Pub Date : 2023-05-22DOI: 10.18502/acta.v61i3.12741
H. Azimi, Seyyed Rasoul Sajjadi, S. Saeed, M. Nakhaee, A. Jafarian, B. Davachi, Arezoo Naderi Moghaddam, Toktam Dehghani, Z. Yousefi
Ovarian cancer management during pregnancy is a topic of limited research due to low occurrence rates of malignant adnexal tumors. To shed further light on this issue, we present a case series of 22 pregnant ovarian cancer patients referred to an academic hospital's gynecology oncology department over six years. Data on each patient's demographic and clinical background were collected using a registry software recording surgical tumor staging, disease-free survival (DFS), and overall survival (OS). According to the data analysis reports, subtype epithelial tumor and germ cell pathology were equally 45.4%. However, sex-cord tumors were observed in a smaller percentage of cases (9.1%). Serous adenocarcinoma was the most common subtype among those with epithelial tumors (60%). Meanwhile, 72.7% of these pregnant women had a palpable mass in physical examination. In addition, adnexal mass was detected in 95.4% of ultrasonography. Due to the young age of the patients, fertility-preserving surgery was performed on 63.6% of patients, and chemotherapy was prescripted on 59% of patients. Over a six-year follow-up period, there was a recurrence rate of 22.7%, while DFS and OS were reported as 56% and 82%, respectively. In conclusion, treatment of ovarian malignancies during pregnancy requires an experienced multidisciplinary approach. However, more extensive studies with larger samples are needed to gain more insight into the treatment of ovarian cancer during pregnancy.
{"title":"Pregnant Women With Malignant Ovarian Tumors: A Case Series","authors":"H. Azimi, Seyyed Rasoul Sajjadi, S. Saeed, M. Nakhaee, A. Jafarian, B. Davachi, Arezoo Naderi Moghaddam, Toktam Dehghani, Z. Yousefi","doi":"10.18502/acta.v61i3.12741","DOIUrl":"https://doi.org/10.18502/acta.v61i3.12741","url":null,"abstract":"Ovarian cancer management during pregnancy is a topic of limited research due to low occurrence rates of malignant adnexal tumors. To shed further light on this issue, we present a case series of 22 pregnant ovarian cancer patients referred to an academic hospital's gynecology oncology department over six years. Data on each patient's demographic and clinical background were collected using a registry software recording surgical tumor staging, disease-free survival (DFS), and overall survival (OS). According to the data analysis reports, subtype epithelial tumor and germ cell pathology were equally 45.4%. However, sex-cord tumors were observed in a smaller percentage of cases (9.1%). Serous adenocarcinoma was the most common subtype among those with epithelial tumors (60%). Meanwhile, 72.7% of these pregnant women had a palpable mass in physical examination. In addition, adnexal mass was detected in 95.4% of ultrasonography. Due to the young age of the patients, fertility-preserving surgery was performed on 63.6% of patients, and chemotherapy was prescripted on 59% of patients. Over a six-year follow-up period, there was a recurrence rate of 22.7%, while DFS and OS were reported as 56% and 82%, respectively. In conclusion, treatment of ovarian malignancies during pregnancy requires an experienced multidisciplinary approach. However, more extensive studies with larger samples are needed to gain more insight into the treatment of ovarian cancer during pregnancy. ","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47894787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.18502/acta.v61i3.12742
K. Aghazadeh, Reza Erfanian Azimzade Khosravi, F. Heidari, Nasim Sodagari, Sepideh Karvanian, B. Rahmaty
Lesions in the parapharyngeal space are rare and account for 0.5-1.5% of all head and neck tumours. Of these, venous malformations represent 1% of all parapharyngeal space tumors. In the current paper, we reported a 5-year-old patient who presented with a soft tissue swelling of the parapharyngeal space that was discovered by her parents after two weeks following adenoidectomy. The MRI revealed a tumour within the parapharyngeal space with a well-defined mass with low-signal intensity on T1 and high on T2. The internal flow voids also proposed phleboliths. Therefore, the tumour was removed by an intraoral approach. The post-op pathology result explicated a venous malformation.
