Ming-Juan Yang, O. Qiao, Du-Hong Xie, Xinyue Zhang, Ya-Ping Bo, Xia Li, Juan Wang, W. Gao
{"title":"Effect of cerebralcare granule® combined with donepezil on Alzheimer’s disease","authors":"Ming-Juan Yang, O. Qiao, Du-Hong Xie, Xinyue Zhang, Ya-Ping Bo, Xia Li, Juan Wang, W. Gao","doi":"10.53388/dct20230002","DOIUrl":"https://doi.org/10.53388/dct20230002","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70806612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chang-Ming Chen, Wei-Jing Wang, Man Wang, L. Hai, Xiao-Nan Wang
{"title":"TCM therapy for patients with positive antibody response to SARS-CoV-2","authors":"Chang-Ming Chen, Wei-Jing Wang, Man Wang, L. Hai, Xiao-Nan Wang","doi":"10.53388/dct20230011","DOIUrl":"https://doi.org/10.53388/dct20230011","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70807060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in a series of inflammatory reactions in the joints, marked by pathologies such as articular bone destruction and erosive synovial inflammatory cartilage [1]. The bone destruction in RA arises from an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts [2]. The pathogenesis of RA remains unknown, and studies have indicated its close relationship with genetics, the environment, immune response, and other factors. Potential genes linked to RA susceptibility include major histocompatibility complex genes, like the single nucleotide polymorphism rs9277535 in the HLA-DP subunit HLA-DPB1, which is strongly associated with RA susceptibility in the Western Chinese population [3]. Furthermore, studies have also identified a correlation between major genes encoding the inflammatory CASPs (CASP1, CASP4, and CASP5) and RA [4]. Environmental factors, including smoking, diet, obesity, and infections, have the ability to trigger RA in susceptible individuals [5, 6]. Regarding the immune response, both immune dysregulation and overactivity can result in an inflammatory response, leading to excessive proliferation of synovial tissue, imbalanced distribution of osteoblasts and osteoclasts, and an irregular proportion of immune cells, culminating in the disease. RA is classified within the arthralgia syndrome according to Traditional Chinese Medicine, and Gancao Fuzi Decoction (GCFZD), a remedy documented over 2,000 years ago in The Synopsis of the Golden Chamber for treating this ailment, has demonstrated its efficacy in clinical practice as confirmed by most traditional Chinese medicine practitioners [7]. Drawing from the accumulated experiences of these treatments, the author presents a summary of the available evidence for this therapeutic approach.
{"title":"Mechanism of Gancao Fuzi Decoction in the treatment of Rheumatoid Arthritis","authors":"Rui Gong, Yousheng Yang, Jia-Xin Yuan, Xin-Ju Li","doi":"10.53388/dct20230015","DOIUrl":"https://doi.org/10.53388/dct20230015","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in a series of inflammatory reactions in the joints, marked by pathologies such as articular bone destruction and erosive synovial inflammatory cartilage [1]. The bone destruction in RA arises from an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts [2]. The pathogenesis of RA remains unknown, and studies have indicated its close relationship with genetics, the environment, immune response, and other factors. Potential genes linked to RA susceptibility include major histocompatibility complex genes, like the single nucleotide polymorphism rs9277535 in the HLA-DP subunit HLA-DPB1, which is strongly associated with RA susceptibility in the Western Chinese population [3]. Furthermore, studies have also identified a correlation between major genes encoding the inflammatory CASPs (CASP1, CASP4, and CASP5) and RA [4]. Environmental factors, including smoking, diet, obesity, and infections, have the ability to trigger RA in susceptible individuals [5, 6]. Regarding the immune response, both immune dysregulation and overactivity can result in an inflammatory response, leading to excessive proliferation of synovial tissue, imbalanced distribution of osteoblasts and osteoclasts, and an irregular proportion of immune cells, culminating in the disease. RA is classified within the arthralgia syndrome according to Traditional Chinese Medicine, and Gancao Fuzi Decoction (GCFZD), a remedy documented over 2,000 years ago in The Synopsis of the Golden Chamber for treating this ailment, has demonstrated its efficacy in clinical practice as confirmed by most traditional Chinese medicine practitioners [7]. Drawing from the accumulated experiences of these treatments, the author presents a summary of the available evidence for this therapeutic approach.","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70807095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lung cancer is a malignant tumor with high incidence and mortality rates in China and worldwide. Approximately 10% of these diseases are caused by multiple primary non-small cell lung cancers (NSCLC). Traditional antitumor therapies, such as chemotherapy, radiotherapy, and targeted therapy, have limited efficacy in the treatment of advanced synchronous multiple primary NSCLC. Immunotherapy is considered the standard of care for advanced or recurrent NSCLC, however, approximately 60% of patients develop primary or secondary resistance to treatment. There are no standard recommendations for overcoming immune resistance. We describe a case of simultaneous multiple primary NSCLC in a patient who received programmed death factor-1 (PD-1) inhibitor monotherapy and developed brain metastases. After receiving second-line treatment with a combination of another PD-1 inhibitor, pemetrexed, and bevacizumab, the patient achieved complete remission, although they experienced grade 3 immune-related adverse reactions. Immune re-challenge is safe and feasible, and choosing a synergistic combination regimen is one of the options to overcome immune resistance. A larger sample size is needed to confirm the effectiveness and safety of this strategy in patients with NSCLC resistant to prior PD-1 inhibitors.
