Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.204-205
D. Farkas, Nikolett Kállai-Szabó, I. Antal
For almost half a century foams have been present in the pharmaceutical markets worldwide. Generally, they can be defined as thin liquid or solid film separated gas bubble agglomerations, but the pharmacopoeial monograph of medicated foams recognizes only the aforementioned 1,2. Pharmaceutical foams offer an outstanding alternative to conventional dosage forms in topical treatment. Apart from the satisfactory drug delivery ability, the ease and convenience of application contributes to the high acceptance and excellent patient compliance of this dosage form. Despite the growing interest for foams, the current pharmacopoeial examinations are not sufficient for the description of their unique nature and virtue. Although image analysis can not provide an exhaustive overview on foams, it offers a great complementary method for their assessment 3,4. This research aims to demonstrate the extensive applicability of image analysis in the evaluation process of pharmaceutical foams. It also aims to make assumptions on important foam characteristics based on the composition and the microand macroscopic properties of foams.
{"title":"Image Analysis: A Novel Method in the Assessment of Pharmaceutical Foams","authors":"D. Farkas, Nikolett Kállai-Szabó, I. Antal","doi":"10.33892/aph.2021.91.204-205","DOIUrl":"https://doi.org/10.33892/aph.2021.91.204-205","url":null,"abstract":"For almost half a century foams have been present in the pharmaceutical markets worldwide. Generally, they can be defined as thin liquid or solid film separated gas bubble agglomerations, but the pharmacopoeial monograph of medicated foams recognizes only the aforementioned 1,2. Pharmaceutical foams offer an outstanding alternative to conventional dosage forms in topical treatment. Apart from the satisfactory drug delivery ability, the ease and convenience of application contributes to the high acceptance and excellent patient compliance of this dosage form. Despite the growing interest for foams, the current pharmacopoeial examinations are not sufficient for the description of their unique nature and virtue. Although image analysis can not provide an exhaustive overview on foams, it offers a great complementary method for their assessment 3,4. This research aims to demonstrate the extensive applicability of image analysis in the evaluation process of pharmaceutical foams. It also aims to make assumptions on important foam characteristics based on the composition and the microand macroscopic properties of foams.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91070820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.328-329
Zsófia Vilimi, M. Hajdú, Nikolett Kállai-Szabó, I. Antal
{"title":"Study on Drug Release from Oleogel Carriers","authors":"Zsófia Vilimi, M. Hajdú, Nikolett Kállai-Szabó, I. Antal","doi":"10.33892/aph.2021.91.328-329","DOIUrl":"https://doi.org/10.33892/aph.2021.91.328-329","url":null,"abstract":"","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91070909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.124-125
I. Toth, M. Skwarczynski
The development of an effective vaccine for group A streptococci (GAS) has been challenged by the induced autoimmunity of epitopes derived from the C-repeat regions. Additionally, there are B-cell epitopes that have been shown to react with human heart tissue. Shorter safe B-cell epitopes, show little or no immunogenicity unless bound to a delivery platform including the conjugation to an inbuilt adjuvant. Self-adjuvanting lipid core peptide (LCP) systems where the antigen(s), carrier and adjuvant were within the same molecular entity has been developed. The LCP amphiphilic construct was incorporated into liposomes to produce particles with the desired size. The construct alone elicited high-levels of antibody titers comparable to that of the positive control (J8 + Complete Freund’s adjuvant). The developed strategy to produce nanoparticles, consisting of a peripheral antigenic epitope layer conjugated to a dendrimer core, which is both self-adjuvanting and produces a strong immune response to the GAS M-protein, offers an attractive alternative to conventional vaccine approaches. The greatest advantage of this system being the generation of protective immune response after oral administration. Our dendrimer-nanoparticles vaccine approach should be readily acquiescent to other pathogenic organisms in addition to GAS, and may prove particularly useful for the design of vaccines against infection deceases know to stimulate autoimmune response in a host.
