{"title":"Research progress on the mechanism of Zuojin Pill in inhibiting cancer","authors":"Weichen Si","doi":"10.53388/dct2022014","DOIUrl":"https://doi.org/10.53388/dct2022014","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70806295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ameliorative effect of naringenin in intoxication cases recovery","authors":"Said Said Elshama","doi":"10.53388/dct2021110503","DOIUrl":"https://doi.org/10.53388/dct2021110503","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the prescription in rules and mechanism for cerebral infarction based on data mining and Network Pharmacology","authors":"Bo Liu, Zixiang Kou","doi":"10.53388/dct2021080502","DOIUrl":"https://doi.org/10.53388/dct2021080502","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiming Bi, Wei Zhang, Yigui Lai, Yingchang Fu, K. Li, Qiang Wang, Xuefeng Jiang, Hongfeng Liang, Huijie Fan
{"title":"Prediction of active ingredients and potential mechanisms of Alisma decoction against atherosclerosis: A study based on UHPLC-Q-Orbitrap-HRMS and network pharmacology","authors":"Yiming Bi, Wei Zhang, Yigui Lai, Yingchang Fu, K. Li, Qiang Wang, Xuefeng Jiang, Hongfeng Liang, Huijie Fan","doi":"10.53388/dct2021110504","DOIUrl":"https://doi.org/10.53388/dct2021110504","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jialin Gu, Jialin Yu, Ziwei Song, Guoli Wei, Yi Ji, Lingchang Li, Canhong Hu, J. Huo
{"title":"Potential active compounds and mechanisms of Shen-Qi-Yi-Chang granule for the treatment of colorectal cancer: an analysis of network pharmacology and molecular docking","authors":"Jialin Gu, Jialin Yu, Ziwei Song, Guoli Wei, Yi Ji, Lingchang Li, Canhong Hu, J. Huo","doi":"10.53388/dct202108053","DOIUrl":"https://doi.org/10.53388/dct202108053","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hindustan Abdul, C. Haranath, B. Pradeepkumar, Beludari Mohammed
{"title":"Hepatoprotective and antioxidant activity of ethanolic extract of Artabotrys odoratissimus stem on rifampicin-induced hepatotoxicity in rats","authors":"Hindustan Abdul, C. Haranath, B. Pradeepkumar, Beludari Mohammed","doi":"10.53388/dct2021050502","DOIUrl":"https://doi.org/10.53388/dct2021050502","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pingping Sun, Na Sun, Yuemin Zhang, Jinguang Wang, Hua-Gang Ma
{"title":"The advantage of low-dose clomiphene citrate for overweight women with anovulation","authors":"Pingping Sun, Na Sun, Yuemin Zhang, Jinguang Wang, Hua-Gang Ma","doi":"10.53388/dct2021050504","DOIUrl":"https://doi.org/10.53388/dct2021050504","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective analysis of the efficacy of traditional Chinese medicine Lianhua Qingwen Capsule for the treatment of novel coronavirus-infected pneumonia","authors":"Peng Chen, Xiong Gan, L. Fang, Jiexin Lei, Fuchao Chen, Yue Wu, GuoHong Pan, Benhong Zhou","doi":"10.53388/dct2021110505","DOIUrl":"https://doi.org/10.53388/dct2021110505","url":null,"abstract":"","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colorectal cancer (CRC) is a major cause of morbidity and mortality and is closely associated with lipid metabolism, of which fatty acid metabolism, the release of fat factors and the abnormal level of blood lipids are all important pathogenic mechanisms. With the increasing awareness of lipid metabolism, advances in lipid-regulating therapy have made it possible for anti-tumor effect in CRC. However, there are still many research gaps and limitations. Given the complexity and uncertainty of targeted lipidregulating therapy for CRC, traditional Chinese medicine (TCM) may have a leg up when it comes to the theory of “holistic concept” and “treatment based on syndrome differentiation”. Meanwhile, proper dietary direction, healthy lifestyles, and normal serum lipid levels contribute directly to the prognosis of CRC patients. Key words—Lipid metabolism, Colorectal cancer, Lipidregulating therapy, Treatment strategies, Traditional Chinese medicine Highlights—Lipid metabolism is closely associated with colorectal carcinogenesis and development, which emerges as a potential therapeutic target gradually. Besides, in view of the complexity and uncertainty of targeted lipid-regulating therapy for colorectal cancer, traditional Chinese medicine might provide novel insights, explanations and directions to the lipid-regulating therapy in colorectal cancer. INTRODUCTION Colorectal cancer (CRC) is one of the most common malignant tumors with the third morbidity and fourth mortality in the global world [1]. The etiology of CRC is unknown but closely related to the environment, heredity, lifestyle and diet [2], as well as metabolic diseases such as obesity, hyperlipidemia, hypertension