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Seasonal variation in the incidence of central serous chorioretinopathy: A systematic review and meta-analysis. 中枢性浆液性脉络膜视网膜病变发病率的季节变化:一项系统回顾和荟萃分析。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-05 DOI: 10.1111/aos.70045
I Made Ferdiko Hutamadella, Emil Ørnberg, Mark P Breazzano, Lasse Jørgensen Cehofski, Chui Ming Gemmy Cheung, Kristina Pfau, M Cem Sabaner, Lorenzo Ferro Desideri, Camiel J F Boon, Yousif Subhi, Elon H C van Dijk

Central serous chorioretinopathy (CSC) is a chorioretinal disease characterised by serous subretinal fluid (SRF) in the macula, resulting in sudden central vision loss. It predominantly affects working-age adults, particularly men aged 30 to 60 years. Its multifactorial pathophysiology is modulated by systemic factors, such as corticosteroid use, psychological stress, and hypertension. Previous studies suggest that broader environmental influences, including seasonal variation, may contribute to disease onset. This study aimed to systematically review and analyse the evidence on seasonal variation in CSC incidence. A systematic search was conducted across 10 databases (PubMed, Embase, Cochrane Central, Web of Science Core Collection, Current Contents Connect, Data Citation Index, Derwent Innovations Index, KCI-Korean Journal Database, ProQuest™ Dissertations and Theses Citation Index, and SciELO Citation Index) on 22 June 2025. Eligible studies included observational designs reporting CSC incidence or frequency across seasons; case reports and reviews were excluded. Five studies, with 907 participants in total, met the inclusion criteria. Three studies with sufficient data were included in quantitative meta-analysis, while the remaining two conference abstracts were included in the qualitative synthesis. Seasonal variation in CSC incidence was reported across studies. Meta-analysis using summer as the reference season showed a significantly increased incidence of CSC in spring (OR 1.42; 95% CI: 1.18-1.73; p = 0.0003) and autumn (OR 1.23; 95% CI: 1.02-1.48; p = 0.03). No significant difference was found for winter (OR 0.97; 95% CI: 0.80-1.19; p = 0.80). The remaining 2 studies not included in the meta-analysis also reported seasonal trends consistent with these findings. The findings indicate a significant seasonal variation in CSC incidence, with a consistently increased risk during spring and autumn compared with summer. Further research is needed to examine how seasonal environmental and physiological mechanisms may contribute to CSC development.

中枢性浆液性脉络膜视网膜病变(CSC)是一种以黄斑浆液性视网膜下液(SRF)为特征的脉络膜视网膜疾病,导致突发性中央视力丧失。它主要影响工作年龄的成年人,特别是30至60岁的男性。其多因素病理生理受全身因素调节,如皮质类固醇的使用、心理应激和高血压。以前的研究表明,更广泛的环境影响,包括季节变化,可能有助于疾病的发病。本研究旨在系统回顾和分析CSC发病率的季节变化证据。于2025年6月22日对10个数据库(PubMed、Embase、Cochrane Central、Web of Science核心馆藏、Current Contents Connect、Data引文索引、Derwent Innovations索引、KCI-Korean Journal Database、ProQuest™学位论文引文索引和SciELO引文索引)进行了系统检索。符合条件的研究包括报告不同季节CSC发病率或频率的观察性设计;排除病例报告和综述。共有907名受试者的5项研究符合纳入标准。有充分数据的三项研究纳入定量荟萃分析,其余两篇会议摘要纳入定性综合。研究报告了CSC发病率的季节性变化。以夏季为参考季节的荟萃分析显示,春季(OR 1.42; 95% CI: 1.18-1.73; p = 0.0003)和秋季(OR 1.23; 95% CI: 1.02-1.48; p = 0.03) CSC的发病率显著增加。冬季无显著差异(OR 0.97; 95% CI: 0.80-1.19; p = 0.80)。其余2项未纳入荟萃分析的研究也报告了与这些发现一致的季节性趋势。研究结果表明,CSC发病率存在显著的季节变化,春季和秋季的风险始终高于夏季。需要进一步研究季节性环境和生理机制如何促进CSC的发展。
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引用次数: 0
Patient preferences for adverse effects of intraocular pressure-lowering eye drops. Results from a Danish large-scale discrete choice experiment: These adverse effects matter to the patients. 患者对眼压降眼液不良反应的偏好。丹麦大规模离散选择实验的结果:这些不良反应对患者很重要。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-04 DOI: 10.1111/aos.70047
Alexander von Spreckelsen, Trine Kjær, Marcel Reimann, Christian Torp-Pedersen, Mikkel Porsborg Andersen, Gianni Virgili, Augusto Azuara-Blanco, Dorte Gyrd-Hansen, Miriam Kolko

