Pub Date : 1970-12-01DOI: 10.3109/rhe1.1970.16.issue-1-4.35
B. Bartholomew, A. L. Perry
SummaryA microassay technique for the evaluation of synovial fluid alpha-mannosidase activity is presented with the evaluation of 184 synovial fluid samples from a variety of arthropathic conditions. The results indicate a close correlation of enzyme activity with synovial fluid cell count and the degree of inflammation associated with the various types of joint disease. It is suggested that the evaluation of this and other lysosomal glycosidases offer a quantitative method for the evaluation of inflammatory joint disease.
{"title":"Alpha-mannosidase activity in synovial fluid.","authors":"B. Bartholomew, A. L. Perry","doi":"10.3109/rhe1.1970.16.issue-1-4.35","DOIUrl":"https://doi.org/10.3109/rhe1.1970.16.issue-1-4.35","url":null,"abstract":"SummaryA microassay technique for the evaluation of synovial fluid alpha-mannosidase activity is presented with the evaluation of 184 synovial fluid samples from a variety of arthropathic conditions. The results indicate a close correlation of enzyme activity with synovial fluid cell count and the degree of inflammation associated with the various types of joint disease. It is suggested that the evaluation of this and other lysosomal glycosidases offer a quantitative method for the evaluation of inflammatory joint disease.","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"56 1","pages":"304-10"},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91341473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-12-01DOI: 10.3109/rhe1.1970.16.issue-1-4.20
O. Wegelius, M. Klockars
SummaryAlthough morphological and functional kidney lesions are well known to occur in rheumatoid arthritis (RA), there appear to be no previous reports on reversible acute renal failure. That interstitial nephritis plays a part in acute renal failure is clinically documented but the pathophysiology is obscure. The role of raised interstitial pressure has often been discussed but convincing evidence is still lacking.Two patients with classical RA complicated by reversible oliguria and impaired kidney function are presented. Renal biopsies revealed no glomerular, tubular or amyloid lesions. The only light microscopic finding was greatly increased interstitial edema, which stained metachromatically with toluidine blue and was hyaluronidase-sensitive.It is supposed that the abnormal concentration of interstitial hyaluronic acid and its high water-binding capacity leads to an increase of interstitial pressure, which is followed by renal insufficiency. The mucinous edema of the kidneys is assumed to be an acut...
{"title":"Reversible acute renal failure complicating rheumatoid arthritis.","authors":"O. Wegelius, M. Klockars","doi":"10.3109/rhe1.1970.16.issue-1-4.20","DOIUrl":"https://doi.org/10.3109/rhe1.1970.16.issue-1-4.20","url":null,"abstract":"SummaryAlthough morphological and functional kidney lesions are well known to occur in rheumatoid arthritis (RA), there appear to be no previous reports on reversible acute renal failure. That interstitial nephritis plays a part in acute renal failure is clinically documented but the pathophysiology is obscure. The role of raised interstitial pressure has often been discussed but convincing evidence is still lacking.Two patients with classical RA complicated by reversible oliguria and impaired kidney function are presented. Renal biopsies revealed no glomerular, tubular or amyloid lesions. The only light microscopic finding was greatly increased interstitial edema, which stained metachromatically with toluidine blue and was hyaluronidase-sensitive.It is supposed that the abnormal concentration of interstitial hyaluronic acid and its high water-binding capacity leads to an increase of interstitial pressure, which is followed by renal insufficiency. The mucinous edema of the kidneys is assumed to be an acut...","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"33 1","pages":"161-8"},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84078006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-12-01DOI: 10.3109/rhe1.1970.16.issue-1-4.27
M. Oka, O. Seppälä
SummaryThe muramidase activity of serum was studied in 27 cases of rheumatoid arthritis. The enzyme activity in rheumatoid serum (mean 11.0 μg./ml.) did not differ significantly from that in the 30 healthy controls (mean 9.4 μg./ml.). The muramidase activity in the synovial fluid of 36 rheumatoid arthritis patients was markedly elevated (mean 20.2 μg./ml.). In osteoarthritic synovial fluid (8 cases) the muramidase activity was low (mean 8.0 μg./ml.).No correlation was found between the total white blood count and the muramidase activity in rheumatoid synovial fluid. A positive relationship was observed between the enzyme activity and the total protein concentration. The elevated concentration of muramidase in synovial fluid of rheumatoid arthritis patients is interpreted as evidence of increased release of hydrolytic lysosomal enzymes. It remains to be shown which type of synovial fluid leukocytes produces the enzyme in question.
{"title":"Muramidase (lysozyme) in joint fluid and serum of rheumatic patients.","authors":"M. Oka, O. Seppälä","doi":"10.3109/rhe1.1970.16.issue-1-4.27","DOIUrl":"https://doi.org/10.3109/rhe1.1970.16.issue-1-4.27","url":null,"abstract":"SummaryThe muramidase activity of serum was studied in 27 cases of rheumatoid arthritis. The enzyme activity in rheumatoid serum (mean 11.0 μg./ml.) did not differ significantly from that in the 30 healthy controls (mean 9.4 μg./ml.). The muramidase activity in the synovial fluid of 36 rheumatoid arthritis patients was markedly elevated (mean 20.2 μg./ml.). In osteoarthritic synovial fluid (8 cases) the muramidase activity was low (mean 8.0 μg./ml.).No correlation was found between the total white blood count and the muramidase activity in rheumatoid synovial fluid. A positive relationship was observed between the enzyme activity and the total protein concentration. The elevated concentration of muramidase in synovial fluid of rheumatoid arthritis patients is interpreted as evidence of increased release of hydrolytic lysosomal enzymes. It remains to be shown which type of synovial fluid leukocytes produces the enzyme in question.","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"27 1","pages":"223-30"},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91374149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-12-01DOI: 10.3109/rhe1.1970.16.issue-1-4.29
E. Munthe
SummaryA selective concentration of antibodies to IgG, both IgM and IgG rheumatoid factors and antibodies to the pepsin site of IgG, was demonstrated in eluates of rheumatoid tissues, but not in control tissues. Many eluates with high amounts of IgG complexes lacked free antibodies to IgG, even when these antibodies were present in the serum. This indicated blocking by IgG complexes. Thus IgM rheumatoid factor could evade detection in some “seronegative” patients by fixation to tissue IgG complexes.
