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Effects of water pilates on urinary loss, genital self-image and sexual function of elderly women 水普拉提对老年妇女失尿、生殖器自我形象及性功能的影响
Pub Date : 2021-02-11 DOI: 10.4025/ACTASCIHEALTHSCI.V43I1.51900
Deise Iop Tavares, Gessica Bordin Viera Schlemmer, Amanda Santos, Milena Ramila Pivetta, G. T. Arruda, Tamires Daros dos Santos, A. P. Vendrusculo, M. Braz
Descriptive, quasi experimental study with pre and post-test, which aimed to investigate the effects of Water Pilates (PA) on urinary incontinence, genital self-image and sexual function of elderly women. The sample consisted of seventeen elderly women aged 60 years or over, from a city in the interior of Rio Grande do Sul. The International Consultation on Incontinence Questionnaire Short Form (ICIQSF) was used as instruments to assess the impact of UI in quality of life and qualify urinary loss, the Female Sexual Function Index (FSFI) to assess sexual function and Female Genital Self-Image Scale (FGSIS) to assess women's perception of their own genitalia. The PA protocol was performed twice a week for 50 minutes performed for eight weeks, totaling 16 sessions. The protocol was divided into warm-up, strengthening exercises and stretching. It was observed that the sample was composed of young elderly women (69.5 ± 5.9 years), overweight and with low FSFI and FGSIS scores. There was no significant change in the mean values before and after the intervention of the ICIQ-SF, FGSIS and FSFI scores. It was concluded that the PA method had no effect on urinary loss, sexual function and genital self-image.
目的探讨水普拉提(PA)对老年女性尿失禁、生殖器自我形象和性功能的影响。样本包括17名60岁或以上的老年妇女,她们来自南里奥格兰德州内陆的一个城市。使用国际尿失禁咨询问卷简表(ICIQSF)评估尿失禁对生活质量的影响,用女性性功能指数(FSFI)评估性功能,用女性生殖器自我形象量表(FGSIS)评估女性对自身生殖器的感知。PA方案每周进行两次,每次50分钟,持续8周,共16次。该方案分为热身,加强锻炼和拉伸。观察到,样本由年轻老年妇女(69.5±5.9岁)组成,超重,FSFI和FGSIS评分较低。干预前后ICIQ-SF、FGSIS和FSFI评分的平均值无显著变化。结论:PA法对尿量、性功能和生殖器自我形象无明显影响。
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引用次数: 2
Influence of Alzheimer’s disease on the relationship between nutritional status and risk of fall 阿尔茨海默病对营养状况与跌倒风险关系的影响
Pub Date : 2021-02-11 DOI: 10.4025/ACTASCIHEALTHSCI.V43I1.48747
M. Haskel, Sara C. S. Souza, Danilo Fernandes da Silva, W. C. D. Silva, J. Bonini
Although malnutrition and risk of falls in the elderly have increased in recent years, uncertainties exist as to whether these conditions are associated after controlling for sociodemographic variables, body composition, metabolic condition, and Alzheimer’s disease (AD). This study aimed to analyze the association between nutritional status and risk of fall in the elderly population. Participants were matched by gender and age, after they had been grouped on the basis of diagnosis of AD. The risk of falls, nutritional status, and mental status were assessed using the Downton Fall Risk Score (FRS), Mini Nutritional Assessment (MNA), and Mini Mental State Evaluation (MMSE), respectively. Logistic regression models adjusted for the main confounders were used in the analyses. Among the 68 elderly individuals studied, participants who were malnourished or at risk of malnutrition were more likely to fall (odds ratio = 8.29; 95% confidence interval = 1.49-46.04) than those with normal nutritional status, regardless of gender, age, education, body composition, and metabolic condition. This association did not remain significant after adjustment for AD, a potential confounder in this association. Malnutrition or its risk was independently associated with high risk of fall; thus, malnutrition should be considered in the prevention of falls among the elderly population.
