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Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood. 儿童期心理弹性促进因素与成年期药物使用障碍风险的关系。
Pub Date : 2023-01-01 DOI: 10.46439/addiction.2.007
Ann Aschengrau, Michael R Winter, Margaret G Shea

Few studies have been conducted on the relationship between "outside-residing" resilience characteristics and the risk of developing drug use disorder later in life. These characteristics include responsive and caring parenting, household routines involving regular family meals and bedtime routines, social support from peers, participation in organized activities, and religious service attendance. We quantified the association between these resilience promotion factors during childhood and the risk of developing criteria for drug use disorder during adulthood using data from a retrospective cohort study of 618 adults born in Massachusetts during 1969-1983, including those with adverse childhood experiences (ACEs). Self-administered questionnaires gathered information on criteria for drug use disorder, ACEs, and family and community resilience promotion factors. Compared to individuals with "low" numbers of resilience promotion factors, 30% (95% CI: 0.5-0.9) and 50% reductions (95% CI: 0.4-0.8) in the risk of developing one or more criteria for drug use disorder were observed among those with "moderate" and "high" numbers of resilience factors, respectively (p value for trend=0.003). Overall, family factors were associated with greater risk reductions than comparable numbers of community factors. Among individuals with ACEs, a "high" number of family factors but not community factors were associated with a reduction in risk (RR:0.6, 95% CI:0.4-1.0 for family factors, RR:1.0, 95% CI:0.5-1.8 for community factors). These results suggest that the risk of developing criteria for drug use disorder decreases in a dose-response fashion according to the number of "outside-residing" resilience promotion factors during childhood, and that family factors are associated with greater risk reductions than community factors, particularly among individuals with ACEs. Coordinated prevention efforts at the family and community level are recommended to reduce the risk of this important societal problem.

很少有研究对“在外居住”的弹性特征与以后生活中发生药物使用障碍的风险之间的关系进行研究。这些特征包括积极响应和关怀的养育方式,包括定期家庭用餐和就寝时间的家庭惯例,同伴的社会支持,参与有组织的活动,以及参加宗教仪式。我们量化了童年时期这些恢复力促进因素与成年期药物使用障碍制定标准的风险之间的关系,使用了一项来自1969-1983年在马萨诸塞州出生的618名成年人的回顾性队列研究数据,包括那些有不良童年经历(ace)的成年人。自我管理的问卷收集了关于药物使用障碍、ace以及家庭和社区恢复力促进因素的标准信息。与心理弹性促进因子数量“低”的个体相比,心理弹性促进因子数量“中等”和“高”的个体制定一项或多项药物使用障碍标准的风险分别降低30% (95% CI: 0.5-0.9)和50% (95% CI: 0.4-0.8)(趋势p值=0.003)。总的来说,家庭因素比同等数量的社区因素与更大的风险降低相关。在ace患者中,“高”数量的家庭因素而非社区因素与风险降低相关(家庭因素的RR:0.6, 95% CI:0.4-1.0,社区因素的RR:1.0, 95% CI:0.5-1.8)。这些结果表明,制定药物使用障碍标准的风险根据儿童时期“在外居住”的恢复力促进因素的数量以剂量-反应方式降低,家庭因素比社区因素与更大的风险降低相关,特别是在ace患者中。建议在家庭和社区一级进行协调一致的预防工作,以减少这一重要社会问题的风险。
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引用次数: 0
Clay eating in pregnancy in French Guiana: How does one understand the practices and act for prevention? 在法属圭亚那怀孕期间吃粘土:人们如何理解这种做法并采取预防措施?
Pub Date : 2022-12-31 DOI: 10.46439/addiction.1.006
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引用次数: 0
Detection of some synthetic cannabinoids (FUB-AMB and AB-FUBINACA) in blood and urine using gas chromatography-mass spectrometry liquid–liquid extraction 气相色谱-质谱-液-液萃取法检测血液和尿液中部分合成大麻素(ub - amb和AB-FUBINACA)
Pub Date : 2022-07-28 DOI: 10.46439/addiction.1.003
AM El-Essawy, Ahmed MA Shihata, Emad HA Mohamed
has a binding affinity CB1 receptor that is four times greater than of THC and ten than Abstract In recent years, various types of synthetic cannabinoids have become widely distributed and are causing social and health problems in most parts of the world. Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer controlled and uncontrolled substances. Some of the most recent synthetic cannabinoids that have distributed on the market among youth are FUB-AMB and AB-FUBINACA. This study quantified blood and urine of two cases smoking tobacco mixed with AMB-FUB 0.06-0.03 ng/mL and 1.7-2.9 ng/mL AB-FUB in urine and blood respectively.
近年来,各种类型的合成大麻素已广泛分布,并在世界大部分地区引起了社会和健康问题。合成大麻素是目前最大的一类新型精神活性物质。那些受法律管制的物质被新的受管制和不受管制的物质所取代。最近在年轻人中销售的一些合成大麻素是FUB-AMB和AB-FUBINACA。本研究对两例吸烟患者的血液和尿液进行了定量分析,其中,AB-FUB分别为0.06 ~ 0.03 ng/mL和1.7 ~ 2.9 ng/mL。
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引用次数: 0
Suicide, opioids, chronic pain, and mental health disorders: a narrative review 自杀、阿片类药物、慢性疼痛和精神健康障碍:叙述性回顾
Pub Date : 2022-07-28 DOI: 10.46439/addiction.1.004
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引用次数: 1
Portrayal of substance use in media and its effects on substance use disorders among youth 媒体对物质使用的描述及其对青少年物质使用障碍的影响
Pub Date : 2022-07-28 DOI: 10.46439/addiction.1.001
Mark A. Stillman, S. T. Daddis
A variety of behavioral, environmental, developmental, and genetic factors have been documented as contributing to the development of Substance Use Disorders (SUDs) in youth. For example, it has been suggested that things such as the perceived availability of substances, familial history of antisocial behavior, and personal attitudes favorable towards drug use all have strong correlations to the development of substance use in youth [1]. What’s especially troubling is that use initiation at younger ages is also correlated with stronger likelihoods of developing a SUD [2]. Thus, it is crucial that researchers continue to explore contributing factors to youth’s likelihood of substance use.
