{"title":"Structural characterization of potential modulation sites in the extracellular domain of the prokaryotic pentameric proton-gated ion channel GLIC","authors":"Z. Fourati, M. Delarue, L. Sauguet","doi":"10.2210/PDB4QH1/PDB","DOIUrl":"https://doi.org/10.2210/PDB4QH1/PDB","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2015-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84894244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structure of Human Saposin a at Lysosomal Ph.","authors":"C. Hill, R. Read, J. Deane","doi":"10.2210/PDB4UEX/PDB","DOIUrl":"https://doi.org/10.2210/PDB4UEX/PDB","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"18 1","pages":"895"},"PeriodicalIF":2.2,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83349528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-01DOI: 10.1107/S1399004714013613
B. Yoon, Yong-Hak Kim, Nahee Kim, Bo-Young Yun, Jin-Sik Kim, Joon-Hee Lee, Hyun-soo Cho, Kangseok Lee, N. Ha
The affiliation of two of the authors of Yoon et al. [(2013). D69, 1867–1875] is corrected.
Yoon等人[(2013)]的两位作者的隶属关系。D69, 1867-1875]是更正的。
{"title":"Structure of the periplasmic copper-binding protein CueP from Salmonella enterica serovar Typhimurium. Corrigendum","authors":"B. Yoon, Yong-Hak Kim, Nahee Kim, Bo-Young Yun, Jin-Sik Kim, Joon-Hee Lee, Hyun-soo Cho, Kangseok Lee, N. Ha","doi":"10.1107/S1399004714013613","DOIUrl":"https://doi.org/10.1107/S1399004714013613","url":null,"abstract":"The affiliation of two of the authors of Yoon et al. [(2013). D69, 1867–1875] is corrected.","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"78 10 1","pages":"2053-2053"},"PeriodicalIF":2.2,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87903742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-26DOI: 10.1107/S1399004714005719
L. Chavas
A review of Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules by Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins and Roland P. May.
Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins和Roland P. May在生物大分子溶液中的小角x射线和中子散射研究综述
{"title":"Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules.","authors":"L. Chavas","doi":"10.1107/S1399004714005719","DOIUrl":"https://doi.org/10.1107/S1399004714005719","url":null,"abstract":"A review of Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules by Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins and Roland P. May.","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"70 1","pages":"1175 - 1176"},"PeriodicalIF":2.2,"publicationDate":"2014-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1107/S1399004714005719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61948336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Ponomarenko, S. Chatziefthimiou, I. Kurkova, Y. Mokrushina, A. Stepanova, I. Smirnov, E. M. Avakyan, T. Bobik, A. Mamedov, V. Mitkevich, A. Belogurov, O. Fedorova, M. Dubina, A. Golovin, V. Lamzin, A. Friboulet, A. Makarov, M. Wilmanns, A. Gabibov
{"title":"Role of Kappa>Lambda Light-Chain Constant-Domain Switch in the Structure and Functionality of A17 Reactibody","authors":"N. Ponomarenko, S. Chatziefthimiou, I. Kurkova, Y. Mokrushina, A. Stepanova, I. Smirnov, E. M. Avakyan, T. Bobik, A. Mamedov, V. Mitkevich, A. Belogurov, O. Fedorova, M. Dubina, A. Golovin, V. Lamzin, A. Friboulet, A. Makarov, M. Wilmanns, A. Gabibov","doi":"10.2210/PDB3ZL4/PDB","DOIUrl":"https://doi.org/10.2210/PDB3ZL4/PDB","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"2 1","pages":"708"},"PeriodicalIF":2.2,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82378644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-06-14DOI: 10.4172/2329-6887.1000E111
M. Rarey, B. Kramer, Thomas Lengauer
Volume 1 • Issue 4 • 1000e111 J Pharmacovigilance ISSN: 2329-6887 JP, an open access journal In today’s world where life is fast-paced, public health is a big concern. With the tremendous ongoing development in the field of pharmaceutical drugs, people can find cure for a vast variety of diseases. These modern-day medicines have been proven to be more effective in treating, managing, controlling and preventing the diseases and their reoccurrence. For example, cancer patients, who had a very low rate of survival in 1970’s, can now be treated more efficiently by chemotherapy. At present, the cancer death rate has declined by 20% in comparison to 1990 [1]. However, along with rapid progress in the efficacy of these pharmaceutical medicines, have come long-term undesirable side effects, poor absorption and clearance, multi-drug resistance, excessive toxicities, and adverse reactions of these medicines. Hence, there is a stringent need to get a closer insight into these drugs in terms of their structure and function, their molecular interactions with large biomolecules (protein, nucleic acids) within the cell, so as to design and/or modify the drugs to have improved potency, fewer side effects and selective binding to their biomolecular target.
{"title":"Structure-based drug design","authors":"M. Rarey, B. Kramer, Thomas Lengauer","doi":"10.4172/2329-6887.1000E111","DOIUrl":"https://doi.org/10.4172/2329-6887.1000E111","url":null,"abstract":"Volume 1 • Issue 4 • 1000e111 J Pharmacovigilance ISSN: 2329-6887 JP, an open access journal In today’s world where life is fast-paced, public health is a big concern. With the tremendous ongoing development in the field of pharmaceutical drugs, people can find cure for a vast variety of diseases. These modern-day medicines have been proven to be more effective in treating, managing, controlling and preventing the diseases and their reoccurrence. For example, cancer patients, who had a very low rate of survival in 1970’s, can now be treated more efficiently by chemotherapy. At present, the cancer death rate has declined by 20% in comparison to 1990 [1]. However, along with rapid progress in the efficacy of these pharmaceutical medicines, have come long-term undesirable side effects, poor absorption and clearance, multi-drug resistance, excessive toxicities, and adverse reactions of these medicines. Hence, there is a stringent need to get a closer insight into these drugs in terms of their structure and function, their molecular interactions with large biomolecules (protein, nucleic acids) within the cell, so as to design and/or modify the drugs to have improved potency, fewer side effects and selective binding to their biomolecular target.","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"1989 1","pages":"379"},"PeriodicalIF":2.2,"publicationDate":"2013-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88758578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-05-01DOI: 10.1107/S0907444913001856
P. Paufler
{"title":"Visualizing the Invisible: Imaging Techniques for the Structural Biologist. By Peter B. Moore. Pp. 368. Oxford University Press, 2012. Price £45. ISBN 978-0-19-976709-0.","authors":"P. Paufler","doi":"10.1107/S0907444913001856","DOIUrl":"https://doi.org/10.1107/S0907444913001856","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":"57 1","pages":"924-924"},"PeriodicalIF":2.2,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84754975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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