{"title":"Lipopeptide Nanoparticulate Vaccine Candidates for the Induction of Protective Immune Responses","authors":"I. Toth, M. Skwarczynski","doi":"10.33892/aph.2021.91.124-125","DOIUrl":"https://doi.org/10.33892/aph.2021.91.124-125","url":null,"abstract":"The development of an effective vaccine for group A streptococci (GAS) has been challenged by the induced autoimmunity of epitopes derived from the C-repeat regions. Additionally, there are B-cell epitopes that have been shown to react with human heart tissue. Shorter safe B-cell epitopes, show little or no immunogenicity unless bound to a delivery platform including the conjugation to an inbuilt adjuvant. Self-adjuvanting lipid core peptide (LCP) systems where the antigen(s), carrier and adjuvant were within the same molecular entity has been developed. The LCP amphiphilic construct was incorporated into liposomes to produce particles with the desired size. The construct alone elicited high-levels of antibody titers comparable to that of the positive control (J8 + Complete Freund’s adjuvant). The developed strategy to produce nanoparticles, consisting of a peripheral antigenic epitope layer conjugated to a dendrimer core, which is both self-adjuvanting and produces a strong immune response to the GAS M-protein, offers an attractive alternative to conventional vaccine approaches. The greatest advantage of this system being the generation of protective immune response after oral administration. Our dendrimer-nanoparticles vaccine approach should be readily acquiescent to other pathogenic organisms in addition to GAS, and may prove particularly useful for the design of vaccines against infection deceases know to stimulate autoimmune response in a host.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90797487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.274-275
B. Buchholcz, G. Mezőhegyi, F. Darvas
{"title":"Space Chemistry Realization via SpaceMedChem","authors":"B. Buchholcz, G. Mezőhegyi, F. Darvas","doi":"10.33892/aph.2021.91.274-275","DOIUrl":"https://doi.org/10.33892/aph.2021.91.274-275","url":null,"abstract":"","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"264 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89357492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.163-164
A. Ács, Dániel Szabó, K. Vékey, G. Sármay, L. Drahos, Lilla Turiák
The process of glycosylation is a highly conserved mechanism among species. The enzymatic addition of oligosaccharide chain to the protein significantly changes the physicochemical properties and protein-protein interactions. Therefore glycosylation considered as a CQA (Critical Quality Attribute) for biopharmaceutical products. At this point there is no routinely used, widespread analytical method to determine glycosylation. This may derive from the fact that the term glycosylation summarizes various features. The most often examined feature is the relative abundance of glycoforms. The position of different sugar residues within the oligosaccharide chain has been less frequently analyzed. In this study we have developed a method which, in addition to the commonly investigated features, determines the structural position of the fucose residue. We have examined glycosylation of three proteins: AGP (alpha-1-acid glycoprotein), PSA (Prostate Specific Antigen) and IgG (Immunoglobulin G).
{"title":"Structural Analysis of Human Glycoproteins by Tandem Mass Spectrometry","authors":"A. Ács, Dániel Szabó, K. Vékey, G. Sármay, L. Drahos, Lilla Turiák","doi":"10.33892/aph.2021.91.163-164","DOIUrl":"https://doi.org/10.33892/aph.2021.91.163-164","url":null,"abstract":"The process of glycosylation is a highly conserved mechanism among species. The enzymatic addition of oligosaccharide chain to the protein significantly changes the physicochemical properties and protein-protein interactions. Therefore glycosylation considered as a CQA (Critical Quality Attribute) for biopharmaceutical products. At this point there is no routinely used, widespread analytical method to determine glycosylation. This may derive from the fact that the term glycosylation summarizes various features. The most often examined feature is the relative abundance of glycoforms. The position of different sugar residues within the oligosaccharide chain has been less frequently analyzed. In this study we have developed a method which, in addition to the commonly investigated features, determines the structural position of the fucose residue. We have examined glycosylation of three proteins: AGP (alpha-1-acid glycoprotein), PSA (Prostate Specific Antigen) and IgG (Immunoglobulin G).","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75879761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.293-295
