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Antimicrobial Activity of the Most Common Antibiotic-Releasing Systems Employed in Current Orthopedic Surgery: in vitro Study. 目前骨科手术中使用的最常见抗生素释放系统的抗菌活性:体外研究。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-06-22 DOI: 10.55095/achot2023/027
R. Sticha, P. Fulin, O. Nyč, V. Gajdošová, D. Pokorny, M. Šlouf
PURPOSE OF THE STUDY Infections of joint replacements represent one of the most serious problems in contemporary orthopedics. The joint infections treatment is usually multimodal and involves various combinations of drug delivery and surgical procedures. The aim of this study was to evaluate and compare the bacteriostatic and bactericidal properties of the most common antibiotic carriers used in orthopedic surgery: bone cements mixed with antibiotic and porous calcium sulfate mixed with antibiotic. MATERIAL AND METHODS Three commercial bone cements (Palacos®, Palacos® R+G, Vancogenx®) and commercial porous sulfate (Stimulan®) were prepared with a known concentration of vancomycin (a glycopeptide antibiotic). Specifically, for the purpose of our study, the testing specimens were prepared to release 0, 1, 2, 4, 8, 16, 32, 64, 128, 256, and 512 mg of vancomycin into 1 liter of solution. The specimens with increasing amount of antibiotic were placed in a separate tubes containing 5 mL of Mueller-Hinton broth inoculated with a suspension (0.1 m, McFarland 1) of the reference strain CCM 4223 Staphylococcus aureus to evaluate their bacteriostatic properties (broth dilution method). After this initial incubation and evaluation of the broth dilution method, an inoculum from each tube was transferred onto blood agar plates. After another 24-hour incubation under the same conditions, we evaluated the bactericidal properties (agar plate method). As many as 132 of independent experiments were performed (4 specimens × 11 concentrations × 3 repetitions = 132). RESULTS The bacteriostatic properties of all investigated samples were excellent, perhaps with the exception of the first bone cement (Palacos®). The sample Palacos® started to exhibit bacteriostatic properties at concentrations ≥ 8 mg/mL, while all other samples (Palacos R+G®, Vancogenx®, and Stimulan®) were bacteriostatic in the whole concentration range starting from 1 mg/mL. The bacteriocidic properties did not show such clear trends, but correlated quite well with different properties of the investigated samples during mixing - the most homogeneous samples seemed to exhibit the best and the most reproducible results. DISCUSSION The reliable and reproducible comparison of ATB carriers is a difficult task. The situation is complicated by high numbers of local antibiotic carriers on the market, numerous antibiotics used, and differences in clinical trials at different laboratories. Simple in vitro testing of bacteriostatic and bacteriocidic properties represents a simple and efficient approach to the problem. CONCLUSIONS The study confirmed that the two most common commercial systems used in the orthopedic surgery (bone cements and porous calcium sulfate) prevent bacterial growth (bacteriostatic effect), but they may not be 100% efficient in complete elimination of bacteria (bacteriocidic effect). The scattered results in the case of bacteriocidic tests seemed to be connected with the homogeneity of ATB
关节置换术感染是当代骨科最严重的问题之一。关节感染的治疗通常是多模式的,包括药物输送和外科手术的各种组合。本研究的目的是评估和比较骨科手术中最常用的抗生素载体:混合抗生素的骨水泥和混合抗生素的多孔硫酸钙的抑菌和杀菌性能。材料和方法用已知浓度的万古霉素(一种糖肽抗生素)制备三种商用骨水泥(Palacos®,Palacos®R+G, Vancogenx®)和商用多孔硫酸盐(刺激an®)。具体来说,为了我们的研究目的,准备测试标本,将0、1、2、4、8、16、32、64、128、256和512 mg万古霉素释放到1升溶液中。将抗生素添加量增加的标本置于单独的管中,管中含有5ml接种参考菌株CCM 4223金黄色葡萄球菌悬浮液(0.1 m, McFarland 1)的muller - hinton肉汤,以评估其抑菌性能(肉汤稀释法)。在初始孵育和肉汤稀释法评估后,将每根试管中的接种物转移到血琼脂板上。在相同条件下再孵育24小时后,我们评估了杀菌性能(琼脂平板法)。独立实验共132次(4个标本× 11个浓度× 3次重复= 132次)。结果除了第一骨水泥(Palacos®)外,所有样品的抑菌性能都很好。样品Palacos®在浓度≥8mg /mL时开始表现出抑菌性能,而所有其他样品(Palacos R+G®,Vancogenx®和Stimulan®)在从1mg /mL开始的整个浓度范围内都具有抑菌作用。在混合过程中,其杀菌性能并没有明显的趋势,但与所研究样品的不同性能有很好的相关性——最均匀的样品似乎表现出最好的和最可重复的结果。ATB携带者的可靠和可重复性比较是一项困难的任务。由于市场上大量的当地抗生素携带者,使用的抗生素种类繁多,以及不同实验室临床试验的差异,情况变得更加复杂。简单的体外抑菌和杀菌性能测试是解决这一问题的一种简单而有效的方法。结论:本研究证实骨科手术中最常用的两种商用系统(骨水泥和多孔硫酸钙)可以防止细菌生长(抑菌作用),但它们可能不是100%有效地完全消除细菌(杀菌作用)。在杀菌剂试验的情况下,分散的结果似乎与系统中ATB分散的均匀性以及所采用的琼脂平板法的低重复性有关。关键词:抗生素局部释放;骨水泥;硫酸钙;抗菌药物的敏感性。
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引用次数: 0
[Incidence, Diagnosis and Risk Factors for Fracture-Related Infection (FRI): 3-Year Experience of Level I Trauma Centre]. [骨折相关感染(FRI)的发生率、诊断和危险因素:三级创伤中心3年经验]。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-06-22 DOI: 10.55095/achot2023/026
J. Rimsa, M. Doležalová Hrubá, J. Urban, M. Peml, K. Holub, M. Kloub