Purpose: Assessment of patient preferences for local adverse effects (AEs) of intraocular pressure (IOP)-lowering eye drops.

Methods: A total of 10 000 eye drop-treated patients aged 40-75 years were sampled from the Danish national registries. A discrete choice experiment (DCE) was distributed to each patient to elicit preferences for distinct levels of five representative local AE attributes of IOP-lowering drops: acute discomfort, persistent discomfort, blurred vision, non-persistent cosmetic changes, and persistent cosmetic changes. Preference weights were computed using conditional logistic regression and normalised using profile-based normalisation. The mildest severity levels were used as a reference. Heterogeneity analyses were conducted across patient covariates to examine variation in preference patterns.

Results: A total of 2445 patients (24% response rate; 55% male; median age: 67 years) completed the DCE, with 2096 providing additional covariate data. 95% reported a diagnosis of glaucoma or ocular hypertension. More females than males reported currently experiencing AEs (48% vs. 35%). 25% had previously discontinued treatment with IOP-lowering eye drops due to AEs. The DCE revealed significant differences in the patients' preferences for avoiding AEs. Severe blurred vision, persistent cosmetic changes, and persistent discomfort exhibited the highest levels of disutility. Moderate acute discomfort and non-persistent cosmetic changes were least important. The patients' preferences varied notably by age and gender.

Conclusion: This study provides novel insight into patients' preferences for AEs of IOP-lowering eye drops by identifying the characteristics that most strongly influence treatment choices. These insights support future clinical studies and shared decision-making, facilitating personalised care that can improve adherence, quality of life, and long-term patient outcomes.

目的:评估患者对降低眼压(IOP)滴眼液局部不良反应的偏好。方法:从丹麦国家登记中心抽取1万例40-75岁的眼药水治疗患者。对每位患者进行离散选择实验(DCE),以诱导患者对五种具有代表性的降眼液局部AE属性的不同水平的偏好:急性不适、持续性不适、视力模糊、非持续性外观改变和持续性外观改变。使用条件逻辑回归计算偏好权重,并使用基于配置文件的规范化进行归一化。最轻微的严重程度被用作参考。异质性分析在患者协变量中进行,以检查偏好模式的变化。结果:共有2445例患者(缓解率24%,男性55%,中位年龄67岁)完成了DCE,其中2096例提供了额外的协变量数据。95%的患者被诊断为青光眼或高眼压。报告目前经历ae的女性多于男性(48%对35%)。25%的患者先前因不良反应而停止使用降眼压滴眼液治疗。DCE显示患者对避免不良事件的偏好有显著差异。严重的视力模糊、持续的外观变化和持续的不适表现出最高水平的负效用。中度急性不适和非持续性美容改变是最不重要的。患者的偏好因年龄和性别而有显著差异。结论:本研究通过确定最强烈影响治疗选择的特征,为患者对降低眼压滴眼液的ae偏好提供了新的见解。这些见解支持未来的临床研究和共同决策,促进个性化护理,从而提高依从性、生活质量和患者的长期预后。
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引用次数: 0
Cataract lens scattering is not suitable as a surrogate parameter for lens autofluorescence. 白内障晶状体散射不适合作为晶状体自身荧光的替代参数。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-04 DOI: 10.1111/aos.70050
Balasooriyage Manthila Dinali Perera, Jana Oertel, Hanan Alderzy, Daniel Meller, Martin Hammer
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引用次数: 0
Validation of the 'TWO-ROP' algorithm in a tertiary Care Centre in Greece. “TWO-ROP”算法在希腊三级医疗中心的验证。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-03 DOI: 10.1111/aos.70053
Stella Moutzouri, Celine Chaaya, Francisco Altamirano, Srujay Pandiri, Sandra Hoyek, Marfy Abousifein, Arthur Brant, Demetrios G Vavvas, Asimina Mataftsi, Nimesh A Patel

