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Safety of cannabidiol products as a social issue: A case series 大麻二酚产品的安全性是一个社会问题:一个案例系列。
IF 1.6 Pub Date : 2024-05-31 DOI: 10.1002/ams2.965
Yukari Maki, Asuka Tsuchiya, Rie Yamamoto, Takeshi Saito, Seiji Morita, Yoshihide Nakagawa

Background

Cannabidiol (CBD) products have increased in popularity in Japan in recent years, particularly among young people. Some CBD products contain tetrahydrocannabinol (THC), the main ingredient of cannabis, and its analogs, which are illegal in Japan and have become a social issue. This report discusses the safety of CBD products.

Case Presentation

Five patients with symptoms of CBD ingestion, including nausea, presented to our hospital. Three of the products these patients ingested contained THC. Metabolites of THC were detected in the blood and urine of all three patients, although there were some discrepancies in the urine drug screening test (DS10®). These examination results differed even when the same product was consumed.

Conclusion

CBD products are unsafe and may unintentionally contain THC. It is also important to understand that CBD can turn into THC, and the effective time needed to conduct urine drug screening.

背景:近年来,大麻二酚(CBD)产品在日本越来越受欢迎,尤其是在年轻人中间。有些 CBD 产品含有大麻的主要成分四氢大麻酚(THC)及其类似物,这在日本是非法的,已成为一个社会问题。本报告讨论了 CBD 产品的安全性:本医院共收治了五名因摄入 CBD 而出现恶心等症状的患者。这些患者摄入的产品中有三种含有四氢大麻酚。所有三名患者的血液和尿液中都检测到了四氢大麻酚的代谢物,但尿液药物筛查测试(DS10®)结果存在一些差异。即使食用的是同一种产品,这些检查结果也不尽相同:结论:CBD 产品不安全,可能无意中含有四氢大麻酚。了解 CBD 可转化为四氢大麻酚以及进行尿液药物筛查所需的有效时间也很重要。
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引用次数: 0
Injury to a cardiopulmonary resuscitation provider by sternal wire 心肺复苏员被胸骨钢丝刺伤
IF 1.6 Pub Date : 2024-05-20 DOI: 10.1002/ams2.969
Mayo Ohkawa, Asuka Tsuchiya, Seiji Morita, Yoshihide Nakagawa

Background

Median sternotomy is a common surgical procedure during cardiac and pulmonary surgeries. There are many reports of patient injury associated with wire breakage. However, there are only a few reports of healthcare worker injuries by sternal wire.

Case Presentation

A patient in his 70s, having a history of thoracic aorta replacement, collapsed suddenly and paramedics started mechanical chest compression. On hospital arrival, the emergency department nurse attempted to initiate manual chest compression but was injured by a sternal wire protrusion on the patient's chest. The emergency physician placed gauze on the sternal wire and continued manual chest compression, but the patient died.

Conclusion

To prevent this injury, cardiopulmonary resuscitation (CPR) providers should consciously check the patient's chest. If they observe wire exposure, they should immediately place a gauze, pad or consider performing mechanical chest compression. Safety measures such as the installing rubber pads in the AED should be considered.

背景 胸骨正中切开术是心肺手术中常见的外科步骤。有许多病人因钢丝断裂而受伤的报道。然而,关于医护人员因胸骨钢丝受伤的报道却寥寥无几。 病例介绍 一位 70 多岁、有胸主动脉置换术史的患者突然晕倒,医护人员开始进行机械胸外按压。到达医院后,急诊科护士试图启动人工胸外按压,但被患者胸前突出的胸骨钢丝所伤。急诊医生将纱布放在胸骨导线上,继续进行人工胸外按压,但患者最终死亡。 结论 为防止这种损伤,心肺复苏(CPR)提供者应有意识地检查病人的胸部。如果发现钢丝外露,应立即放置纱布、垫子或考虑进行机械胸外按压。应考虑采取安全措施,例如在自动体外除颤器中安装橡胶垫。
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引用次数: 0
Pneumocephalus resulting from traumatic pneumothorax and brachial plexus avulsion 外伤性气胸和臂丛神经撕脱导致的气胸
IF 1.6 Pub Date : 2024-05-16 DOI: 10.1002/ams2.956
Naoki Date, Hiroshi Hamakawa, Ichiro Sakanoue, Tomoki Saito, Yutaka Takahashi

Background

Traumatic pneumocephalus is commonly encountered after basal skull fractures and rarely associated with blunt chest trauma. Here, we report a case of pneumocephalus caused by traumatic pneumothorax and brachial plexus avulsion.