尽管近年来老年人营养不良和跌倒的风险有所增加,但在控制了社会人口统计学变量、身体组成、代谢状况和阿尔茨海默病(AD)后,这些情况是否相关仍存在不确定性。本研究旨在分析老年人营养状况与跌倒风险之间的关系。在根据AD的诊断进行分组之后,参与者按性别和年龄进行匹配。分别采用唐顿跌倒风险评分(FRS)、迷你营养评估(MNA)和迷你精神状态评估(MMSE)对跌倒风险、营养状况和精神状态进行评估。在分析中使用调整了主要混杂因素的逻辑回归模型。在研究的68名老年人中,营养不良或有营养不良风险的参与者更容易跌倒(优势比= 8.29;(95%可信区间= 1.49-46.04),无论性别、年龄、受教育程度、身体成分和代谢状况如何,均高于营养状况正常的人群。在调整了AD(一个潜在的混杂因素)后,这种关联不再显著。营养不良或其风险与跌倒的高风险独立相关;因此,在预防老年人跌倒时应考虑营养不良。
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引用次数: 0
Cases of leprosy notified in the municipality of Parnaíba, state of Piauí, Brazil, 2007-2016 2007-2016年巴西Piauí州Parnaíba市通报的麻风病病例
Pub Date : 2021-02-11 DOI: 10.4025/ACTASCIHEALTHSCI.V43I1.51445
J. Almeida, Maria do Socorro Costa, Paulo Roberto Fagundes da Silva, F. Silva, Gerarlene Ponte Guimarães Santos, Rayla Maria Pontes Guimarães Costa, A. Sardinha, M. R. Branco
This study aimed to describe the epidemiological and clinical characteristics of leprosy cases reported in the municipality of Parnaíba, State of Piauí. This was a cross-sectional study of leprosy cases, living in Parnaíba, State of Piauí, reported to the National System of Notifiable Diseases (SINAN), from 2007 to 2016. There were 582 cases of leprosy with hyperendemic detection in the general population in 2008, 2009 and 2016; and under < 15 years of age in 2008, 2014 and 2016, with a predominance of females (53.1%), brown (62.2%), aged 20-64 years (74.7%), complete and incomplete elementary school (56.4%), housewives (20.7%), living in the urban area (87.1%), reported by primary care (69.2%). The most frequent clinical and therapeutic findings were: multibacillary operational classification (53.8%); clinical forms: undetermined (30.6%) and virchowian (24.3%); single lesion (34.8%); no affected nerves (86.7%); degree of disability zero (70.6%); bacilloscopy not performed (26.7%); therapeutic regimen 12 doses (53.7%) and no reaction (70.8%). Regarding the mode of input, predominated new case (88.8%); mode of output, cure (87.9%) and detection mode: spontaneous demand (45.8%). Out of 2,106 registered contacts, 60.6% were examined. Leprosy is endemic to Parnaíba, State of Piauí. It is noteworthy that the hyperendemic detection rates occurred during years when there was intensification of active search for contacts and cases in the population.
