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The effect of digital nerve block on the accuracy of hemoglobin monitoring during surgery: A randomized clinical trial 指神经阻滞对术中血红蛋白监测准确性的影响:一项随机临床试验
Q4 ANESTHESIOLOGY Pub Date : 2021-12-01 DOI: 10.56126/72.4.3
R. S. Moharari, B. M. Davani, P. Pourfakhr, R. Y. Nooraie, M. Khajavi, F. Etezadi, A. Najafi
Background: The decision to transfuse blood products to patients during surgery is critical, due to the potential complications and costs of transfusion. Measuring hemoglobin level by spectrophotometry (SpHb) plays an important role in making this decision. The accuracy of SpHb depends on the finger perfusion. Since digital nerve blocks (DNB) can enhance blood circulation, we aimed at investigating DNB effects on the accuracy of SpHb.Methods: Patients undergoing spine surgery were randomly assigned to two groups. Group A received DNB in the left hand, and group B received DNB in the right hand. In each group, the other hand was considered as the control. Rainbow adult ReSposable sensors were attached to the patients’ both hands. Before surgical incision and every 1.5 hours, the SpHb values of both hands and the perfusion index were recorded. Concomitantly, arterial blood samples were drawn and sent to the lab for hemoglobin concentration measurement. This served as the gold standard for assessing hemoglobin levels (labHb). We used a mixed-effects generalized linear model to test the effect of independent variables on the difference between SpHb and labHb at each time point.Results: The SpHb displayed higher hemoglobin levels than those assessed by the lab. For lower labHb values, the SpHb-labHb differences were larger. A one-unit decrease in labHb increased the difference between SpHb and labHb by 0.56 g dL -1 , which was statistically significant.DNB significantly increased the difference between SpHb and labHb by 0.42 g dL -1 . The effect of DNB on the difference between SpHb and labHb was significant up to three hours after the beginning of surgery (0.58 g dL -1 difference between blocked and non-blocked hands).Conclusion: This study shows that, when hemoglobin levels are low, the accuracy of spectrophotometry decreases. Although DNB increases finger perfusion, it leads to an overestimation of hemoglobin levels by SpHb.
背景:由于输血的潜在并发症和成本,在手术期间向患者输血的决定至关重要。通过分光光度法测量血红蛋白水平(SpHb)在做出这一决定中起着重要作用。SpHb的准确性取决于手指的灌注。由于指神经阻滞(DNB)可以增强血液循环,我们旨在研究DNB对SpHb准确性的影响。方法:将接受脊柱手术的患者随机分为两组。A组左手接受DNB,B组右手接受DNB。在每组中,另一只手被视为对照。Rainbow成人ReSposable传感器连接在患者的双手上。在手术切口前和每1.5小时,记录双手的SpHb值和灌注指数。同时,抽取动脉血样并送往实验室进行血红蛋白浓度测量。这是评估血红蛋白水平(labHb)的金标准。我们使用混合效应广义线性模型来测试自变量对每个时间点SpHb和labHb之间差异的影响。结果:SpHb显示出比实验室评估的血红蛋白水平更高的血红蛋白水平。对于较低的labHb值,SpHb和labHb的差异更大。labHb降低一个单位,SpHb和labHb之间的差异增加了0.56 g dL-1,这在统计学上是显著的。DNB显著增加SpHb和labHb之间的差异0.42gdL-1。DNB对SpHb和labHb之间差异的影响在手术开始后三小时内是显著的(阻塞和未阻塞的手之间的差异为0.58 g dL-1)。结论:本研究表明,当血红蛋白水平较低时,分光光度法的准确性会降低。尽管DNB增加了手指灌注,但它会导致SpHb对血红蛋白水平的高估。
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引用次数: 0
Prinzmetal’s variant angina during laparoscopy: a case report of vasospasm in the context of cardiac arrest 腹腔镜检查时的变异性心绞痛:一例心脏骤停时血管痉挛的报告
Q4 ANESTHESIOLOGY Pub Date : 2021-12-01 DOI: 10.56126/72.4.6
C. Houbotte, L. Hankenne