{"title":"A Large Parapharyngeal Mass in A Five-Year-Old Girl: A Case Report","authors":"K. Aghazadeh, Reza Erfanian Azimzade Khosravi, F. Heidari, Nasim Sodagari, Sepideh Karvanian, B. Rahmaty","doi":"10.18502/acta.v61i3.12742","DOIUrl":"https://doi.org/10.18502/acta.v61i3.12742","url":null,"abstract":"Lesions in the parapharyngeal space are rare and account for 0.5-1.5% of all head and neck tumours. Of these, venous malformations represent 1% of all parapharyngeal space tumors. In the current paper, we reported a 5-year-old patient who presented with a soft tissue swelling of the parapharyngeal space that was discovered by her parents after two weeks following adenoidectomy. The MRI revealed a tumour within the parapharyngeal space with a well-defined mass with low-signal intensity on T1 and high on T2. The internal flow voids also proposed phleboliths. Therefore, the tumour was removed by an intraoral approach. The post-op pathology result explicated a venous malformation.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47163550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.18502/acta.v61i3.12740
S. Shahinpour, Niusha Momeni, Mahdi Yaqubnejad, M. Khajavi, Pejman Pourfakhr
Postoperative Nausea and vomiting (PONV) are the most complications after laparoscopic surgeries, especially laparoscopic bariatric surgeries. The incidence of PONV has been estimated in over two-thirds of patients undergoing laparoscopic bariatric surgeries. Prophylactic combined antiemetic therapy is recommended for patients undergoing these surgeries. This is a double-blinded randomized clinical trial. Eighty-three patients of ASA physical status I and II undergoing elective bariatric laparoscopic surgery were enrolled in this clinical trial and divided into two equal groups through simple randomization using a random number table. One group (group A) received a combination of ondansetron, dexamethasone, and haloperidol (ODH); and the other group (group B) received a combination of ondansetron, dexamethasone, and promethazine (ODP). The ODP group received promethazine 25 mg IM 30 minutes before extubation and ODH group received haloperidol 2 mg IM at the beginning of the surgery. Nausea and vomiting were assessed in terms of severity and frequency in the recovery room, 6, and 24 hours postoperatively in both groups using the Numeric Verbal Rating Scale (NVRS). The frequency of PONV was significantly lower in the ODH group compared to the ODP group in the recovery room (20% versus 40%). PONV severity was lower in the ODH group compared to the ODP group. The time to first rescue antiemetic prescription in the ODP group was more than in the ODH group (7.2 h versus 2.6 h). In morbidly obese patients undergoing laparoscopic bariatric surgery, both antiemetic combinations decreased the incidence of PONV, but the combination of haloperidol, dexamethasone, and ondansetron was more effective than promethazine, dexamethasone, and ondansetron.
{"title":"Evaluation and Comparison of Two Different Combined Regimens for Prophylaxis of Nausea and Vomiting After Laparoscopic Bariatric Surgery: A Double-Blinded Randomized Clinical Trial","authors":"S. Shahinpour, Niusha Momeni, Mahdi Yaqubnejad, M. Khajavi, Pejman Pourfakhr","doi":"10.18502/acta.v61i3.12740","DOIUrl":"https://doi.org/10.18502/acta.v61i3.12740","url":null,"abstract":"Postoperative Nausea and vomiting (PONV) are the most complications after laparoscopic surgeries, especially laparoscopic bariatric surgeries. The incidence of PONV has been estimated in over two-thirds of patients undergoing laparoscopic bariatric surgeries. Prophylactic combined antiemetic therapy is recommended for patients undergoing these surgeries. This is a double-blinded randomized clinical trial. Eighty-three patients of ASA physical status I and II undergoing elective bariatric laparoscopic surgery were enrolled in this clinical trial and divided into two equal groups through simple randomization using a random number table. One group (group A) received a combination of ondansetron, dexamethasone, and haloperidol (ODH); and the other group (group B) received a combination of ondansetron, dexamethasone, and promethazine (ODP). The ODP group received promethazine 25 mg IM 30 minutes before extubation and ODH group received haloperidol 2 mg IM at the beginning of the surgery. Nausea and vomiting were assessed in terms of severity and frequency in the recovery room, 6, and 24 hours postoperatively in both groups using the Numeric Verbal Rating Scale (NVRS). The frequency of PONV was significantly lower in the ODH group compared to the ODP group in the recovery room (20% versus 40%). PONV severity was lower in the ODH group compared to the ODP group. The time to first rescue antiemetic prescription in the ODP group was more than in the ODH group (7.2 h versus 2.6 h). In morbidly obese patients undergoing laparoscopic bariatric surgery, both antiemetic combinations decreased the incidence of PONV, but the combination of haloperidol, dexamethasone, and ondansetron was more effective than promethazine, dexamethasone, and ondansetron.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45246952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.18502/acta.v61i3.12737