本研究旨在描述Piauí州Parnaíba市报告的麻风病病例的流行病学和临床特征。这是对2007年至2016年向国家法定疾病系统(SINAN)报告的居住在Piauí州Parnaíba的麻风病病例的横断面研究。2008年、2009年和2016年,在普通人群中发现麻风高流行病例582例;2008年、2014年和2016年年龄< 15岁,以女性(53.1%)为主,棕色皮肤(62.2%),20-64岁(74.7%),小学毕业和未毕业(56.4%),家庭主妇(20.7%),居住在城市(87.1%),通过初级保健(69.2%)报告。最常见的临床和治疗表现为:多菌性手术分型(53.8%);临床表现:不确定(30.6%)和病毒型(24.3%);单发病变(34.8%);无受累神经(86.7%);残疾程度为零(70.6%);未行杆菌镜检查(26.7%);治疗方案12剂(53.7%),无反应(70.8%)。在输入方式上,以新增病例为主(88.8%);输出方式:治愈(87.9%),检测方式:自发需求(45.8%)。在2106名登记接触者中,60.6%接受了检查。麻风病是Piauí州Parnaíba的地方性疾病。值得注意的是,高流行检出率发生在加强对人群中的接触者和病例的积极搜索的年份。
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引用次数: 0
The correlation between children’s own health control and their health perceptions and behaviours, and the associated factors 儿童自身健康控制与健康观念和行为的相关性及其相关因素
Pub Date : 2021-02-11 DOI: 10.4025/ACTASCIHEALTHSCI.V43I1.52849
Yildirim Hilal, Isik Kevser, Gulcek Emral
The study was conducted as a correlational descriptive study to determine the correlation between children’s own health control and their health perceptions and behaviours, as well as the associated factors. The sample of the study consisted of 963 children in the age group of 7-12 years studying at one primary schools affiliated with the Ministry of National Education. It was determined that age affected health control and health perception and behaviours in children. A positive significant correlation was found between the health locus of control and health perceptions and behaviours of the children. The children had positive health behaviours, and they had high internal control in their own health management. In accordance with these results, children’s own health management should be increased to increase their positive perceptions and behaviours.
本研究作为一项相关描述性研究进行,以确定儿童自身健康控制与他们的健康观念和行为之间的相关性,以及相关因素。本研究的样本包括963名7-12岁的儿童,他们在一所国家教育部附属小学就读。确定年龄影响儿童的健康控制、健康感知和行为。健康控制点与儿童的健康感知和健康行为呈显著正相关。儿童健康行为积极,自我健康管理内控程度高。根据这些结果,应加强儿童自身的健康管理,以增加其积极的认知和行为。
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引用次数: 0
Prevalence of alcohol consumption and factors associated with binge drinking behavior among adolescents in the state of Pernambuco, Brazil, 2016 2016年巴西伯南布哥州青少年酒精消费流行率及与酗酒行为相关的因素
Pub Date : 2021-02-11 DOI: 10.4025/ACTASCIHEALTHSCI.V43I1.52633
Claudio Monteiro Freitas, J. Bezerra, F. Soares, Mallu Dias Soares, R. Lima, Fabiana de Godoy Bene Bezerra, M. Barros
To investigate the prevalence of alcohol consumption and the factors associated with binge drinking behavior among adolescents in the state of Pernambuco, Brazil. A cross-sectional study with a probabilistic sample of 6,002 adolescents composed of students from public high schools in Pernambuco, Brazil, aged 14 to 19 years. Binge drinking behavior was used as a dependent variable. The following were evaluated as possible risk factors: sociodemographic variables (gender, maternal education, marital status, work, religion); indicators of psychosocial stress (feelings of sadness; suicidal thoughts; feelings of loneliness; friends) and health risk behaviors (physical inactivity; number of sexual partners; drug use; and involvement in fights in the last year). Logistic regression was used to estimate odds ratios (OR). A total of 6,002 adolescents participated, with 75% reporting having consumed alcoholic beverages at least once in their lives. The prevalence of binge drinking in the last month was 17%. Adolescents without a religion had 81% (95%CI: 1.51; 2.16) more chance of consuming alcohol in excess. Adolescents who felt sad were 29% more likely to binge drink (95%CI: 1.08; 1.54), and adolescents who had already thought about suicide had 41% (95%CI: 1.13; 1.76) more chance to drink excessively. Adolescents who used illicit drugs had 4.6 times the chance (95%CI: 3.51; 6.17) of excessive drinking. Adolescents who engaged in four or more fights during the year were twice as likely to binge drink as those who did not fight (95%CI: 1.36; 2.88). The prevalence of alcohol consumption and binge drinking behavior was high. Sociodemographic factors, psychosocial stress and health risk behaviors were associated with binge drinking.