Case Presentation

A 20-year-old male was admitted to our hospital following a motorcycle accident with complete paralysis of the right upper limb. 2 days later, follow-up computed tomography revealed a slight right pneumothorax, pneumomediastinum around the neck, and intracranial air without skull fracture. Air migrates into the subarachnoid space through a dural tear caused by a brachial plexus avulsion. The pneumocephalus immediately improved after the insertion of a chest drain.

Conclusion

Pneumothorax combined with brachial plexus avulsion could lead to pneumocephalus. Immediate chest drainage might be the best way to stop the migration of air; however, care should be taken to not worsen cerebrospinal fluid leakage.

背景创伤性气胸常见于颅底骨折,很少与钝性胸部创伤有关。在此,我们报告了一例由外伤性气胸和臂丛神经撕脱引起的气胸。 病例介绍 一名 20 岁的男性因摩托车事故导致右上肢完全瘫痪而入院。2 天后,随访的计算机断层扫描显示患者有轻微的右侧气胸、颈部周围的气胸和颅内积气,但无颅骨骨折。空气通过臂丛神经撕脱造成的硬脑膜撕裂进入蛛网膜下腔。插入胸腔引流管后,气胸立即好转。 结论 气胸合并臂丛神经撕脱可导致气胸。立即进行胸腔引流可能是阻止空气移位的最佳方法,但应注意不要加重脑脊液漏。
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引用次数: 0
Multidisciplinary approach to a 93-year-old survivor with crush syndrome: A 124-h rescue operation after the 2024 Noto Peninsula earthquake 对一名患有挤压综合征的 93 岁幸存者采取多学科方法:2024 年能登半岛地震后的 124 小时救援行动
IF 1.6 Pub Date : 2024-05-15 DOI: 10.1002/ams2.967
Mototaka Inaba, Hiromichi Naito, Masaki Hisamura, Kaoru Harada, Atsunori Nakao

Natural disasters, such as earthquakes, pose significant global threats. On January 1, 2024, a devastating 7.6 magnitude earthquake struck Japan's Noto Peninsula, causing widespread destruction and loss of life. The quake resulted in at least 241 deaths, 1536 injuries, and extensive damage to buildings, leading to 34,694 people seeking refuge in shelters.1 The survival of a 93-year-old woman trapped for over 5 days sheds light on human resilience and medical management during disasters. This letter describes a rare extrication scenario in a disaster setting, focusing on a successful multidisciplinary approach used to manage crush injuries.

On January 6, 2024, amidst the chaos following the earthquake, a critical rescue operation was undertaken in Suzu City to save a 93-year-old woman trapped under debris. A team comprising police, firefighters, and medical personnel, including a doctor and two nurses from a medical non-governmental organization, collaborated on the rescue efforts. The patient, found with her thighs pinned under heavy beams, displayed signs of subsequent crush injury. Her initial medical assessment revealed unstable vital signs with low blood pressure. The administration of 2500 mL of lactated Ringer's solution, 40 mL of sodium bicarbonate, and 10 mL of calcium gluconate, along with the use of hot bags for warming, was instrumental in stabilizing the patient's condition before extrication (Figure 1). The medical team worked in the hot zone (collapsed home confined space) for 15 min. In addition to these medical interventions, we used hot water-filled plastic bags placed against her torso to counteract potential hypothermia. Additionally, continuous verbal reassurance was provided by the rescue team, an essential part of maintaining her consciousness and morale during the entrapment. Decompression occurred 150 min after the initial intervention, and the patient was extracted 240 min after first contact (124 h after onset). Post-extraction, the patient's Glasgow Coma Scale score improved from E3V2M6 to E3V4M6, with sensory disturbances noted in her left lower limb. She was admitted to a nearby tertiary hospital. Laboratory tests showed creatine kinase of 13,475 U/L, potassium of 5.5.mmol/L and creatinine of 1.74 mg/dL confirming crush syndrome and compartment syndrome in the left leg, necessitating a fasciotomy. She was treated with fluid therapy; dialysis was unnecessary. The patient continued her recovery.

