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Letter to “Refractory cardiogenic shock due to atomoxetine overdose rescued by venoarterial extracorporeal membrane oxygenation: A case report” 致“托莫西汀过量致难治性心源性休克经静脉外膜氧合抢救1例”的信
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-01 DOI: 10.1002/ams2.70028
Ju-Tae Sohn
<p>I commend Komoriya et al.<span><sup>1</sup></span> for their successful treatment described in the case report titled “Refractory cardiogenic shock due to atomoxetine overdose rescued by venoarterial extracorporeal membrane oxygenation: A case report,” recently published in <i>Acute Medicine & Surgery</i>. Lipid emulsions are commonly used to manage local anesthetic systemic toxicity (LAST) and as an effective adjuvant therapy for mitigating severe cardiovascular depression caused by toxic doses of non-local anesthetic drugs with high lipid solubility (log P = log [octanol/water] partition coefficient: >2).<span><sup>2</sup></span> Moreover, lipid emulsion improves the condition of patients with seizure caused by norepinephrine reuptake inhibitor atomoxetine toxicity, which is unresponsive to intravenous benzodiazepine, suggesting lipid sink.<span><sup>3</sup></span> To help the readers better understand this case report, I would like to explain the possible mechanisms of lipid emulsion treatment for drug toxicity. The mechanism comprises indirect and direct effects.<span><sup>2</sup></span> The widely accepted lipid shuttle mechanism suggests that lipid emulsions absorb highly lipophilic drugs, such as bupivacaine (log P: 3.41), from tissues such as the brain and heart.<span><sup>2</sup></span> Once absorbed, they transport these drugs to the liver, muscles, and adipose tissue, where the drugs are detoxified and stored.<span><sup>2</sup></span> QT prolongation induced by bupivacaine, which produces Torsades de Pointes, is due to the inhibition of rapidly activating delayed rectifier potassium channels encoded by human ether-à-go-go-related gene (hERG).<span><sup>2</sup></span> Bupivacaine inhibits hERG potassium channels, which contributes to QT prolongation and cardiac arrest induced by LAST.<span><sup>2</sup></span> However, lipid emulsions reduce the bupivacaine-induced increase in the T-peak to T-end interval and restore the sinus rhythm.<span><sup>2</sup></span> Similar to local anesthetics, an overdose of atomoxetine in an 11-year-old patient produces life-threatening QT prolongation, which may be due to inhibition of hERG.<span><sup>4</sup></span> The direct effects of lipid emulsions include a positive inotropic effect, supplying fatty acids, and reducing mitochondrial dysfunction.<span><sup>2</sup></span> Considering previous reports,<span><sup>2-4</sup></span> scavenging lipid soluble atomoxetine (log P: 3.9) and the positive inotropic effect induced by lipid emulsions may have contributed to the early removal of the venoarterial extracorporeal membrane oxygenation (ECMO) in this patient. The authors stated that the potential side effects of lipid emulsions in the concomitant use of lipid emulsions and ECMO include layering, agglutination in the tube, and cracking of the stopcock.<span><sup>1</sup></span> A high dose of lipid emulsion (20 mL/kg, 4 g/kg) as an adjuvant drug to treat toxicity produces layering of the blood and
我赞扬Komoriya et al.1在最近发表在《急性医学》杂志上的题为“静脉体外膜氧合挽救托莫西汀过量引起的难治性心源性休克:一个病例报告”的病例报告中所描述的成功治疗方法。手术。脂质乳剂通常用于控制局麻全身毒性(LAST),并作为减轻高脂溶性非局麻药物毒性剂量引起的严重心血管抑制的有效辅助治疗(log P = log[辛醇/水]分配系数:>;2)此外,脂质乳改善了去甲肾上腺素再摄取抑制剂阿托西汀毒性引起的癫痫发作患者的病情,而静脉注射苯二氮卓类药物对癫痫发作无反应,提示脂质下沉为了帮助读者更好地理解这个病例报告,我想解释一下脂质乳治疗药物毒性的可能机制。这一机制包括间接效应和直接效应广泛接受的脂质穿梭机制表明,脂质乳剂从大脑和心脏等组织吸收高度亲脂性药物,如布比卡因(log P: 3.41)一旦被吸收,它们就把这些药物运送到肝脏、肌肉和脂肪组织,在那里药物被解毒并储存起来布比卡因引起的QT间期延长是由于抑制了人类醚-à-go-go-related基因(hERG)编码的延迟整流钾通道的快速激活布比卡因抑制hERG钾通道,导致QT延长和last2诱导的心脏骤停。2然而,脂质乳可降低布比卡因诱导的t峰至t端间期的增加,恢复窦性心律与局麻药类似,11岁患者过量使用托莫西汀可导致危及生命的QT间期延长,这可能是由于抑制herg所致脂质乳的直接作用包括正性肌力作用、提供脂肪酸和减少线粒体功能障碍考虑到先前的报道,2-4清除脂溶性阿托西汀(log P: 3.9)和脂质乳诱导的正性肌力作用可能是导致该患者早期去除静脉动脉体外膜氧合(ECMO)的原因。作者指出,同时使用脂质乳剂和ECMO时,潜在的副作用包括分层、管内凝集和塞子开裂高剂量的脂质乳剂(20ml /kg, 4g /kg)作为治疗毒性的辅助药物,在ECMO回路中产生血液和脂质乳剂的分层因此,一些专家建议在ecmo期间限制脂质乳的使用不超过10ml /kg。此外,LAST主要由静脉给药引起,而非局麻药物引起的药物毒性主要由口服引起。在药代动力学方面(口服:胃肠道吸收时间延长,首过效应,生物利用度降低),非局麻药口服引起的药物毒性与LAST不同。因此,对于非局部麻醉药物引起的ECMO患者的药物毒性,需要进一步研究脂质乳的最佳剂量。此外,还需要进一步研究脂质乳联合ECMO治疗阿托西汀毒性的方式。作者声明无利益冲突。不适用。
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引用次数: 0
The effect of ICU diary on psychiatric symptoms after ICU discharge among adult critically ill patients: A prospective comparative study ICU日记对成人重症患者出院后精神症状的影响:一项前瞻性比较研究
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-28 DOI: 10.1002/ams2.70026
Mami Shibata, Kyohei Miyamoto, Nozomu Shima, Tsuyoshi Nakashima, Junichi Fukushima, Shinichi Yamada, Sohei Kimoto, Shigeaki Inoue