We report the case of a 43-year-old male patient who experienced cardiac arrest during two elective laparoscopies for cholecystectomy. The first procedure was prematurely interrupted after the return of spontaneous circulation (ROSC) while the other was continued under intravenous (IV) perfusion of nitrates (isosorbide dinitrate). At each time, after a cycle of cardiopulmonary resuscitation (CPR) and injection of atropine 0.5 mg, sinus rhythm was restored. Only 3-lead electrocardiogram (ECG) outlines were recorded, showing ST-elevation in lead II. During the first incident, a coronary angiography was performed showing a vasospasm of the left anterior descending (LAD) coronary artery, reversible upon intracoronary injection of nitrates. ECG during catheterization showed ST-elevation in the anterior coronary territory. Calcium-channel blockers (CCB) were prescribed, and oral nitrates were added after the second episode. Cardiovascular prevention consisted in smoking cessation, aspirin and statins. Reporting this case seems to be relevant due to its unusual presentation: Prinzmetal’s angina is usually described as morning chest pains, and it rarely concerns Caucasian men. Moreover, the vasospasm was associated with cardiac arrest and ECG changes suggestive of ST-elevation myocardial infarction (STEMI). The final diagnosis was myocardial infarction with non-obstructive coronary arteries (MINOCA) due to coronary vasospasm, a few minutes after insufflation of pneumoperitoneum. So far, few cases have been described during non-cardiac surgery, and even fewer during laparoscopy. Sharing our experience seems important to attract attention to cardiovascular events that can occur under general anesthesia, especially when clinical presentation is rare.
我们报告的情况下,43岁的男性患者谁经历心脏骤停在两个选择性腹腔镜胆囊切除术。第一个手术在恢复自然循环(ROSC)后过早中断,而另一个手术在静脉(IV)灌注硝酸盐(硝酸异山梨酯)下继续进行。每次进行一个周期心肺复苏并注射阿托品0.5 mg后,窦性心律恢复。仅记录3导联心电图(ECG)轮廓,显示II导联st段抬高。在第一次事件中,冠状动脉造影显示左前降支(LAD)冠状动脉血管痉挛,冠状动脉内注射硝酸盐后可逆转。置管期间心电图显示冠状动脉前区st段抬高。处方钙通道阻滞剂(CCB),并在第二次发作后添加口服硝酸盐。心血管疾病的预防包括戒烟、阿司匹林和他汀类药物。报告这个病例似乎是相关的,因为它的不寻常的表现:Prinzmetal的心绞痛通常被描述为早晨胸痛,很少涉及白人男性。此外,血管痉挛与心脏骤停和提示st段抬高型心肌梗死(STEMI)的心电图变化有关。最终诊断为非阻塞性冠状动脉心肌梗死(MINOCA),由于冠状血管痉挛,气腹充气后几分钟。到目前为止,在非心脏手术中很少有病例被描述,在腹腔镜手术中更少。分享我们的经验对于引起人们对全身麻醉下可能发生的心血管事件的关注似乎很重要,尤其是在临床表现罕见的情况下。
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引用次数: 1
Effect of walking to the operating room on preoperative anxiety in patients scheduled for outpatient laser therapy for venous insufficiency. A monocentric randomized study 走进手术室对门诊激光治疗静脉功能不全患者术前焦虑的影响。单中心随机研究
Q4 ANESTHESIOLOGY Pub Date : 2021-12-01 DOI: 10.56126/72.4.2
N. Samalea Suarez, C. Hallet, F. Lois, J. Joris, J. Brichant
Background: Preoperative anxiety in day surgery is associated with a higher incidence of post-operative complications such as postoperative nausea and vomiting, pain or unplanned admission.Objectives: To evaluate the effect of walking to the operating room (OR) on anxiety in ambulatory patients undergoing minimal invasive laser therapy for venous insufficiency.Design and setting: Randomized study in a tertiary hospital between May and November 2019.Methods: 100 patients scheduled for ambulatory laser therapy for venous insufficiency were included. Patients were randomized to walk to the OR (study group, n=50) on even weeks or to lie in a bed to the OR (control group, n=50) on odd weeks.Main outcome measures: Baseline anxiety was assessed using the Amsterdam Preoperative Anxiety and Information Scale (APAIS) and Numerical Rating Scale of anxiety (anxiety-NRS) from 0 to 10 when prepared for departure to OR. Preoperative anxiety-NRS assessment was performed upon arrival in the OR.Results: Patients’ characteristics were similar in both groups. Baseline anxiety-NRS was significantly lower in the study group than in the control group: 2 (1-3) vs. 4 (2-6.5) (p=.013) respectively. No difference was observed between the groups for preoperative anxiety-NRS. A significant reduction in anxiety-NRS on arrival at the OR was observed in the control group compared with the study group (p=.019).Conclusion: Walking to the OR does not reduce anxiety in ambulatory patients undergoing minimal invasive laser therapy for venous insufficiency. But, preparing them to walk to the OR could possibly reduce baseline anxiety while waiting for surgery.
