Pub Date : 2015-10-01DOI: 10.1007/s00261-015-0459-z
S Mulé, A Colosio, J Cazejust, R Kianmanesh, P Soyer, C Hoeffel
Several benign and malignant liver diseases may require surgical treatment for cure, including anatomical resections based on the segmental anatomy of the liver, non-anatomical (wedge) resections, and surgical management of biliary cysts. The type of surgery depends not only on the location and the nature of the disease, but also on the expertise of the surgeon. Whereas ultrasonography is often the first-line imaging examination in case of suspected postoperative complication, multidetector computed tomography (MDCT) is of greater value for identifying normal findings after surgery, early postoperative pathologic fluid collections and vascular thromboses, and tumor recurrence in patients who have undergone hepatic surgery. Magnetic resonance cholangiopancreatography (MRCP) is the imaging modality of choice for depicting early postoperative bile duct injuries and ischemic cholangitis that may occur in the late postoperative phase. Both MDCT and MRCP can accurately depict tumor recurrence. Radiologists should become familiar with these surgical procedures to better understand postoperative changes, and with the normal imaging appearances of various postoperative complications to better differentiate between complications and normal findings.
{"title":"Imaging of the postoperative liver: review of normal appearances and common complications.","authors":"S Mulé, A Colosio, J Cazejust, R Kianmanesh, P Soyer, C Hoeffel","doi":"10.1007/s00261-015-0459-z","DOIUrl":"https://doi.org/10.1007/s00261-015-0459-z","url":null,"abstract":"<p><p>Several benign and malignant liver diseases may require surgical treatment for cure, including anatomical resections based on the segmental anatomy of the liver, non-anatomical (wedge) resections, and surgical management of biliary cysts. The type of surgery depends not only on the location and the nature of the disease, but also on the expertise of the surgeon. Whereas ultrasonography is often the first-line imaging examination in case of suspected postoperative complication, multidetector computed tomography (MDCT) is of greater value for identifying normal findings after surgery, early postoperative pathologic fluid collections and vascular thromboses, and tumor recurrence in patients who have undergone hepatic surgery. Magnetic resonance cholangiopancreatography (MRCP) is the imaging modality of choice for depicting early postoperative bile duct injuries and ischemic cholangitis that may occur in the late postoperative phase. Both MDCT and MRCP can accurately depict tumor recurrence. Radiologists should become familiar with these surgical procedures to better understand postoperative changes, and with the normal imaging appearances of various postoperative complications to better differentiate between complications and normal findings. </p>","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 7","pages":"2761-76"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-015-0459-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33341821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-10-01DOI: 10.1007/s00261-015-0419-7
Carly S Gardner, Tracy A Jaffe, Rendon C Nelson
Purpose: The purpose of the study was to document the clinical impact of CT in elderly patients presenting to the emergency department (ED) with abdominal pain.
Methods: This retrospective IRB-approved study from 2006 to 2013 evaluated 464 patients ≥80 years (mean 89 years, range 80-100: M150, W314), who presented to the ED with acute abdominal symptoms and underwent CT. CTs were divided into those negative and positive for actionable findings, defined as potentially requiring a change in surgical or medical management. Physician diagnosis, treatment plan, and disposition before and after CT were reviewed in the electronic medical record to assess CT influence on management and disposition. CT diagnosis was confirmed with final clinical diagnosis, surgical intervention, pathology, and follow-up. Descriptive statistics were used.
Results: CTs were positive in 55%. The most common diagnoses were SBO (18%), diverticulitis (9%), non-ischemic vascular-related emergency (6%), bowel ischemia (4%), appendicitis (3%), and colonic obstruction (2%). These diagnoses were clinically unsuspected prior to CT in 43% (p < 0.05), with significant difficultly in diagnosing SBO (p < 0.05), diverticulitis (p < 0.01), and colonic obstruction (p < 0.01). Positive CT results influenced treatment plans in 65%, surgical in 48%, and medical in 52%. Disposition from the ED was significantly affected by CT (p < 0.001), 65% of admissions with positive CT (p < 0.001) and 63% of discharges with negative CT (p < 0.001).