Aim

Psychiatric problems are common in critically ill patients after discharge from an intensive care unit (ICU). The effect of intensive care unit (ICU) diaries on psychiatric symptoms after ICU discharge was investigated in this prospective study.

Methods

Enrolled were critically ill adult patients who were emergently admitted to an ICU and expected to stay for at least 2 days. These patients received ICU diaries filled out by healthcare professionals and family members. Comparison was made with a historical cohort from a previous trial conducted in the same ICU but without ICU diaries. The primary outcome was the presence of significant post-traumatic stress disorder (PTSD) symptoms 3 months after ICU discharge. Secondary outcomes included significant symptoms of anxiety and depression.

Results

Among 61 patients with ICU diaries, questionnaires were sent to 44 patients 3 months after ICU discharge; 29 patients responded and were analyzed (ICU diary group). Seventy-four patients from a historical cohort were used as a control group. The proportion of patients with significant PTSD symptoms was 19% in the ICU diary group and 16% in the control group (adjusted odds ratio [aOR] [95% confidence interval: 95% CI]: 0.98 [0.26–3.70]). For anxiety and depression, the proportions were 25% and 29% in the ICU diary group, and 38% and 45% in the control group (aOR [95% CI]: 0.46 [0.15–1.38] for anxiety, aOR [95% CI] 0.40 [0.14–1.16] for depression).

Conclusion

ICU diaries were not associated with a reduced incidence of PTSD symptoms 3 months after ICU discharge.

