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Autoimmune Encephalitis with Antibodies Against A-Amino-3hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor and γ-Aminobutyric Acid-Beta Receptor: Case Report. 自身免疫性脑炎伴有针对A-氨基-3羟基-5-甲基-4-异恶唑丙酸受体和γ-氨基丁酸-β受体的抗体:病例报告。
IF 1.1 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2024-02-23 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28388
Faruk Uğur Doğan, Bedia Samanci, Vuslat Yilmaz, Haşmet Ayhan Hanağasi, İbrahim Hakan Gürvit, Erdem Tüzün, Başar Bilgiç

Introduction: Limbic encephalitis is a rapidly progressing disease that presents with seizures, psychiatric symptoms, and recent memory loss. Detection of more than one autoantibody is a rare condition in this disease where an underlying autoantibody is frequently detected. Although different autoantibodies have been reported in the literature, no case has been reported regarding the association of anti-γ-aminobutyric acid-beta-receptor (anti-GABABR) and anti-α-amino-3 hydroxy-5-methyl-4-isoxazolepropionic acid (anti-AMPAR).

Case: In this presentation, a 46-year-old female patient with subacute development of short-term memory loss and behavioral symptoms will be described. Anti-GABABR and anti-AMPAR were positive in the anti-neuronal antibody panel sent from the cerebrospinal fluid and serum. Small cell lung cancer was detected as a result of malignancy screening tests. The patient's complaints and autoantibody positivity regressed after immunotherapy.

Conclusion: In this case report, a case with coexistence of anti-GABABR and anti-AMPAR antibodies, which has not been previously reported in the literature, is described. As more cases with the coexistence of these two antibodies are detected, knowledge on clinical aspect, laboratory and treatment will increase.

简介边缘性脑炎是一种进展迅速的疾病,表现为癫痫发作、精神症状和近期记忆丧失。在这种疾病中,检测到一种以上的自身抗体是一种罕见的情况,在这种疾病中经常检测到一种潜在的自身抗体。虽然文献中报道了不同的自身抗体,但还没有关于抗γ-氨基丁酸-β-受体(抗-GABABR)和抗α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(抗-AMPAR)相关联的病例。脑脊液和血清中的抗神经元抗体检测结果显示,抗-GABABR 和抗-AMPAR 阳性。恶性肿瘤筛查检测发现了小细胞肺癌。免疫治疗后,患者的主诉和自身抗体阳性症状消失:本病例报告描述了一例抗-GABABR和抗-AMPAR抗体共存的病例,这在以前的文献中从未报道过。随着这两种抗体同时存在的病例越来越多,有关临床、实验室和治疗方面的知识也会越来越丰富。
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引用次数: 0
Manipulative overconfidence and the cost of unbiased reporting 操纵性过度自信和不带偏见报道的代价
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2024-01-12 DOI: 10.1080/00014788.2023.2288578
Nikolaj Niebuhr Lambertsen
I study earnings management in a principal-agent model where the agent is overconfident in their ability to manage earnings, and the principal may induce the agent to communicate earnings truthfull...
我在一个委托-代理模型中研究收益管理,在该模型中,代理人对其管理收益的能力过于自信,委托人可能会诱使代理人如实告知收益。
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引用次数: 0
Earnings management by acquiring firms in cash mergers 现金兼并中收购公司的收益管理
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2024-01-12 DOI: 10.1080/00014788.2023.2288567
Kamran T. Malikov, Alaa Mansour Zalata
We examine earnings management by cash bidders with debt financing. We hypothesise and find that highly leveraged cash bidders seeking to fund bids with debt manage earnings in the pre-merger perio...
我们研究了利用债务融资的现金竞标者的收益管理。我们假设并发现,高杠杆现金竞标者在寻求债务融资时,会在合并前对盈利进行管理。
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引用次数: 0
Examining an expanded repertoire of finance functions: effects on performance and the moderating role of environmental uncertainty 研究扩大后的财务职能范围:对绩效的影响以及环境不确定性的调节作用
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2024-01-09 DOI: 10.1080/00014788.2023.2267443
Henrik Nielsen, Thomas Toldbod, Thomas Borup Kristensen
The literature recognises that the activities of contemporary finance functions are expanding. Guided by the competing values framework, we group the results of previous research into four roles pe...