PURPOSE OF THE STUDY The study aims to determine the incidence of fracture-related infection (hereinafter referred to as the FRI) at a Level I trauma centre over a three-year period. It also aimed to determine the risk factors, to observe confirmatory and suggestive criteria in line with the applicable recommendations, and to evaluate the bacterial spectrum in a diagnosed FRI. MATERIAL AND METHODS It is a retrospective-prospective study carried out through studying the documentation. The study included all patients diagnosed with FRI and treated between 2019 and 2021, except for the patients with hand fractures since minor phalangeal fractures of the fingers were largely treated by the outpatient department, no osteosynthesis was performed in the operating room, and these patients were not followed up at our department. RESULTS The FRI incidence was 2.33% of all osteosyntheses performed at the Level 1 trauma centre in the period 2019-2021. The FRI was most often caused by pyogenic cocci agents and the FRI developed most frequently within 6 months after osteosynthesis. The site at risk was the lower limb region. The FRI incidence was most often indicated by suggestive clinical criteria (redness, secretion, pain) and radiological criteria (delayed healing, non-union). Overall, 42.19% of treated nonunions were later diagnosed as FRI. At the time of FRI diagnosis, the CRP values were normal in 21.7% of patients. DISCUSSION The FRI incidence rate in 2019-2021 was 2.33%, which corresponds with the values reported in other papers focusing on the incidence of infectious complications after osteosynthesis. Fang and Depypere reported 1-2% of infectious complications. The most common risk factors are open fractures, which account for 20.16% in our cohort. Ktistakis and Depypere describe the incidence of osteomyelitis in 30% of treated open fractures. In our cohort, the incidence of FRI was significantly higher in lower limb fractures. Bezstarosti, Wang and Pesch published similar results, with some deviations. The time from osteosynthesis to final FRI diagnosis varied from a few weeks to several years. In more than half of the patients the FRI developed within 6 months after performed osteosynthesis. Metsemakers and Fang refer to the very same trend. The CRP levels in the study population varied a lot. Xing-qi Zhao describes CRP as a less sensitive (sensitivity 65.6%) but more specific marker (specificity 75.4%). According to the available literature, the most common agents causing infectious complications of osteosynthesis are gram-positive cocci, S. aureus in particular. In our study, G+ pyogenic cocci were clearly the most commonly detected, which is consistent with the results of studies by Fang and Depypere, focused on the incidence of infectious complications. The most common FRI clinical manifestations included wound secretion, redness, swelling and pain. Furthermore, suggestive radiological criteria, especially delayed healing and non-union also ind
研究目的本研究旨在确定三级创伤中心三年时间内骨折相关感染(以下简称FRI)的发生率。该研究还旨在确定危险因素,观察符合适用建议的验证性和提示性标准,并评估诊断为FRI的细菌谱。材料和方法通过研究文献进行回顾性-前瞻性研究。本研究纳入所有诊断为FRI并在2019 - 2021年间治疗的患者,除手部骨折患者外,由于手指小指骨骨折主要在门诊治疗,未在手术室进行植骨手术,未在我科进行随访。结果2019-2021年期间,在1级创伤中心进行的所有骨融合术中,FRI发生率为2.33%。FRI最常由化脓性球菌引起,最常见于骨融合术后6个月内。危险部位为下肢区域。FRI的发生率通常由提示性临床标准(发红、分泌物、疼痛)和放射学标准(延迟愈合、不愈合)来指示。总体而言,42.19%的治疗后骨不连被诊断为FRI,在FRI诊断时,21.7%的患者CRP值正常。2019-2021年FRI发病率为2.33%,与其他文献报道的有关骨植入术后感染性并发症发生率的数值一致。Fang和Depypere报告了1-2%的感染并发症。最常见的危险因素是开放性骨折,在我们的队列中占20.16%。Ktistakis和Depypere描述了30%的开放性骨折治疗中骨髓炎的发生率。在我们的队列中,下肢骨折的FRI发生率明显更高。Bezstarosti、Wang和Pesch发表了类似的结果,但有一些偏差。从植骨到最终FRI诊断的时间从几周到几年不等。超过一半的患者在骨融合术后6个月内出现FRI。Metsemakers和Fang提到了同样的趋势。研究人群的CRP水平变化很大。赵星琪将CRP描述为敏感性较低(敏感性65.6%)但特异性较高的标志物(特异性75.4%)。根据现有文献,最常见的药物引起感染性并发症的骨整合是革兰氏阳性球菌,特别是金黄色葡萄球菌。在我们的研究中,G+化脓性球菌显然是最常见的,这与Fang和Depypere的研究结果一致,他们的研究重点是感染并发症的发生率。FRI最常见的临床表现为创面分泌物、红肿、疼痛。此外,暗示的放射学标准,特别是延迟愈合和不愈合也提示FRI的发生。据方医生介绍,感染性并发症最常见的临床表现包括疼痛、肿胀、红肿和伤口裂开。Fang报告说,最常见的影像学表现是骨膜反应、植入物松动、愈合延迟或不愈合,这与我们的研究结果一致。在我科手术治疗的骨不连队列中,42.19%的病例随后确诊为FRI。结论2019-2021年,一级创伤中心手术骨折的FRI发生率为2.33%,其中化脓性球菌是最常见的感染源。FRI通常在骨融合术后6个月内发生。FRI发展的典型部位是下肢区域,持续的FRI通过提示性临床标准(发红、分泌、疼痛)和放射学标准(延迟愈合和不愈合)来指示。总体而言,42.19%的治疗后骨不连被诊断为FRI。关键词:骨折相关感染,FRI,提示标准,确认标准,FRI诊断,微生物,微生物谱,骨整合,并发症,骨不连。
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引用次数: 0
A Meta-Analysis on Comparison of Open vs Closed Reduction of Gartland Type 3 Supracondylar Humerus Fractures in Children. 儿童Gartland 3型肱骨髁上骨折开放复位与闭合复位比较的Meta分析。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-06-22 DOI: 10.55095/achot2023/023
S. Barik, Vaibhav Garg, S. Sinha, S. Chaudhary, P. Kandwal, V. Singh
