Pub Date : 2024-02-18DOI: 10.18502/acta.v61i8.14908
Barbara Marčić, L. Marčić, Marino Marčić
Stroke has many different symptoms, isolated hand weakness is the rarest one. Even less common are concomitant radial nerve lesions and ischemic stroke that leads to isolated hand weakness. We report a patient with sudden onset of right wrist drop mimicking radial nerve palsy, found to be due to a acute cerebral infarct and radial nerve palsy in the same time. A well-taken history of the patient's illness and thorough clinical examination can differentiate stroke from peripheral neuropathy as the cause of hand weakness. Modern neuroradiological methods such as brain MSCT or MRI can quickly and reliably indicate the etiology of a neurological disease. In every patient who presents with isolated arm weakness, and for whom we are not sure whether it is a lesion of the central or peripheral nervous system, cerebral infarction must be included as a critical differential diagnosis because it can divert attention from sometimes harmful thrombolytic therapy.
{"title":"Wrist Drop: Acute Ischemic Stroke or Radial Nerve Palsy or Both","authors":"Barbara Marčić, L. Marčić, Marino Marčić","doi":"10.18502/acta.v61i8.14908","DOIUrl":"https://doi.org/10.18502/acta.v61i8.14908","url":null,"abstract":"Stroke has many different symptoms, isolated hand weakness is the rarest one. Even less common are concomitant radial nerve lesions and ischemic stroke that leads to isolated hand weakness. We report a patient with sudden onset of right wrist drop mimicking radial nerve palsy, found to be due to a acute cerebral infarct and radial nerve palsy in the same time. A well-taken history of the patient's illness and thorough clinical examination can differentiate stroke from peripheral neuropathy as the cause of hand weakness. Modern neuroradiological methods such as brain MSCT or MRI can quickly and reliably indicate the etiology of a neurological disease. In every patient who presents with isolated arm weakness, and for whom we are not sure whether it is a lesion of the central or peripheral nervous system, cerebral infarction must be included as a critical differential diagnosis because it can divert attention from sometimes harmful thrombolytic therapy.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-18DOI: 10.18502/acta.v61i8.14906
Athena Behforouz, Hajar Abbasi
Heterotopic pregnancy, a rare form of pregnancy, can occur Simultaneously intrauterine and extrauterine. This can be a life-threatening condition and can be easily overlooked if undiagnosed. The patient was a 27-year-old woman, gravid3, para1, live1 and abortion1, at 10 weeks and 1 day by last menstrual period who went to the emergency room complaining of pain in the lower abdomen form 3 days ago. Pelvic ultrasound revealed both live intrauterine and extrauterine pregnancy by gestational age based on the Crown-rump length diameter, 9 weeks and 3 days with moderate to severe hemoperitoneum. The heterotopic pregnancy diagnosis is difficult and requires a high index of suspicion.
{"title":"Spontaneous Heterotopic Pregnancy: Case Report and Literature Review","authors":"Athena Behforouz, Hajar Abbasi","doi":"10.18502/acta.v61i8.14906","DOIUrl":"https://doi.org/10.18502/acta.v61i8.14906","url":null,"abstract":"Heterotopic pregnancy, a rare form of pregnancy, can occur Simultaneously intrauterine and extrauterine. This can be a life-threatening condition and can be easily overlooked if undiagnosed. The patient was a 27-year-old woman, gravid3, para1, live1 and abortion1, at 10 weeks and 1 day by last menstrual period who went to the emergency room complaining of pain in the lower abdomen form 3 days ago. Pelvic ultrasound revealed both live intrauterine and extrauterine pregnancy by gestational age based on the Crown-rump length diameter, 9 weeks and 3 days with moderate to severe hemoperitoneum. The heterotopic pregnancy diagnosis is difficult and requires a high index of suspicion.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-18DOI: 10.18502/acta.v61i8.14901
H. M. valandani, R. M. Khalilabadi, Amir Mohammad Zahedi
Recently, extracellular vesicles (EVs) are generating considerable interest in terms of their ability. EVs defined themselves as a route for intercellular communication between the origin cells and the recipient ones by transferring information. This paper investigates the influence of peripheral blood mononuclear cells derived EVs on proliferation and apoptosis of the chronic myelogenous leukemia cell line k562. Trypan blue staining was used to detect cell viability subsequently, metabolic activity was assessed by the MTT assay. Cell apoptosis and cell cycle progression were evaluated using flowcytometric assay after treatment of k562 cell line with MNC derived EVs. Our results showed that MNC-EVs have no inhibitory effect on k562 cell growth and proliferation. Our data did not reveal any significant variations in the case of enhancing k562 cell line growth following treatment with MNC derived EVs. It seems tumour-derived extracellular vesicles support tumour cells growth by communicating with each other through their extracellular vesicles.