背景:日间手术中的术前焦虑与术后并发症的发生率较高有关,如术后恶心呕吐、疼痛或意外入院。目的:评估步行到手术室(OR)对接受微创激光治疗静脉功能不全的门诊患者焦虑的影响。设计和设置:2019年5月至11月在一家三级医院进行的随机研究。方法:纳入100名计划接受静脉功能不全门诊激光治疗的患者。患者被随机分组,在偶数周步行到手术室(研究组,n=50),或在奇数周躺在手术室的床上(对照组,n=50%)。主要结果测量:在准备前往手术室时,使用阿姆斯特丹术前焦虑和信息量表(APAIS)和焦虑数字评定量表(焦虑NRS)从0到10对基线焦虑进行评估。到达手术室后进行术前焦虑NRS评估。结果:两组患者的特征相似。研究组的基线焦虑NRS显著低于对照组:分别为2(1-3)和4(2-6.5)(p=0.013)。术前焦虑NRS在两组之间没有观察到差异。与研究组相比,对照组到达手术室时的焦虑NRS显著降低(p=0.019)。结论:在接受微创激光治疗静脉功能不全的门诊患者中,步行到手术室并不能减轻焦虑。但是,让他们步行去手术室可能会减少等待手术时的基线焦虑。
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引用次数: 0
Unusual cause of obstructive shock following esophagectomy: a case report 食管切除术后梗阻性休克的不寻常原因1例
Q4 ANESTHESIOLOGY Pub Date : 2021-12-01 DOI: 10.56126/72.4.5
S. Boccar, R. Rubay, M. Richard, P. Reper, G. Horlait, A. Goussen, V. De Moor, P. Bulpa
Obstructive shock usually has an intrathoracic origin, such as pneumothorax, pericardial tamponade or pulmonary embolism. We report a case of hemo- dynamic shock in a 74-year-old patient four days after esophagectomy, just after the start of mechanical ventilation for bilateral pneumonia. The sudden onset of severe abdominal distension and the presence of air in the intra-abdominal drain suggested tension pneumoperitoneum, confirmed by radiography. No pneumothorax was associated. Urgent decompression was required to improve hemodynamics. Perforation of the gastrointestinal tract was ruled out. The cause was a bronchopleural fistula opened by mechanical ventilation. Rarely, cardiorespiratory failure may occur after tension pneumoperitoneum by reducing lung volume and cardiac preload, similar to obstructive shock from the usual intrathoracic causes or acting as an abdominal compartment syndrome (ACS). Its recognition and abdominal decompression are key steps in the patient’s recovery. Tension pneumoperitoneum related to mechanical ventilation and airway injury without associated pneumothorax is exceptional and, to our knowledge, has never been reported as a postoperative complication of esophagectomy.