Duong Thi Thuan, A. Isomäki, Urve Paaver, Ivo Laidmäe, A. Tõnisoo, Tran Thi Hai Yen, Karin Kogermann, A. Raal, J. Heinämäki, Pham Thi Minh Hue
The poor solubility in water is very often a problem for active pharmaceutical substances of plant origin. The formulation of such drugs as liposomal preparations enables to improve the bioavailability of these drugs. Berberine (BBR) is a quaternary isoquinoline alkaloid derived from many native plant species (Coptis spp., Berberis spp., Hydrastis canadensis etc.). BBR has been traditionally used for the treatment of different disorders including hyper-cholesterolemia and cardiovascular diseases [1,2]. BBR has a strong antimicrobial activity enabling the use of it as an anti-diarrheal, anti-protozoal, fungal, candida, yeast, and parasitic intestinal active ingredient [3]. In addition, BBR has shown an anti-inflammatory, anti-diabetic, lipid peroxidation, and neuroprotective activity [3,4]. Unfortunaterly, BBR is poorly soluble in water and has a low bioavailability (<10%) due to the induced activity of multidrug efflux transporter Pglycoprotein (P-gp) in the intestine itself [2]. Such limitations associated with a poor oral bioavailability of BBR could be overcome by nanoformulating BBR to liposomes. Pharmaceutical liposomes can be fabricated by ethanol-injection and thin-film hydration methods. The lamellarity, size, shape and ultra-structure of liposomes can be determined by using different advanced techniques, such as cryogenic electron microscopy (Cryo-EM), dynamic light scattering (DLS), size-exclusion chromatography (SEC), and atomic force microscopy (AFM) [5]. Confocal laser scanning microscopy (CLSM) has been also used for such imaging [6]. The aim of our study is to investigate ethanolinjection and film hydration methods for generating BBR-loaded liposomes and to study the structure, size, size distribution and entrapment efficiency of the liposomes. The liposomes are ultimately intended for the oral treatment of hypercholesterolemia.
{"title":"Berberine-loaded Nano-Liposomes Generated with Ethanol-Injection and Thin-film Hydration Methods","authors":"Duong Thi Thuan, A. Isomäki, Urve Paaver, Ivo Laidmäe, A. Tõnisoo, Tran Thi Hai Yen, Karin Kogermann, A. Raal, J. Heinämäki, Pham Thi Minh Hue","doi":"10.33892/aph.2021.91.293-295","DOIUrl":"https://doi.org/10.33892/aph.2021.91.293-295","url":null,"abstract":"The poor solubility in water is very often a problem for active pharmaceutical substances of plant origin. The formulation of such drugs as liposomal preparations enables to improve the bioavailability of these drugs. Berberine (BBR) is a quaternary isoquinoline alkaloid derived from many native plant species (Coptis spp., Berberis spp., Hydrastis canadensis etc.). BBR has been traditionally used for the treatment of different disorders including hyper-cholesterolemia and cardiovascular diseases [1,2]. BBR has a strong antimicrobial activity enabling the use of it as an anti-diarrheal, anti-protozoal, fungal, candida, yeast, and parasitic intestinal active ingredient [3]. In addition, BBR has shown an anti-inflammatory, anti-diabetic, lipid peroxidation, and neuroprotective activity [3,4]. Unfortunaterly, BBR is poorly soluble in water and has a low bioavailability (<10%) due to the induced activity of multidrug efflux transporter Pglycoprotein (P-gp) in the intestine itself [2]. Such limitations associated with a poor oral bioavailability of BBR could be overcome by nanoformulating BBR to liposomes. Pharmaceutical liposomes can be fabricated by ethanol-injection and thin-film hydration methods. The lamellarity, size, shape and ultra-structure of liposomes can be determined by using different advanced techniques, such as cryogenic electron microscopy (Cryo-EM), dynamic light scattering (DLS), size-exclusion chromatography (SEC), and atomic force microscopy (AFM) [5]. Confocal laser scanning microscopy (CLSM) has been also used for such imaging [6]. The aim of our study is to investigate ethanolinjection and film hydration methods for generating BBR-loaded liposomes and to study the structure, size, size distribution and entrapment efficiency of the liposomes. The liposomes are ultimately intended for the oral treatment of hypercholesterolemia.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77176836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.276-277
Á. Móricz, D. Krüzselyi, Maryam Jamshidi-Aidji, P. Ott, G. Morlock