调查巴西伯南布哥州青少年中酒精消费的流行程度以及与酗酒行为相关的因素。对巴西伯南布哥州公立高中的6,002名14至19岁的青少年进行了横断面研究。酗酒行为被用作因变量。评估了以下可能的风险因素:社会人口变量(性别、母亲教育、婚姻状况、工作、宗教);心理社会压力的指标(悲伤的感觉;自杀的念头;孤独的感觉;朋友)和健康风险行为(缺乏身体活动;性伴侣数量;药物使用;去年还参与了打斗)。采用Logistic回归估计比值比(OR)。共有6002名青少年参与了这项研究,其中75%的人报告说他们一生中至少喝过一次酒精饮料。上个月酗酒的流行率为17%。无宗教信仰的青少年有81% (95%CI: 1.51;2.16)更有可能过量饮酒。感到悲伤的青少年酗酒的可能性要高出29%(95%置信区间:1.08;1.54),已经想过自杀的青少年有41% (95%CI: 1.13;(1.76)更容易酗酒。青少年使用非法药物的机会是4.6倍(95%CI: 3.51;6.17)过量饮酒。一年中参与四次或四次以上打架的青少年酗酒的可能性是没有打架的青少年的两倍(95%置信区间:1.36;2.88)。酒精消费和酗酒行为的患病率很高。社会人口因素、心理社会压力和健康风险行为与酗酒有关。
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引用次数: 2
Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats 茴香叶的抗氧化活性及降糖作用评价Wistar大鼠的骨骼
Pub Date : 2021-02-11 DOI: 10.4025/ACTASCIHEALTHSCI.V43I1.52931
L. Moreira, J. L. Santos, Lúcio Marques Vieira Souza, A. C. Marçal, A. S. Dias, S. S. Araújo, B. Araújo, C. Estevam
Syzygium cumini (L.) Skeels was adapted to the climatic conditions and soil types in Brazil. Its fruits, leaves and inner bark are used in folk medicine due to their high antioxidant, anti-inflammatory, anticarcinogenic and antidiabetic activities mainly associated with the presence of phenolic compounds. It is estimated that at least 300 million people worldwide develop diabetes and approximately 11 million people are carriers of the disease in Brazil. The objective of this work was to evaluate the in vitro antioxidant activity, as well as the hypoglycemic action of hydroethanolic extract (HEE), the ethyl acetate (EAF) and hydromethanolic (HMF) fractions from leaves of S. cumini (L.) Skeels in rats. All assays were carried out in three replications. Data were expressed as mean  SD and significance was evaluated by ANOVA and Bonferroni test (p < 0.05). The results indicate a significant (p < 0.05) total phenol content (207 ± 2.3 GAE mg g) and antioxidant activity (EC50 = 9.05 ± 0.170 μg mL) for EAF. HEE and its fractions showed no significant (p > 0.05) action to modulate glucose by the OGTT assay in nondiabetic mice compared to control. Thus the use of the plant against diabetes in individuals is not proven.