有文献指出,当代财务职能部门的活动范围正在不断扩大。在竞争价值观框架的指导下,我们将以往的研究成果归纳为四种角色,分别是...
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引用次数: 0
Accounting and Business Research – ESG themed issue 会计与商业研究》--ESG 主题期刊
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2023-12-21 DOI: 10.1080/00014788.2024.2282208
Mark Clatworthy, Juan Manuel Garcia Lara, Edward Lee
Published in Accounting and Business Research (Vol. 54, No. 1, 2024)
发表于《会计与商业研究》(第 54 卷第 1 期,2024 年)
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引用次数: 0
Integrating contemporary accounting and international business research: progress so far and opportunities for the future 整合当代会计和国际商务研究:迄今取得的进展和未来的机遇
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2023-12-12 DOI: 10.1080/00014788.2023.2271295
Salvador Carmona, Igor Filatotchev, Jan Hendrik Fisch, Gilad Livne
To date, the accounting and international business (IB) research fields have been developing rather independently, although some cross-discipline fertilisation is emerging. This paper aims to illus...
迄今为止,会计和国际商务(IB)研究领域的发展一直比较独立,尽管正在出现一些跨学科的融合。本文旨在阐明会计与国际商务(IB)之间的关系。
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引用次数: 0
Mythmaking in audit regulation: the Canadian initiative on ‘enhancing audit quality’ 审计监管中的规则制定:加拿大关于 "提高审计质量 "的倡议
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2023-12-09 DOI: 10.1080/00014788.2023.2278727
Simon Dermarkar, Anna Samsonova-Taddei, Yves Gendron
Although extant literature has provided accounts of regulatory processes that failed to produce new or improved regulation, we know less about how regulators attempt to devise an ‘illusion of regul...
尽管现有文献对未能产生新监管或改进监管的监管过程进行了描述,但我们对监管者如何试图设计一种 "监管假象 "却知之甚少。
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引用次数: 0
Transformational leadership style and holistic accountability mechanisms in not-for-profit organisations 非营利组织的变革型领导风格和整体问责机制
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2023-11-30 DOI: 10.1080/00014788.2023.2277919
Graeme Harrison, Jinhua Chen, Lu Jiao
This study examines: (i) the ability of the transformational leadership style of top management to effect holistic accountability in not-for-profit organisations (NFPs) through the use of downward ...
本研究考察:(i)高层管理变革型领导风格在非营利组织(NFPs)中通过使用向下…
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引用次数: 0
Does high-frequency trading cause stock prices to deviate from fundamental values? 高频交易是否会导致股价偏离基本价值?
IF 1.7 4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2023-11-23 DOI: 10.1080/00014788.2023.2258787
Michael Jung, Kyung Yoon Kwon, Hyungshin Park
We examine whether high-frequency trading (HFT) is associated with greater deviations of stock prices from firms’ fundamental, intrinsic values. Prior studies show that HFT can improve market liqui...