最近，细胞外囊泡（EVs）的能力引起了人们的极大兴趣。EVs是来源细胞和接受细胞之间通过传递信息进行细胞间交流的途径。本文研究了外周血单核细胞衍生的EVs对慢性骨髓性白血病细胞株k562增殖和凋亡的影响。采用胰蓝染色法检测细胞活力，然后用 MTT 法评估代谢活性。用 MNC 衍生的 EV 处理 k562 细胞系后，使用流式细胞计数法评估细胞凋亡和细胞周期进展。结果表明，MNC-EV 对 k562 细胞的生长和增殖没有抑制作用。我们的数据没有显示用 MNC 衍生 EV 处理 k562 细胞株后，其生长增强情况有任何明显变化。由此看来，肿瘤衍生的细胞外囊泡通过细胞外囊泡之间的交流支持了肿瘤细胞的生长。
{"title":"Effect of Extracellular Vesicles Derived From Peripheral Blood Mononuclear Cells on K562 Leukemia Cell Line","authors":"H. M. valandani, R. M. Khalilabadi, Amir Mohammad Zahedi","doi":"10.18502/acta.v61i8.14901","DOIUrl":"https://doi.org/10.18502/acta.v61i8.14901","url":null,"abstract":"Recently, extracellular vesicles (EVs) are generating considerable interest in terms of their ability. EVs defined themselves as a route for intercellular communication between the origin cells and the recipient ones by transferring information. This paper investigates the influence of peripheral blood mononuclear cells derived EVs on proliferation and apoptosis of the chronic myelogenous leukemia cell line k562. Trypan blue staining was used to detect cell viability subsequently, metabolic activity was assessed by the MTT assay. Cell apoptosis and cell cycle progression were evaluated using flowcytometric assay after treatment of k562 cell line with MNC derived EVs. Our results showed that MNC-EVs have no inhibitory effect on k562 cell growth and proliferation. Our data did not reveal any significant variations in the case of enhancing k562 cell line growth following treatment with MNC derived EVs. It seems tumour-derived extracellular vesicles support tumour cells growth by communicating with each other through their extracellular vesicles.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"2 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-18DOI: 10.18502/acta.v61i8.14904
Hamida S. Jasim, Farqad B. Hamdan, H. Shareef
The goal of this study is to compare the brain connectivity patterns of autistic patients with those of children who are developing normally and analyzing quantitative electroencephalography in children with autism. The study included 50 children who were developing normally and 60 preschoolers who met the DSM-V criteria for autism spectrum disorder. Routine and quantitative electroencephalography were carried out on each subject, as well as a Childhood Autism Rating Scale. The electroencephalograms of 76.67% of autistic children were normal; 6.67% showed focal changes, and 16.67% showed generalized changes. While the alpha power in the central and temporal areas is significantly lower in autistic children, it is unchanged in the frontal and parieto-occipital regions. Children with autism have significantly higher absolute delta and theta band activity both globally and locally. It was shown that the total and regional absolute delta and theta power activity had a significant positive correlation with the disease severity score. Quantitative electroencephalography is a more effective tool for assessing and diagnosing children with autism spectrum disorder because it shows abnormalities in all autistic children. A correlation exists between the quantitative electroencephalography data and the disease severity score.