PURPOSE OF THE STUDY Although there are numerous studies on outcomes and comparison of open and closed reduction but there is no clarity on relationship between outcomes and complications with type of surgical intervention done for Type 3 Gartland supracondylar humerus fracture. The aim of this study is to compare the outcomes and complications of closed vs open reduction in Type 3 Gartland supracondylar humerus fractures. MATERIAL AND METHODS Electronic literature searches of Embase, MEDLINE and the Cochrane Library was conducted in February 2022 using the terms "supracondylar", "humerus", "fracture", "Gartland type 3" and synonymous. The data extracted included the study details, demographic data, procedure performed, final functional and cosmetic outcome according to Flynn criteria and complications of included studies. RESULTS Pooled data analysis revealed no significant difference in mean satisfactory outcome rate according to Flynn cosmetic criteria in open group (97%, 95% CI 95.5%-98.5%), as compared to closed group (97.5%, 95% CI 96.3%-98.7%), although a statistically significant difference in mean satisfactory rate according to Flynn functional criteria in open group (93.4%, 95% CI 90.8%- 96.1%) as compared to closed group (98.5%, 95% CI 97.5%-99.4%) was noted. On separate comparison of the two-arm studies, closed reduction favoured better functional outcomes (RR 0.92, 95% CI 0.86-0.99). CONCLUSIONS Closed reduction and percutaneous fixation have better functional outcome than open reduction with K-wire fixation. But there was no significant difference in cosmetic outcomes, overall complication rate and nerve injury with either open or closed reduction. The threshold of converting a closed reduction to an open reduction in supracondylar humerus fractures of children should be high. Key words: supracondylar humerus, open reduction, percutaneous pinning, Flynn criteria.
研究目的:虽然有很多关于开放性复位和闭合性复位的结果和比较的研究,但对于3型Gartland肱骨髁上骨折的手术干预类型,结果和并发症之间的关系尚不明确。本研究的目的是比较3型Gartland肱骨髁上骨折的闭合复位和开放复位的结果和并发症。材料与方法于2022年2月对Embase、MEDLINE和Cochrane图书馆进行电子文献检索,检索词为“髁上”、“肱骨”、“骨折”、“Gartland 3型”和同义词。提取的数据包括研究细节、人口统计数据、进行的手术、根据Flynn标准的最终功能和美容结果以及纳入研究的并发症。结果合并数据分析显示,开放组按照Flynn美容标准的平均满意率(97%,95% CI 95.5%-98.5%)与封闭组(97.5%,95% CI 96.3%-98.7%)相比无显著差异,但开放组按照Flynn功能标准的平均满意率(93.4%,95% CI 90.8%- 96.1%)与封闭组(98.5%,95% CI 97.5%-99.4%)有统计学差异。在两组研究的单独比较中,闭合复位有利于更好的功能预后(RR 0.92, 95% CI 0.86-0.99)。结论闭合复位经皮内固定比切开复位加克氏针内固定具有更好的功能效果。但两组在美容效果、总并发症发生率和神经损伤方面均无显著差异。儿童肱骨髁上骨折的闭合复位到开放复位的阈值应该很高。关键词:肱骨髁上,切开复位,经皮钉钉,Flynn标准。
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引用次数: 0
[Pathological Lesions and Fractures of the Proximal Femur]. [股骨近端病理病变及骨折]。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/019
M. Urban, L. Lunacek, R. Bartoška, J. Maleř, J. Skála-Rosenbaum
PURPOSE OF THE STUDY The aim of the study was to determine the incidence of primary malignancies metastasizing to the area of the proximal femur, to evaluate the localization of the lesions and fractures, to compare the results of the selected surgical therapy, survival time of the patients and postoperative complications. MATERIAL AND METHODS We retrospectively evaluated the group of patients operated on from 2012 to 2021. The study included 45 patients (24 women and 21 men) with a pathological lesion or a pathological fracture in the area of the proximal femur. The average age was 67 years (38-90). There were 30 (67%) cases of pathological fracture and 15 (33%) cases of pathological lesions in the cohort. In each patient, the perioperative biopsy or resected sample was sent for histological examination. The type of primary malignancy with the localization of lesions and fractures was assessed. Furthermore, we evaluated the outcomes of the surgical method chosen and its complications. We monitored the patients' functional score using the Karnofsky performance status and survival interval. RESULTS The most common primary malignancy was multiple myeloma in 10 cases (22%), followed by seven cases (16%) of breast and lung cancer and 6 cases (13%) of clear cell renal cell carcinoma. Internal fixation was used in 15 cases (33%). Tumor resection with hip joint replacement was performed in 29 patients (64%). One patient was treated with percutaneous femoroplasty. Out of a total of 45 patients, 10 patients (22%) survived for less than three months. The survival rate of more than one year was observed in 21 patients (47%). A total of seven complications occurred in six patients (15%). Fewer complications occurred in the group of patients with a pathological fracture compared to the group with an impending fracture. DISCUSSION Pathological lesions in the bone or an already existing pathological fracture are signs of advanced cancer. Better outcomes are reported in patients who underwent prophylactic surgery, which was, however, not confirmed by our study. The incidence of individual primary