我们研究高频交易(HFT)是否与股票价格偏离公司基本内在价值的较大偏差有关。已有研究表明,高频交易可以提高市场流动性。
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引用次数: 0
The impact of cost stickiness on income smoothing: evidence from employment protection regulations 成本粘性对收入平滑的影响:来自就业保护法规的证据
4区 管理学 Q2 BUSINESS, FINANCE Pub Date : 2023-11-07 DOI: 10.1080/00014788.2023.2266803
Andrei Filip, Junqi Liu, Daphne Lui
AbstractPrior literature suggests that cost stickiness increases the ex-ante volatility and reduces the predictability of earnings. We examine whether managers intentionally undo such consequences by dampening earnings volatility. Exploiting the staggered adoption of wrongful discharge laws as an exogenous instrument for cost stickiness, we document that cost stickiness increases managers’ income-smoothing activities. This response is more pronounced in firms whose earnings are more sensitive to labour costs than their industry peers are and in firms with stronger information-provision incentives. Additional analyses indicate that income smoothing improves sticky-cost firms’ earnings informativeness and that the identified impact of cost stickiness is primarily driven by labour costs. Our results suggest that labour regulations can influence managers’ financial reporting incentives via cost behaviour.Keywords: cost stickinessincome smoothingemployment protectionearnings informativeness AcknowledgmentsWe are heavily indebted to the associated editor Stefano Cascino and two anonymous reviewers for their constructive and thoughtful guidance. We thank Beatriz García-Osma, Thomas Jeanjean, Anne Jeny, Sanjay Kallapur, Itay Kama, Reuven Lehavy, Andreea Moraru-Arfire, Naomi Soderstrom, Samuel Tan (discussant), and workshop participants at ESSEC Business School and the EAA Annual Congress 2019 in Paphos for their helpful comments and suggestions. Junqi Liu also gratefully acknowledges the financial support from the National Natural Science Foundation of China (NSFC), grant number 72202190, from the Social Science Foundation of Fujian Province, grant number FJ2022C034, from the Fundamental Research Funds for the Central Universities, grant number 20720221042, and from the Association Francophone de Comptabilité (AFC). All remaining errors are our own.Disclosure statementNo potential conflict of interest was reported by the author(s).Notes1 Cost stickiness arises primarily from the asymmetry in managers’ real resource commitment. When activity levels increase, managers add resources to meet growing demand; when activity levels fall, they retain some of their underutilized resources, because they perceive the adjustment costs of reducing the resources as higher than the costs of holding them (Anderson et al. Citation2003). In this sense, cost stickiness is distinct from managers’ financial reporting choice.2 In this study, we focus on accrual-based income smoothing, which reflects managerial effort to reduce earnings volatility through accounting methods (in contrast to real activities); see Section 2.2 for more detail. We do not discuss income smoothing through real activities such as discretionary adjustments of R&D or marketing expenditures because such activities are likely detrimental to firm performance in the long run.3 For example, if each employee uses a truck or a software license (i.e. complements to labour), then greater labour cost stickiness wi