Purpose: The TWO-ROP algorithm is a modified screening protocol based on US data for low-risk infants that limits screening to a single outpatient exam at 38 or 40 weeks to reduce the retinopathy of prematurity (ROP) screening burden without compromising safety. The aim of this study was to validate the algorithm on an external data set outside the United States.

Methods: This is a retrospective study of premature infants screened for ROP at a tertiary centre in Greece. Infants with higher birth weight (BW) and greater gestational age (GA) were included and stratified into three groups: group 1 (BW < 1500 g, GA ≥ 32 weeks), group 2 (BW ≥ 1500 g, GA < 32 weeks) and group 3 (BW ≥ 1500 g, GA ≥ 32 weeks). The rate of ROP and type 1 ROP were evaluated.

Results: Five hundred and fifty-three of the 1251 infants (44.2%) met the inclusion criteria. Groups 1, 2 and 3 had 139 (25.1%), 283 (51.2%) and 131 (23.7%) patients. Fourteen patients (2.5%) had ROP, including 7 in group 1, 7in group 2 and 0 in group 3 (p < 0.001). No patient met the criteria for type 1 ROP. No cases of treatment warranted ROP (TW-ROP) were observed in the cohort, indicating no missed cases under the TWO-ROP algorithm. When applying the algorithm, 14.3%-14.9% (mean 14.6%) of ROP examinations were saved.

Conclusion: The TWO-ROP algorithm can reduce examinations while ensuring safety in Greece when using the local screening guidelines. This is the first ex-US validation and supports the potential for risk-stratified screening globally to optimize resources while maintaining safety.

目的:TWO-ROP算法是一种基于美国低风险婴儿数据的改进筛查方案,该方案将筛查限制在38或40周时进行一次门诊检查,以减少早产儿视网膜病变(ROP)筛查负担,同时不影响安全性。本研究的目的是在美国以外的外部数据集上验证该算法。方法:这是一个回顾性研究早产儿筛选ROP在希腊三级中心。结果:1251例新生儿中553例(44.2%)符合纳入标准。1、2、3组分别有139例(25.1%)、283例(51.2%)、131例(23.7%)。14例(2.5%)患者发生ROP,其中组1 7例,组2 7例,组3 0例(p结论:在希腊,使用当地筛查指南时,TWO-ROP算法可以减少检查,同时确保安全性。这是美国以外的第一次验证,支持全球风险分层筛查的潜力,以优化资源,同时保持安全性。
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引用次数: 0
Corneal power modelling with OCT data - Thin and thick lens paraxial models versus raytracing. 用OCT数据建立角膜功率模型-薄透镜和厚透镜近轴模型与射线追踪。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-02 DOI: 10.1111/aos.70052
Achim Langenbucher, Nóra Szentmáry, Alan Cayless, Peter Hoffmann, Jascha Wendelstein

Background: Evaluating keratometric power with Zeiss index (PKZ), paraxial thick cornea power (Gullstrand [PG]) and power referenced to the front (PFV) and back vertex plane (PBV) and raytracing power (PR), and modelling the deviation from PKZ with a multivariable linear prediction model.

Methods: A dataset of 4604 Casia2 measurements from a cataractous population was Copula expanded to N = 30 000 maintaining the individual univariate distributions and interactions. PKZ was compared with paraxial thick lens corneal power PG, PFV, PBV, and PR using measured pupil size and variations of apertures from 1 to 6 mm.

Results: On average, PKZ/PG/PFV/PBV was 43.05/42.74/42.83/43.59 D, and PR was 43.03 D with the measured pupil size. Varying pupil size from 1 (1) 6 mm increased mean PR with aperture size (42.84/42.91/43.02/43.17/43.37/43.62 D). The multivariate linear models predicting the deviation of PG-PKZ, PFV-PKZ, and PBV-PKZ with corneal radii and central thickness performed well, with R2 = 0.93 and a root mean squared prediction error of 0.01 D, whereas the equivalent model for PR-PKZ with corneal radii and asphericities, corneal thickness, and aperture sizes performed less well, with R2 = 0.79 and a root mean squared prediction error of 0.18 D.