{"title":"Quantitative Electroencephalography in Children With Autism Spectrum Disorders","authors":"Hamida S. Jasim, Farqad B. Hamdan, H. Shareef","doi":"10.18502/acta.v61i8.14904","DOIUrl":"https://doi.org/10.18502/acta.v61i8.14904","url":null,"abstract":"The goal of this study is to compare the brain connectivity patterns of autistic patients with those of children who are developing normally and analyzing quantitative electroencephalography in children with autism. The study included 50 children who were developing normally and 60 preschoolers who met the DSM-V criteria for autism spectrum disorder. Routine and quantitative electroencephalography were carried out on each subject, as well as a Childhood Autism Rating Scale. The electroencephalograms of 76.67% of autistic children were normal; 6.67% showed focal changes, and 16.67% showed generalized changes. While the alpha power in the central and temporal areas is significantly lower in autistic children, it is unchanged in the frontal and parieto-occipital regions. Children with autism have significantly higher absolute delta and theta band activity both globally and locally. It was shown that the total and regional absolute delta and theta power activity had a significant positive correlation with the disease severity score. Quantitative electroencephalography is a more effective tool for assessing and diagnosing children with autism spectrum disorder because it shows abnormalities in all autistic children. A correlation exists between the quantitative electroencephalography data and the disease severity score.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"5 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-23DOI: 10.18502/acta.v61i7.14492
Parisa Saberi-Hasanabadi, Milad Esmaeilzadeh Farmad, Sajad Aboulfazli, Ali Kheirandish, A. Ataie, Somayyeh Boshtam, R. Ataee
The coronavirus disease (COVID)-19 pandemic led to a new challenge in the field of effective treatment methods for this disease. Antiviral and immunomodulatory agents were suggested as potential therapeutic methods in this field. Since the most severe clinical symptoms associated with COVID-19 disease appear to be acute respiratory syndrome, azithromycin has been proposed as a potentially effective drug in this context. We have updated the evidence and selected all relevant items to understand the mechanism of role of azithromycin, clinical efficacy, and their side effects in coronavirus disease-19 treatment on July 20th and updated on March 20th, 2020. A literature search of electronic databases including the Web of Science, PubMed, and Google Scholar was conducted by searching keywords such as "Azithromycin", "COVID-19", and "Combination therapy". The ultimate goal of this review was identifying eligible studies about the pharmacological activities, safety, and effectiveness of azithromycin in treating COVID-19 patients. Immunomodulatory properties of azithromycin include the ability to reduce cytokine production, maintain epithelial cell integrity, or prevent lung fibrosis. The use of azithromycin in some studies was associated with a decrease in mortality and need for ventilation in patients. These properties can be useful during the period of COVID-19 infection, especially in patients with underlying diseases. However, the evidence for the use of azithromycin is still scarce and the quality of the studies is low. In some retrospective studies, azithromycin was mainly evaluated in combination with hydroxychloroquine, which showed no particular advantage. The results of this review showed that azithromycin has appropriate and well-known safety characteristics in the treatment of patients with COVID-19. However, the most appropriate dosage in different stages of the disease and the effect of its combination with other drugs are important questions that should be considered in future clinical trials.
{"title":"Azithromycin for COVID-19: Pharmacological Mechanisms, Challenges, and Prospects","authors":"Parisa Saberi-Hasanabadi, Milad Esmaeilzadeh Farmad, Sajad Aboulfazli, Ali Kheirandish, A. Ataie, Somayyeh Boshtam, R. Ataee","doi":"10.18502/acta.v61i7.14492","DOIUrl":"https://doi.org/10.18502/acta.v61i7.14492","url":null,"abstract":"The coronavirus disease (COVID)-19 pandemic led to a new challenge in the field of effective treatment methods for this disease. Antiviral and immunomodulatory agents were suggested as potential therapeutic methods in this field. Since the most severe clinical symptoms associated with COVID-19 disease appear to be acute respiratory syndrome, azithromycin has been proposed as a potentially effective drug in this context. We have updated the evidence and selected all relevant items to understand the mechanism of role of azithromycin, clinical efficacy, and their side effects in coronavirus disease-19 treatment on July 20th and updated on March 20th, 2020. A literature search of electronic databases including the Web of Science, PubMed, and Google Scholar was conducted by searching keywords such as \"Azithromycin\", \"COVID-19\", and \"Combination therapy\". The ultimate goal of this review was identifying eligible studies about the pharmacological activities, safety, and effectiveness of azithromycin in treating COVID-19 patients. Immunomodulatory properties of azithromycin include the ability to reduce cytokine production, maintain epithelial cell integrity, or prevent lung fibrosis. The use of azithromycin in some studies was associated with a decrease in mortality and need for ventilation in patients. These properties can be useful during the period of COVID-19 infection, especially in patients with underlying diseases. However, the evidence for the use of azithromycin is still scarce and the quality of the studies is low. In some retrospective studies, azithromycin was mainly evaluated in combination with hydroxychloroquine, which showed no particular advantage. The results of this review showed that azithromycin has appropriate and well-known safety characteristics in the treatment of patients with COVID-19. However, the most appropriate dosage in different stages of the disease and the effect of its combination with other drugs are important questions that should be considered in future clinical trials.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"57 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-23DOI: 10.18502/acta.v61i7.14495