目的重症监护病房(ICU)重症患者出院后常见精神问题。本前瞻性研究探讨重症监护病房(ICU)日记对出院后精神症状的影响。方法入选患者为重症监护室紧急收治的危重成人患者,预计住院时间至少2天。这些患者收到由医疗保健专业人员和家庭成员填写的ICU日记。与先前在同一ICU中进行但没有ICU日记的试验的历史队列进行比较。主要结局是在ICU出院3个月后出现明显的创伤后应激障碍(PTSD)症状。次要结局包括显著的焦虑和抑郁症状。结果在61例ICU日记患者中,有44例患者在出院后3个月进行问卷调查;29例患者有反应并进行分析(ICU日记组)。从历史队列中选取74名患者作为对照组。ICU日记组有显著PTSD症状的患者比例为19%,对照组为16%(校正优势比[aOR][95%可信区间:95% CI]: 0.98[0.26-3.70])。对于焦虑和抑郁,ICU日记组分别为25%和29%,对照组分别为38%和45%(焦虑组aOR [95% CI]: 0.46[0.15-1.38],抑郁组aOR [95% CI]: 0.40[0.14-1.16])。结论ICU日记与出院后3个月PTSD症状发生率降低无相关性。
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引用次数: 0
Cardiac rupture caused by penetration of the heart by fractured costal cartilage following blunt chest trauma: A case report 胸部钝伤后肋软骨骨折穿透心脏导致心脏破裂:病例报告
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-24 DOI: 10.1002/ams2.70024
Masao Hattori, Mayo Akita, Kotaro Mori, Michitaro Ichikawa, Kanako Takeshige, Hiroshi Kamijo, Katsunori Mochizuki, Hiroshi Imamura, Haruki Tanaka, Tetsu Takeda

Background

Cardiac rupture is rare but has a high mortality rate. Cardiac rupture due to blunt trauma is generally caused by the heart being pinched into the bony thorax.

Case Presentation

A 90-year-old man in shock was transported to the hospital after his precordium was stepped on by a cow. He developed right atrial rupture from penetration of the heart by fractured and calcified costal cartilage, with massive hemothorax, hemorrhagic shock, and respiratory failure. We immediately performed cardiac injury repair. The patient was discharged without sequelae.

Conclusion

Emergency physicians should be aware that secondary cardiac rupture can show a penetrating injury-like presentation due to calcified costal cartilage caused by blunt chest trauma.

背景 心脏破裂虽然罕见,但死亡率很高。钝性外伤导致的心脏破裂通常是由于心脏被挤压到骨质胸腔内所致。 病例介绍 一位 90 岁的老人被一头牛踩到心前区,休克后被送往医院。他的心脏被断裂和钙化的肋软骨穿透,导致右心房破裂,并伴有大量血胸、失血性休克和呼吸衰竭。我们立即进行了心脏损伤修补术。患者出院后没有留下后遗症。 结论 急诊医生应注意,由于钝性胸部创伤导致肋软骨钙化,继发性心脏破裂可表现为类似穿透性损伤的症状。
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引用次数: 0
Retroperitoneal hemorrhage due to ruptured artery induced by median arcuate ligament syndrome in patients with COVID-19: A case series COVID-19患者正中弓形韧带综合征引起的动脉破裂导致腹膜后出血:病例系列。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-20 DOI: 10.1002/ams2.70015
Nao Okuno, Shuhei Maruyama, Daiki Wada, Atsushi Komemushi, Haruka Shimazu, Shuji Kanayama, Fukuki Saito, Yasushi Nakamori, Yasuyuki Kuwagata

Background

Median arcuate ligament syndrome describes a clinical presentation associated with direct compression of the celiac artery by the median arcuate ligament. Decreased blood flow from the celiac artery and increased flow from superior mesenteric artery causes blood flow in the pancreatic arcade to increase, and aneurysms can form. We report our experience with six cases of retroperitoneal hemorrhage induced by median arcuate ligament syndrome in patients during the COVID-19 period.