Crush syndrome, a significant concern in earthquake disasters, is known to be one of the leading causes of mortality, even after successful rescues.2, 3 This was evident in the 2024 Noto Peninsula earthquake, where at least six fatalities were reported due to crush syndrome, underscoring the severity of the condition in post-disaster medical challenges. Comparatively, the 2023 Kahramanmaras earthquake in Turkey also caused a considerable number of crush injuries, 7.7

地震等自然灾害对全球构成重大威胁。2024 年 1 月 1 日,日本能登半岛发生 7.6 级破坏性地震,造成大面积破坏和人员伤亡。地震造成至少 241 人死亡,1536 人受伤,大量建筑物受损,导致 34,694 人到避难所避难。1 一位被困超过 5 天的 93 岁老妇人的生还经历揭示了人类在灾难中的恢复能力和医疗管理。2024 年 1 月 6 日,在地震后的一片混乱中,珠洲市开展了一次关键的救援行动,以拯救一名被困在废墟中的 93 岁老妇人。一支由警察、消防员和医务人员(包括来自非政府医疗组织的一名医生和两名护士)组成的队伍共同参与了救援工作。病人被发现时,大腿被压在沉重的横梁下,有随后挤压受伤的迹象。初步医疗评估显示,她的生命体征不稳定,血压偏低。使用 2500 毫升乳酸林格氏液、40 毫升碳酸氢钠和 10 毫升葡萄糖酸钙,并使用热袋进行加温后,患者的病情才得以稳定(图 1)。医疗小组在热区(坍塌房屋密闭空间)工作了 15 分钟。除了这些医疗干预措施外,我们还用装满热水的塑料袋抵住她的躯干,以抵消潜在的低体温。此外,救援小组还不断对她进行口头安抚,这对她在被困期间保持意识和士气至关重要。减压发生在首次干预后 150 分钟,患者在首次接触后 240 分钟(发病后 124 小时)被救出。拔出后,患者的格拉斯哥昏迷量表评分从 E3V2M6 提高到 E3V4M6,左下肢出现感觉障碍。她被送往附近的一家三级医院。实验室检查显示肌酸激酶为 13,475 U/L,血钾为 5.5.mmol/L,肌酐为 1.74 mg/dL,证实了左腿挤压综合征和室间隔综合征,需要进行筋膜切开术。她接受了输液治疗,没有必要进行透析。挤压综合征是地震灾害中的一个重要问题,众所周知,它是导致死亡的主要原因之一,即使在成功营救之后也是如此。2, 3 这一点在 2024 年能登半岛地震中非常明显,据报道至少有 6 人死于挤压综合征,凸显了该病症在灾后医疗挑战中的严重性。相比之下,2023 年土耳其卡赫拉曼马拉什地震也造成了相当数量的挤压伤,占受伤总人数的 7.7%,4 突显了这一问题在全球地震事件中的普遍性。然而,与震后挤压综合征相关的数据仍然很少,因此需要进行全面的报告和分析,以更好地了解病理状况和死亡率。这是日本地震后第一例及时、实用的密闭空间救援和医疗报告。通过早期输液治疗和多学科护理,对 93 岁幸存者的挤压综合征进行了积极的处理,为她的存活做出了贡献。我们相信,救援队、警察和医疗队之间的这种协作努力是这次灾难现场复杂行动取得成功的决定性因素。我们的经验加深了我们对灾难医学所面临的挑战和所需策略的理解。为了尽量减少偏见,他们没有参与所有与接受这篇文章发表相关的编辑决策:知情同意:是。研究/试验的注册机构和注册编号:不适用:动物实验动物研究:不适用。
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引用次数: 0
Association between the severity of hypothermia and in-hospital mortality in patients with infectious diseases: The J-Point registry 传染病患者体温过低的严重程度与院内死亡率之间的关系:J点登记
IF 1.6 Pub Date : 2024-05-15 DOI: 10.1002/ams2.964
Tadaharu Shiozumi, Yuki Miyamoto, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Yohei Okada, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Tasuku Matsuyama