{"title":"Successful re-challenge of PD-1 inhibitors in combination with bevacizumab and pemetrexed for multiple primary NSCLC progressing on prior PD-1 inhibitor therapy: one case report","authors":"Sheng-hong Wu, Mei Wang, Ying Zhu, Zhong-Hui He","doi":"10.53388/dct20230013","DOIUrl":"https://doi.org/10.53388/dct20230013","url":null,"abstract":"Lung cancer is a malignant tumor with high incidence and mortality rates in China and worldwide. Approximately 10% of these diseases are caused by multiple primary non-small cell lung cancers (NSCLC). Traditional antitumor therapies, such as chemotherapy, radiotherapy, and targeted therapy, have limited efficacy in the treatment of advanced synchronous multiple primary NSCLC. Immunotherapy is considered the standard of care for advanced or recurrent NSCLC, however, approximately 60% of patients develop primary or secondary resistance to treatment. There are no standard recommendations for overcoming immune resistance. We describe a case of simultaneous multiple primary NSCLC in a patient who received programmed death factor-1 (PD-1) inhibitor monotherapy and developed brain metastases. After receiving second-line treatment with a combination of another PD-1 inhibitor, pemetrexed, and bevacizumab, the patient achieved complete remission, although they experienced grade 3 immune-related adverse reactions. Immune re-challenge is safe and feasible, and choosing a synergistic combination regimen is one of the options to overcome immune resistance. A larger sample size is needed to confirm the effectiveness and safety of this strategy in patients with NSCLC resistant to prior PD-1 inhibitors.","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70806890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi-Xuan Wang, Yu-Xi Huang, Xu-hui Wang, Feng Xie, Xiang-Long Duan, Cui Li
{"title":"Compatibility mechanism of Chinese medicine formula: state of the art and perspectives","authors":"Yi-Xuan Wang, Yu-Xi Huang, Xu-hui Wang, Feng Xie, Xiang-Long Duan, Cui Li","doi":"10.53388/dct20230006","DOIUrl":"https://doi.org/10.53388/dct20230006","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70807037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the potential molecular mechanism of JinlingziSan in the treatment of endometriosis based on network pharmacology system","authors":"Li-jun Zhou, Wen Li, Yuan Wang, Ke Sun","doi":"10.53388/dct20230008","DOIUrl":"https://doi.org/10.53388/dct20230008","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70807229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“Astragali Radix - Salviae Miltiorrhizae Radix Et Rhizoma” herb pair in the treatment of liver cirrhosis and its pharmacological mechanisms","authors":"Zhehao Xu, Hui-fang Zhou, Boran Gong, Zhao Li, Zi-Xin Li, L. Wang, Yuhan Bian","doi":"10.53388/20230009","DOIUrl":"https://doi.org/10.53388/20230009","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70801803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng-lin Liu, Long-jian Li, Hui Ma, Qiuping Zhong, J. Ke, Hu Zhang
{"title":"Mechanism of action of Zhishi Daozhi decoction in the treatment of diarrhea based on network pharmacology and molecular docking","authors":"Zheng-lin Liu, Long-jian Li, Hui Ma, Qiuping Zhong, J. Ke, Hu Zhang","doi":"10.53388/dct20230003","DOIUrl":"https://doi.org/10.53388/dct20230003","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70806631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zi-Tong Fu, Jia-Yu Wang, Yi Liu, J. Xiong, Guo-wei Zhang
{"title":"The mechanism of TCM prevention and treatment of heavy COVID-19 based on data mining and network pharmacology","authors":"Zi-Tong Fu, Jia-Yu Wang, Yi Liu, J. Xiong, Guo-wei Zhang","doi":"10.53388/dct20230010","DOIUrl":"https://doi.org/10.53388/dct20230010","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70806882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zi-Yang Chen, Hang Yuan, Xiaoyan Zhang, Li-Ke Xie, X. Hao
Object: The aim is to evaluate how effective Traditional Chinese Medicine (TCM) is in treating patients who have central retinal vein occlusion with macular edema (CRVO-ME) in a real-world study. Furthermore, the objective of the research was to examine the TCM prescription trends in the management of CRVO-ME. Method: A single-center real-world study (RWS) was carried out over a span of 19 years, following the established design. The study encompassed 113 patients diagnosed with CRVO-ME. Out of these, 74 patients received TCM treatment, while the remaining individuals underwent a combined therapy involving TCM and anti-VEGF drugs through intravitreal injection. The patients were matched using propensity score matching (PSM). The result measured in the RWS was BCVA. The oral prescriptions for CRVO-ME that led to observable and effective outcomes were collected. Excel and the TCM Inheritance Auxiliary Platform V2.5 were utilized to optimize mutual