Conclusion: Utilization of abdominopelvic CT in geriatric patients presenting to the ED with acute abdominal symptoms strongly influences clinical management and significantly affects disposition. As the US population ages, the clinical impact of emergent CT in the elderly will intensify.
{"title":"Impact of CT in elderly patients presenting to the emergency department with acute abdominal pain.","authors":"Carly S Gardner, Tracy A Jaffe, Rendon C Nelson","doi":"10.1007/s00261-015-0419-7","DOIUrl":"https://doi.org/10.1007/s00261-015-0419-7","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of the study was to document the clinical impact of CT in elderly patients presenting to the emergency department (ED) with abdominal pain.</p><p><strong>Methods: </strong>This retrospective IRB-approved study from 2006 to 2013 evaluated 464 patients ≥80 years (mean 89 years, range 80-100: M150, W314), who presented to the ED with acute abdominal symptoms and underwent CT. CTs were divided into those negative and positive for actionable findings, defined as potentially requiring a change in surgical or medical management. Physician diagnosis, treatment plan, and disposition before and after CT were reviewed in the electronic medical record to assess CT influence on management and disposition. CT diagnosis was confirmed with final clinical diagnosis, surgical intervention, pathology, and follow-up. Descriptive statistics were used.</p><p><strong>Results: </strong>CTs were positive in 55%. The most common diagnoses were SBO (18%), diverticulitis (9%), non-ischemic vascular-related emergency (6%), bowel ischemia (4%), appendicitis (3%), and colonic obstruction (2%). These diagnoses were clinically unsuspected prior to CT in 43% (p < 0.05), with significant difficultly in diagnosing SBO (p < 0.05), diverticulitis (p < 0.01), and colonic obstruction (p < 0.01). Positive CT results influenced treatment plans in 65%, surgical in 48%, and medical in 52%. Disposition from the ED was significantly affected by CT (p < 0.001), 65% of admissions with positive CT (p < 0.001) and 63% of discharges with negative CT (p < 0.001).</p><p><strong>Conclusion: </strong>Utilization of abdominopelvic CT in geriatric patients presenting to the ED with acute abdominal symptoms strongly influences clinical management and significantly affects disposition. As the US population ages, the clinical impact of emergent CT in the elderly will intensify.</p>","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 7","pages":"2877-82"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-015-0419-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33207347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-08-01DOI: 10.1007/s00261-015-0441-9
James L Patrick, Joshua R Bakke, Peter Bannas, David H Kim, Meghan G Lubner, Perry J Pickhardt
{"title":"Erratum to: objective volumetric comparison of room air versus carbon dioxide for colonic distention at screening CT colonography.","authors":"James L Patrick, Joshua R Bakke, Peter Bannas, David H Kim, Meghan G Lubner, Perry J Pickhardt","doi":"10.1007/s00261-015-0441-9","DOIUrl":"https://doi.org/10.1007/s00261-015-0441-9","url":null,"abstract":"","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 6","pages":"2067"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-015-0441-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33287607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-08-01DOI: 10.1007/s00261-014-0344-1
Venkata S Katabathina, Wojciech Kapalczynski, Anil K Dasyam, Victor Anaya-Baez, Christine O Menias
Approximately 20% of choledochal cysts (CC) present in adult patients and they are commonly associated with a high risk of complications, including malignancy. Additionally, children who underwent internal drainage procedures for CCs can develop complications during adulthood despite treatment. Concepts regarding classification and pathogenesis of the CCs have been evolving. While new subtypes are being added to the widely accepted Todani classification system, simplified classification schemes have also been proposed to guide appropriate management. The exact etiology of CCs is currently unknown. The two leading theories involve either the presence of an anomalous pancreatico-biliary junction with associated reflux of pancreatic juice into the biliary system or, more recently, some form of antenatal biliary obstruction with resulting proximal bile duct dilation. Imaging studies play an important role in the initial diagnosis, surgical planning, and long-term surveillance of CCs.