牛耳草(L.)骷髅适应了巴西的气候条件和土壤类型。它的果实、叶子和树皮被用于民间医学,因为它们具有高抗氧化、抗炎、抗癌和抗糖尿病的活性,主要与酚类化合物的存在有关。据估计,全世界至少有3亿人患有糖尿病,巴西约有1100万人是该疾病的携带者。摘要本研究旨在探讨芫荽叶中氢乙醇提取物(HEE)、乙酸乙酯(EAF)和氢甲醇提取物(HMF)的体外抗氧化活性和降血糖作用。老鼠的骨骼。所有试验均进行3次重复。数据以平均值SD表示,采用方差分析(ANOVA)和Bonferroni检验(p < 0.05)评估显著性。结果表明,EAF的总酚含量(207±2.3 GAE mg g)和抗氧化活性(EC50 = 9.05±0.170 μ mL)显著(p < 0.05)。通过OGTT试验,与对照组相比,HEE及其组分对非糖尿病小鼠的葡萄糖调节作用无显著性(p > 0.05)。因此,这种植物对个人糖尿病的疗效尚未得到证实。
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引用次数: 2
Evaluation of anxiety-like behaviors following ethanol withdrawal in mice: effects of cannabidiol 对小鼠乙醇戒断后焦虑样行为的评价:大麻二酚的作用
Pub Date : 2020-07-29 DOI: 10.4025/actascihealthsci.v42i1.53001
Leticia Pin Coltri, V. T. Bonassoli, H. Milani, Rubia M W Oliveira
The abrupt interruption of ethanol consumption increases anxiety-like behaviors in rodents and may reflect different aspects of ethanol dependence in humans. Measuring emotional behaviors resulting from ethanol withdrawal may aid in testing potential pharmacological agents for the treatment of ethanol dependence. In the present study, we used forced expositon to ethanol 20% during 10 days to mice, followed by abrupt withdrawal of the substance. The animals were evaluated 7, 24 and 35 h after ethanol withdrawal in three different behavioral paradigms, i.e., the open field (OF), light dark (LD) transition and elevated plus maze (EPM), tests usually used to measure anxiety-like behaviors. This was done with the aim of identifying the best interval as well as the most appropriate behavioral test to detect the effects of drugs that can relieve anxiety induced by ethanol withdrawal in mice. We also evaluated the effect of cannabidiol (CBD 10, 30 and 60 mg kg) in ethanol withdrawn mice because it has been shown to alliviate drug addicton and present anti-anxiety effects. Our results show significant behavioral changes at 24 h following ethanol withdrawal. Diazepam (4 mg kg), used as a positive control, counteracted the effects of ethanol withdrawal in OF, LD box and EPM. Cannabidiol attenuated anxiety-like behavior produced at 24 h after abstinence from ethanol exposure only in the EPM test.
乙醇消耗的突然中断增加了啮齿动物的焦虑样行为,可能反映了人类对乙醇依赖的不同方面。测量酒精戒断引起的情绪行为可能有助于测试治疗酒精依赖的潜在药理学药物。在本研究中,我们对小鼠进行了为期10天的20%乙醇强制暴露,然后突然退出该物质。在乙醇戒断后7、24和35 h,分别对动物进行开放场(OF)、明暗过渡(LD)和升高加迷宫(EPM)三种不同的行为模式的评估,这三种模式通常用于测量焦虑样行为。这样做的目的是确定最佳的间隔时间,以及最合适的行为测试,以检测药物的效果,可以缓解乙醇戒断引起的小鼠焦虑。我们还评估了大麻二酚(CBD 10、30和60 mg kg)对乙醇戒断小鼠的影响,因为它已被证明可以缓解药物成瘾并具有抗焦虑作用。我们的研究结果显示,在乙醇戒断后24小时,行为发生了显著变化。以地西泮(4 mg kg)作为阳性对照,可抵消乙醇对of、LD盒和EPM的影响。大麻二酚仅在EPM试验中减轻乙醇暴露戒断后24小时产生的焦虑样行为。
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引用次数: 0
Effect of horse riding equipment in activity of trunk and lower limb muscles in equine-assisted therapy 骑马器材对马辅助治疗中躯干和下肢肌肉活动的影响
Pub Date : 2020-07-23 DOI: 10.4025/actascihealthsci.v42i1.52739
J. B. Lage, M. F. Ribeiro, V. Teixeira, R. Rosa, A. A. Ferreira, Ana Paula Espindula
Equine-assisted therapy uses the horse in rehabilitation and/or education of people, such as Down syndrome (SD), cerebral palsy (PC) and intellectual disability (DI). In context, the rehabilitation program and horse riding equipment should be used according to the specific characteristics of each individual, becoming an ally in the quest for excellence in equine-assisted therapy programs. The aim was to evaluate the effect of riding equipment used in equine-assisted therapy on the muscular activity of trunk and lower limb of individuals with SD, PC and DI. The study included 15 individuals equally assigned to each group: SD, PC and