malignancies, the postoperative complications and the patient survival corresponded to the statistical data reported by the other authors. CONCLUSIONS In patients with a pathological lesion of the proximal femur, operative treatment will increase the quality of life, either when choosing osteosynthesis or joint replacement, while prophylactic treatment is usually associated with a better prognosis. As a less invasive procedure with lower blood loss, osteosynthesis is indicated for palliative therapy in patients with a limited expected survival time or in patients with a prognosis of healing of the lesion. Reconstruction of the joint with an arthroplasty is indicated in patients with a better prognosis or in cases excluding safe osteosynthesis. Our study confirmed good outcomes with the use of an uncemented revision femoral component. Key words: metastasis, osteolysis, p
该研究的目的是确定原发性恶性肿瘤转移到股骨近端区域的发生率,评估病变和骨折的定位,比较选择的手术治疗结果,患者的生存时间和术后并发症。材料和方法回顾性评估2012年至2021年接受手术的患者组。该研究包括45名患者(24名女性和21名男性),在股骨近端区域有病理性病变或病理性骨折。平均年龄为67岁(38-90岁)。该队列中有30例(67%)病理性骨折和15例(33%)病理性病变。每例患者围手术期活检或切除标本送行组织学检查。评估原发性恶性肿瘤的类型与病灶和骨折的定位。此外,我们评估了所选择的手术方法及其并发症的结果。我们使用Karnofsky性能状态和生存期来监测患者的功能评分。结果原发性恶性肿瘤以多发性骨髓瘤10例(22%)最为常见,其次为乳腺癌和肺癌7例(16%),透明细胞肾细胞癌6例(13%)。15例(33%)采用内固定。29例(64%)患者行肿瘤切除联合髋关节置换术。1例患者行经皮股骨成形术。在45例患者中,10例(22%)患者存活时间少于3个月。生存率超过1年的患者21例(47%)。6例患者共发生7例并发症(15%)。病理性骨折组与即将发生骨折组相比,并发症发生率更低。骨的病理病变或已经存在的病理性骨折是晚期癌症的迹象。据报道,接受预防性手术的患者预后较好,然而,我们的研究并未证实这一点。个体原发性恶性肿瘤发生率、术后并发症及患者生存率与其他作者报道的统计数据一致。结论:对于股骨近端病理性病变患者,手术治疗可提高患者的生活质量,无论是选择植骨术还是关节置换术,而预防性治疗通常预后较好。作为一种侵入性小、出血量少的手术,骨融合术适用于预期生存时间有限的患者或预后病变愈合的患者的姑息治疗。在预后较好的患者或不能进行安全骨融合术的病例中,可采用关节置换术重建关节。我们的研究证实了使用非骨水泥股骨假体翻修的良好结果。关键词:转移,骨溶解,病理性骨折,股骨近端。
{"title":"[Pathological Lesions and Fractures of the Proximal Femur].","authors":"M. Urban, L. Lunacek, R. Bartoška, J. Maleř, J. Skála-Rosenbaum","doi":"10.55095/achot2023/019","DOIUrl":"https://doi.org/10.55095/achot2023/019","url":null,"abstract":"PURPOSE OF THE STUDY The aim of the study was to determine the incidence of primary malignancies metastasizing to the area of the proximal femur, to evaluate the localization of the lesions and fractures, to compare the results of the selected surgical therapy, survival time of the patients and postoperative complications. MATERIAL AND METHODS We retrospectively evaluated the group of patients operated on from 2012 to 2021. The study included 45 patients (24 women and 21 men) with a pathological lesion or a pathological fracture in the area of the proximal femur. The average age was 67 years (38-90). There were 30 (67%) cases of pathological fracture and 15 (33%) cases of pathological lesions in the cohort. In each patient, the perioperative biopsy or resected sample was sent for histological examination. The type of primary malignancy with the localization of lesions and fractures was assessed. Furthermore, we evaluated the outcomes of the surgical method chosen and its complications. We monitored the patients' functional score using the Karnofsky performance status and survival interval. RESULTS The most common primary malignancy was multiple myeloma in 10 cases (22%), followed by seven cases (16%) of breast and lung cancer and 6 cases (13%) of clear cell renal cell carcinoma. Internal fixation was used in 15 cases (33%). Tumor resection with hip joint replacement was performed in 29 patients (64%). One patient was treated with percutaneous femoroplasty. Out of a total of 45 patients, 10 patients (22%) survived for less than three months. The survival rate of more than one year was observed in 21 patients (47%). A total of seven complications occurred in six patients (15%). Fewer complications occurred in the group of patients with a pathological fracture compared to the group with an impending fracture. DISCUSSION Pathological lesions in the bone or an already existing pathological fracture are signs of advanced cancer. Better outcomes are reported in patients who underwent prophylactic surgery, which was, however, not confirmed by our study. The incidence of individual primary malignancies, the postoperative complications and the patient survival corresponded to the statistical data reported by the other authors. CONCLUSIONS In patients with a pathological lesion of the proximal femur, operative treatment will increase the quality of life, either when choosing osteosynthesis or joint replacement, while prophylactic treatment is usually associated with a better prognosis. As a less invasive procedure with lower blood loss, osteosynthesis is indicated for palliative therapy in patients with a limited expected survival time or in patients with a prognosis of healing of the lesion. Reconstruction of the joint with an arthroplasty is indicated in patients with a better prognosis or in cases excluding safe osteosynthesis. Our study confirmed good outcomes with the use of an uncemented revision femoral component. Key words: metastasis, osteolysis, p","PeriodicalId":6980,"journal":{"name":"Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca","volume":"90 2 1","pages":"138-145"},"PeriodicalIF":0.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fixation of Knee Osteochondral Lesions in Pediatric Patients with Magnesium-Based Implants. 镁基植入物固定儿童膝关节骨软骨损伤。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/014