Conclusion: Corneal power derived using the paraxial thick cornea model differs from keratometric power and a linear model performs well in predicting the differences. However, raytracing power differs even more from keratometry with the linear model far less effective.

研究背景:利用蔡司指数(Zeiss index, PKZ)、近轴厚角膜度数(Gullstrand [PG])、参照前顶点平面(PFV)和后顶点平面(PBV)的度数以及光线追踪力(raytracing power, PR)评价角膜度数,并利用多变量线性预测模型对与PKZ的偏差进行建模。方法:对来自白内障人群的4604个Casia2测量数据集进行Copula扩展至N = 30000,保持个体单变量分布和相互作用。通过测量瞳孔大小和孔径从1到6 mm的变化,将PKZ与近轴厚晶状体角膜度数PG、PFV、PBV和PR进行比较。结果:随瞳孔大小的变化,PKZ/PG/PFV/PBV平均为43.05/42.74/42.83/43.59 D, PR平均为43.03 D。瞳孔大小从1(1)到6 mm不等,平均PR随孔径大小的增加而增加(42.84/42.91/43.02/43.17/43.37/43.62 D)。预测PG-PKZ、PFV-PKZ和PBV-PKZ与角膜半径和中心厚度偏差的多元线性模型效果较好,R2 = 0.93,均方根预测误差为0.01 D,而预测PR-PKZ与角膜半径和非球面度、角膜厚度和孔径大小偏差的多元线性模型效果较差,R2 = 0.79,均方根预测误差为0.18 D。使用近轴厚角膜模型得出的角膜度数不同于角膜度数,线性模型在预测差异方面表现良好。然而,光线追踪的能力与角化测量法的差异更大,线性模型的效果要差得多。
{"title":"Corneal power modelling with OCT data - Thin and thick lens paraxial models versus raytracing.","authors":"Achim Langenbucher, Nóra Szentmáry, Alan Cayless, Peter Hoffmann, Jascha Wendelstein","doi":"10.1111/aos.70052","DOIUrl":"https://doi.org/10.1111/aos.70052","url":null,"abstract":"<p><strong>Background: </strong>Evaluating keratometric power with Zeiss index (PKZ), paraxial thick cornea power (Gullstrand [PG]) and power referenced to the front (PFV) and back vertex plane (PBV) and raytracing power (PR), and modelling the deviation from PKZ with a multivariable linear prediction model.</p><p><strong>Methods: </strong>A dataset of 4604 Casia2 measurements from a cataractous population was Copula expanded to N = 30 000 maintaining the individual univariate distributions and interactions. PKZ was compared with paraxial thick lens corneal power PG, PFV, PBV, and PR using measured pupil size and variations of apertures from 1 to 6 mm.</p><p><strong>Results: </strong>On average, PKZ/PG/PFV/PBV was 43.05/42.74/42.83/43.59 D, and PR was 43.03 D with the measured pupil size. Varying pupil size from 1 (1) 6 mm increased mean PR with aperture size (42.84/42.91/43.02/43.17/43.37/43.62 D). The multivariate linear models predicting the deviation of PG-PKZ, PFV-PKZ, and PBV-PKZ with corneal radii and central thickness performed well, with R<sup>2</sup> = 0.93 and a root mean squared prediction error of 0.01 D, whereas the equivalent model for PR-PKZ with corneal radii and asphericities, corneal thickness, and aperture sizes performed less well, with R<sup>2</sup> = 0.79 and a root mean squared prediction error of 0.18 D.</p><p><strong>Conclusion: </strong>Corneal power derived using the paraxial thick cornea model differs from keratometric power and a linear model performs well in predicting the differences. However, raytracing power differs even more from keratometry with the linear model far less effective.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of macular drusen in an East Asian population. The Beijing Eye Study. 东亚人群黄斑水肿的相关性研究。北京眼科研究。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-02 DOI: 10.1111/aos.70043
Jost B Jonas, Songhomitra Panda-Jonas, Ya Xing Wang, Rahul A Jonas

Purpose: To assess associations of macular drusen in a general population, affected by age-related macular degeneration (AMD) or free of any retinal disease.