Case Presentation

The time from the onset of COVID-19 to that of abdominal pain in the patients ranged from 3 to 9 days. None of the patients required oxygen for COVID-19. We used contrast-enhanced computed tomography to diagnose retroperitoneal hemorrhage and formation of a visceral pseudoaneurysm or aneurysm due to median arcuate ligament syndrome. Five patients underwent transcatheter arterial embolization. One patient suffered complications of duodenal stenosis and another suffered portal vein thrombosis.

Conclusions

Retroperitoneal hemorrhage associated with median arcuate ligament syndrome is rare. However, it might be triggered by COVID-19 disease, resulting in arterial disruption and hemorrhage.

背景:正中弓形韧带综合征是一种与腹腔动脉直接受正中弓形韧带压迫有关的临床表现。腹腔动脉血流减少和肠系膜上动脉血流增加会导致胰弧血流增加,从而形成动脉瘤。我们报告了在 COVID-19 期间六例正中弓形韧带综合征患者诱发腹膜后出血的经验:病例介绍:患者从 COVID-19 发生到出现腹痛的时间为 3 到 9 天不等。没有一名患者因 COVID-19 而需要吸氧。我们使用造影剂增强计算机断层扫描诊断出腹膜后出血和内脏假动脉瘤或动脉瘤的形成是由正中弓形韧带综合征引起的。五名患者接受了经导管动脉栓塞术。一名患者出现十二指肠狭窄并发症,另一名患者出现门静脉血栓:结论:与弓状韧带综合征相关的腹膜后出血非常罕见。结论:腹膜后出血伴有正中弓形韧带综合征的情况非常罕见,但它可能由COVID-19疾病引发,导致动脉中断和出血。
{"title":"Retroperitoneal hemorrhage due to ruptured artery induced by median arcuate ligament syndrome in patients with COVID-19: A case series","authors":"Nao Okuno,&nbsp;Shuhei Maruyama,&nbsp;Daiki Wada,&nbsp;Atsushi Komemushi,&nbsp;Haruka Shimazu,&nbsp;Shuji Kanayama,&nbsp;Fukuki Saito,&nbsp;Yasushi Nakamori,&nbsp;Yasuyuki Kuwagata","doi":"10.1002/ams2.70015","DOIUrl":"10.1002/ams2.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Median arcuate ligament syndrome describes a clinical presentation associated with direct compression of the celiac artery by the median arcuate ligament. Decreased blood flow from the celiac artery and increased flow from superior mesenteric artery causes blood flow in the pancreatic arcade to increase, and aneurysms can form. We report our experience with six cases of retroperitoneal hemorrhage induced by median arcuate ligament syndrome in patients during the COVID-19 period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>The time from the onset of COVID-19 to that of abdominal pain in the patients ranged from 3 to 9 days. None of the patients required oxygen for COVID-19. We used contrast-enhanced computed tomography to diagnose retroperitoneal hemorrhage and formation of a visceral pseudoaneurysm or aneurysm due to median arcuate ligament syndrome. Five patients underwent transcatheter arterial embolization. One patient suffered complications of duodenal stenosis and another suffered portal vein thrombosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Retroperitoneal hemorrhage associated with median arcuate ligament syndrome is rare. However, it might be triggered by COVID-19 disease, resulting in arterial disruption and hemorrhage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"11 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of penetrating neck injury in zone II treated with combined endovascular and surgical management 一例颈部穿透性损伤(位于 II 区),采用血管内治疗和外科治疗相结合的方法进行治疗
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-14 DOI: 10.1002/ams2.70022
Youhei Nakamura, Shunichiro Nakao, Takeshi Nishida, Hiroshi Ito, Tomohiko Ozaki, Jun Oda

Background

We report a case of zone II penetrating neck trauma with active bleeding in which endovascular treatment was performed prior to neck exploration to identify and control the bleeding point.

Case Presentation

A man in his 50s presented to our emergency department in hemorrhagic shock stemming from a penetrating knife wound injury to the right side of his neck. He was bleeding massively from the right neck wound and oral cavity. Cervical angiography showed bleeding from the right external carotid artery and intimal injury to the right internal carotid artery. Balloon occlusion at the common carotid artery origin and distal to the injured internal carotid artery controlled active bleeding. During vascular balloon occlusion, definitive hemostatic treatment was achieved through ligation of the proximal external carotid artery.