DI with a mean age of 16.2 (± 1.10), 16 (± 1.22) e 16 (±0) years, respectively. The analysis of muscle activity was performed through surface electromyography, using four variations of horse riding equipment: saddle with and without feet supported on the stirrups and blanket with and without feet supported on the stirrups. Sigma Stat 3.5 software was used for statistical analysis. The Shapiro Wilk’s test was used for normality of the data, the Bartlett test for homogeneity of the variances and the Kruskal-Wallis test for repeated measures with no normal distribution. Statistically significant differences were observed for p < 0.05. The SD group presented a greater muscular activity of trunk and lower limbs with blanket equipment without the feet supported in the stirrups (H = 15.078, p = 0.002), as in the DI group (H = 8.302, p = 0.040), while in PC group was the saddle with feet supported in the stirrups (H = 11.137, p = 0.011). The choice of riding equipment used in equine-assisted therapy interferes differently in the pattern of muscular activation of the trunk and the lower limbs, according to the pathological processes of the practitioners. It should be an important aspect to consider when planning a treatment.
马辅助疗法利用马对唐氏综合症(SD)、脑瘫(PC)和智力残疾(DI)等人进行康复和/或教育。在这种情况下,康复计划和骑马设备应该根据每个人的具体特点来使用,在寻求卓越的马辅助治疗计划中成为一个盟友。目的是评估马辅助治疗中使用的骑马设备对SD、PC和DI患者躯干和下肢肌肉活动的影响。研究纳入15例个体,平均分为SD、PC和DI组,平均年龄分别为16.2(±1.10)岁、16(±1.22)岁和16(±0)岁。通过表面肌电图分析肌肉活动,使用四种不同的骑马设备:有和没有脚支撑在马镫上的马鞍,有和没有脚支撑在马镫上的毯子。采用Sigma Stat 3.5软件进行统计分析。数据的正态性采用夏皮罗·威尔克检验,方差的齐性采用巴特利特检验,非正态分布的重复测量采用Kruskal-Wallis检验。差异有统计学意义,p < 0.05。SD组与DI组相比(H = 8.302, p = 0.040),有毯子装备的躯干和下肢肌肉活动更大(H = 15.078, p = 0.002),而PC组则是有鞍具,有马镫支撑的脚(H = 11.137, p = 0.011)。在马辅助治疗中使用的骑马设备的选择,根据从业者的病理过程,对躯干和下肢肌肉激活的模式有不同的干扰。在计划治疗时,这应该是一个重要的考虑因素。
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引用次数: 2
Occurrence of Mycoplasma spp. and Ureaplasma spp. in genital specimens 生殖道标本支原体和脲原体的发生
Pub Date : 2020-07-23 DOI: 10.4025/actascihealthsci.v42i1.50926
Nathally Claudiane de Souza Santos, R. B. Scodro, Vanessa Tatiana de Andrade, V. Siqueira, K. R. Caleffi-Ferracioli, Rubia Andreia Falleiros Padua, D. Micheletti, R. F. Cardoso
Mycoplasma spp. and Ureaplasma spp. belong to humans’ genitourinary microbiota and sometimes are associated with infections of the genitourinary tract. The aim of this study was to evaluate the occurrence of Mycoplasma spp. and Ureaplasma spp. in genital specimens from patients of the 15 Regional de Saúde of Paraná State, Brazil, and to correlate the results with clinical and laboratory data. A retrospective cross-sectional study was conducted, based on the analysis of results of vaginal, endocervical, urine and urethral culture for mycoplasmas from patients attended in a reference laboratory, from January 2009 to December 2016. We evaluated 2,475 results of culture for mycoplasmas. A total of 50.8% patients were positive for mycoplasmas. Of these, 76.8% had positive culture exclusively for Ureaplasma spp. and 4.7% for Mycoplasma hominis. Both microorganisms were isolated in the microbiology culture of 18.5% of patients. Among the positive culture, 81.4% had significant concentrations. Bacterial vaginosis was the most common alteration observed in association with mycoplasmas. The high positivity of cultures for mycoplasmas, especially Ureaplasma spp. found in our study, highlight the presence of these microorganisms in many of the genital tract disorders that can be sexually transmitted and, consequently, should not be neglected.