Methods: Participants of the population-based cross-sectional Beijing Eye Study underwent optical coherence tomography. Macular volume scans were assessed for macular drusen.

Results: The study included 870 eyes (870 participants) (age: 64.7 ± 9.9 years; range: 50-91 years), randomly selected within the groups of early AMD (n = 356 (40.9%) eyes), intermediate AMD (n = 201; 23.1%), late AMD (n = 6; 0.7%) and within eyes without AMD (n = 307; 35.3%). In multivariable analysis, higher drusen count was associated (r2 = 25) with older age (beta: 0.08; p = 0.048), higher serum concentration of cholesterol (beta: 0.10; p = 0.008), shorter axial length (beta: -0.09; p = 0.03), thicker subfoveal choroidal thickness (beta: 0.08; p = 0.04), higher prevalences of macular hyperpigmentations (beta: 0.13; p < 0.001), hyperreflective foci (HRFs) (beta: 0.12; p = 0.004) and reticular pseudodrusen (beta: 0.27; p < 0.001), and a lower prevalence of a visible Henle's layer (beta: -0.15; p < 0.001). Larger drusen size was associated with shorter axial length (beta: -0.08; p = 0.03), thicker subfoveal choroidal thickness (beta: 0.18; p < 0.001), higher prevalences of macular hypopigmentations (beta: 0.14; p < 0.001) and HRFs (beta: 0.31; p < 0.001), and lower prevalences of a visible Henle's layer (beta: -0.19; p < 0.001) and of reticular pseudodrusen (beta: -0.09; p = 0.02).

Conclusions: In this population-based study on Chinese, higher macular drusen count was associated with shorter axial length, thicker subfoveal choroidal thickness, higher prevalences of macular hyperpigmentations, HRFs and reticular pseudodrusen and lower prevalence of a visible Henle's layer. These findings may be clinically helpful and etiologically interesting.