Aim

Hypothermia is associated with poor prognosis in patients with sepsis. However, no studies have explored the correlation between the severity of hypothermia and prognosis.

Methods

Using data from the Japanese accidental hypothermia network registry (J-Point registry), we examined adult patients aged ≥18 years with infectious diseases whose initial body temperature was ≤35°C from April 1, 2011 to March 31, 2016, in 12 centers. Patients were divided into three groups according to their body temperature: Tertile 1 (T1) (32.0–35.0°C), Tertile 2 (T2) (28.0–31.9°C), and Tertile 3 (T3) (<28.0°C). In-hospital mortality was employed as a metric to assess outcomes. We conducted a multivariate logistic regression analysis to investigate the relationship between the three categories and the occurrence of in-hospital mortality.

Results

A total of 572 patients were registered, and 170 eligible patients were identified. Of these patients, 55 were in T1 (32.0–35.0°C), 76 in T2 (28.0–31.9°C), and 39 in T3 (<28.0°C) groups. The overall in-hospital mortality rate in accidental hypothermia (AH) patients with infectious diseases was 34.1%. The in-hospital mortality rates in the T1, T2, and T3 groups were 34.5%, 36.8%, and 28.2%, respectively. The multivariable analysis demonstrated no significant differences regarding in-hospital mortality among the three groups (T2 vs. T1, adjusted odds ratio [OR]: 1.29; 95% confidence interval [CI]: 0.58–2.89 and T3 vs. T1, adjusted OR: 0.83; 95% CI: 0.30–2.31).

Conclusion

In this multicenter retrospective observational study, hypothermia severity was not associated with in-hospital mortality in AH patients with infectious diseases.