In the last decade, effect-directed analysis (EDA) gave new impetus for the discovery of new potential drug compounds from natural sources. Highperformance thin-layer chromatography (HPTLC) was established as a high-throughput and reliable separation technique that is frequently utilized for screening of highly complex samples, such as crude plant extracts. HPTLC combined with biological and biochemical assays and high-resolution mass spectrometry (HRMS) followed by bioassay-guided isolation and NMR was demonstrated as a straightforward strategy for bioanalysis of natural products [1,2]. Diabetes and Alzheimer’s disease (AD) represent two of the global health issues. Type 2 diabetic patients, the majority of the people with diabetes, suffer from the hyperglycemia. The salivary and pancreatic α-amylases and αand β-glucosidases are involved in the degradation and digestion of polyand oligosaccharides to glucose, hence, glucosidase and amylase inhibitors are of therapeutic interest in type 2 diabetes as well as overweight and obesity [3,4]. AD is associated with the loss of cholinergic neurons in the brain and decrease in the neurotransmitter acetylcholine. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucially involved in the hydrolysis of the acetylcholine into choline. Hence, AChE-selective and dual AChE/BChE inhibitors represented the first generation of medicines for the decrease of the AD progression rate [5]. The fight against infectious diseases, a major global public hazard, is also a challenge due to the increase in the emergence of the (multi)drug-resistant microorganisms [6]. In this study (HP)TLC combined with direct αand β-glucosidase, α-amylase and antimicrobial assays will be demonstrated for the comparison of the bio-profiles (the enzyme inhibitory and antibacterial potentials) of invasive goldenrod species.
{"title":"High-Throughput Screening for Bioactive Natural Compounds from Plant Extracts by HPTLC Hyphenations","authors":"Á. Móricz, D. Krüzselyi, Maryam Jamshidi-Aidji, P. Ott, G. Morlock","doi":"10.33892/aph.2021.91.276-277","DOIUrl":"https://doi.org/10.33892/aph.2021.91.276-277","url":null,"abstract":"In the last decade, effect-directed analysis (EDA) gave new impetus for the discovery of new potential drug compounds from natural sources. Highperformance thin-layer chromatography (HPTLC) was established as a high-throughput and reliable separation technique that is frequently utilized for screening of highly complex samples, such as crude plant extracts. HPTLC combined with biological and biochemical assays and high-resolution mass spectrometry (HRMS) followed by bioassay-guided isolation and NMR was demonstrated as a straightforward strategy for bioanalysis of natural products [1,2]. Diabetes and Alzheimer’s disease (AD) represent two of the global health issues. Type 2 diabetic patients, the majority of the people with diabetes, suffer from the hyperglycemia. The salivary and pancreatic α-amylases and αand β-glucosidases are involved in the degradation and digestion of polyand oligosaccharides to glucose, hence, glucosidase and amylase inhibitors are of therapeutic interest in type 2 diabetes as well as overweight and obesity [3,4]. AD is associated with the loss of cholinergic neurons in the brain and decrease in the neurotransmitter acetylcholine. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucially involved in the hydrolysis of the acetylcholine into choline. Hence, AChE-selective and dual AChE/BChE inhibitors represented the first generation of medicines for the decrease of the AD progression rate [5]. The fight against infectious diseases, a major global public hazard, is also a challenge due to the increase in the emergence of the (multi)drug-resistant microorganisms [6]. In this study (HP)TLC combined with direct αand β-glucosidase, α-amylase and antimicrobial assays will be demonstrated for the comparison of the bio-profiles (the enzyme inhibitory and antibacterial potentials) of invasive goldenrod species.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77562632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.177-178
Á. Barna, K. Sántha, Nikolett Kállai-Szabó, E. Balogh, Bálint Basa, G. Jakab, I. Antal
{"title":"Comparative Dissolution Study of Coated Pellets Containing Microcrystalline Cellulose and Lactose As Core Materials","authors":"Á. Barna, K. Sántha, Nikolett Kállai-Szabó, E. Balogh, Bálint Basa, G. Jakab, I. Antal","doi":"10.33892/aph.2021.91.177-178","DOIUrl":"https://doi.org/10.33892/aph.2021.91.177-178","url":null,"abstract":"","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79478837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-15DOI: 10.33892/aph.2021.91.247-248
Adrienn Kazsoki, A. Farkas, Diána Balogh‐Weiser, E. Mancuso, P. Sharma, D. Lamprou, R. Zelkó