F. Hanák, V. Havlas
PURPOSE OF THE STUDY Fixation of osteochondral fragments are relatively common procedures in pediatric orthopaedic surgery. The use of biodegradable magnesium implants in these indications appears to be a promising alternative to polymer implants due to their favorable mechanical properties and biological behavior. The purpose of this study is to evaluate the short-term clinical and radiological outcomes of the fixation of unstable or displaced osteochondral fractures and osteochondritis dissecans lesions in the knee joint using MAGNEZIX® screws and pins in pediatric patients. MATERIAL AND METHODS In this study, 12 patients (5 girls, 7 boys) were included. The inclusion criteria were as follows (1) age below 18 years; (2) unstable or displaced osteochondral fragments secondary to trauma or as a result of osteochondritis dissecans, Grades III and IV in the ICRS (International Cartilage Repair Society) score, confirmed by imaging methods and indicated for surgical fixation; (3) fixation performed using screws or pins made of the magnesium-based MAGNEZIX® alloy; (4) minimum postoperative interval of 12 months. X-rays and clinical evaluation were assessed 1 day, 6 weeks, 3, 6, and 12 months after the operation. MRIs were performed 1-year postoperatively for evaluation of bone response and degradation behavior of implants. RESULTS The mean age at surgery was 13.3 ± 1.6 years. A total of 25 screws were used in 11 patients, a mean of 2.4 ± 1 per patient, 4 pins were used in 1 patient. In 2 patients, fixation with screws was complemented with fibrin glue. The mean follow-up was 14.2 ± 3.3 months. All patients exhibited complete functional recovery while showing no signs of pain at 6 months postoperatively. No adverse local reactions were observed. At 1-year follow-up, no implant failure has been reported. Complete radiographic healing occurred in 12 cases. Mild radiolucent zones were observed around the implants. CONCLUSIONS The use of screws and pins MAGNEZIX® has been found to provide satisfactory outcomes in terms of fracture healing and very good functional outcomes at 1 year postoperatively. Key words: biodegradable implants, magnesium-based implants, osteochondral fracture, osteochondritis dissecans, MAGNEZIX®.
骨软骨碎片的固定是儿科骨科手术中相对常见的手术。在这些适应症中使用可生物降解的镁植入物似乎是聚合物植入物的一种有前途的替代品,因为它们具有良好的机械性能和生物行为。本研究的目的是评估儿童患者使用MAGNEZIX®螺钉和销钉固定膝关节不稳定或移位的骨软骨骨折和剥脱性骨软骨炎病变的短期临床和放射学结果。材料和方法在本研究中,包括12名患者(5名女孩,7名男孩)。纳入标准如下:(1)年龄在18岁以下;(2) 创伤继发或剥脱性骨软骨炎引起的不稳定或移位的骨软骨碎片,ICRS(国际软骨修复学会)评分中的III级和IV级,通过成像方法确认,并适合手术固定;(3) 使用镁基MAGNEZIX®合金制成的螺钉或销钉进行固定;(4) 最小术后间隔12个月。术后1天、6周、3个月、6个月和12个月进行X光检查和临床评估。术后1年进行核磁共振成像,以评估植入物的骨反应和降解行为。结果平均手术年龄为13.3±1.6岁。11名患者共使用了25枚螺钉,平均每位患者2.4±1枚,1名患者使用了4枚销钉。在2例患者中,螺钉固定辅以纤维蛋白胶。平均随访14.2±3.3个月。术后6个月,所有患者均表现出完全的功能恢复,但没有疼痛迹象。未观察到局部不良反应。在1年的随访中,没有植入失败的报告。12例影像学检查完全治愈。在植入物周围观察到轻微的射线透射区。结论已发现使用螺钉和销钉MAGNEZIX®在骨折愈合方面提供了令人满意的结果,并在术后1年提供了非常好的功能结果。关键词:可生物降解植入物,镁基植入物,骨软骨骨折,剥脱性骨软骨炎,MAGNEZIX®。
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引用次数: 0
[Surgical Treatment of Tuberculous Spondylodiscitis]. 结核性脊柱炎的外科治疗。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/016
J. Včelák, A. Kral, M. Šlégl, J. Lesensky, M. Macko
PURPOSE OF THE STUDY The paper presents a monocentric retrospective study of patients treated surgically for spinal tuberculosis. Clinical and radiological results are analysed, early and late complications are recorded. The study aims to answer the following questions. 1. Can we use instrumentation to restore the stability and alignment in the infected spinal focus? 2. Should we always perform radical anterior resection of TBC lesions? 