Conclusion

Neck exploration combined with endovascular treatment may be one option as a treatment strategy for patients with zone II penetrating neck injury.

背景 我们报告了一例 II 区穿透性颈部创伤伴活动性出血的病例,该病例在颈部探查前进行了血管内治疗,以确定并控制出血点。 病例介绍 一名 50 多岁的男子因右侧颈部穿透性刀伤导致失血性休克而到我院急诊科就诊。他的右颈部伤口和口腔大量出血。颈部血管造影显示右颈外动脉出血,右颈内动脉内膜损伤。在颈总动脉源头和受伤的颈内动脉远端进行了球囊闭塞,控制了活动性出血。在血管球囊闭塞期间,通过结扎近端颈外动脉实现了最终止血治疗。 结论 颈部探查结合血管内治疗可能是 II 区颈部穿透性损伤患者的治疗策略之一。
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引用次数: 0
Risk factors, complications and biomarkers associated with acute kidney injury after craniotomy: a comprehensive mini-review 开颅手术后急性肾损伤的相关风险因素、并发症和生物标志物:综合微型综述。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-11 DOI: 10.1002/ams2.70020
Davood Dalil, Joben Kianparsa, Mahdi Isakhani, Mahdieh Ostadzadeh, Fatemeh Ravand

Acute kidney injury (AKI) is a devastating medical condition that occurs mostly in hospitalized patients after a serious illness or major surgery and imposes a great health and financial burden on patients. Craniotomy is one of the major surgeries in which people who undergo this operation experience critical clinical conditions. Systemic inflammation, hemodynamic variation, and pharmacological agents administered during and after craniotomy can lead to the development of AKI and a poor prognosis. Moreover, AKI itself could cause other significant complications and increase the mortality rate in patients who undergo craniotomy. Determining the pre-, peri-, and postoperative risk factors associated with AKI after craniotomy is important for its prevention. Efficient care of patients after craniotomy and effective treatment approaches should be implemented to maintain normal metabolism, enhance nerve function recovery, and control inflammation. Novel biomarkers have been recognized as reliable indicators for the diagnosis and prognosis of AKI after brain surgery. This study aimed to summarize the most relevant literature regarding the risk factors, postoperative complications, and mortality associated with AKI after craniotomy. Moreover, we reviewed the approaches to postoperative care, followed by an overview of the significant diagnostic or prognostic biomarkers of AKI following craniotomy to provide a basis for preventing and decreasing AKI.

急性肾损伤(AKI)是一种破坏性的医疗状况,主要发生在重病或大手术后的住院病人身上,给病人带来巨大的健康和经济负担。开颅手术是重大手术之一,接受该手术的患者会出现危急的临床症状。开颅手术过程中和手术后的全身炎症、血流动力学变化和使用的药物都可能导致患者发生 AKI,并导致不良预后。此外,AKI 本身还可能引起其他重大并发症,并增加开颅手术患者的死亡率。确定开颅手术后与 AKI 相关的术前、围手术期和术后风险因素对预防 AKI 非常重要。应在开颅手术后对患者实施高效护理和有效的治疗方法,以维持正常代谢、促进神经功能恢复并控制炎症。新型生物标志物已被认为是诊断和预后脑手术后 AKI 的可靠指标。本研究旨在总结与开颅手术后 AKI 相关的风险因素、术后并发症和死亡率方面最相关的文献。此外,我们还回顾了术后护理的方法,随后概述了开颅手术后 AKI 的重要诊断或预后生物标志物,为预防和减少 AKI 提供依据。
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引用次数: 0
Training in trauma surgical techniques using cryopreserved porcine organs 利用低温保存的猪器官进行创伤外科技术培训。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-11 DOI: 10.1002/ams2.70018
Tsubasa Fujikawa, Hiroshi Homma, Yuri Ishii, Yusuke Tanino, Yuta Ishigami, Shoji Suzuki, Hidefumi Sano, Junya Tsurukiri

Aim

To develop a trauma surgery training program using porcine organs and evaluate its usefulness. This program allows participants to experience the tactile sensation of organs and bleeding, which are impossible in trauma surgery training using a cadaver.