目的:评估受年龄相关性黄斑变性(AMD)影响或无任何视网膜疾病的普通人群中黄斑水肿的相关性。方法:以人群为基础的横断面北京眼研究的参与者进行了光学相干断层扫描。黄斑体积扫描评估黄斑水肿。结果:共纳入870只眼(870名受试者)(年龄:64.7±9.9岁,年龄范围:50-91岁),随机选择早期AMD (n = 356只(40.9%)眼)、中期AMD (n = 201只,23.1%)、晚期AMD (n = 6只,0.7%)和非AMD (n = 307只,35.3%)眼。在多变量分析中,较高的drusen计数与年龄较大(β: 0.08, p = 0.048)、较高的血清胆固醇浓度(β: 0.10, p = 0.008)、较短的轴长(β: -0.09, p = 0.03)、较厚的中央窝下脉络膜厚度(β: 0.08, p = 0.04)、较高的黄斑色素沉着发生率(β: 0.13, p = 0.08)相关。结论:在这项以人群为基础的中国研究中,较高的黄斑结节计数与较短的轴长、较厚的中央凹下脉络膜厚度、较高的黄斑色素沉着、HRFs和网状假性结节患病率以及较低的可见亨利氏层患病率相关。这些发现可能在临床上有帮助,在病因学上也很有趣。
{"title":"Associations of macular drusen in an East Asian population. The Beijing Eye Study.","authors":"Jost B Jonas, Songhomitra Panda-Jonas, Ya Xing Wang, Rahul A Jonas","doi":"10.1111/aos.70043","DOIUrl":"https://doi.org/10.1111/aos.70043","url":null,"abstract":"<p><strong>Purpose: </strong>To assess associations of macular drusen in a general population, affected by age-related macular degeneration (AMD) or free of any retinal disease.</p><p><strong>Methods: </strong>Participants of the population-based cross-sectional Beijing Eye Study underwent optical coherence tomography. Macular volume scans were assessed for macular drusen.</p><p><strong>Results: </strong>The study included 870 eyes (870 participants) (age: 64.7 ± 9.9 years; range: 50-91 years), randomly selected within the groups of early AMD (n = 356 (40.9%) eyes), intermediate AMD (n = 201; 23.1%), late AMD (n = 6; 0.7%) and within eyes without AMD (n = 307; 35.3%). In multivariable analysis, higher drusen count was associated (r<sup>2</sup> = 25) with older age (beta: 0.08; p = 0.048), higher serum concentration of cholesterol (beta: 0.10; p = 0.008), shorter axial length (beta: -0.09; p = 0.03), thicker subfoveal choroidal thickness (beta: 0.08; p = 0.04), higher prevalences of macular hyperpigmentations (beta: 0.13; p < 0.001), hyperreflective foci (HRFs) (beta: 0.12; p = 0.004) and reticular pseudodrusen (beta: 0.27; p < 0.001), and a lower prevalence of a visible Henle's layer (beta: -0.15; p < 0.001). Larger drusen size was associated with shorter axial length (beta: -0.08; p = 0.03), thicker subfoveal choroidal thickness (beta: 0.18; p < 0.001), higher prevalences of macular hypopigmentations (beta: 0.14; p < 0.001) and HRFs (beta: 0.31; p < 0.001), and lower prevalences of a visible Henle's layer (beta: -0.19; p < 0.001) and of reticular pseudodrusen (beta: -0.09; p = 0.02).</p><p><strong>Conclusions: </strong>In this population-based study on Chinese, higher macular drusen count was associated with shorter axial length, thicker subfoveal choroidal thickness, higher prevalences of macular hyperpigmentations, HRFs and reticular pseudodrusen and lower prevalence of a visible Henle's layer. These findings may be clinically helpful and etiologically interesting.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-resolution OCT and in vivo confocal microscopy in corneal epithelial disorders. 高分辨率OCT和体内共聚焦显微镜在角膜上皮疾病中的应用。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-02 DOI: 10.1111/aos.70041
Katarzyna Walasz, Ewa Wróblewska-Czajka, Adam Wylęgała, Edward Wylęgała
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引用次数: 0
Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on. 儿童肾小管间质性肾炎和葡萄膜炎综合征:需要注意什么?
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-01 DOI: 10.1111/aos.70042
Jytte Hendrikse, Anne Sina Paula Simon, Viera Kalinina Ayuso, Joke Helena de Boer, Gerrit van den Berg

Purpose: The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long-term outcome and the incidence of complications such as chronic kidney disease (CKD).

Methods: We retrospectively analysed the recorded clinical characteristics of 32 children with TINU at their first presentation (baseline) and during a follow-up period of up to 27 months (range: 21-27 months).

Results: The majority of patients (27/32; 84.4%) presented initially with ophthalmological symptoms. The most common initial ophthalmological presentation was anterior unilateral or bilateral uveitis, which in 23 patients progressed to chronic bilateral panuveitis. Patients who presented initially to their paediatrician with nephritis developed ocular symptoms within 4 months following the onset of nephritis. Inflammatory markers of active tubulointerstitial nephritis resolved more quickly than markers of active uveitis (p-value = 0.001). At 21-27 months, 7/23 patients (30.4%) had chronic kidney disease (CKD); moreover, these patients with CKD were significantly less likely to have received systemic corticosteroids at the onset of TINU compared to those without CKD (p-value = 0.045).

Conclusion: Due to its heterogeneity in clinical presentation, all paediatric patients presenting with unilateral or bilateral uveitis should be screened for TINU. Likewise, patients who present with tubulointerstitial nephritis should be screened for the development of uveitis within the first several months. Ophthalmological outcome is favourable after long-term treatment with immunosuppressive medications. Finally, identifying tubulointerstitial nephritis early is important, as nearly one-third of cases can develop CKD and may therefore benefit from early treatment with corticosteroids.