目的 低体温与败血症患者的不良预后有关。然而,还没有研究探讨过体温过低的严重程度与预后之间的相关性。 方法 我们利用日本意外低体温网络登记处(J-Point 登记处)的数据,对 2011 年 4 月 1 日至 2016 年 3 月 31 日期间 12 个中心的年龄≥18 岁、初始体温≤35°C 的感染性疾病成年患者进行了研究。根据体温将患者分为三组:1级(T1)(32.0-35.0°C)、2级(T2)(28.0-31.9°C)和3级(T3)(<28.0°C)。院内死亡率被用作评估结果的指标。我们进行了多变量逻辑回归分析,以研究三个类别与院内死亡率之间的关系。 结果 共登记了 572 名患者,确定了 170 名符合条件的患者。其中,T1(32.0-35.0°C)组 55 人,T2(28.0-31.9°C)组 76 人,T3(28.0°C)组 39 人。感染性疾病的意外低体温症(AH)患者的总体院内死亡率为34.1%。T1、T2和T3组的院内死亡率分别为34.5%、36.8%和28.2%。多变量分析表明,三组患者的院内死亡率无明显差异(T2 组与 T1 组相比,调整后的几率比 [OR]:1.29; 95% 置信区间 [CI]:0.58-2.89;T3 vs. T1,调整后的比值比[OR]:0.83;95% 置信区间[CI]:0.30-2.31)。 结论 在这项多中心回顾性观察研究中,低体温严重程度与感染性疾病的 AH 患者的院内死亡率无关。
{"title":"Association between the severity of hypothermia and in-hospital mortality in patients with infectious diseases: The J-Point registry","authors":"Tadaharu Shiozumi,&nbsp;Yuki Miyamoto,&nbsp;Sachiko Morita,&nbsp;Naoki Ehara,&nbsp;Nobuhiro Miyamae,&nbsp;Yohei Okada,&nbsp;Takaaki Jo,&nbsp;Yasuyuki Sumida,&nbsp;Nobunaga Okada,&nbsp;Makoto Watanabe,&nbsp;Masahiro Nozawa,&nbsp;Ayumu Tsuruoka,&nbsp;Yoshihiro Fujimoto,&nbsp;Yoshiki Okumura,&nbsp;Tetsuhisa Kitamura,&nbsp;Tasuku Matsuyama","doi":"10.1002/ams2.964","DOIUrl":"https://doi.org/10.1002/ams2.964","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Hypothermia is associated with poor prognosis in patients with sepsis. However, no studies have explored the correlation between the severity of hypothermia and prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using data from the Japanese accidental hypothermia network registry (J-Point registry), we examined adult patients aged ≥18 years with infectious diseases whose initial body temperature was ≤35°C from April 1, 2011 to March 31, 2016, in 12 centers. Patients were divided into three groups according to their body temperature: Tertile 1 (T1) (32.0–35.0°C), Tertile 2 (T2) (28.0–31.9°C), and Tertile 3 (T3) (&lt;28.0°C). In-hospital mortality was employed as a metric to assess outcomes. We conducted a multivariate logistic regression analysis to investigate the relationship between the three categories and the occurrence of in-hospital mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 572 patients were registered, and 170 eligible patients were identified. Of these patients, 55 were in T1 (32.0–35.0°C), 76 in T2 (28.0–31.9°C), and 39 in T3 (&lt;28.0°C) groups. The overall in-hospital mortality rate in accidental hypothermia (AH) patients with infectious diseases was 34.1%. The in-hospital mortality rates in the T1, T2, and T3 groups were 34.5%, 36.8%, and 28.2%, respectively. The multivariable analysis demonstrated no significant differences regarding in-hospital mortality among the three groups (T2 vs. T1, adjusted odds ratio [OR]: 1.29; 95% confidence interval [CI]: 0.58–2.89 and T3 vs. T1, adjusted OR: 0.83; 95% CI: 0.30–2.31).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this multicenter retrospective observational study, hypothermia severity was not associated with in-hospital mortality in AH patients with infectious diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ams2.964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and outcomes of out-of-hospital cardiac arrest in a hilly area: Utstein Registry data from the Nagasaki Medical Region, Japan 丘陵地区院外心脏骤停的特征和结果:来自日本长崎医疗区的 Utstein 登记数据
IF 1.6 Pub Date : 2024-05-15 DOI: 10.1002/ams2.966
Valeryia Zmushka, Goro Tajima, Keita Iyama, Koichi Hayakawa, Kazunori Yamashita, Takamitsu Inokuma, Hiroo Izumino, Takanobu Otaguro, Eri Uemura, Tomohiro Ueki, Shimon Murahashi, Shuhei Yamano, Kensuke Takahashi, Yoshihiro Aoki, Atsuko Tachikawa, Osamu Tasaki

Aim

To analyze characteristics and investigate prognostic indicators of out-of-hospital cardiac arrest (OHCA) in a hilly area in Japan.

Methods

A retrospective population-based study was conducted using the Utstein Registry for 4280 OHCA patients in the Nagasaki Medical Region (NMR) registered over the 10-year period from 2011 to 2020. The main outcome measure was a favorable cerebral performance category (CPC 1–2). Sites at which OHCA occurred were classified into “sloped places (SPs)” (not easily accessible by emergency medical services [EMS] personnel due to slopes) and “accessible places (APs)” (EMS personnel could park an ambulance close to the site). The characteristics and prognosis based on CPC were compared between SPs and APs, and multivariable analysis was performed.