支原体和脲原体属于人类泌尿生殖道微生物群,有时与泌尿生殖道感染有关。本研究的目的是评估支原体和脲原体在巴西巴拉南州15个地区患者生殖器标本中的发生率,并将结果与临床和实验室数据相关联。基于2009年1月至2016年12月在参考实验室就诊的患者阴道、宫颈、尿液和尿道支原体培养结果分析,进行回顾性横断面研究。我们评估了2475例支原体培养结果。支原体阳性率为50.8%。其中脲原体培养阳性率76.8%,人支原体培养阳性率4.7%。在18.5%的患者微生物培养中分离出这两种微生物。阳性培养中,81.4%的人浓度显著。细菌性阴道病是与支原体相关的最常见的改变。支原体培养的高阳性,特别是在我们的研究中发现的脲支原体,突出了这些微生物在许多生殖道疾病中的存在,这些疾病可以通过性传播,因此不应被忽视。
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引用次数: 1
Linear mixed model for weight analysis in mice infected by Trypanosoma cruzi 克氏锥虫感染小鼠体重分析的线性混合模型
Pub Date : 2020-07-20 DOI: 10.4025/actascihealthsci.v42i1.49916
Roney Peterson Pereira, T. A. Guedes, É. C. Ferreira, S. M. Araújo, Larissa Aparecida Ricardini, L. Ciupa
The use of linear mixed models for nested structure longitudinal data is called hierarchical linear modeling. This modeling takes into account the dependence of existing data within each level and between hierarchical levels. The process of modeling, estimating and analyzing diagnoses was illustrated through data on the weights of mice experimentally infected by Trypanosoma cruzi, divided into different treatment groups, with the purpose of verifying the evolution of their body weight as a result of using different types of biotherapeutics produced from Gallus gallus domesticus (chicken) serum to treat Trypanosoma cruzi. Through the model selection criteria AIC and BIC and the likelihood ratio test, a model was chosen to describe the data correctly. Model diagnoses were then performed by means of residual analysis for both levels and an analysis of influential observations to verify if any observations were signaled as influencing the fixed effects, the components of variance and the adjusted values. After the analysis, it was possible to notice that the observations that were signaled as influential had little impact on the Model chosen initially, so it was maintained, with no differences being evidenced between the treatments with the biotherapeutics tested; only the Time variable and the Random intercept were necessary to describe the weight of the mice.
对嵌套结构纵向数据使用线性混合模型称为层次线性建模。该建模考虑了每个级别内和分层级别之间现有数据的依赖性。通过实验感染克氏锥虫的小鼠体重数据来说明建模、估计和诊断分析的过程,并将其分为不同的治疗组,目的是验证使用不同类型的鸡血清生产的生物治疗药物治疗克氏锥虫对小鼠体重的影响。通过模型选择准则AIC和BIC以及似然比检验,选择了能够正确描述数据的模型。然后通过对两个水平的残差分析和对有影响的观测值的分析来进行模型诊断,以验证是否有任何观测值被标记为影响固定效应、方差成分和调整值。在分析之后,可以注意到,被标记为有影响力的观察结果对最初选择的模型影响很小,因此它被维持,治疗与测试的生物治疗药物之间没有差异被证明;只有时间变量和随机截距是描述小鼠体重的必要条件。
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引用次数: 0
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