目的:本研究的目的是确定小管间质性肾炎和葡萄膜炎(TINU)综合征患者的病程,重点关注长期预后和慢性肾脏疾病(CKD)等并发症的发生率。方法:我们回顾性分析了32例首次出现(基线)和长达27个月的随访期间(范围:21-27个月)的TINU患儿的临床特征。结果:绝大多数患者(27/32,84.4%)最初表现为眼科症状。最常见的最初眼科表现是单侧或双侧前葡萄膜炎,其中23例发展为慢性双侧全葡萄膜炎。最初以肾炎向儿科医生就诊的患者在肾炎发病后4个月内出现眼部症状。活动性小管间质性肾炎的炎症标志物比活动性葡萄膜炎的标志物消退得更快(p值= 0.001)。21-27个月时,7/23例患者(30.4%)患有慢性肾脏疾病(CKD);此外,与没有CKD的患者相比,这些CKD患者在TINU发病时接受全体性皮质激素治疗的可能性显着降低(p值= 0.045)。结论:由于其临床表现的异质性,所有以单侧或双侧葡萄膜炎为表现的儿科患者都应进行TINU筛查。同样,出现小管间质性肾炎的患者应在最初几个月内筛查是否发展为葡萄膜炎。长期使用免疫抑制药物治疗后,眼科预后良好。最后,早期发现小管间质性肾炎是很重要的,因为近三分之一的病例会发展为CKD,因此可能受益于皮质类固醇的早期治疗。
{"title":"Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on.","authors":"Jytte Hendrikse, Anne Sina Paula Simon, Viera Kalinina Ayuso, Joke Helena de Boer, Gerrit van den Berg","doi":"10.1111/aos.70042","DOIUrl":"https://doi.org/10.1111/aos.70042","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long-term outcome and the incidence of complications such as chronic kidney disease (CKD).</p><p><strong>Methods: </strong>We retrospectively analysed the recorded clinical characteristics of 32 children with TINU at their first presentation (baseline) and during a follow-up period of up to 27 months (range: 21-27 months).</p><p><strong>Results: </strong>The majority of patients (27/32; 84.4%) presented initially with ophthalmological symptoms. The most common initial ophthalmological presentation was anterior unilateral or bilateral uveitis, which in 23 patients progressed to chronic bilateral panuveitis. Patients who presented initially to their paediatrician with nephritis developed ocular symptoms within 4 months following the onset of nephritis. Inflammatory markers of active tubulointerstitial nephritis resolved more quickly than markers of active uveitis (p-value = 0.001). At 21-27 months, 7/23 patients (30.4%) had chronic kidney disease (CKD); moreover, these patients with CKD were significantly less likely to have received systemic corticosteroids at the onset of TINU compared to those without CKD (p-value = 0.045).</p><p><strong>Conclusion: </strong>Due to its heterogeneity in clinical presentation, all paediatric patients presenting with unilateral or bilateral uveitis should be screened for TINU. Likewise, patients who present with tubulointerstitial nephritis should be screened for the development of uveitis within the first several months. Ophthalmological outcome is favourable after long-term treatment with immunosuppressive medications. Finally, identifying tubulointerstitial nephritis early is important, as nearly one-third of cases can develop CKD and may therefore benefit from early treatment with corticosteroids.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic C-reactive protein levels and central serous chorioretinopathy: A systematic review with meta-analysis. 系统性c反应蛋白水平与中枢性浆液性脉络膜视网膜病变:荟萃分析的系统综述。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-01 DOI: 10.1111/aos.70049
Vanessa S Vimalasingam, Nathalie S Eriksen, Rodrigo Anguita, Lasse J Cehofski, Elon H C van Dijk, Lorenzo Ferro Desideri, Peter Kiraly, Laurenz Pauleikhoff, Mehmet Cem Sabaner, Danson V Muttuvelu, Yousif Subhi

Elevated corticosteroid levels are the strongest known risk factor for central serous chorioretinopathy (CSC), and previous studies have explored if alterations in systemic immunity could play a role in CSC. Here, we explored if elevated systemic C-reactive protein (CRP), a marker of systemic low-grade inflammation, is associated with CSC. We systematically searched 12 literature databases on 12 April 2025 for studies in which blood CRP is measured in both patients with CSC and a comparable control group. Studies were reviewed qualitatively. Meta-analysis using the random-effects model was performed on the weighted mean difference in systemic CRP levels between patients with CSC and controls. Six studies comprising 544 patients with CSC and 655 control individuals were eligible for this review. The meta-analysis of the difference in CRP between patients with CSC and controls showed no statistically significant difference at 0.86 mg/L (95% CI: -1.03-2.75 mg/L; p = 0.37). One study reported a very high degree of association between elevated CRP and CSC, which was not reproduced in the other studies. The lack of association remained consistent in the sensitivity analyses. Current evidence does not suggest that elevated systemic CRP levels are associated with CSC. Further studies on CSC pathophysiology are warranted.