N. Kassem, Ibtessam Saadeldin, H. Zawam, Hebatallah A. Kassem
Multiple myeloma (MM) is a human B-cell neoplasia arising from malignant plasma cells. Vascular endothelial growth factor (VEGF) is among growth factors essential for angiogenesis in MM. However, chemokine (C-X-C motif) ligand 13 (CXCL13) allows the chemotaxis of mature B cells expressing its receptor CXCR5.CXCL13-CXCR5 interactions are involved in MM progression. This study aimed at investigating 2 serum biomarkers; VEGF-A and CXCL13 levels using enzyme linked immunosorbent assays (ELISA) in 48 Egyptian myeloma patients as well as correlation with different clinic-pathological features, survival and therapy response. VEGF-A and CXCL13 levels were significantly higher in MM cases in comparison to control group (P=0.04* and 0.01*, respectively). An indirect proportional relation between VEGF-A and CXCL13 levels in myeloma patients was found (r= -0.27, P=0.22). Alb/creat ratio change showed indirect proportional relation with VEGF-A (r= -0.446, P=0.043*). Patients obtained complete remission (CR)had insignificantly lower VEGF-A and higher CXCL13 levels compared to other patients, P=0.2 and 0.7, respectively. In conclusion, production of variety of growth factors and cytokines such as VEGF-A and CXCL13 was higher in MM patients. However, our experiment has to be done on larger sample size and extended period of follow up to validate the participation of the VEGF-A and CXCL13 in disease progression and clinical outcome.
{"title":"Clinical Significance of Serum Biomarkers: Vascular Endothelial Growth Factor-A and Chemokine (C-X-C motif) Ligand 13 in Egyptian Multiple Myeloma Patients","authors":"N. Kassem, Ibtessam Saadeldin, H. Zawam, Hebatallah A. Kassem","doi":"10.18502/acta.v61i3.12737","DOIUrl":"https://doi.org/10.18502/acta.v61i3.12737","url":null,"abstract":"Multiple myeloma (MM) is a human B-cell neoplasia arising from malignant plasma cells. Vascular endothelial growth factor (VEGF) is among growth factors essential for angiogenesis in MM. However, chemokine (C-X-C motif) ligand 13 (CXCL13) allows the chemotaxis of mature B cells expressing its receptor CXCR5.CXCL13-CXCR5 interactions are involved in MM progression. This study aimed at investigating 2 serum biomarkers; VEGF-A and CXCL13 levels using enzyme linked immunosorbent assays (ELISA) in 48 Egyptian myeloma patients as well as correlation with different clinic-pathological features, survival and therapy response. VEGF-A and CXCL13 levels were significantly higher in MM cases in comparison to control group (P=0.04* and 0.01*, respectively). An indirect proportional relation between VEGF-A and CXCL13 levels in myeloma patients was found (r= -0.27, P=0.22). Alb/creat ratio change showed indirect proportional relation with VEGF-A (r= -0.446, P=0.043*). Patients obtained complete remission (CR)had insignificantly lower VEGF-A and higher CXCL13 levels compared to other patients, P=0.2 and 0.7, respectively. In conclusion, production of variety of growth factors and cytokines such as VEGF-A and CXCL13 was higher in MM patients. However, our experiment has to be done on larger sample size and extended period of follow up to validate the participation of the VEGF-A and CXCL13 in disease progression and clinical outcome.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49358427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-24DOI: 10.18502/acta.v61i2.12557
A. Halefoglu
Hemangioblastoma (HB) is one of the most common primary neoplasms of the posterior fossa in adults. Although single tumors can be sporadic, multiple tumors are almost always associated with von Hippel-Lindau (VHL) disease. In our case report, we are describing a 39-year-old woman with complaints of severe headache, pain, and numbness in both arms. She had a history of VHL disease. We performed contrast-enhanced cranial and cervical spine magnetic resonance imaging (MRI) examinations. Given the patient’s history of VHL disease and characteristic MR imaging features of lesions, cranial and cervical HBs were considered for diagnosis. Surgical excision is the main treatment of these tumors and follow-up optimal imaging of these patients is crucial. In the screening of VHL patients, whole spinal axis imaging in conjunction with routine MRI studies must always be performed to rule out spinal HBs.