M. Shafie, A. Moghadasi, Sina Kazemian, Mahsa Mayeli, Narges Shakerian, Mohaddeseh Azadvari
The COVID-19 pandemic restrictions may have significant implications for patients with multiple sclerosis (MS). The objective of this study is to explore the impact of the pandemic on physical activity levels and health outcomes among MS patients, as well as to examine potential associations between these factors. In this cross-sectional study, 197 patients with confirmed MS diagnosis were included. Physical activity and health status were assessed using international physical activity questionnaire-long form (IPAQ-LF) and short form 36 health survey questionnaire (SF-36) during the period of restrictions. The relationship between clinical characteristics, physical activity levels and health status parameters were examined. A total of 45 participants (22.8%) scored low, 73 (37.1%) scored moderate, and 79 (49.1%) achieved a high level of physical activity during the COVID-19 pandemic. We observed no significant association between total physical activity and any domains of SF-36 health status, except for pain. However, correlations were found between IPAQ and SF-36 domains. Specifically, walking showed positive correlations with physical functioning, physical limitation, general health, and physical component summary score. Vigorous activity demonstrated a negative correlation with social functioning, while moderate activity displayed a positive correlation with energy levels. Despite the challenges of home isolation and quarantine, most of our participants managed to achieve a moderate to high level of physical activity, while their overall health status was found to be moderate. Additionally, significant correlations were identified between the domains of health status and different types of physical activity, particularly walking. Further studies are warranted to optimize the care and support provided to patients with MS.
{"title":"The Impact of COVID-19 Pandemic on Physical Activity and Health Measures in Patients With Multiple Sclerosis","authors":"M. Shafie, A. Moghadasi, Sina Kazemian, Mahsa Mayeli, Narges Shakerian, Mohaddeseh Azadvari","doi":"10.18502/acta.v61i7.14495","DOIUrl":"https://doi.org/10.18502/acta.v61i7.14495","url":null,"abstract":"The COVID-19 pandemic restrictions may have significant implications for patients with multiple sclerosis (MS). The objective of this study is to explore the impact of the pandemic on physical activity levels and health outcomes among MS patients, as well as to examine potential associations between these factors. In this cross-sectional study, 197 patients with confirmed MS diagnosis were included. Physical activity and health status were assessed using international physical activity questionnaire-long form (IPAQ-LF) and short form 36 health survey questionnaire (SF-36) during the period of restrictions. The relationship between clinical characteristics, physical activity levels and health status parameters were examined. A total of 45 participants (22.8%) scored low, 73 (37.1%) scored moderate, and 79 (49.1%) achieved a high level of physical activity during the COVID-19 pandemic. We observed no significant association between total physical activity and any domains of SF-36 health status, except for pain. However, correlations were found between IPAQ and SF-36 domains. Specifically, walking showed positive correlations with physical functioning, physical limitation, general health, and physical component summary score. Vigorous activity demonstrated a negative correlation with social functioning, while moderate activity displayed a positive correlation with energy levels. Despite the challenges of home isolation and quarantine, most of our participants managed to achieve a moderate to high level of physical activity, while their overall health status was found to be moderate. Additionally, significant correlations were identified between the domains of health status and different types of physical activity, particularly walking. Further studies are warranted to optimize the care and support provided to patients with MS.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"16 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-23DOI: 10.18502/acta.v61i7.14494
F. Etezadi, Mohsen Sabouri, Pejman Pourfakhr, R. S. Moharari, Hossein Zabihi Mahmoudabadi, M. Khajavi
Upper airway management in morbid obese patients undergoing bariatric surgery is a major challenge during induction of anesthesia. Bed side Thyromental Height Test (TMHT) is an easy and valid predictor for prediction of difficult airway in non‑obese patients, but its precision in morbid obese patients haven’t been evaluated yet. The purpose of present study is to find the accuracy of TMHT for the prediction of difficult laryngoscopy in morbid obese patients undergoing bariatric surgery. The present prospective observational study was performed on 95 morbid obese patients at Sina hospital during 2020. Preoperative exams of patients include the assessment of Mallampati classification, thyromental height, thyromental, sternomental and interincisor distances. After induction of anesthesia, the laryngoscopy view was evaluated using the Cormack Lehane classification, and the relationship between these tests to prediction of difficult laryngoscopy view based on the Cormack Lehane degrees (grades 3,4) were evaluated. A total of 95 morbid obese patients with a mean BMI of 44.7±5.6 kg/m2.were included in the study. 67.3% of them were women. The incidence of difficult laryngoscopy (C & L III, IV) was 16.8%. TMHT less than 56.5 mm, with 98% positive predictive value and 93% accuracy was the best predictor of difficult intubation in these patients. The accuracy of thyromental, sternomental and interincisor distance, with cut off value less than 51.5 mm, 89.5 mm, 41.5 mm respectively was less than TMHT in prediction of difficult laryngoscopy in morbid obese patients. In morbid obese patients with a BMI greater than 40, thyromental height less than 56.5 mm with 98% positive predictive value and 93% accuracy is the best predictor for difficult laryngoscopy view.