摘要已有文献表明,成本粘性增加了事前波动性,降低了收益的可预测性。我们考察了管理者是否有意通过抑制收益波动来消除这种后果。利用错误解雇法的交错采用作为成本粘性的外生工具,我们证明成本粘性增加了管理者的收入平滑活动。这种反应在收入对劳动力成本比同行更敏感的公司和信息提供激励更强的公司中更为明显。进一步的分析表明,收入平滑提高了粘性成本企业的收益信息,成本粘性的确定影响主要由劳动力成本驱动。我们的研究结果表明,劳动法规可以通过成本行为影响管理人员的财务报告激励。关键字:成本粘性收入平滑就业保护收入信息确认我们非常感谢联合编辑Stefano Cascino和两位匿名审稿人的建设性和周到的指导。我们感谢Beatriz García-Osma、Thomas Jeanjean、Anne Jeny、Sanjay Kallapur、Itay Kama、Reuven Lehavy、Andreea Moraru-Arfire、Naomi Soderstrom、Samuel Tan(讨教嘉宾)以及ESSEC商学院和2019年帕福斯EAA年会上的研讨会参与者提供的宝贵意见和建议。刘俊琪也感谢国家自然科学基金(基金号:72202190)、福建省社会科学基金(基金号:FJ2022C034)、中央高校基本科研业务费(基金号:20720221042)和法语国家计算机协会(AFC)的资助。所有剩下的错误都是我们自己的。披露声明作者未报告潜在的利益冲突。注1成本粘性主要源于管理者实际资源承诺的不对称。当活动水平提高时,管理者会增加资源以满足不断增长的需求;当活动水平下降时,他们会保留一些未充分利用的资源,因为他们认为减少资源的调整成本高于持有资源的成本(Anderson等)。Citation2003)。从这个意义上说,成本粘性不同于管理者的财务报告选择在本研究中,我们关注基于权责发生制的收入平滑,这反映了管理层通过会计方法减少盈余波动的努力(与实际活动相反);参见2.2节了解更多细节。我们不讨论通过实际活动(如研发或营销支出的酌情调整)实现的收入平滑,因为从长远来看,这些活动可能对公司绩效有害例如,如果每个员工都使用卡车或软件许可证(即对劳动力的补充),那么更大的劳动力成本粘性将导致相关卡车或软件成本的更大粘性。或者,如果公司使用暂时闲置的员工来执行通常外包给外部承包商的任务(内部劳动力的替代品),那么更大的劳动力成本粘性可能导致这些外部成本的粘性降低。为此,运营成本适当地反映了这些跨资源效应最近的文献也确定了成本表现出抗粘性的条件(如Kama和Weiss Citation2013, Banker等)。Citation2014, Chen等。Citation2019)。我们将讨论重点放在成本粘性上,因为这是一个明显更为普遍的现象,我们采用WDL的设置主要增加了劳动力的调整成本,因此导致更强的运营成本粘性未列表分析表明,成本粘性与盈余持续性呈负相关,与预管理盈余波动性和经营性现金流波动性呈正相关,进一步证明成本粘性可能会降低盈余信息性,增加事前盈余波动性。我们对预管理盈余的定义见附录B.6。从理论上讲,低成本弹性(即成本对活动增加和减少的对称反应)也可能导致高盈余波动性。然而,投资者可以预测到响应活动变化的成本变化的对称模式(Banker和Chen Citation2006)。因此,与高成本粘性不同,低成本弹性对收益的可预测性没有影响(Hutton等)。引文2012),因为它不会阻碍投资者正确评估负面冲击在销售下降期间保留未使用的资源时,管理者牺牲了当前的收益,但节省了预期的未来调整成本,从而产生了未来的经济效益。 19在未制表的试验中,我们取消了11年的窗口限制,并将处理样本的所有观察结果保持在整个35年的样本周期内,我们的推断在质量上保持相似收入平滑度量(smooth +1)的描述性统计数据与Hamm等人(Citation2018)和Tucker和Zarowin (Citation2006)等其他研究中报告的统计数据相似我们需要提醒的是,我们的回归模型与Heath等人(2022)的标准规范不同,这种差异可能会导致统计推断目的的不同临界值我们不控制列(1)和(2)中的状态固定效应,因为在控制了公司固定效应之后,状态固定效应实际上是多余的。未列示的结果表明(1)和(2)列的结果在加入状态固定效应后没有变化相对于没有自举调整的估计的标准误差(0.035),有自举调整的STICKYt的标准误差(0.074)增加了一倍以上如果公司支持或反对即将采用的WDL,他们可以自行选择迁入或迁出一个州。为了减轻这种对企业自我选择与可观察变量相关的担忧,我们在一个未制表的测试中,在熵平衡样本中重复了这两个阶段的测试。质量相似的结果减轻了企业的自我区位选择驱动我们的结果的担忧我们警告说,可自由支配的收入只包括公司可自由支配的应计利润的一部分。基于可自由支配应计利润的收入平滑度量可能会忽略管理人员用来平滑收益的其他应计利润组成部分,从而导致可能存在偏差的结果。因此,我们在主要分析中不使用这种度量我们通过将ROAt-1替换为cft -1,并根据Baik等人(Citation2020)的公式(3)和脚注17排除ROAt-1,获得了相同的推断计算不同版本EPL分数的数据和方法可在www.oecd.org/employment/protection上获得。我们使用第一个版本的EPL分数,因为它涵盖了整个样本时期。版本2只有常规合同的分数,而版本3从2008年开始覆盖,这将大大减少我们的样本量。在未制表的测试中,我们也使用版本2和3中的分数作为捕获EPL严格性的替代方法,结果在质量上是相似的未列表的结果表明,EPL分数与运营成本的其他组成部分(即运营成本减去劳动力成本)无关,这表明运营成本的结果主要反映了对劳动力成本的影响。刘俊奇感谢中国国家自然科学基金委员会(NSFC)资助,资助号为72202190,福建省社会科学基金资助,资助号为FJ2022C034,中央高校基本科研业务费资助,资助号为20720221042,以及法语国家计算机协会(AFC)的资助。所有剩下的错误都是我们自己的。
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