{"title":"Von Hippel-Lindau Disease Presenting With Cranial and Spinal Hemangioblastomas: MRI Findings","authors":"A. Halefoglu","doi":"10.18502/acta.v61i2.12557","DOIUrl":"https://doi.org/10.18502/acta.v61i2.12557","url":null,"abstract":"Hemangioblastoma (HB) is one of the most common primary neoplasms of the posterior fossa in adults. Although single tumors can be sporadic, multiple tumors are almost always associated with von Hippel-Lindau (VHL) disease. In our case report, we are describing a 39-year-old woman with complaints of severe headache, pain, and numbness in both arms. She had a history of VHL disease. We performed contrast-enhanced cranial and cervical spine magnetic resonance imaging (MRI) examinations. Given the patient’s history of VHL disease and characteristic MR imaging features of lesions, cranial and cervical HBs were considered for diagnosis. Surgical excision is the main treatment of these tumors and follow-up optimal imaging of these patients is crucial. In the screening of VHL patients, whole spinal axis imaging in conjunction with routine MRI studies must always be performed to rule out spinal HBs.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48250935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-24DOI: 10.18502/acta.v61i2.12556
A. Kamali, A. Chehrei, M. Hasanian, M. Sofian, M. Bahrami, Behzad Khansarinejad, N. Zarinfar, R. Moradzadeh, H. Sarmadian, F. Safi
Novel coronavirus disease 2019 (COVID-19) has become a public health concern with over 6.5 million cases and 390,000 deaths around the world. This research aimed to find an association between computed tomography (CT) scores and clinical and laboratory findings to estimate the extent of lung infection in patients with COVID-19. The study sample enrolled 129 patients diagnosed with COVID-19 from January to February 2020. The chest CT images and clinical data were reviewed, images were segmented and scored by the degree of involvement from 0 to 4, and the relationship between them and clinical and laboratory findings were analyzed statistically. This study included 74 men and 59 women with a mean age of 55.08 years. Different abnormalities were observed; the mean CT score was 8.52 (7.83 to 9.21) and the most frequent lesions were GGO and consolidation. Our results revealed significant differences between groups categorized by dyspnea, sore throat, and low oxygen saturation concerning CT scores. There was also a significant correlation between CT scores and WBC counts and CRP levels (P<0.05). The evidence from this study implies that clinical and laboratory data, such as CRP, dyspnea, lymphopenia, and symptom onset closely correspond to chest CT scores and may be employed as initial tools to estimate the extent of lung involvement in COVID-19 patients.