{"title":"Evaluation of Thyromental Height Test for Predicting Difficult Laryngoscopy in Morbid Obese Patients Candidate for Bariatric Surgery: An Observational Study","authors":"F. Etezadi, Mohsen Sabouri, Pejman Pourfakhr, R. S. Moharari, Hossein Zabihi Mahmoudabadi, M. Khajavi","doi":"10.18502/acta.v61i7.14494","DOIUrl":"https://doi.org/10.18502/acta.v61i7.14494","url":null,"abstract":"Upper airway management in morbid obese patients undergoing bariatric surgery is a major challenge during induction of anesthesia. Bed side Thyromental Height Test (TMHT) is an easy and valid predictor for prediction of difficult airway in non‑obese patients, but its precision in morbid obese patients haven’t been evaluated yet. The purpose of present study is to find the accuracy of TMHT for the prediction of difficult laryngoscopy in morbid obese patients undergoing bariatric surgery. The present prospective observational study was performed on 95 morbid obese patients at Sina hospital during 2020. Preoperative exams of patients include the assessment of Mallampati classification, thyromental height, thyromental, sternomental and interincisor distances. After induction of anesthesia, the laryngoscopy view was evaluated using the Cormack Lehane classification, and the relationship between these tests to prediction of difficult laryngoscopy view based on the Cormack Lehane degrees (grades 3,4) were evaluated. A total of 95 morbid obese patients with a mean BMI of 44.7±5.6 kg/m2.were included in the study. 67.3% of them were women. The incidence of difficult laryngoscopy (C & L III, IV) was 16.8%. TMHT less than 56.5 mm, with 98% positive predictive value and 93% accuracy was the best predictor of difficult intubation in these patients. The accuracy of thyromental, sternomental and interincisor distance, with cut off value less than 51.5 mm, 89.5 mm, 41.5 mm respectively was less than TMHT in prediction of difficult laryngoscopy in morbid obese patients. In morbid obese patients with a BMI greater than 40, thyromental height less than 56.5 mm with 98% positive predictive value and 93% accuracy is the best predictor for difficult laryngoscopy view.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"13 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-23DOI: 10.18502/acta.v61i7.14498
Sahar Asvar, Farahnaz Jazaeri, M. Algazo, Razieh Mohammad Jafari, A. Dehpour
Cirrhotic patients have hyperdynamic circulation and at-rest tachycardia, and agents that activate the sympathetic pathway, such as physical practice and pharmacologic stimulations, compared with the normal population, cannot cause enough increase in heartbeat, a condition known as cirrhotic cardiomyopathy. Concerning the presentation of 5-HT2 & 5-HT3 receptors in rat hearts, we used Ketanserin as a 5-HT2 receptor inhibitor & Tropisetron as a 5-HT3 receptor inhibitor to evaluate chronic therapeutic effects of 5-HT2 & 5-HT3 antagonists on the cardiac chronotropic response of cirrhotic rats to adrenergics. Cirrhosis was induced by surgical ligation of the bile duct in Male Wistar rats, and another group remained sham. A week after bile duct ligation or sham surgery, the subjects were given an intraperitoneal injection of either saline or Tropisetron (2 mg/kg). In other BDL & Sharm groups, the subjects were given an intraperitoneal injection of either saline or Ketanserin (6 mg/kg) every other 3 days in the last 3 weeks. Four weeks after bile duct ligation or sham surgery, the atria were isolated and chronotropic responsiveness to Isoproterenol was assessed using a standard organ bath. Our data showed that chronic treatment with Tropisetron (5-HT3 antagonist) in cirrhotic rats could decrease the cardiac chronotropic response. Chronic treatment with Tropisetron can cause a significant decrease in cardiac chronotropic response to Isoproterenol in healthy and cirrhotic rats, even lower than that in cirrhotic rats (without any special treatment). Chronic treatment with Ketanserin cannot change their impaired chronotropic response to Isoproterenol.