3. What is the prognosis of surgical treatment of TBC patients with neurological deficit manifestation? MATERIAL AND METHODS Between 2010 and 2020, a total of 12 patients were treated for spinal tuberculosis at our department, of whom 9 patients (5 men, 4 women) with the mean age of 47.3 years (range 29 to 83 years) underwent a surgery. A total of three patients were operated on before the final confirmation of the TBC and treatment with antituberculosis medication, four patients in the initial therapy phase and two patients in the continuous phase. Two patients only underwent a non-instrumented decompression surgery followed by external support fixation. In the other seven patients, always with spinal deformity, instrumentation was used (3 cases of isolated posterior decompression, transpedicular fixation, posterior fusion, 4 cases of anteroposterior instrumented reconstruction). In 2 cases a structural bone graft and in 2 cases an expandable titanium cage were used for anterior column reconstruction. RESULTS Of the total number of patients, altogether eight patients were assessed at 1 year after surgery (one 83-year-old patient died from heart failure 4 months after surgery). Of the remaining eight patients, three patients exhibited a neurological deficit and postoperative regression of the finding. The McCormick score improved from the preoperative mean score of 3.25 to 1.62 at 1 year after surgery (p < 0.001). The clinical VAS score regressed from 5.75 to 1.63 at 1 year after surgery (p < 0.001). Radiographic healing of the anterior fusion was achieved in all patients, both after decompression and instrumented surgery. The initial mean kyphosis of 20.36 degrees of the operated segment measured by the mCobb angle was corrected to 14.6 degrees postoperatively, with a subsequent slight deterioration to 14.86 degrees (p < 0.05). The greatest correction was achieved in patients who had undergone a two-stage surgery with anterior resection and AP reconstruction. DISCUSSION In our cohort, titanium instrumentation was used in seven of nine patients. One patient only manifested persistent tuberculosis with nonspecific bacterial flora superinfection. Revision surgery with anterior radical debridement and subsequent treatment with antituberculotic drugs healed the patient. There were four patients with major preoperative neurological deficit persisting more than 2 weeks before the final treatment with subsequent improvement in all cases. These patients were treated with anteroposterior reconstruction and anterior radical
研究目的:本文对脊柱结核手术治疗患者进行单中心回顾性研究。分析临床和影像学结果,记录早期和晚期并发症。本研究旨在回答以下问题。1. 我们可以使用内固定来恢复受感染脊柱焦点的稳定性和对齐吗?2. 我们是否应该总是对TBC病变进行根治性前切除术?3.有神经功能缺损表现的TBC患者手术治疗的预后如何?材料与方法2010 - 2020年,我科共收治脊柱结核患者12例,其中9例(男5例,女4例)接受手术治疗,平均年龄47.3岁(29 - 83岁)。共有3例患者在最终确认TBC并接受抗结核药物治疗前接受手术治疗,4例患者处于初始治疗阶段,2例患者处于持续治疗阶段。两名患者仅接受了非器械减压手术,随后进行了外支撑固定。其余7例均为脊柱畸形,均采用内固定(3例为孤立后路减压、经椎弓根固定、后路融合,4例为前后路内固定重建术)。2例采用结构性骨移植物,2例采用可膨胀钛笼进行前柱重建。在患者总数中,共有8例患者在术后1年接受评估(1例83岁患者在术后4个月死于心力衰竭)。在剩下的8名患者中,3名患者表现出神经功能缺损和术后症状消退。术后1年McCormick评分从术前平均3.25分提高到1.62分(p < 0.001)。术后1年临床VAS评分从5.75降至1.63 (p < 0.001)。所有患者在减压和器械手术后均实现了前路融合的影像学愈合。术后mCobb角测量的手术节段初始平均后凸为20.36度,术后矫正为14.6度,随后轻微恶化为14.86度(p < 0.05)。最大的矫正是在患者接受了两个阶段的手术前切除和AP重建。在我们的队列中,9例患者中有7例使用了钛器械。1例患者仅表现为持续性结核伴非特异性菌群重复感染。前路根治性清创手术及抗结核药物治疗使患者痊愈。有4例患者术前主要神经功能缺损在最终治疗前持续超过2周,所有病例随后均有所改善。这些患者均行前后位重建和前路根治性清创。结论:本研究未发现与脊柱内固定使用相关的复发感染风险增加。对有明显后凸畸形和椎管压迫的患者行前路根治性清创,然后用结构性骨移植物或钛笼重建。其他患者的治疗是基于“最佳”清创的原则,有或没有使用经椎弓根器械。如果获得足够的椎管减压和稳定,即使在严重的神经缺陷的情况下,也可以预期神经系统的改善。关键词:脊柱结核,结核性脊柱炎,波特病,前路清创,脊柱内固定。
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引用次数: 0
Assessing Knee Stability in Adolescent Athletes with Osgood-Schlatter Disease Using the Y-Balance Test. 用Y平衡测试评估青少年奥斯古德-施拉特病运动员的膝关节稳定性。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/015
V. Hladký, A. Kaplan, J. Smetanova, V. Havlas
PURPOSE OF THE STUDY Osgood-Schlatter disease develops secondary to chronic patellar tendon overloading. The present study was designed to determine whether athletes with Osgood-Schlatter disease perform significantly worse in the Y-Balance Test compared to healthy subjects in a control group. MATERIAL AND METHODS The study involved ten boys (average age 13.7 years). Seven participants had bilateral knee pain, swelling and tenderness whereas three had unilateral knee pain, swelling and tenderness (left knee in two cases, and right knee in one). Overall, 17 knees were assessed (left knee in nine cases and right knee in eight).Ten healthy adolescent professional football players (mean age 14.6 years) were selected as a control group. In both groups, complex knee stability was assessed using the Y-Balance Test and their data were analyzed using the methodology developed by Plisky et al. The test outcome was expressed in indexed (normalized) values for the right and left lower extremities, and averaged values for the individual directions were compared. RESULTS Significant differences between both groups were shown in the posteromedial and posterolateral directions. CONCLUSIONS Using the Y-Balance Test, our study documented reduced performance in the above directions in patients with OsgoodSchlatter disease. Key words: Osgood-Schlatter disease, knee, balance test, movement patterns patellar tendon overload.