Methods

Resected organs (heart, lung, liver, spleen, kidney, small intestine, bladder, and external carotid artery) from slaughtered pigs for medical research were perfused with saline solution, flash-frozen in a deep freezer, and thawed naturally on the morning of training. The training program consisted of half-day practical training in suture repair of artificially created damage to the parenchymal organs and suture or anastomotic repair of damage to the luminal organs. We injected the parenchymal organs' arteries with porcine blood and the renal ureters with saline solution to create models of organ hemorrhage and urinary leakage. The training's usefulness was evaluated using a participant questionnaire that included an 11-point self-assessment of confidence level (SACL) form.

Results

Nine training seminars were conducted from September 2018 to February 2023, attended by 67 participants who were in their 1st to 20th post-graduate year. The mean SACL significantly increased immediately after the seminar but decreased half-year thereafter. However, it was maintained for those with surgical residency. It was also maintained for those with no surgical residency through seminar repetition.

Conclusions

Training in trauma surgical techniques using porcine organs is beneficial regardless of whether the participant has prior surgical residency.

目的:开发使用猪器官的创伤外科培训项目,并评估其实用性。该项目可让参与者体验器官和出血的触觉,而这在使用尸体进行的创伤外科培训中是不可能实现的:方法:从用于医学研究的屠宰猪身上切除的器官(心、肺、肝、脾、肾、小肠、膀胱和颈外动脉)用生理盐水灌注,在深冷冻箱中速冻,并在培训当天上午自然解冻。培训项目包括为期半天的实际操作培训,内容为人工造成的实质器官损伤的缝合修复,以及管腔器官损伤的缝合或吻合修复。我们向实质器官动脉注入猪血,向肾输尿管注入生理盐水,以制作器官出血和漏尿模型。培训的实用性通过学员问卷进行评估,问卷中包括一份11点自信水平自我评估表(SACL):从 2018 年 9 月到 2023 年 2 月,共举办了 9 次培训研讨会,67 名研究生 1 至 20 年级的学员参加了培训。研讨会结束后,SACL的平均值立即明显上升,但半年后有所下降。不过,有外科住院医师经历的学员的平均SACL保持不变。通过重复参加研讨会,没有外科住院医师经历的人也保持了这一水平:结论:使用猪器官进行创伤外科技术培训是有益的,无论学员之前是否有外科住院医师经验。
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引用次数: 0
Obturator dislocation of hip with femoral neck fracture 髋关节脱位伴股骨颈骨折。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-11 DOI: 10.1002/ams2.70013
Atsuhiro Ijiri, Hiroshi Kato, Hiroki Kobayashi, Yasumasa Sekine, Tetsuro Kiyozumi

A 68-year-old woman was brought to the emergency department after being struck by a car from behind while walking. She complained of left hip pain and underwent pelvic radiography, computed tomography (CT), and three-dimensional CT, which revealed a fracture of the left femoral neck and insertion of the left femoral head into the left obturator foramen (Figure 1). Indirect traction was performed in the emergency room, and the femoral head, firmly seated in the obturator foramen, was removed later by an anterolateral approach to the hip, followed by total hip arthroplasty (THA). Obturator dislocation of the hip joint is rarely associated with a femoral neck fracture, and there are only nine reports of such cases in English literature.1 Anterior dislocation occurs when the hip is forced into abduction and external rotation, causing impingement of the femoral neck or greater trochanter and acetabulum, and the femoral head is pulled forward from the acetabulum.2 Anterior hip joint dislocation can be classified into obturator dislocation and suprapubic dislocation. However, obturator dislocation is reported to occur when the hip joint is externally rotated in the flexed position, and further forced external rotation can result in a femoral neck fracture.3 In some cases, osteosynthesis has been chosen for surgery in younger patients, but THA is recommended for elderly patients to avoid complications such as avascular necrosis and nonunion.1

The authors declare no conflicts of interest.