{"title":"Adult choledochal cysts: current update on classification, pathogenesis, and cross-sectional imaging findings.","authors":"Venkata S Katabathina, Wojciech Kapalczynski, Anil K Dasyam, Victor Anaya-Baez, Christine O Menias","doi":"10.1007/s00261-014-0344-1","DOIUrl":"https://doi.org/10.1007/s00261-014-0344-1","url":null,"abstract":"<p><p>Approximately 20% of choledochal cysts (CC) present in adult patients and they are commonly associated with a high risk of complications, including malignancy. Additionally, children who underwent internal drainage procedures for CCs can develop complications during adulthood despite treatment. Concepts regarding classification and pathogenesis of the CCs have been evolving. While new subtypes are being added to the widely accepted Todani classification system, simplified classification schemes have also been proposed to guide appropriate management. The exact etiology of CCs is currently unknown. The two leading theories involve either the presence of an anomalous pancreatico-biliary junction with associated reflux of pancreatic juice into the biliary system or, more recently, some form of antenatal biliary obstruction with resulting proximal bile duct dilation. Imaging studies play an important role in the initial diagnosis, surgical planning, and long-term surveillance of CCs. </p>","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 6","pages":"1971-81"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-014-0344-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-08-01DOI: 10.1007/s00261-015-0355-6
Thomas J Vogl, Parviz Farshid, Nagy N N Naguib, Stefan Zangos, Boris Bodelle, Jijo Paul, Emannuel C Mbalisike, Martin Beeres, Nour-Eldin A Nour-Eldin
Purpose: The aim of the study is to retrospectively evaluate and compare the therapeutic response of Radiofrequency (RF) and Microwave (MW) ablation therapy of hepatocellular carcinoma (HCC).
Materials and methods: 53 consecutive patients (42 males, 11 females; mean age 59 years, range: 40-68, SD: 4.2) underwent CT-guided percutaneous RF and MW ablation of 68 HCC liver lesions. The morphologic tumor response (number, location and size) was evaluated by magnetic resonance imaging. The follow-up protocol was 24 h post-ablation then within 3 monthly intervals post-ablation in the first year and 6 monthly intervals thereafter.
Results: Complete therapeutic response was noted in 84.4% (27/32) of lesions treated with RFA and in 88.9% (32/36) of lesions treated with MW ablation (P = 0.6). Complete response was achieved in all lesions ≤2.0 cm in diameter in both groups. There was no significant difference in rates of residual foci of HCC lesions between RF and MW ablation groups (P = 0.15, Log-rank test). Recurrence rate for 3, 6, 9, and 12 months in patients with HCC who underwent RF ablation compared with MW ablation were 6.3%, 3.1%, 3.1% versus 0%, 5.6%, 2.8%, and 2.8%. Progression-Free Survival rates for treated patients with RF ablation of 1, 2, and 3 years were 96.9%, 93.8%, and 90.6% and treated with MW ablation therapy were 97.2%, 94.5%, and 91.7, respectively (P = 0.98).
Conclusion: In conclusion, RF and MW ablation therapy showed no significant difference in the treatment of HCC regarding the complete response, rates of residual foci of untreated disease, and recurrence rate.
{"title":"Ablation therapy of hepatocellular carcinoma: a comparative study between radiofrequency and microwave ablation.","authors":"Thomas J Vogl, Parviz Farshid, Nagy N N Naguib, Stefan Zangos, Boris Bodelle, Jijo Paul, Emannuel C Mbalisike, Martin Beeres, Nour-Eldin A Nour-Eldin","doi":"10.1007/s00261-015-0355-6","DOIUrl":"https://doi.org/10.1007/s00261-015-0355-6","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study is to retrospectively evaluate and compare the therapeutic response of Radiofrequency (RF) and Microwave (MW) ablation therapy of hepatocellular carcinoma (HCC).</p><p><strong>Materials and methods: </strong>53 consecutive patients (42 males, 11 females; mean age 59 years, range: 40-68, SD: 4.2) underwent CT-guided percutaneous RF and MW ablation of 68 HCC liver lesions. The morphologic tumor response (number, location and size) was evaluated by magnetic resonance imaging. The follow-up protocol was 24 h post-ablation then within 3 monthly intervals post-ablation in the first year and 6 monthly intervals thereafter.