研究目的奥斯古德-施拉特病继发于慢性髌腱过载。本研究旨在确定与对照组的健康受试者相比,患有奥斯古德-施拉特病的运动员在Y平衡测试中的表现是否明显较差。材料和方法本研究涉及10名男孩(平均年龄13.7岁)。7名参与者出现双侧膝盖疼痛、肿胀和压痛,3名参与者出现单侧膝盖疼痛、溶胀和压痛(2例为左膝,1例为右膝)。总共评估了17个膝盖(左膝9例,右膝8例)。10名健康的青少年职业足球运动员(平均年龄14.6岁)被选为对照组。在这两组中,使用Y平衡测试评估复杂的膝关节稳定性,并使用Plisky等人开发的方法分析其数据。测试结果用左右下肢的指数(归一化)值表示,并比较各个方向的平均值。结果两组在后内侧和后外侧方向上有显著差异。结论使用Y平衡测试,我们的研究记录了OsgoodSchlatter病患者在上述方向上的表现下降。关键词:奥氏病,膝关节,平衡测试,运动模式,髌腱过载。
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引用次数: 0
[Modified Harrington Procedure in the Treatment of Extensive Tumor Defects of the Acetabulum]. [改良Harrington手术治疗髋臼广泛肿瘤缺损]。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/017
J. Lesensky, O. Blecha, J. Včelák
PURPOSE OF THE STUDY The increasing prevalance of patients with metastatic bone cancer and their improved survival puts more emphasis on the quality of treatment of bone metastases. Although most pelvic lesions are treated non-operatively, extensive destruction of the acetabular segment poses a therapeutic challenge. A potential treatment option may be the modified Harrington procedure. MATERIAL AND METHODS At our department, this surgical procedure has been opted for in 14 patients (5 men and 9 women) since 2018. The mean age at the time of surgery was 59 years (range 42 to 73). Twelve patients suffered from metastatic cancer, one patient had a fibrosarcoma metastasis and one female patient presented with aggressive pseudotumor. Radiological and clinical followup of the patients was performed. Pain was assessed using the Visual Analogue Scale, and the Harris Hip Score and the MSTS score were used to evaluate the functional outcome. The paired samples Wilcoxon test was used to analyze the statistical significance of the difference. RESULTS The mean follow-up period was 25 months. At the time of assessment, ten patients were alive with the mean follow-up of 29 months (range 2 to 54 months) and four patients had died of cancer progression, with the mean follow-up being 16 months. No perioperative death or mechanical failure were reported. One female patient developed a hematogenous infection during febrile neutropenia, which was successfully managed with early revision and implant preservation. Statistically, a significant improvement in the MSTS (median 23) and HHS (median 86) functional scores compared to the preoperative values (MSTS median 2, p<0.01, r-effect size = 0.6; HHS preop median 0, p<0.005, r-effect size = -0.7) was observed. There was also a statistically significant reduction in pain (VAS postoperative median 1, VAS preoperative median 8, p<0.01, r-effect size = -0.6). All patients were capable of independent ambulation after the surgery, nine patients walked without support. DISCUSSION There are not many alternatives to this surgical procedure. Apart from non-operative palliative treatment, the options include ice cream cone prostheses or customized 3D implants which are, impractical in terms of time and cost. Our results are comparable to other studies, confirming the reproducibility and reliability of the method. CONCLUSIONS The Harrington procedure is an efective method for management of large acetabular tumor defects with good functional outcomes, an acceptable perioperative risk and a low risk of failure in the medium term, thus suitable also for patients with good cancer prognosis. Key words: umor, metastasis, acetabulum, pelvis, Harrington, reconstruction.
研究目的癌症骨转移患者的患病率和生存率的提高越来越重视骨转移的治疗质量。尽管大多数骨盆病变都是非手术治疗的,但髋臼段的广泛破坏对治疗提出了挑战。一个潜在的治疗方案可能是改良的Harrington程序。材料和方法自2018年以来,在我们科室,14名患者(5名男性和9名女性)选择了这种手术方式。手术时的平均年龄为59岁(42至73岁)。12名患者患有转移性癌症,1名患者患有纤维肉瘤转移,1名女性患者出现侵袭性假肿瘤。对患者进行了放射学和临床随访。使用视觉模拟量表评估疼痛,并使用Harris髋关节评分和MSTS评分评估功能结果。配对样本Wilcoxon检验用于分析差异的统计学意义。结果平均随访25个月。在评估时,10名患者存活,平均随访29个月(2至54个月),4名患者死于癌症进展,平均随访16个月。无围手术期死亡或机械故障报告。一名女性患者在发热性中性粒细胞减少症期间出现血行感染,通过早期翻修和植入物保存成功治疗。从统计数据来看,与术前值相比,MSTS(中位数23)和HHS(中位数86)功能评分有显著改善(MSTS中位数2,p<0.01,r效应大小=0.6;HHS术前中位数0,p<0.05,r效应值=0.7)。疼痛也有统计学意义的减轻(VAS术后中位数1,VAS术前中位数8,p<0.01,r效应大小=-0.6)。所有患者在手术后都能独立行走,9名患者在没有支撑的情况下行走。讨论这种外科手术没有太多的替代方法。除了非手术姑息治疗外,这些选择还包括冰淇淋锥假体或定制的3D植入物,这在时间和成本方面都是不切实际的。我们的结果与其他研究相当,证实了该方法的再现性和可靠性。结论Harrington手术是治疗髋臼大肿瘤缺损的有效方法,功能良好,围手术期风险可接受,中期失败风险低,因此也适用于癌症预后良好的患者。关键词:肿瘤,转移,髋臼,骨盆,Harrington,重建。
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引用次数: 0
Type IV Titanium Hypersensitivity: Rare, or Rarely Detected? IV型钛超敏反应:罕见还是罕见?