Results

No significant improvement in prognosis occurred in the NMR from 2011 to 2020. Prognosis in SPs was significantly worse than that in APs. However, multivariable analysis did not identify SP as a prognostic indicator. The following factors were associated with survival and CPC 1–2: age group, witness status, first documented rhythm, bystander-initiated cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) use, use of mechanical CPR (m-CPR) device or esophageal obturator airway (EOA), and year. Both m-CPR and EOA use were associated with a poor prognosis.

Conclusion

In a hilly area, OHCA patients in SPs had a worse prognosis than those in APs, but SPs was not significantly associated with prognosis by multivariable analysis. Interventions to increase bystander-initiated CPR and AED use could potentially improve outcomes of OHCA in the NMR.

目的 分析日本丘陵地区院外心脏骤停(OHCA)的特征并研究其预后指标。 方法 使用 Utstein 登记系统对长崎医疗区(NMR)2011 年至 2020 年 10 年间登记的 4280 名院外心脏骤停患者进行了一项基于人群的回顾性研究。主要结果指标是良好脑功能分类(CPC 1-2)。发生 OHCA 的地点被分为 "斜坡地 (SP)"(由于斜坡,紧急医疗服务 [EMS] 人员不易到达)和 "可到达地 (AP)"(紧急医疗服务人员可将救护车停放在地点附近)。比较了SP和AP的特征和基于CPC的预后,并进行了多变量分析。 结果 从 2011 年到 2020 年,NMR 的预后没有明显改善。SP的预后明显差于AP。然而,多变量分析并未将 SP 确定为预后指标。以下因素与存活率和 CPC 1-2 相关:年龄组、目击者身份、首次记录的心律、旁观者启动的心肺复苏(CPR)和自动体外除颤器(AED)的使用、机械心肺复苏(m-CPR)设备或食管闭塞气道(EOA)的使用以及年份。使用机械心肺复苏器和食道闭塞气道与预后不良有关。 结论 在丘陵地区,SPs 中的 OHCA 患者的预后比 APs 中的患者差,但通过多变量分析,SPs 与预后的关系并不明显。采取干预措施,增加旁观者启动心肺复苏术和自动体外除颤器的使用,有可能改善北地中海地区 OHCA 的预后。
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引用次数: 0
Significance of perioperative inter-departmental collaboration for obstetric emergency response: A mini-review 围手术期部门间合作对产科急诊响应的意义:微型综述
IF 1.6 Pub Date : 2024-05-07 DOI: 10.1002/ams2.962
Nobuyasu Komasawa

This review underscores the crucial role of interdisciplinary collaboration in managing obstetric emergencies such as crisis bleeding. Prompt clinical judgment and coordinated interventions involving various departments are emphasized for the well-being of both the mother and newborn. The review explores the importance of emergency response infrastructure in obstetric facilities and delves into the 2022 Obstetric Crisis Bleeding Guidelines, emphasizing the relevance of a DIC score for severity assessment. The collaborative efforts within the operating room, involving different healthcare professionals, are detailed, stressing meticulous coordination during emergencies like massive bleeding. The necessity of interprofessional collaboration for building a responsive perioperative management team is discussed, with a focus on leadership, followership, and effective communication. The abstract also proposes simulation-based education for inter-departmental training, emphasizing a modified non-technical skill evaluation tool tailored to the unique characteristics of obstetric crisis management in the operating room. Continuous formative assessment of these factors is deemed essential for effective training in various obstetric emergency situations.

