Q Yang
Objective: To examine the role of intestinal macrophages and the mechanism by which they produce reactive oxygen species (ROS) in abdominal pain induced by food antigens in mice with visceral hypersensitivity. Methods: Mouse models of visceral hypersensitivity were established by subjecting animals to acute cold restraint stress (ACRS) or acetic acid enema (AAE). Visceral sensitivity was evaluated using food antigen ovalbumin (OVA)-induced responses and rectal reflex measurements following ROS scavenging. The activity of intestinal macrophages was assessed using flow cytometry. In vitro enzyme immunoassays and in vivo imaging techniques were employed to quantify ROS levels. Furthermore, the influence of OVA on ROS levels following intestinal macrophage depletion was investigated. Cell culture experiments were conducted to investigate the effects of OVA on intestinal macrophage function and ROS production. Results: The two visceral hypersensitivity mouse models exhibited a significantly lower pain threshold compared to the control group. OVA-induced visceral hypersensitivity mice demonstrated enhanced visceral motor responses (VMRs), with an increase in abdominal ROS levels (ACRS vs. control: 62.00±7.68 vs. 19.80±2.39, P<0.001; AAE vs. control: 461.80±17.25 vs. 19.80±2.39, P<0.001). When ROS were cleared from the abdominal cavity of mice, VMRs were restored to normal levels (AAE vs. AAE+ROS: 83.50±8.72 vs. 71.66±2.67, P=0.010). In this mouse model, intestinal macrophages could be classified into CD45Med and CD45High subtypes based on the level of CD45 expression. In the AAE group, the expression of CD45Med macrophages in the intestinal tract decreased (AAE vs. control: 0.121±0.026 vs. 0.194±0.021, P=0.007), whereas the expression of CD45High macrophages increased (AAE vs. control: 0.249±0.087 vs. 0.018±0.003, P=0.027). Compared with the control group, the expression of CD11b in both types of macrophages increased significantly (CD45Med vs. control: 39 547.00±4 422.59 vs. 4 055.67±506.05, P<0.05; CD45High vs. control: 18 960.00±1 197.84 vs. 3 147.50±286.38, P=0.008), while the expression of F4/80 decreased (CD45Med vs. control: 6 141.67±750.06 vs. 10 544.33±974.92, P=0.008; CD45High vs. control: 1 291.50±119.50 vs. 4 007.50±327.39, P<0.001). These findings suggest that the activity of intestinal macrophages in visceral hypersensitivity mice is altered following OVA induction. By injecting different populations of macrophages into the peritoneal cavity of mice, it was found that compared to the AAE group, the injection of CD45High macrophages significantly increased the VMR in mice (AAE vs. AAE CD45High: 83.50±8.72 vs. 114.38±7.15, P<0.001), and aggravated the severity of diarrhea significantly. In vitro experiments revealed that food antigens co
目的：探讨肠道巨噬细胞在食物抗原引起的内脏过敏小鼠腹痛中的作用及其产生活性氧（ROS）的机制。方法：采用急性冷约束应激（ACRS）和醋酸灌肠（AAE）两种方法建立小鼠内脏超敏反应模型。通过食物抗原卵清蛋白（OVA）诱导的反应和清除活性氧后的直肠反射测量来评估内脏敏感性。采用流式细胞术检测肠巨噬细胞活性。采用体外酶免疫测定和体内成像技术定量ROS水平。此外，我们还研究了OVA对肠道巨噬细胞耗竭后ROS水平的影响。通过细胞培养实验研究OVA对肠巨噬细胞功能和ROS生成的影响。结果：与对照组相比，两种内脏超敏小鼠模型的痛阈值明显降低。ova诱导的内脏超敏小鼠表现出内脏运动反应（VMRs）增强，腹部ROS水平增加（ACRS与对照组相比：62.00±7.68 vs. 19.80±2.39，PPP=0.010）。在该小鼠模型中，根据CD45的表达水平可将肠巨噬细胞分为CD45Med和CD45High亚型。AAE组小鼠肠道CD45Med巨噬细胞表达降低（AAE组与对照组比较：0.121±0.026比0.194±0.021，P=0.007）， CD45High巨噬细胞表达升高（AAE组与对照组比较：0.249±0.087比0.018±0.003，P=0.027）。与对照组相比，两种巨噬细胞中CD11b的表达均显著升高（CD45Med比对照组：39 547.00±4 422.59比4 055.67±506.05，PHigh比对照组：18 960.00±1 197.84比3 147.50±286.38，P=0.008）， F4/80的表达降低(CD45Med比对照组：6 141.67±750.06比10 544.33±974.92，P=0.008；CD45High与对照组相比：1 291.50±119.50 vs. 4 007.50±327.39，高水平巨噬细胞显著提高小鼠VMR （AAE vs. AAE CD45High: 83.50±8.72 vs. 114.38±7.15）结论：食物抗原可能作用于肠道巨噬细胞，通过ROS途径诱导内脏过敏小鼠腹痛和腹泻。CD45High巨噬细胞可能在这一过程中起关键作用。
{"title":"[Role of intestinal macrophages in food antigen-induced abdominal pain in mice with visceral hypersensitivity].","authors":"L Liu, Z P Zhao, X H Shen, Y W Wang, C Q Yang","doi":"10.3760/cma.j.cn112138-20241015-00690","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20241015-00690","url":null,"abstract":"<p><p><b>Objective:</b> To examine the role of intestinal macrophages and the mechanism by which they produce reactive oxygen species (ROS) in abdominal pain induced by food antigens in mice with visceral hypersensitivity. <b>Methods:</b> Mouse models of visceral hypersensitivity were established by subjecting animals to acute cold restraint stress (ACRS) or acetic acid enema (AAE). Visceral sensitivity was evaluated using food antigen ovalbumin (OVA)-induced responses and rectal reflex measurements following ROS scavenging. The activity of intestinal macrophages was assessed