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/012
J. Voves, O. Merka, K. Čabanová, J. Janošek, G. Bajor
The presented review aims to summarize the current knowledge of hypersensitivity to titanium - a material widely used in medical applications thanks to its exceptional chemical stability, resistance to corrosion, low specific weight and high strength. The hypersensitivity to metals is usually caused by the Type IV immunopathological reaction. Case reports on allergic reactions to titanium are rare but the actual occurrence can be expected to be much higher, especially due to its problematic detection. Although cutaneous patch tests are widely accepted and used for the diagnosis of hypersensitivity of numerous metals (e.g. Ni), it is notoriously unreliable in case of allergies to titanium, which may be associated with the low percutaneous transport of titanium and its salts. The Lymphocyte Transformation Test has superior sensitivity but it remains mostly unknown among clinicians and there are not many laboratories capable of performing it. This review presents numerous case reports indicating, in combination with the above-mentioned facts, that hypersensitivity to titanium should be considered as a possible cause also in non-specific problems associated with titanium implant failure. Key words: titanium, allergy, patch test, lymphocyte transformation test.
本文旨在总结目前对钛的超敏反应的认识。钛是一种因其优异的化学稳定性、耐腐蚀性、低比重和高强度而广泛应用于医学应用的材料。对金属的超敏反应通常是由IV型免疫病理反应引起的。对钛过敏反应的病例报告很少,但实际发生率预计会高得多,尤其是由于其检测存在问题。尽管皮肤贴剂试验被广泛接受并用于诊断多种金属(如镍)的超敏反应,但在对钛过敏的情况下,它是出了名的不可靠,这可能与钛及其盐的低经皮转运有关。淋巴细胞转化测试具有较高的灵敏度,但临床医生对其大多一无所知,也没有多少实验室能够进行。本综述提供了大量病例报告,结合上述事实,表明,对钛的超敏反应也应被视为与钛植入失败相关的非特异性问题的可能原因。关键词:钛,过敏,贴片试验,淋巴细胞转化试验。
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引用次数: 1
The Tibia Plafond Horizontal Orientation Angle for Frontal Alignment Evaluation of the Distal Lower Extremity. 胫骨板水平方位角用于下肢远端正面对齐评估。
IF 0.4 4区 医学 Q4 ORTHOPEDICS Pub Date : 2023-04-01 DOI: 10.55095/achot2023/018
M. Alshrouf, M. Ahrend, C. Konrads
PURPOSE OF THE STUDY Osteotomies around the knee are an established technique for treating knee osteoarthritis and other knee conditions by redistributing the body's weight and force within and around the knee joint. The aim of this study was to determine if the Tibia Plafond Horizontal Orientation Angle (TPHA) is a reliable measure for describing ankle alignment of the distal tibia in the coronal plane. MATERIALS AND METHODS This retrospective study included patients who underwent supracondylar rotational osteotomies for correction of femoral torsion. All patients had standing radiographs taken preoperatively and postoperatively with both knees pointed forward. Five variables, including Mechanical Lateral Distal Tibia Angle (mLDTA), Mechanical Malleolar Angle (mMA), Malleolar Horizontal Orientation Angle (MHA), Tibia Plafond Horizontal Orientation Angle (TPHA), and Tibio Talar Tilt Angle (TTTA), were collected. The preoperative and postoperative measurements were compared to each other using the Wilcoxon signed rank test. RESULTS A total of 146 patients were included in the study, with a mean age of 51.47 ± 11.87 years. There were 92 (63.0%) males and 54 (37.0%) females. MHA decreased from 14.0° ± 5.32° preoperatively to 10.59° ± 3.93° (p < 0.001) postoperatively, and TPHA decreased from 4.88° ± 4.07° preoperatively to 3.82 ± 3.10° (p = 0.013) postoperatively. The change in TPHA was significantly correlated with the change in MHA (r = 0.185, CI 0.023 - 0.337; p = 0.025). No differences were found between the measurements of mLDTA, mMA, and mMA pre- and postoperatively. DISCUSSION The orientation of the ankle should be taken into consideration during preoperative planning of osteotomies and should be measured in cases of postoperative ankle pain. CONCLUSIONS The TPHA is a reliable measure for describing ankle alignment of the distal tibia in the frontal plane. Key words: osteotomy, ankle, realignment, coronal alignment, preoperative planning.
膝关节周围截骨术是一种通过在膝关节内和周围重新分配身体重量和力量来治疗膝骨关节炎和其他膝关节疾病的既定技术。本研究的目的是确定胫骨平台水平方位角(TPHA)是否是描述胫骨远端在冠状面上脚踝对齐的可靠指标。材料和方法这项回顾性研究包括接受髁上旋转截骨术矫正股骨扭转的患者。所有患者在术前和术后均进行了站立放射线照相,双膝向前。收集了5个变量,包括机械性胫骨远端外侧角(mLDTA)、机械性踝关节角(mMA)、踝关节水平定向角(MHA)、胫骨平台水平方位角(TPHA)和胫骨-距骨倾斜角(TTTA)。使用Wilcoxon符号秩检验对术前和术后测量值进行比较。结果本研究共纳入146例患者,平均年龄为51.47±11.87岁。其中男性92例(63.0%),女性54例(37.0%)。MHA从术前14.0°±5.32°降至术后10.59°±3.93°(p<0.001),TPHA从术前4.88°±4.07°降至术前3.82±3.10°(p=0.013)。TPHA的变化与MHA的变化显著相关(r=0.185,CI 0.023-0.337;p=0.025)。术前和术后的mLDTA、mMA和mMA测量值之间没有差异。讨论在截骨术前计划时应考虑踝关节的方向,并在术后踝关节疼痛的情况下进行测量。结论TPHA是一种可靠的测量方法,可用于描述胫骨远端踝关节在额平面上的对齐情况。关键词:截骨,踝关节,复位,冠状位对齐,术前计划。
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引用次数: 0
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