Approval of the research protocol: None.

Informed consent: Informed consent was obtained from the patient.

Registry and the registration no. of the study/trial: None.

Animal studies: None.

一名 68 岁的妇女在走路时被一辆汽车从后面撞倒,随后被送到急诊科。她诉说左侧髋部疼痛,接受了骨盆X光、计算机断层扫描(CT)和三维CT检查,结果显示左侧股骨颈骨折,左侧股骨头插入左侧闭孔(图1)。在急诊室进行了间接牵引,随后通过髋关节前外侧入路取出了稳固位于闭孔内的股骨头,随后进行了全髋关节置换术(THA)。髋关节闭孔脱位很少伴有股骨颈骨折,在英文文献中仅有九篇关于此类病例的报道。1 当髋关节被迫外展和外旋时,股骨颈或大转子与髋臼发生撞击,股骨头从髋臼中被向前拉出,即发生髋关节前脱位。然而,有报道称,髋关节在屈曲位外旋时发生钝头脱位,进一步强行外旋可导致股骨颈骨折。3 在某些病例中,年轻患者选择骨合成手术,但建议老年患者行 THA 手术,以避免出现血管性坏死和骨不连等并发症:知情同意:研究/试验的注册机构和注册号:无:动物实验:无:动物实验:无。
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引用次数: 0
Use of an eligibility checklist on arrival of emergency room as a registry system for corneal donation—A 9-year retrospective cohort study 使用抵达急诊室时的资格核对表作为角膜捐献登记系统--一项为期 9 年的回顾性队列研究。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-10 DOI: 10.1002/ams2.70014
Haruaki Wakatake, Koichi Hayashi, Miyuki Kurisu, Minoru Yoshida, Ken Tsutsumi, Hiroki Saito, Yu Nomura, Toru Yoshida, Yuka Kitano, Yoshihiro Masui, Shigeki Fujitani

Aim

This study aimed to evaluate whether the use of an eligibility checklist uncovered potential corneal donors among deceased outpatients and increased the donation.

Methods

In this retrospective cohort study, we applied the eligibility checklist to nearly all outpatients (age ≥ 18 y/o) who were transferred to our emergency department and identified as deceased between 2012 and 2020. Whether the use of the checklist contributed to the increase in corneal donation was examined, and the reasons for refusal of the donation were also evaluated. Furthermore, yearly changes in the number of the donation were assessed, with the data obtained before initiation of the checklist in 2010–2011 as references. The primary outcome was the number of corneal donors, with yearly changes in donation numbers assessed using data from 2010 to 2011 as a reference before the checklist was introduced.

Results

Among 1776 outpatients to whom the eligibility checklist was applied, 1169 patients were regarded as potential donors. Of them, 126 families gave consent and 80 patients finally donated cornea; medical diseases as a cause of death were less likely to retract donation offer (OR = 0.31 [95% CI: 0.09–0.99]). The number of corneal donors in 2010–2011 corresponded to 1.6% of the deceased outpatients but increased since the checklist was introduced the total number of donors reached 87 (4.3%) during 2012–2020.

Conclusion

A routine use of the eligibility checklist at the initial interview will reinforce the awareness of corneal donation among the families of patients and contribute to the increased number of corneal donors.