</p><p><strong>Results: </strong>Complete therapeutic response was noted in 84.4% (27/32) of lesions treated with RFA and in 88.9% (32/36) of lesions treated with MW ablation (P = 0.6). Complete response was achieved in all lesions ≤2.0 cm in diameter in both groups. There was no significant difference in rates of residual foci of HCC lesions between RF and MW ablation groups (P = 0.15, Log-rank test). Recurrence rate for 3, 6, 9, and 12 months in patients with HCC who underwent RF ablation compared with MW ablation were 6.3%, 3.1%, 3.1% versus 0%, 5.6%, 2.8%, and 2.8%. Progression-Free Survival rates for treated patients with RF ablation of 1, 2, and 3 years were 96.9%, 93.8%, and 90.6% and treated with MW ablation therapy were 97.2%, 94.5%, and 91.7, respectively (P = 0.98).</p><p><strong>Conclusion: </strong>In conclusion, RF and MW ablation therapy showed no significant difference in the treatment of HCC regarding the complete response, rates of residual foci of untreated disease, and recurrence rate.</p>","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 6","pages":"1829-37"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-015-0355-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33310709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-08-01DOI: 10.1007/s00261-015-0354-7
Ryan B Schwope, Lauren A May, Michael J Reiter, Christopher J Lisanti, Daniel J A Margolis
Gadoxetic acid is a hepatocyte-specific magnetic resonance imaging contrast agent with the ability to detect and characterize focal liver lesions and provide structural and functional information about the hepatobiliary system. Knowledge of the pharmacokinetics of gadoxetic acid is paramount to understanding imaging protocol and lesion appearance and facilitates identification and avoidance of undesired effects with use of this intravenous contrast agent. This article reviews the utility of gadoxetic acid in liver and biliary imaging, with emphasis on the hepatobiliary phase.
{"title":"Gadoxetic acid: pearls and pitfalls.","authors":"Ryan B Schwope, Lauren A May, Michael J Reiter, Christopher J Lisanti, Daniel J A Margolis","doi":"10.1007/s00261-015-0354-7","DOIUrl":"https://doi.org/10.1007/s00261-015-0354-7","url":null,"abstract":"<p><p>Gadoxetic acid is a hepatocyte-specific magnetic resonance imaging contrast agent with the ability to detect and characterize focal liver lesions and provide structural and functional information about the hepatobiliary system. Knowledge of the pharmacokinetics of gadoxetic acid is paramount to understanding imaging protocol and lesion appearance and facilitates identification and avoidance of undesired effects with use of this intravenous contrast agent. This article reviews the utility of gadoxetic acid in liver and biliary imaging, with emphasis on the hepatobiliary phase. </p>","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 6","pages":"2012-29"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-015-0354-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32995934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-08-01DOI: 10.1007/s00261-014-0320-9
Zhu Wang, He Zhao, Xiaoze Wang, Hailong Zhang, Mingshan Jiang, Jiaywei Tsauo, Xuefeng Luo, Li Yang, Xiao Li
The aim of this study is to compare the clinical outcomes of transjugular intrahepatic portosystemic shunt (TIPS) and endoscopic band ligation (EBL) in patients with cirrhosis and portal vein thrombosis (PVT). We retrospectively reviewed the January to September 2010 data from our database and included 25 patients with cirrhosis and PVT who underwent successful TIPS creation. We selected another 25 patients who underwent EBL matching for age, sex, and Child-Pugh-Turcotte class. The outcome measures included changes in the PVT status before and after the treatments, the rebleeding rate, and the overall survival. The mean follow-up was 25.1 ± 8.7 months in the EBL group and 25.6 ± 8.5 months in the TIPS group (P = 0.85). After treatments, the PVT severity improved in 40% and worsened in 25% of patients who did not undergo TIPS, compared with 87% and none of the patients who underwent TIPS (P < 0.001). Previous splenectomy (OR 0.13, 95% CI 0.02-0.76, P = 0.024) and patency status of TIPS (OR 20.8, 95% CI 3.0-141.8, P = 0.002) were the independent factors associated with PVT disappearance. The 1- and 2-year rebleeding rates were, respectively, 44.6% and 59.0% in the EBL group, and 12.5% and 25.2% in the TIPS group (P = 0.002). The 1- and 2-year survival rates were, respectively, 95.7% and 85.2% in the EBL group, and 96% and 78.7% in the TIPS group (P = 0.203). The MELD score was the only independent predictive factor for survival (HR 1.73, 95% CI 1.27-2.37, P = 0.001). Compared with EBL, TIPS contributed to PVT improvement and reduced the risk of rebleeding without providing a survival benefit for patients with PVT.