{"title":"Relationship between IgG complexes and anti-IgG antibodies in rheumatoid arthritis.","authors":"E. Munthe","doi":"10.3109/rhe1.1970.16.issue-1-4.29","DOIUrl":"https://doi.org/10.3109/rhe1.1970.16.issue-1-4.29","url":null,"abstract":"SummaryA selective concentration of antibodies to IgG, both IgM and IgG rheumatoid factors and antibodies to the pepsin site of IgG, was demonstrated in eluates of rheumatoid tissues, but not in control tissues. Many eluates with high amounts of IgG complexes lacked free antibodies to IgG, even when these antibodies were present in the serum. This indicated blocking by IgG complexes. Thus IgM rheumatoid factor could evade detection in some “seronegative” patients by fixation to tissue IgG complexes.","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"12 1","pages":"240-56"},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73576411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-12-01DOI: 10.3109/rhe1.1970.16.issue-1-4.06
S. Sitáj, T. Urbanek, K. Boŝmanský
SummaryThe aim of the study was to find the most reliable and precise incidence of rheumatic fever attacks in the general population. All new cases of rheumatic fever were recorded in an area of 100,000 population. The frequency of first attacks and recurrences decreased from 53 per 100,000 inhabitants to 15 in 1968. Less pronounced was the fall in the incidence of first attacks. The prevalence of rheumatic heart diseases in the studied group of patients was relatively low.Epidemiological studies are one of the most important components of the surveillance of rheumatic fever. Further important tasks are early diagnosis and hospitalization, introduction of adequate therapy and (effective) prophylactic measures, with periodic checkups.
{"title":"Some aspects of epidemiology and surveillance of rheumatic fever.","authors":"S. Sitáj, T. Urbanek, K. Boŝmanský","doi":"10.3109/rhe1.1970.16.issue-1-4.06","DOIUrl":"https://doi.org/10.3109/rhe1.1970.16.issue-1-4.06","url":null,"abstract":"SummaryThe aim of the study was to find the most reliable and precise incidence of rheumatic fever attacks in the general population. All new cases of rheumatic fever were recorded in an area of 100,000 population. The frequency of first attacks and recurrences decreased from 53 per 100,000 inhabitants to 15 in 1968. Less pronounced was the fall in the incidence of first attacks. The prevalence of rheumatic heart diseases in the studied group of patients was relatively low.Epidemiological studies are one of the most important components of the surveillance of rheumatic fever. Further important tasks are early diagnosis and hospitalization, introduction of adequate therapy and (effective) prophylactic measures, with periodic checkups.","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"17 1","pages":"30-9"},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73955512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-12-01DOI: 10.3109/rhe1.1970.16.issue-1-4.25
L. Hellgren
SummaryThe inheritance of rheumatoid arthritis was investigated in three areas in Sweden where nearly the total population over the age of seven (22,707 persons) was examined for the prevalence of rheumatoid arthritis (ARA-criteria). No significantly higher frequencies of rheumatoid arthritis were found among relatives of rheumatoid arthritics than among matched relatives of matched controls. The results are disappointing and throw no new light on possible inheritance of rheumatoid arthritis.
{"title":"Inheritance of rheumatoid arthritis.","authors":"L. Hellgren","doi":"10.3109/rhe1.1970.16.issue-1-4.25","DOIUrl":"https://doi.org/10.3109/rhe1.1970.16.issue-1-4.25","url":null,"abstract":"SummaryThe inheritance of rheumatoid arthritis was investigated in three areas in Sweden where nearly the total population over the age of seven (22,707 persons) was examined for the prevalence of rheumatoid arthritis (ARA-criteria). No significantly higher frequencies of rheumatoid arthritis were found among relatives of rheumatoid arthritics than among matched relatives of matched controls. The results are disappointing and throw no new light on possible inheritance of rheumatoid arthritis.","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"12 1","pages":"211-6"},"PeriodicalIF":0.0,"publicationDate":"1970-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78044610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Wawrzynska-Pagowska, B Brzezinska, M Brzozowska, T Graff, T Juszczyk, J Michalski, A Pakula, D Piotrowska, M Wojcik-Scislowska
{"title":"Observations on the symptoms and signs of \"early\" rheumatoid arthritis in a prospective study.","authors":"J Wawrzynska-Pagowska, B Brzezinska, M Brzozowska, T Graff, T Juszczyk, J Michalski, A Pakula, D Piotrowska, M Wojcik-Scislowska","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7146,"journal":{"name":"Acta rheumatologica Scandinavica","volume":"16 2","pages":"99-105"},"PeriodicalIF":0.0,"publicationDate":"1970-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16505166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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