这篇综述强调了跨学科合作在处理危急出血等产科急症中的关键作用。为了孕产妇和新生儿的福祉,我们强调要有及时的临床判断和各部门的协调干预。综述探讨了产科设施中应急基础设施的重要性,并深入研究了《2022 年产科危机出血指南》,强调了 DIC 评分对严重程度评估的相关性。详细介绍了手术室内涉及不同医护专业人员的协作工作,强调了在大出血等紧急情况下的细致协调。摘要讨论了跨专业合作对于建立一支反应迅速的围手术期管理团队的必要性,重点关注领导力、追随力和有效沟通。摘要还提出了跨科室培训的模拟教育,强调针对手术室产科危机管理的独特性,对非技术性技能评估工具进行修改。对这些因素进行持续的形成性评估被认为是在各种产科紧急情况下进行有效培训的关键。
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引用次数: 0
Carbazochrome sodium sulfonate and tranexamic acid combination therapy to reduce blood transfusions after 24 h of injury: A retrospective study 卡巴克络磺酸钠和氨甲环酸联合疗法可减少受伤 24 小时后的输血量:回顾性研究
IF 1.6 Pub Date : 2024-05-06 DOI: 10.1002/ams2.961
Hiroki Nagasawa, Kazuhiko Omori, Soichirou Ota, Ken-ichi Muramatsu, Ikuto Takeuchi, Hiromichi Ohsaka, Youichi Yanagawa

Aim

Reducing the blood transfusion volume is important in severe trauma. We hypothesized that carbazochrome sodium sulfonate (CSS) combined with tranexamic acid (TXA) would reduce blood transfusions in severe trauma.

Methods

From April 2017 to March 2023, data were collected from patients (aged ≥16 years) admitted to our hospital for trauma and administered packed red blood cells (pRBC) and plasma transfusions within 12 h postinjury. Patients infused with CSS and TXA (CSS + TXA group) were compared with those infused with TXA alone (TXA group). The outcomes were blood product transfusion volumes within and after 24 h, the number of patients receiving >6 units of pRBC transfusion after 24 h, duration of intensive care unit and in-hospital stays, and 28-day in-hospital mortality.

Results

In total, 138 patients were included in the study. In the univariate analyses, the CSS + TXA group (n = 62) showed a significant reduction in the total pRBC transfusion volume, in-hospital days, and number of patients receiving >6 units of pRBCs in the delayed phase. Based on the multivariate logistics regression analysis, only the CSS + TXA group had a significantly lower adjusted odds ratio for receiving >6 units of pRBC transfusion after 24 h. During the in-hospital days, the CSS + TXA group did not experience an increased incidence of major complications when compared with the TXA group.

Conclusion

In patients with trauma, treatment with CSS with TXA may reduce the requirement for blood transfusion after 24 h. Moreover, this treatment can improve admission outcomes without increasing complications.

目的 减少输血量对严重创伤非常重要。我们假设卡巴克酸钠磺酸盐(CSS)联合氨甲环酸(TXA)可减少严重创伤患者的输血量。 方法 从 2017 年 4 月至 2023 年 3 月,我们收集了因创伤入院并在伤后 12 小时内输注了包装红细胞(pRBC)和血浆的患者(年龄≥16 岁)的数据。输注 CSS 和 TXA 的患者(CSS + TXA 组)与仅输注 TXA 的患者(TXA 组)进行了比较。结果包括 24 小时内和 24 小时后的血液制品输注量、24 小时后接受 6 单位 pRBC 输注的患者人数、重症监护室和住院时间以及 28 天的住院死亡率。 结果 总共有 138 名患者被纳入研究。在单变量分析中,CSS + TXA 组(n = 62)的 pRBC 输血总量、住院天数和延迟阶段接受 >6 单位 pRBC 的患者人数均显著减少。根据多变量物流回归分析,只有 CSS + TXA 组在 24 小时后接受 >6 单位 pRBC 输血的调整后几率明显降低。与 TXA 组相比,CSS + TXA 组在住院期间主要并发症的发生率没有增加。 结论 在创伤患者中,使用 CSS + TXA 治疗可减少 24 小时后的输血需求。
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引用次数: 0
Acute alcohol intoxication presenting acquired lesion of the corpus callosum in a young healthy woman: A case of possible Marchiafava–Bignami disease 一名年轻健康女性因急性酒精中毒导致胼胝体后天性病变:一个可能患有马奇亚法瓦-比尼亚米病的病例
IF 1.6 Pub Date : 2024-05-02 DOI: 10.1002/ams2.960
Makoto Watanabe, Nobuhito Atagi, Yosuke Makino, Kunihiko Kooguchi, Bon Ohta

Background

Marchiafava–Bignami disease is a rare neurological disease characterized by acquired lesions of the corpus callosum. Although the major causative etiology is chronic alcoholism, a case caused by acute alcohol intoxication has not yet been reported.