本研究的目的是比较经颈静脉肝内门静脉分流术(TIPS)和内镜下结扎术(EBL)治疗肝硬化和门静脉血栓形成(PVT)患者的临床结果。我们回顾性地回顾了2010年1月至9月数据库中的数据,包括25例肝硬化和PVT患者,他们成功地进行了TIPS创建。我们选择了另外25名患者,根据年龄、性别和Child-Pugh-Turcotte类别进行EBL匹配。结果测量包括治疗前后PVT状态的变化、再出血率和总生存率。EBL组平均随访25.1±8.7个月,TIPS组平均随访25.6±8.5个月(P = 0.85)。治疗后,未接受TIPS治疗的患者中有40%的PVT严重程度改善,25%的PVT严重程度恶化,而接受TIPS治疗的患者中有87%的PVT严重程度改善(P < 0.001)。既往脾切除术(OR 0.13, 95% CI 0.02 ~ 0.76, P = 0.024)和TIPS通畅状态(OR 20.8, 95% CI 3.0 ~ 141.8, P = 0.002)是与PVT消失相关的独立因素。EBL组1年和2年再出血率分别为44.6%和59.0%,TIPS组为12.5%和25.2% (P = 0.002)。EBL组1年、2年生存率分别为95.7%、85.2%,TIPS组为96%、78.7% (P = 0.203)。MELD评分是唯一独立的生存预测因子(HR 1.73, 95% CI 1.27-2.37, P = 0.001)。与EBL相比,TIPS有助于改善PVT,降低再出血风险,但不提高PVT患者的生存期。
{"title":"Clinical outcome comparison between TIPS and EBL in patients with cirrhosis and portal vein thrombosis.","authors":"Zhu Wang, He Zhao, Xiaoze Wang, Hailong Zhang, Mingshan Jiang, Jiaywei Tsauo, Xuefeng Luo, Li Yang, Xiao Li","doi":"10.1007/s00261-014-0320-9","DOIUrl":"https://doi.org/10.1007/s00261-014-0320-9","url":null,"abstract":"<p><p>The aim of this study is to compare the clinical outcomes of transjugular intrahepatic portosystemic shunt (TIPS) and endoscopic band ligation (EBL) in patients with cirrhosis and portal vein thrombosis (PVT). We retrospectively reviewed the January to September 2010 data from our database and included 25 patients with cirrhosis and PVT who underwent successful TIPS creation. We selected another 25 patients who underwent EBL matching for age, sex, and Child-Pugh-Turcotte class. The outcome measures included changes in the PVT status before and after the treatments, the rebleeding rate, and the overall survival. The mean follow-up was 25.1 ± 8.7 months in the EBL group and 25.6 ± 8.5 months in the TIPS group (P = 0.85). After treatments, the PVT severity improved in 40% and worsened in 25% of patients who did not undergo TIPS, compared with 87% and none of the patients who underwent TIPS (P < 0.001). Previous splenectomy (OR 0.13, 95% CI 0.02-0.76, P = 0.024) and patency status of TIPS (OR 20.8, 95% CI 3.0-141.8, P = 0.002) were the independent factors associated with PVT disappearance. The 1- and 2-year rebleeding rates were, respectively, 44.6% and 59.0% in the EBL group, and 12.5% and 25.2% in the TIPS group (P = 0.002). The 1- and 2-year survival rates were, respectively, 95.7% and 85.2% in the EBL group, and 96% and 78.7% in the TIPS group (P = 0.203). The MELD score was the only independent predictive factor for survival (HR 1.73, 95% CI 1.27-2.37, P = 0.001). Compared with EBL, TIPS contributed to PVT improvement and reduced the risk of rebleeding without providing a survival benefit for patients with PVT.</p>","PeriodicalId":7014,"journal":{"name":"Abdominal Imaging","volume":"40 6","pages":"1813-20"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00261-014-0320-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32905125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}