梗阻性休克通常起源于胸内,如气胸、心包填塞或肺栓塞。我们报告一例74岁的患者,在双侧肺炎开始机械通气后,食道切除术后4天发生血液动力学休克。突然发作的严重腹胀和腹内引流管中存在空气提示张力性气腹,经x线摄影证实。无气胸相关。需要紧急减压以改善血流动力学。排除了胃肠道穿孔。原因是机械通气导致支气管胸膜瘘。紧张性气腹术后,肺容量和心脏预负荷减少,可能导致心肺衰竭,类似于通常胸腔内原因引起的阻塞性休克,或表现为腹腔隔室综合征(ACS)。其识别和腹部减压是患者康复的关键步骤。张力性气腹与机械通气和气道损伤相关,无气胸是例外,据我们所知,从未报道过作为食管切除术术后并发症。
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引用次数: 0
The use of methylprednisolone in patients with Coronavirus disease 2019 (COVID-19) requiring intensive care hospitalization: a longitudinal observational study 甲基强的松龙在需要重症监护住院的2019冠状病毒病(COVID-19)患者中的应用:一项纵向观察研究
Q4 ANESTHESIOLOGY Pub Date : 2021-09-01 DOI: 10.56126/72.3.4
L. Doucet, S. Hoflack, L. Van Slambrouck, P. Lormans
The use of methylprednisolone in patients with Coronavirus disease 2019 (COVID-19) requiring intensive care hospitalization: a longitudinal observational study.Background : For a long time, the use of corticosteroids in critically ill patients with coronavirus disease 2019 (COVID-19) has been a controversial treatment. How- ever, given the conflicting evidence on this topic, we studied the effects of methylprednisolone on critically ill patients and - share here our experience on laboratory findings and the Pa02/FiO2 ratio (ratio of partial oxygen concentration on arterial blood gas sample to fraction of inspired oxygen).Methods : In a population of 68 patients hospitalized in the intensive care unit due because of COVID-19 infection, 28 patients with severe respiratory failure received methylprednisolone on a fixed 12-day regimen (125 mg IV for 2 days, followed by 2x0.5 mg/kg IV twice daily for 5 days, and then a decreasing regimen for 4 days until discontinuation). After day 5 and day 10, we analyzed the levels of CRP (C-reactive protein), lymphocytosis, D-dimer, LDH (lactate dehydrogenase) and PaO 2 /FiO 2 ratio of our patients.Results : We observed a significant decrease in median CRP levels between day 0 (start of methylprednisolone treatment) and day 5 (p=0.001), and between day 0 and day 10 (p=0.005). No decrease was seen between day 5 and 10 (p=0.352). The same increase in PaO 2 /FiO 2 was recorded between day 0 and day 5 (p=0.009), and between 0 and day 10 (p=0.019). For D-dimer, only a significant difference was found between day 0 and day 10 (p=0.018). No significant difference could be observed for lymphocytosis and LDH levels between the beginning of the treatment and day 5 or day 10.Conclusion : There is a strong and sustained significant decrease in CRP levels and a tilt in the PaO2/FiO2 ratio after starting methylprednisolone. A slower, but also significant decrease was found for D-dimer. Further research and control group analyses are needed to confirm that this effect is due to corticostreoid treatment. However, this indicates that methylprednisolone may play a very important role in the treatment of the severely ill COVID-19 patients requiring ICU admission.
甲基强的松龙在需要重症监护住院治疗的2019冠状病毒病(新冠肺炎)患者中的使用:一项纵向观察研究。背景:长期以来,在2019冠状病毒病(新冠肺炎)危重患者中使用皮质类固醇一直是一种有争议的治疗方法。然而,鉴于这一主题的相互矛盾的证据,我们研究了甲基强的松龙对危重患者的影响,并在这里分享了我们在实验室发现和Pa02/FiO2比率(动脉血气样本的部分氧浓度与吸入氧分数的比率)方面的经验。方法:在68名因新冠肺炎感染而在重症监护室住院的患者中,28名严重呼吸衰竭患者接受了为期12天的固定方案甲基强的松龙治疗(125 mg IV,为期2天,随后2次0.5 mg/kg IV,为期5天,每天两次,然后递减方案,为期4天,直至停药)。在第5天和第10天之后,我们分析了我们的患者的CRP(C反应蛋白)、淋巴细胞增多症、D-二聚体、LDH(乳酸脱氢酶)和PaO2/FiO2比率的水平。结果:我们观察到,在第0天(开始甲基强的松龙治疗)到第5天(p=0.001),以及第0天到第10天(p=0.005),中位CRP水平显著下降。在第5天到第十天之间没有下降(p=0.052)。在第0天至第5天之间(p=0.009)和第0天至第10天之间(p=0.019),在第0天和第10天之间仅发现显著差异(p=0.018)。在治疗开始和第5天或第10天期间,淋巴细胞增多症和LDH水平没有观察到显著差异。结论:在开始甲基强的松龙后,CRP水平显著且持续地显著下降,PaO2/FiO2比率倾斜。D-二聚体的下降速度较慢,但也很显著。需要进一步的研究和对照组分析来证实这种影响是由皮质类固醇治疗引起的。然而,这表明甲基强的松龙可能在治疗需要入住ICU的重症新冠肺炎患者中发挥非常重要的作用。