and diabetes [3]. Lipid metabolism is emerging as a potential therapeutic target gradually. Besides, TCM might provide novel insights, explanations and directions to the lipid-regulating therapy. Therefore, this study reviewed and investigated the mechanism of lipid metabolism and TCM comment. LIPID METABOLIC ALTERATIONS OF TUMOR CELLS Tumor metabolism is more exuberant than that of normal cells, with obvious differences in energy metabolism such as sugar, lipid, nucleic acid and protein. Since Weinberg put forward the anaerobic glycolysis of tumor cells, researches on tumor metabolism have been deepened. Lipids play an essential role in the cellular structure and function, involved in biofilm formation, Qian-Qian Niu is with Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Tianjin, 300385, China. Yuan-Hong Zhao is with Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Tianjin, 300385, China. E-mail: yuanhongzh98@163.com (Corresponding author). signaling and energy supply. Lipid metabolic alterations are the key feature of tumor cells, which is mainly characterized by the enhancement of de novo synthesized fatty acid to promote early tumor progression mediated by various transcriptional factors and lipid metabolic enzymes [4]
{"title":"Therapeutic strategy in colorectal cancer based on Traditional Chinese and Western Medicine: from the lipid metabolism perspective","authors":"Qian-qian Niu, Yuanhong Zhao","doi":"10.53388/dct2021110501","DOIUrl":"https://doi.org/10.53388/dct2021110501","url":null,"abstract":"Colorectal cancer (CRC) is a major cause of morbidity and mortality and is closely associated with lipid metabolism, of which fatty acid metabolism, the release of fat factors and the abnormal level of blood lipids are all important pathogenic mechanisms. With the increasing awareness of lipid metabolism, advances in lipid-regulating therapy have made it possible for anti-tumor effect in CRC. However, there are still many research gaps and limitations. Given the complexity and uncertainty of targeted lipidregulating therapy for CRC, traditional Chinese medicine (TCM) may have a leg up when it comes to the theory of “holistic concept” and “treatment based on syndrome differentiation”. Meanwhile, proper dietary direction, healthy lifestyles, and normal serum lipid levels contribute directly to the prognosis of CRC patients. Key words—Lipid metabolism, Colorectal cancer, Lipidregulating therapy, Treatment strategies, Traditional Chinese medicine Highlights—Lipid metabolism is closely associated with colorectal carcinogenesis and development, which emerges as a potential therapeutic target gradually. Besides, in view of the complexity and uncertainty of targeted lipid-regulating therapy for colorectal cancer, traditional Chinese medicine might provide novel insights, explanations and directions to the lipid-regulating therapy in colorectal cancer. INTRODUCTION Colorectal cancer (CRC) is one of the most common malignant tumors with the third morbidity and fourth mortality in the global world [1]. The etiology of CRC is unknown but closely related to the environment, heredity, lifestyle and diet [2], as well as metabolic diseases such as obesity, hyperlipidemia, hypertension and diabetes [3]. Lipid metabolism is emerging as a potential therapeutic target gradually. Besides, TCM might provide novel insights, explanations and directions to the lipid-regulating therapy. Therefore, this study reviewed and investigated the mechanism of lipid metabolism and TCM comment. LIPID METABOLIC ALTERATIONS OF TUMOR CELLS Tumor metabolism is more exuberant than that of normal cells, with obvious differences in energy metabolism such as sugar, lipid, nucleic acid and protein. Since Weinberg put forward the anaerobic glycolysis of tumor cells, researches on tumor metabolism have been deepened. Lipids play an essential role in the cellular structure and function, involved in biofilm formation, Qian-Qian Niu is with Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Tianjin, 300385, China. Yuan-Hong Zhao is with Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Tianjin, 300385, China. E-mail: yuanhongzh98@163.com (Corresponding author). signaling and energy supply. Lipid metabolic alterations are the key feature of tumor cells, which is mainly characterized by the enhancement of de novo synthesized fatty acid to promote early tumor progression mediated by various transcriptional factors and lipid metabolic enzymes [4]","PeriodicalId":68926,"journal":{"name":"药物联合治疗","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70805755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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