information, hierarchical clustering based on entropy, and other techniques to extract medication regulations and features. Result: After applying PSM, each group comprised 29 cases. Both groups exhibited improved BCVA following treatment; however, there was no statistically significant distinction in BCVA or effectiveness between the two groups (all P > 0.05). Apart from the analysis of oral prescriptions for CRVO-ME, the investigation pinpointed the most frequently used TCMs, namely Flos Carthami, Semen Persicae, Radix Angelica sinensis, Radix Rehmanniae, and Radix et Rhizoma Notoginseng. Frequently utilized medications tended to possess cold, warm, or mild attributes and exhibited a taste profile that was either bitter or sweet. The primary meridians associated with the medicines employed in treating CRVO-ME were liver, spleen, stomach, heart, and lung. Through the application of association rule analysis, it was discerned that there were 195 commonly employed combinations of medicines. Additionally, a complex system entropy cluster analysis unveiled 13 key combinations of medicines. By employing an unsupervised entropy hierarchical clustering analysis, a novel prescription was formulated. Conclusion: Within a real-world population of CRVO-ME patients, TCM exhibited its effectiveness. The treatment approach for CRVO-ME predominantly involved the regulation of qi (Qi is an exceedingly subtle substance within the human body, brimming with vitality and ceaseless motion. It constitutes the fundamental element that shapes and sustains the various processes of human life.) and blood as well as the resolution of dampness. The oral prescriptions frequently targeted the meridians of liver, spleen, stomach, heart, and lungs.
{"title":"Real-World Study on the Treatment of Macular Edema in Central Retinal Vein Occlusion Using Traditional Chinese Medicine (TCM) and Its Medication Guidelines","authors":"Zi-Yang Chen, Hang Yuan, Xiaoyan Zhang, Li-Ke Xie, X. Hao","doi":"10.53388/dct20230014","DOIUrl":"https://doi.org/10.53388/dct20230014","url":null,"abstract":"Object: The aim is to evaluate how effective Traditional Chinese Medicine (TCM) is in treating patients who have central retinal vein occlusion with macular edema (CRVO-ME) in a real-world study. Furthermore, the objective of the research was to examine the TCM prescription trends in the management of CRVO-ME. Method: A single-center real-world study (RWS) was carried out over a span of 19 years, following the established design. The study encompassed 113 patients diagnosed with CRVO-ME. Out of these, 74 patients received TCM treatment, while the remaining individuals underwent a combined therapy involving TCM and anti-VEGF drugs through intravitreal injection. The patients were matched using propensity score matching (PSM). The result measured in the RWS was BCVA. The oral prescriptions for CRVO-ME that led to observable and effective outcomes were collected. Excel and the TCM Inheritance Auxiliary Platform V2.5 were utilized to optimize mutual information, hierarchical clustering based on entropy, and other techniques to extract medication regulations and features. Result: After applying PSM, each group comprised 29 cases. Both groups exhibited improved BCVA following treatment; however, there was no statistically significant distinction in BCVA or effectiveness between the two groups (all P > 0.05). Apart from the analysis of oral prescriptions for CRVO-ME, the investigation pinpointed the most frequently used TCMs, namely Flos Carthami, Semen Persicae, Radix Angelica sinensis, Radix Rehmanniae, and Radix et Rhizoma Notoginseng. Frequently utilized medications tended to possess cold, warm, or mild attributes and exhibited a taste profile that was either bitter or sweet. The primary meridians associated with the medicines employed in treating CRVO-ME were liver, spleen, stomach, heart, and lung. Through the application of association rule analysis, it was discerned that there were 195 commonly employed combinations of medicines. Additionally, a complex system entropy cluster analysis unveiled 13 key combinations of medicines. By employing an unsupervised entropy hierarchical clustering analysis, a novel prescription was formulated. Conclusion: Within a real-world population of CRVO-ME patients, TCM exhibited its effectiveness. The treatment approach for CRVO-ME predominantly involved the regulation of qi (Qi is an exceedingly subtle substance within the human body, brimming with vitality and ceaseless motion. It constitutes the fundamental element that shapes and sustains the various processes of human life.) and blood as well as the resolution of dampness. The oral prescriptions frequently targeted the meridians of liver, spleen, stomach, heart, and lungs.","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70807013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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