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引用次数: 0
Postoperative pain after cesarean section: an audit of practice after implementation of the PROSPECT recommendations 剖宫产术后疼痛:实施PROSPECT建议后的实践审计
Q4 ANESTHESIOLOGY Pub Date : 2021-09-01 DOI: 10.56126/72.3.1
N. Gharae, E. Roofthooft, N. Fileticci, S. Devroe, P. Vanhove, S. Rex, M. Van de Velde
Cesarean section (CS) is the most frequently performed surgical intervention worldwide. Post- cesarean pain is often underestimated and undertreated and can impair rapid maternal recovery, mother and child bonding and breastfeeding. Recently, PROSPECT recommendations on postoperative pain for CS were published and they include systematic paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs), intravenous dexamethasone, neuraxial morphine/dia- morphine or an abdominal wall block or wound infiltration, abdominal wall binders, non-closure of the peritoneum and a Joel-Cohen incision. Opioids are administered as rescue. In UZ Leuven, these PROSPECT recommendations were implemented at the end of 2020. To evaluate the efficacy of these PROSPECT recommendations, a prospective audit was performed from January 1 st , 2021 till April 30 th , 2021. All patients with a CS were prospectively followed for correct implementation of the pain protocol and for pain scores in rest and at mobilization. Rescue opioid consumption as well as patient satisfaction were recorded. 185 consecutive patients that had undergone a CS were included in the audit. In 55 patients the pain protocol was not followed mostly due to no or reduced administration of NSAIDs. Patient satisfaction was high, especially in patients in which the protocol was followed. Pain scores at rest and at mobilization were low and the percentage of patients having pain scores above 30 mm VAS remained low. Rescue opioid consumption was low. We conclude that the implementation of the PROSPECT based pain protocol after CS was effective in controlling pain, reducing opioid consumption and resulted in high patient satisfaction especially if the protocol was correctly followed. Omission of NSAIDs is occurring relatively frequent, but mostly because of valid medical reasons to omit NSAIDs.
剖宫产(CS)是世界上最常见的外科干预措施。剖宫产后的疼痛往往被低估和治疗不足,会影响产妇的快速康复、母子关系和母乳喂养。最近,发表了关于CS术后疼痛的PROSPECT建议,其中包括系统性对乙酰氨基酚和非甾体抗炎药(NSAIDs)、静脉注射地塞米松、轴索吗啡/二吗啡或腹壁阻滞或伤口浸润、腹壁粘合剂、腹膜不闭合和Joel Cohen切口。阿片类药物是作为抢救用药的。在鲁汶大学,这些PROSPECT建议于2020年底实施。为了评估这些前瞻性建议的有效性,从2021年1月1日至2021年4月30日进行了前瞻性审计。对所有CS患者进行前瞻性随访,以正确执行疼痛方案,并在休息和活动时进行疼痛评分。记录了救援阿片类药物的消耗量以及患者的满意度。185名连续接受CS的患者被纳入审计。在55名患者中,疼痛方案没有得到遵守,主要是由于没有服用或减少服用非甾体抗炎药。患者满意度很高,尤其是在遵守方案的患者中。休息和活动时的疼痛评分较低,疼痛评分超过30mm VAS的患者比例仍然较低。救援阿片类药物的消费量很低。我们得出的结论是,CS后实施基于PROSPECT的疼痛方案在控制疼痛、减少阿片类药物消耗方面是有效的,并导致患者的高满意度,尤其是在正确遵循该方案的情况下。非甾体抗炎药的省略相对频繁,但主要是因为省略非甾体消炎药的正当医学原因。
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引用次数: 1
Internal jugular vein valves complicating central venous catheter placement: a case report 颈内静脉瓣膜合并中心静脉导管置入术1例
Q4 ANESTHESIOLOGY Pub Date : 2021-09-01 DOI: 10.56126/72.3.6
S. Pissens, M. Peetermans, A. Wilmer
Placement of central venous catheters in the internal jugular vein is a frequently performed procedure. We present the case of a patient with venous valves causing an unexpected anatomic hindrance in the placement of a central venous catheter in the internal jugular vein. Venous valves are common in the internal jugular vein and can hinder cannulation. Ultrasound can be of use in the proper placement of a central venous line in a patient where cannulation is complicated by venous valves.