{"title":"The Extent of Lung Involvement Based on CT-Scores, Compared to Clinical Symptoms and Laboratory Findings in COVID-19 Patients","authors":"A. Kamali, A. Chehrei, M. Hasanian, M. Sofian, M. Bahrami, Behzad Khansarinejad, N. Zarinfar, R. Moradzadeh, H. Sarmadian, F. Safi","doi":"10.18502/acta.v61i2.12556","DOIUrl":"https://doi.org/10.18502/acta.v61i2.12556","url":null,"abstract":"Novel coronavirus disease 2019 (COVID-19) has become a public health concern with over 6.5 million cases and 390,000 deaths around the world. This research aimed to find an association between computed tomography (CT) scores and clinical and laboratory findings to estimate the extent of lung infection in patients with COVID-19. The study sample enrolled 129 patients diagnosed with COVID-19 from January to February 2020. The chest CT images and clinical data were reviewed, images were segmented and scored by the degree of involvement from 0 to 4, and the relationship between them and clinical and laboratory findings were analyzed statistically. This study included 74 men and 59 women with a mean age of 55.08 years. Different abnormalities were observed; the mean CT score was 8.52 (7.83 to 9.21) and the most frequent lesions were GGO and consolidation. Our results revealed significant differences between groups categorized by dyspnea, sore throat, and low oxygen saturation concerning CT scores. There was also a significant correlation between CT scores and WBC counts and CRP levels (P<0.05). The evidence from this study implies that clinical and laboratory data, such as CRP, dyspnea, lymphopenia, and symptom onset closely correspond to chest CT scores and may be employed as initial tools to estimate the extent of lung involvement in COVID-19 patients.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45428844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-24DOI: 10.18502/acta.v61i2.12558
Seyede Tahereh Mousavi, Farshad Zohrabi, M. Farzaneh
Sexual precocity in boys is defined as any sign of secondary sexual characteristics present before the age of 9. Leydig cell tumors of the testes are a rare cause of peripheral precocious puberty in boys. Here, we report 8 years and 4-month-old boys with signs of peripheral precocious puberty because of a testicular Leydig cell tumor that developed true precocious puberty after surgical removal. Examination of genitalia showed Tanner 4 hair growth. The penis length was 14.5 cm with a 2.5 cm width. The right testis was enlarged but the left testis was measured at 2cm in length and 1 cm in width. Laboratory results showed low serum gonadotropin levels and increased androgen levels. Testicular sonography reported one solid mass measured 31×28×15 millimeters. With a presumptive diagnosis of Leydig cell tumor, the patient underwent radical orchiectomy. Pathologic evaluation confirmed it. Two months after surgery, the diagnosis of central precocious puberty was confirmed according to physical examination and rising of serum gonadotropins. We started treatment with a Gonadotropin-releasing hormone (GnRH) agonist. Leydig cell tumor in children is an uncommon cause of precocious puberty. In every boy with the sign of peripheral precocious puberty and asymmetrical testicular enlargement, the testicular tumor should be considered. It may induce central precocious puberty after surgical resection and this diagnosis should be considered in the patient’s follow-up in the next visits.
{"title":"A Testicular Leydig Cell Tumor; An Uncommon Cause of Precocious Puberty: A Case Report With Secondary Central Precocious Puberty","authors":"Seyede Tahereh Mousavi, Farshad Zohrabi, M. Farzaneh","doi":"10.18502/acta.v61i2.12558","DOIUrl":"https://doi.org/10.18502/acta.v61i2.12558","url":null,"abstract":"Sexual precocity in boys is defined as any sign of secondary sexual characteristics present before the age of 9. Leydig cell tumors of the testes are a rare cause of peripheral precocious puberty in boys. Here, we report 8 years and 4-month-old boys with signs of peripheral precocious puberty because of a testicular Leydig cell tumor that developed true precocious puberty after surgical removal. Examination of genitalia showed Tanner 4 hair growth. The penis length was 14.5 cm with a 2.5 cm width. The right testis was enlarged but the left testis was measured at 2cm in length and 1 cm in width. Laboratory results showed low serum gonadotropin levels and increased androgen levels. Testicular sonography reported one solid mass measured 31×28×15 millimeters. With a presumptive diagnosis of Leydig cell tumor, the patient underwent radical orchiectomy. Pathologic evaluation confirmed it. Two months after surgery, the diagnosis of central precocious puberty was confirmed according to physical examination and rising of serum gonadotropins. We started treatment with a Gonadotropin-releasing hormone (GnRH) agonist. Leydig cell tumor in children is an uncommon cause of precocious puberty. In every boy with the sign of peripheral precocious puberty and asymmetrical testicular enlargement, the testicular tumor should be considered. It may induce central precocious puberty after surgical resection and this diagnosis should be considered in the patient’s follow-up in the next visits.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41778834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-24DOI: 10.18502/acta.v61i2.12559
S. Khemiri, J. Feki, N. Toumi, A. Khanfir
The association between multiple myeloma and solid cancers is rarely described in the literature. Some authors report that multiple myeloma increases the risk of developing some cancers such as breast cancer. We report three cases of multiple myeloma and breast cancer metachronous in order to study the etiopathogenesis of this association. Such a big spectrum of these studies should be done to understand whether there is a relation between causes of these two diseases or the risk factors behind this rare association. Our objective is to be able to define patients with high and low risk of developing secondary cancer in order to adapt the therapies and propose possibly screening for colon and breast cancers every two years for patients with high-risk multiple myeloma.