{"title":"Investigating the Effect of Serotonin II and III Receptor Inhibitors on the Chronotropic Changes of the Heart to Isoproterenol in Rat Models of Biliary Cirrhosis","authors":"Sahar Asvar, Farahnaz Jazaeri, M. Algazo, Razieh Mohammad Jafari, A. Dehpour","doi":"10.18502/acta.v61i7.14498","DOIUrl":"https://doi.org/10.18502/acta.v61i7.14498","url":null,"abstract":"Cirrhotic patients have hyperdynamic circulation and at-rest tachycardia, and agents that activate the sympathetic pathway, such as physical practice and pharmacologic stimulations, compared with the normal population, cannot cause enough increase in heartbeat, a condition known as cirrhotic cardiomyopathy. Concerning the presentation of 5-HT2 & 5-HT3 receptors in rat hearts, we used Ketanserin as a 5-HT2 receptor inhibitor & Tropisetron as a 5-HT3 receptor inhibitor to evaluate chronic therapeutic effects of 5-HT2 & 5-HT3 antagonists on the cardiac chronotropic response of cirrhotic rats to adrenergics. Cirrhosis was induced by surgical ligation of the bile duct in Male Wistar rats, and another group remained sham. A week after bile duct ligation or sham surgery, the subjects were given an intraperitoneal injection of either saline or Tropisetron (2 mg/kg). In other BDL & Sharm groups, the subjects were given an intraperitoneal injection of either saline or Ketanserin (6 mg/kg) every other 3 days in the last 3 weeks. Four weeks after bile duct ligation or sham surgery, the atria were isolated and chronotropic responsiveness to Isoproterenol was assessed using a standard organ bath. Our data showed that chronic treatment with Tropisetron (5-HT3 antagonist) in cirrhotic rats could decrease the cardiac chronotropic response. Chronic treatment with Tropisetron can cause a significant decrease in cardiac chronotropic response to Isoproterenol in healthy and cirrhotic rats, even lower than that in cirrhotic rats (without any special treatment). Chronic treatment with Ketanserin cannot change their impaired chronotropic response to Isoproterenol.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"51 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-23DOI: 10.18502/acta.v61i7.14501
H. Azimi, A. Jafarian, B. Davachi, E. Zandieh, Fatemeh Shirzadeh, Z. Yousefi
Choriocarcinoma usually occurs in the uterine body. Non-gestational choriocarcinoma is an extremely rare malignant tumor with a poor prognosis and is difficult to distinguish from gestational choriocarcinoma. In this case report, we describe a case of pure non-gestational choriocarcinoma. A 35-year-old woman was referred to our academic hospital with a pathology report of non-gestational choriocarcinoma of right ovarian cystectomy. Since the diagnosis did not coordinate with the patient's symptoms, PCR amplifying, and genomic DNA were performed. Finally, the diagnosis of pure non-gestational choriocarcinoma was confirmed. In follow-up, lung and brain metastasis was determined. Brain radiotherapy and BEP regimen chemotherapy were prescribed. However, the response was not appropriate, so she is currently undergoing palliative chemotherapy. Stage IV primary pure ovarian choriocarcinoma is a very aggressive tumor. Regardless of the nature of the tumor, the response to the treatment may not be good. Indeed the treatment of each case should be individualized.
绒毛膜癌通常发生在子宫体。非妊娠期绒毛膜癌是一种极为罕见的恶性肿瘤，预后较差，而且很难与妊娠期绒毛膜癌区分开来。在本病例报告中，我们描述了一例纯粹的非妊娠绒毛膜癌。一名 35 岁的女性因右侧卵巢囊肿切除术病理报告为非妊娠绒毛膜癌而被转诊至我院。由于诊断结果与患者的症状不符，我们对其进行了 PCR 扩增和基因组 DNA 检测。最后，确诊为纯合性非妊娠绒毛膜癌。在后续治疗中，确定了肺转移和脑转移。患者接受了脑部放疗和 BEP 方案化疗。然而，反应并不理想，因此她目前正在接受姑息化疗。IV 期原发性纯卵巢绒毛膜癌是一种侵袭性很强的肿瘤。无论肿瘤的性质如何，对治疗的反应都不一定好。事实上，每个病例的治疗都应因人而异。
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