在颈内静脉中放置中心静脉导管是一种经常进行的手术。我们介绍了一例患者的静脉瓣膜在颈内静脉放置中心静脉导管时造成意外的解剖障碍。静脉瓣膜常见于颈内静脉,可阻碍插管。在静脉瓣膜使插管复杂的患者中,超声可用于正确放置中心静脉线。
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引用次数: 0
Management of anesthesia for surgery in prone position for a patient with hereditary neuropathy with liability to pressure palsies. A case report and narrative literature review 易患压力性麻痹的遗传性神经病变患者俯卧位手术的麻醉管理。个案报告与叙述性文献综述
Q4 ANESTHESIOLOGY Pub Date : 2021-09-01 DOI: 10.56126/72.3.7
C. Moerman, T. Van Havenbergh, P. Van Houwe, S. Casaer
The reported case describes a patient with hereditary neuropathy with liability to pressure palsies (HNPP) requiring a neurosurgical laminotomy procedure for an arachnoid cyst with medullary compression. HNPP is a rare pathology requiring meticulous anesthetic and surgical management. We give a detailed overview of the planning, simulation, and performance of the anesthesia procedure in order to minimize all potential risk factors for perioperative nerve injury. During the preparation of this case, where the positioning was extremely challenging, we reviewed the available literature for guidance. A few papers report the use of neuraxial anesthesia in patients previously diagnosed with HNPP. No reports could be found on the management of general anesthesia and positioning for major surgery in those patients.
报告的病例描述了一个遗传性神经病变与压力性麻痹(HNPP)的易感性,需要神经外科椎板切开术治疗蛛网膜囊肿与髓质压迫。HNPP是一种罕见的病理,需要细致的麻醉和手术治疗。为了尽量减少围手术期神经损伤的所有潜在危险因素,我们将详细概述麻醉过程的计划、模拟和执行。在本案例的准备过程中,定位极具挑战性,我们查阅了现有文献以寻求指导。一些论文报道了在先前诊断为HNPP的患者中使用神经轴麻醉。在这些患者的大手术中,没有关于全身麻醉和体位管理的报道。
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引用次数: 1
A comparative study of transdiscal versus transaortic celiac plexus neurolytic block for upper gastrointestinal cancer patients. A prospective, randomized control study 上消化道癌症患者经椎间盘与经皮质腹腔丛神经阻滞的比较研究。一项前瞻性随机对照研究
Q4 ANESTHESIOLOGY Pub Date : 2021-09-01 DOI: 10.56126/72.3.3
A. Rath, Reena, A. Paswan, M. Tewari
Aim: To compare transdiscal and transaortic techniques of neurolytic celiac plexus block for upper gastrointestinal cancer patients.Methods: In this prospective randomized study 60 patients with upper gastrointestinal malignancies were included and randomly divided into two groups, group TD and group TA, receiving neurolytic celiac plexus blocks via transdiscal and transaortic techniques, respectively. The primary outcome was quality of life (QoL) as assessed by WHOQOL BREF questionnaire and secondary outcomes were pain relief using visual analogue scale (VAS), and occurrence of complications like hypotension, loose motion, bleeding and discitis.Result: QoL and VAS score were significantly improved in both groups post procedure. Transdiscal approach is more effective in improving VAS score than transaortic approach (1 vs 3) after 1 week and the relief of pain was better in TD group (3 vs 6) at the end of 2 months. Transdiscal approach was found to be more effective in improving QoL (227.00±28.85 vs 191.17±35.78) as compared to transaortic approach. However, post-procedural QoL improved in both groups when compared to pre-procedural QoL (p<0.05). Hypotension, diarrhea and bleeding from aorta were higher in TA group; however, no serious complications were seen in any of the groups.Conclusion: Transdiscal technique is better in terms of adequate pain relief and improving QoL as compared to transaortic technique of NCPB in patients of upper GI malignancies and is associated with lesser incidences of complications.