Case Presentation

A 19-year-old female with no known medical history or a history of chronic alcohol consumption was brought to the emergency department in a coma after binge alcohol consumption. Even after an overnight observation, she remained comatose. After a thorough examination including magnetic resonance imaging, which showed lesions of the corpus callosum, she was treated with thiamine for Marchiafava–Bignami disease. She recovered completely and at the follow-up, the callosum lesion had resolved.

Conclusion

This is a rare case within the spectrum of Marchiafava–Bignami disease caused by acute consumption of alcohol. Clinicians should be aware of this potentially devastating critical condition among patients with severe alcohol intoxication, which might have been overlooked.

背景 Marchiafava-Bignami 病是一种罕见的神经系统疾病,以胼胝体后天性病变为特征。虽然主要的致病病因是慢性酒精中毒,但因急性酒精中毒引起的病例尚未见报道。 病例介绍 一名没有已知病史或慢性饮酒史的 19 岁女性在暴饮暴食后昏迷不醒,被送到急诊科。即使经过一夜的观察,她仍然处于昏迷状态。在对她进行了包括磁共振成像在内的全面检查后,发现她的胼胝体有病变,于是对她进行了硫胺素治疗,以治疗马奇亚法瓦-比尼亚米病。她完全康复了,随访时,胼胝体病变已经消失。 结论 这是急性酒精中毒引起的马奇亚法瓦-比尼亚米病的一个罕见病例。临床医生应注意严重酒精中毒患者中这种可能被忽视的破坏性危重症。
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引用次数: 0
Respiratory-like movements during an apnea test 在呼吸暂停测试中出现类似呼吸的动作
IF 1.6 Pub Date : 2024-04-24 DOI: 10.1002/ams2.959
Shinichi Kida, Isao Nagata, Tetsuhiro Takei, Kazuhiro Yoshizawa, Taketo Suzuki, Hiroyuki Yamada, Yusuke Nakayama

Background

Despite the possible occurrence of spontaneous movements during an apnea test, respiratory-like movements are rare.

Case Presentation

A 51-year-old man was transferred to our hospital when a sudden disturbance of consciousness developed into cardiac arrest. After spontaneous circulation returned, we diagnosed bilateral cerebellar hemorrhage. He remained comatose with dilated pupils, absent brainstem reflexes, spontaneous breathing, and electrocerebral activity. After being considered brain dead, his family opted for organ donation. The first legal brain death examination on day 5 was aborted because of respiratory-like movements mimicking repetitive abdominal respiration during the apnea test. However, an enhanced magnetic resonance image of the head indicated no blood flow and somatosensory evoked potential testing revealed no brain-derived potentials.

Conclusion

Respiratory-like movements can occur during the apnea test in patients considered brain dead. Further research is required to understand this phenomenon.

背景 尽管在进行呼吸暂停测试时可能会出现自发运动,但类似呼吸运动的情况却很少见。 病例介绍 一名 51 岁的男性因突发意识障碍发展为心脏骤停而被转入我院。自主循环恢复后,我们诊断为双侧小脑出血。他一直处于昏迷状态,瞳孔散大,脑干反射消失,自主呼吸和脑电活动正常。在被认为脑死亡后,他的家人选择了器官捐献。第 5 天的首次法定脑死亡检查因在呼吸暂停测试中出现模仿重复腹式呼吸的呼吸样运动而中止。然而,头部增强磁共振成像显示没有血流,体感诱发电位测试显示没有脑源性电位。 结论 被认为脑死亡的病人在呼吸暂停测试期间可能会出现类似呼吸的动作。要了解这一现象,还需要进一步的研究。
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引用次数: 0
期刊
Acute Medicine & Surgery
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