using flow cytometry. In vitro enzyme immunoassays and in vivo imaging techniques were employed to quantify ROS levels. Furthermore, the influence of OVA on ROS levels following intestinal macrophage depletion was investigated. Cell culture experiments were conducted to investigate the effects of OVA on intestinal macrophage function and ROS production. <b>Results:</b> The two visceral hypersensitivity mouse models exhibited a significantly lower pain threshold compared to the control group. OVA-induced visceral hypersensitivity mice demonstrated enhanced visceral motor responses (VMRs), with an increase in abdominal ROS levels (ACRS vs. control: 62.00±7.68 vs. 19.80±2.39, <i>P</i><0.001; AAE vs. control: 461.80±17.25 vs. 19.80±2.39, <i>P</i><0.001). When ROS were cleared from the abdominal cavity of mice, VMRs were restored to normal levels (AAE vs. AAE+ROS: 83.50±8.72 vs. 71.66±2.67, <i>P</i>=0.010). In this mouse model, intestinal macrophages could be classified into CD45<sup>Med</sup> and CD45<sup>High</sup> subtypes based on the level of CD45 expression. In the AAE group, the expression of CD45<sup>Med</sup> macrophages in the intestinal tract decreased (AAE vs. control: 0.121±0.026 vs. 0.194±0.021, <i>P</i>=0.007), whereas the expression of CD45<sup>High</sup> macrophages increased (AAE vs. control: 0.249±0.087 vs. 0.018±0.003, <i>P</i>=0.027). Compared with the control group, the expression of CD11b in both types of macrophages increased significantly (CD45<sup>Med</sup> vs. control: 39 547.00±4 422.59 vs. 4 055.67±506.05, <i>P</i><0.05; CD45<sup>High</sup> vs. control: 18 960.00±1 197.84 vs. 3 147.50±286.38, <i>P=</i>0.008), while the expression of F4/80 decreased (CD45<sup>Med</sup> vs. control: 6 141.67±750.06 vs. 10 544.33±974.92, <i>P=</i>0.008; CD45<sup>High</sup> vs. control: 1 291.50±119.50 vs. 4 007.50±327.39, <i>P</i><0.001). These findings suggest that the activity of intestinal macrophages in visceral hypersensitivity mice is altered following OVA induction. By injecting different populations of macrophages into the peritoneal cavity of mice, it was found that compared to the AAE group, the injection of CD45<sup>High</sup> macrophages significantly increased the VMR in mice (AAE vs. AAE CD45<sup>High</sup>: 83.50±8.72 vs. 114.38±7.15, <i>P</i><0.001), and aggravated the severity of diarrhea significantly. In vitro experiments revealed that food antigens co","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"745-752"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20250124-00058
S Z Yao, Y Shan, H Liu, W T Liu, K Jiang
{"title":"[A case report of adulthood Alagille syndrome].","authors":"S Z Yao, Y Shan, H Liu, W T Liu, K Jiang","doi":"10.3760/cma.j.cn112138-20250124-00058","DOIUrl":"10.3760/cma.j.cn112138-20250124-00058","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"774-777"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20240918-00587
B Zhang, H Lu, W P Li, D M Liu, X Zhang, S H Zhan, K C Li, Y Wang, Q X Yang, X S Gu, T S Xu
{"title":"[The application value of olfactory brain imaging combined with olfactory-stimulating and brain-invigorating acupuncture in the early diagnosis and treatment of Alzheimer's disease].","authors":"B Zhang, H Lu, W P Li, D M Liu, X Zhang, S H Zhan, K C Li, Y Wang, Q X Yang, X S Gu, T S Xu","doi":"10.3760/cma.j.cn112138-20240918-00587","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20240918-00587","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"801-806"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20250401-00190
W Y Dang, Y L Duan, C J Zhou, S Y Zhao, L Jin, J Yang, M Jin, S Huang, M Zhang, Y H Zhang
{"title":"[Long-term follow-up of a novel SH2D1A gene mutation associated disease: a case report].","authors":"W Y Dang, Y L Duan, C J Zhou, S Y Zhao, L Jin, J Yang, M Jin, S Huang, M Zhang, Y H Zhang","doi":"10.3760/cma.j.cn112138-20250401-00190","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20250401-00190","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"770-773"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.3760/cma.j.cn112138-20241007-00654
T T Gong, X N Shen, C H Zhou, D W Zou
{"title":"[Type 1 autoimmune pancreatitis combined with pancreatic cysts: a report of four cases].","authors":"T T Gong, X N Shen, C H Zhou, D W Zou","doi":"10.3760/cma.j.cn112138-20241007-00654","DOIUrl":"10.3760/cma.j.cn112138-20241007-00654","url":null,"abstract":"","PeriodicalId":68309,"journal":{"name":"中华内科杂志","volume":"64 8","pages":"778-781"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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