目的:比较上消化道癌症患者腹腔神经丛阻滞的经椎间盘和经皮质技术。方法:在这项前瞻性随机研究中,60名上消化道恶性肿瘤患者被纳入并随机分为两组,TD组和TA组,分别通过经椎间和经皮质技术接受腹腔神经丛阻滞。主要结果是通过WHOQOL BREF问卷评估的生活质量(QoL),次要结果是使用视觉模拟量表(VAS)缓解疼痛,以及低血压、松动、出血和椎间盘炎等并发症的发生。结果:两组患者术后生活质量和VAS评分均有明显改善。1周后,经椎间盘入路在改善VAS评分方面比经皮质入路(1比3)更有效,并且在2个月结束时,TD组的疼痛缓解效果更好(3比6)。与经皮质入路相比,经椎间盘入路在改善生活质量方面更有效(227.00±28.85 vs 191.17±35.78)。但与术前相比,两组术后生活质量均有改善(p<0.05)。TA组低血压、腹泻和主动脉出血率较高;然而,在任何一组中都没有发现严重的并发症。结论:在上消化道恶性肿瘤患者中,与经皮质NCPB技术相比,经椎间盘技术在充分缓解疼痛和改善生活质量方面更好,并且并发症发生率更低。
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引用次数: 0
Comparison between mephentermine and ondansetron for the prevention of post spinal hypotension: a prospective randomized trial 甲芬特明和昂丹司琼预防脊髓后低血压的比较:一项前瞻性随机试验
Q4 ANESTHESIOLOGY Pub Date : 2021-09-01 DOI: 10.56126/72.3.5
K. Shah, P. Dubey, A. Bharti, S. Singh
Background and Aims: Spinal anesthesia is a technique often associated with side effects like hypotension and bradycardia. Recent studies have shown that the use of ondansetron leads to a decreased incidence of hypotension induced by spinal anesthesia. This prospective, randomized, controlled, double-blind study was done to compare the efficacy of the prophylactic use of intravenous (IV) ondansetron and mephentermine on post-spinal hypotension.Methods: A total of 130 patients were randomly allocated to one of two groups: Group O received 4 mg IV ondansetron and Group M received 6 mg of IV mephentermine. All patients received spinal anesthesia using 3 mL of 0.5% hyperbaric bupivacaine. Assessment of blood pressure and heart rate (HR) was done for 30 minutes after spinal anesthesia was performed. Quantitative data were analyzed using ANOVA tests and qualitative data were analyzed using the Chi-square tests.Results: Both groups were comparable regarding demographic data. Mean arterial blood pressure (MAP) in Group O was lower than Group M at 5 to 25 minutes and difference of MAP between the two groups was > 20% of baseline values (p < 0.05). HR was comparable between groups. No statistically significant differences were seen in side effects between the two groups.Conclusion: Our study shows that the preemptive use of both ondansetron and mephentermine significantly decreases the incidence of post-spinal hypotension.
背景和目的:脊髓麻醉是一种常伴有低血压和心动过缓等副作用的技术。最近的研究表明,使用昂丹司琼可降低由脊髓麻醉引起的低血压的发生率。这项前瞻性、随机、对照、双盲研究的目的是比较预防性静脉注射昂丹司琼和甲芬特明治疗脊柱后低血压的疗效。方法:将130例患者随机分为两组:O组给予静脉注射昂丹司琼4 mg, M组给予静脉注射甲非明6 mg。所有患者均使用3ml 0.5%高压布比卡因进行脊髓麻醉。脊髓麻醉后30分钟测量血压和心率(HR)。定量资料采用方差分析,定性资料采用卡方检验。结果:两组人口统计数据具有可比性。5 ~ 25 min时,O组平均动脉血压(MAP)低于M组,两组间MAP差异为基线值的20% (p < 0.05)。两组间人力资源具有可比性。两组的副作用无统计学差异。结论:我们的研究表明,优先使用昂丹司琼和甲非明可显著降低脊髓后低血压的发生率。
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Acta anaesthesiologica Belgica
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