皮质类固醇水平升高是已知的中枢性浆液性脉络膜视网膜病变(CSC)的最强危险因素,以前的研究已经探讨了全身免疫的改变是否在CSC中起作用。在这里,我们探讨了是否升高的全身性c反应蛋白(CRP),一个全身性低度炎症的标志,与CSC有关。我们于2025年4月12日系统地检索了12个文献数据库,寻找在CSC患者和可比对照组中测量血液CRP的研究。对研究进行了定性评价。采用随机效应模型对CSC患者和对照组之间系统CRP水平的加权平均差异进行meta分析。包括544名CSC患者和655名对照个体的6项研究符合本综述的条件。对CSC患者与对照组CRP差异的meta分析显示,CRP水平为0.86 mg/L,差异无统计学意义(95% CI: -1.03-2.75 mg/L; p = 0.37)。一项研究报告了CRP升高和CSC之间的高度关联,这在其他研究中没有得到证实。缺乏相关性在敏感性分析中保持一致。目前的证据并不表明全身CRP水平升高与CSC有关。CSC的病理生理学有待进一步研究。
{"title":"Systemic C-reactive protein levels and central serous chorioretinopathy: A systematic review with meta-analysis.","authors":"Vanessa S Vimalasingam, Nathalie S Eriksen, Rodrigo Anguita, Lasse J Cehofski, Elon H C van Dijk, Lorenzo Ferro Desideri, Peter Kiraly, Laurenz Pauleikhoff, Mehmet Cem Sabaner, Danson V Muttuvelu, Yousif Subhi","doi":"10.1111/aos.70049","DOIUrl":"https://doi.org/10.1111/aos.70049","url":null,"abstract":"<p><p>Elevated corticosteroid levels are the strongest known risk factor for central serous chorioretinopathy (CSC), and previous studies have explored if alterations in systemic immunity could play a role in CSC. Here, we explored if elevated systemic C-reactive protein (CRP), a marker of systemic low-grade inflammation, is associated with CSC. We systematically searched 12 literature databases on 12 April 2025 for studies in which blood CRP is measured in both patients with CSC and a comparable control group. Studies were reviewed qualitatively. Meta-analysis using the random-effects model was performed on the weighted mean difference in systemic CRP levels between patients with CSC and controls. Six studies comprising 544 patients with CSC and 655 control individuals were eligible for this review. The meta-analysis of the difference in CRP between patients with CSC and controls showed no statistically significant difference at 0.86 mg/L (95% CI: -1.03-2.75 mg/L; p = 0.37). One study reported a very high degree of association between elevated CRP and CSC, which was not reproduced in the other studies. The lack of association remained consistent in the sensitivity analyses. Current evidence does not suggest that elevated systemic CRP levels are associated with CSC. Further studies on CSC pathophysiology are warranted.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal replacement therapy in postmenopausal women is not associated with the incidence of cataract surgery: Evidence from 43 116 females in a Finnish nested case-control study. 绝经后妇女的激素替代治疗与白内障手术的发生率无关:来自芬兰巢式病例对照研究的43116名女性的证据。
IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-11-30 DOI: 10.1111/aos.70051
Sirpa Loukovaara, Jari Haukka
{"title":"Hormonal replacement therapy in postmenopausal women is not associated with the incidence of cataract surgery: Evidence from 43 116 females in a Finnish nested case-control study.","authors":"Sirpa Loukovaara, Jari Haukka","doi":"10.1111/aos.70051","DOIUrl":"https://doi.org/10.1111/aos.70051","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Acta Ophthalmologica
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