In the recent past, one of the major challenges of the pharmaceutical industry was to overcome the poor aqueous solubility and permeability of new drug candidates, leading to their low bioavailability [1]. To solve these problems, novel structures were developed involving the polymer-based nanofibrous drug delivery systems [2,3]. The unique properties of the nanofibers as the high porosity with interconnected pore network and the increased surface area of the fibrous sheets, together with the active pharmaceutical ingredients can be embedded into the polymeric matrix carrier in an amorphous state, could lead to an increased dissolution and thus the bioavailability of drugs with a lower solubility [4,5]. Due to their structure, the formulation of nanofibrous materials loaded with different drugs have been widely used as drug delivery systems, scaffolds for tissue engineering and wound bandage. Electrospinning is a well controllable, simple and cost-effective technique for preparing matrices with nanometer-sized fibers with similar features and morphologies to the extracellular matrix (ECM) [6]. The ECM is the non-cellular component presents within all tissues and organs and plays a vital role in the wound healing process [7]. Therefore from those materials which can mimic their structure are believed to stimulate cell proliferation and could help the wound healing [6]. The diverse field of application of the nanofibrous materials required adequate functionalityrelated characteristics. One of the emerging improvements is the development of a bi-component core-shell fiber structure [8], which can offer several benefits for these samples: the core polymer/ composite can provide the required mechanical, physicochemical properties, and can control the release of the incorporated drug(s). The shell materials could preserve the unstable active pharmaceutical ingredients embedded into the core from the unfavorable environmental effect, which can increase the hydrophilicity and the biocompatibility of the fibrous samples. Besides that, one of the significant advantages of this core-shell nanostructures lies in the potential to tailor release properties of the incorporated drug and combine features of different polymers to achieve the required functionality-related characteristic and mechanical properties also [5].
{"title":"Formulation and Complex Morphological Characterization of Core-Shell Fibrous Mats for Chronic Wound Healing","authors":"Adrienn Kazsoki, A. Farkas, Diána Balogh‐Weiser, E. Mancuso, P. Sharma, D. Lamprou, R. Zelkó","doi":"10.33892/aph.2021.91.247-248","DOIUrl":"https://doi.org/10.33892/aph.2021.91.247-248","url":null,"abstract":"In the recent past, one of the major challenges of the pharmaceutical industry was to overcome the poor aqueous solubility and permeability of new drug candidates, leading to their low bioavailability [1]. To solve these problems, novel structures were developed involving the polymer-based nanofibrous drug delivery systems [2,3]. The unique properties of the nanofibers as the high porosity with interconnected pore network and the increased surface area of the fibrous sheets, together with the active pharmaceutical ingredients can be embedded into the polymeric matrix carrier in an amorphous state, could lead to an increased dissolution and thus the bioavailability of drugs with a lower solubility [4,5]. Due to their structure, the formulation of nanofibrous materials loaded with different drugs have been widely used as drug delivery systems, scaffolds for tissue engineering and wound bandage. Electrospinning is a well controllable, simple and cost-effective technique for preparing matrices with nanometer-sized fibers with similar features and morphologies to the extracellular matrix (ECM) [6]. The ECM is the non-cellular component presents within all tissues and organs and plays a vital role in the wound healing process [7]. Therefore from those materials which can mimic their structure are believed to stimulate cell proliferation and could help the wound healing [6]. The diverse field of application of the nanofibrous materials required adequate functionalityrelated characteristics. One of the emerging improvements is the development of a bi-component core-shell fiber structure [8], which can offer several benefits for these samples: the core polymer/ composite can provide the required mechanical, physicochemical properties, and can control the release of the incorporated drug(s). The shell materials could preserve the unstable active pharmaceutical ingredients embedded into the core from the unfavorable environmental effect, which can increase the hydrophilicity and the biocompatibility of the fibrous samples. Besides that, one of the significant advantages of this core-shell nanostructures lies in the potential to tailor release properties of the incorporated drug and combine features of different polymers to achieve the required functionality-related characteristic and mechanical properties also [5].","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84413145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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