目的:本研究旨在评估使用资格检查表是否能在已故门诊患者中发现潜在的角膜捐献者并增加捐献量:在这项回顾性队列研究中,我们对2012年至2020年间转入急诊科并被确认为死亡的几乎所有门诊患者(年龄≥18岁/o)应用了资格检查表。我们研究了该清单的使用是否有助于角膜捐献的增加,并评估了拒绝捐献的原因。此外,还评估了捐献数量的年度变化,并以2010-2011年开始使用核对表之前获得的数据作为参考。主要结果是角膜捐献者的数量,并以2010年至2011年的数据作为参考,评估捐献数量的年度变化:结果:在1776名采用资格检查表的门诊患者中,有1169名患者被视为潜在捐献者。其中,126 个家庭同意捐献角膜,80 名患者最终捐献了角膜;以内科疾病为死因的患者撤回捐献意愿的可能性较低(OR = 0.31 [95% CI: 0.09-0.99])。2010-2011年的角膜捐献者人数相当于门诊死亡患者的1.6%,但自采用核对表以来,捐献者人数有所增加,2012-2020年期间捐献者总人数达到87人(4.3%):在初次面谈时例行使用资格核对表将加强患者家属对角膜捐献的认识,并有助于增加角膜捐献者的数量。
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引用次数: 0
Impact of urinary culture on diagnosis and treatment strategy after empiric therapy in febrile neutropenic patients 发热性中性粒细胞减少症患者经验疗法后尿培养对诊断和治疗策略的影响。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-06 DOI: 10.1002/ams2.70012
Natsumi Hata, Takateru Ihara

Aim

Febrile neutropenia (FN) is treated by a broad-spectrum antimicrobial. Subsequent antimicrobial therapy depends on identifying the source of the infection. Although urinary tract infections (UTIs) are common and urine culture (UC) is a valuable diagnostic tool, uncertainties remain about the specific indications for conducting UC in FN. This study examined whether performing routine UC would affect the subsequent antimicrobial therapy in FN.

Methods

All emergency department patients who received chemotherapy for malignancy and met the definition of FN (neutrophil count <0.5 × 109/L and fever >37.5°C) were included. The patient's demographic data, clinical symptoms, urinalysis results, urine and blood culture results, antibiotic therapy and duration, and patient outcomes were extracted from electronic medical records. UC was defined as positive if >105 colony-forming units/L were detected.

Results

In total, 115 of the initial 124 cases were included in the analysis. Thirty-one cases met the Infectious Diseases Society of America guideline definition for recommending UC (recommended group) and 84 cases did not (non-recommended group). In the recommended group, 16 of 31 cases had a positive UC, and antibiotics were changed for nine, based on UC results. In the non-recommended group, 15 of 84 cases had a positive UC, and antibiotics were changed for two. The same organism were identified in blood cultures. Seven of 115 cases were detected for the same pathogen in blood and urine cultures.

Conclusion

Performing UC regardless of symptoms could diagnose several asymptomatic UTIs in FN, but seldom impact an antimicrobial treatment strategy.

目的:发热性中性粒细胞减少症(FN)需要使用广谱抗菌药物进行治疗。随后的抗菌治疗取决于感染源的确定。虽然尿路感染(UTI)很常见,尿培养(UC)也是一种有价值的诊断工具,但在 FN 中进行 UC 的具体适应症仍不确定。本研究探讨了常规尿培养是否会影响 FN 的后续抗菌治疗:方法:纳入所有因恶性肿瘤接受化疗且符合 FN 定义(中性粒细胞计数 9/L,发热 >37.5°C)的急诊患者。从电子病历中提取患者的人口统计学数据、临床症状、尿液分析结果、尿液和血液培养结果、抗生素治疗和持续时间以及患者的治疗结果。如果检测到的菌落形成单位大于 105 个/L,则定义为 UC 阳性:在最初的 124 个病例中,共有 115 个病例被纳入分析。其中 31 例符合美国传染病学会推荐 UC 的指南定义(推荐组),84 例不符合(非推荐组)。在推荐组中,31 例病例中有 16 例 UC 呈阳性,其中 9 例根据 UC 结果更换了抗生素。在非推荐组中,84 个病例中有 15 个 UC 呈阳性,其中两个病例更换了抗生素。在血液培养中也发现了相同的病原体。115 例病例中有 7 例在血液和尿液培养中检测到相同的病原体:结论:不考虑症状而进行尿液检查可诊断出 FN 中的几种无症状尿路感染,但很少影响抗菌治疗策略。
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引用次数: 0
期刊
Acute Medicine & Surgery
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