{"title":"Etiopathogeny of Multiple Myeloma Associated With Breast Cancer: Case Reports","authors":"S. Khemiri, J. Feki, N. Toumi, A. Khanfir","doi":"10.18502/acta.v61i2.12559","DOIUrl":"https://doi.org/10.18502/acta.v61i2.12559","url":null,"abstract":"The association between multiple myeloma and solid cancers is rarely described in the literature. Some authors report that multiple myeloma increases the risk of developing some cancers such as breast cancer. We report three cases of multiple myeloma and breast cancer metachronous in order to study the etiopathogenesis of this association. Such a big spectrum of these studies should be done to understand whether there is a relation between causes of these two diseases or the risk factors behind this rare association. Our objective is to be able to define patients with high and low risk of developing secondary cancer in order to adapt the therapies and propose possibly screening for colon and breast cancers every two years for patients with high-risk multiple myeloma.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45668620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.18502/acta.v61i2.12532
F. Abbasi, H. Dadgostar, Mahrokhsadat Vaziri, S. Lotfian
The number of mountaineers and climbers has increased over the last few years. Considering the geographical features of Iran, this increase in the number of climbers is more significant in this country. Because of the importance of mountaineering injuries, a comprehensive survey of these injuries is needed. In this base, we designed a survey to investigate skeletal injuries in mountaineering accidents. This cross-sectional study was conducted on athletes from the Mountaineering Federation of Islamic Republic of the Iran (MFIRI) in 2015 and 2016. A total of 110 athletes were included using a simple random sampling method, and they were examined for any complications after skeletal injuries. Their medical records were reviewed. A total of 110 mountaineers completed the checklists, and 15 mountaineers reported a rock-climbing trauma and injury during 2015 and 2016. The most traumatic location was the lower extremities (46.7%). Additionally, most of trauma occurrences were in descent (80%) and times of day between noon and midnight (64.3%). The mean age of the mountaineers who had a trauma incidence was 37.95±8.76 years. Smoking was significantly different between the two groups. Skeletal injuries during mountaineering and rock climbing mostly affect the lower extremities, followed by the upper extremities and spine. There was no significant difference in age, sex or climbing equipment between the group who had an accident and the group who did not. In this study, there was a relationship between smoking cigarettes and an increased incidence of climbing accidents. Longitudinal studies with larger sample sizes are needed to evaluate this relationship.
{"title":"Skeletal Injuries and Their Pattern Following Mountaineering and Climbing Accidents in Iranian Athletes","authors":"F. Abbasi, H. Dadgostar, Mahrokhsadat Vaziri, S. Lotfian","doi":"10.18502/acta.v61i2.12532","DOIUrl":"https://doi.org/10.18502/acta.v61i2.12532","url":null,"abstract":"The number of mountaineers and climbers has increased over the last few years. Considering the geographical features of Iran, this increase in the number of climbers is more significant in this country. Because of the importance of mountaineering injuries, a comprehensive survey of these injuries is needed. In this base, we designed a survey to investigate skeletal injuries in mountaineering accidents. This cross-sectional study was conducted on athletes from the Mountaineering Federation of Islamic Republic of the Iran (MFIRI) in 2015 and 2016. A total of 110 athletes were included using a simple random sampling method, and they were examined for any complications after skeletal injuries. Their medical records were reviewed. A total of 110 mountaineers completed the checklists, and 15 mountaineers reported a rock-climbing trauma and injury during 2015 and 2016. The most traumatic location was the lower extremities (46.7%). Additionally, most of trauma occurrences were in descent (80%) and times of day between noon and midnight (64.3%). The mean age of the mountaineers who had a trauma incidence was 37.95±8.76 years. Smoking was significantly different between the two groups. Skeletal injuries during mountaineering and rock climbing mostly affect the lower extremities, followed by the upper extremities and spine. There was no significant difference in age, sex or climbing equipment between the group who had an accident and the group who did not. In this study, there was a relationship between smoking cigarettes and an increased incidence of climbing accidents. Longitudinal studies with larger sample sizes are needed to evaluate this relationship.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48030155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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