各种各样的行为、环境、发育和遗传因素已经被证明是导致青少年物质使用障碍(sud)发展的原因。例如,有人认为,诸如物质的可获得性、家族反社会行为史和个人对吸毒的态度等因素都与青少年物质使用的发展有很强的相关性[1]。尤其令人不安的是,在更年轻的年龄开始使用也与发生SUD的可能性更大相关[2]。因此,至关重要的是,研究人员继续探索影响青少年药物使用可能性的因素。
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引用次数: 0
Filter ventilation and the risk associated with cigarette smoking 过滤嘴通风与吸烟相关的风险
Pub Date : 2022-07-28 DOI: 10.46439/addiction.1.005
P. Lee
It has long been clear that cigarette smoking is causally linked to many diseases, particularly lung cancer, chronic obstructive pulmonary disease and various forms of cardiovascular disease. For lung cancer, for example, a meta-analysis my colleagues and I conducted, based on epidemiological evidence published in the 1900s [1], estimated that current smoker/never smoker relative risks, were around 10 in North America and Europe, though lower (around three) in Asia. They were higher for squamous cell carcinoma than for adenocarcinoma, were very strongly related to amount smoked, and declined with increasing years of cessation of smoking.
长期以来,吸烟与许多疾病,特别是肺癌、慢性阻塞性肺病和各种形式的心血管疾病有因果关系,这一点已经很清楚。以肺癌为例,根据20世纪初发表的流行病学证据[1],我和我的同事进行了一项荟萃分析,估计目前吸烟者/从不吸烟者的相对风险在北美和欧洲约为10,而在亚洲则较低(约为3)。鳞状细胞癌的风险高于腺癌,与吸烟量密切相关,并随着戒烟年限的增加而下降。
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引用次数: 0
Predictors of relapse in alcohol use disorder: Identifying individuals most vulnerable to relapse 酒精使用障碍复发的预测因素:识别最容易复发的个体
Pub Date : 2022-07-28 DOI: 10.46439/addiction.1.002
Mark A. Stillman, Jane Sutcliff
linear new multiple Abstract This paper reviews the literature discussing the various biological, psychological, environmental, and social factors contributing to the risk of relapse for individuals with Alcohol Use Disorder (AUD). Identifying these risk factors and understanding their complex interactions in contributing to relapse vulnerability is crucial to improving relapse prevention interventions and outcomes. The impact of chronic alcohol abuse on brain structure and function are discussed. Specifically, altered reward circuitry, modified stress pathways, and compromised frontal white matter integrity in regions associated with decision making, impulse control, and executive functioning are identified as risk factors associated with predicting long- term abstinence. Neural adaptations increased craving, which has been attributed to relapse vulnerability. The literature examined alcohol attentional-bias, coping style, early onset alcohol dependence, duration of treatment, attendance at AA, personality traits, self-efficacy, comorbid depression, deficits in social cognition, interpersonal relationships, and facial emotion recognition ability as risk factors that may be predictive of relapse. Clinicians should encourage AA attendance, treat depressive symptoms, address coping mechanisms, and enhance social support in the first year of abstinence. Future studies that focus on establishing the strength of the predictability of these risk factors, as well as identifying protective factors, could make substantive contributions to improving outcomes for individuals who are most vulnerable to the relapse process. Identifying risk factors at the brain and biological level could establish biomarkers for relapse risk, which would have implications for clinical practice and treatment of AUD by enhancing targeted interventions and individualized care.
摘要本文综述了有关酒精使用障碍(AUD)患者复发风险的生物、心理、环境和社会因素的相关文献。识别这些风险因素并了解它们在促进复发易感性方面的复杂相互作用对于改善复发预防干预措施和结果至关重要。本文讨论了慢性酒精滥用对大脑结构和功能的影响。具体来说,与决策、冲动控制和执行功能相关区域的奖赏回路改变、应激通路改变和额叶白质完整性受损被认为是预测长期戒断的危险因素。神经适应增加了渴望,这被归因于易复发性。文献将酒精注意偏差、应对方式、早发性酒精依赖、治疗持续时间、参加嗜酒者互戒会、人格特质、自我效能、共病性抑郁、社会认知缺陷、人际关系和面部情绪识别能力作为可能预测复发的危险因素。临床医生应该鼓励参加嗜酒者互诫协会,治疗抑郁症状,解决应对机制,并在戒断的第一年加强社会支持。未来的研究重点是建立这些风险因素的可预测性,以及确定保护因素,可以为改善最容易复发的个体的结果做出实质性贡献。在大脑和生物学水平上识别危险因素可以建立复发风险的生物标志物,这将对临床实践和通过加强针对性干预和个性化护理来治疗AUD具有重要意义。
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引用次数: 6
Personality, Internet Addiction, and Other Technological Addictions 个性、网络成瘾和其他技术成瘾
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8449-0.CH003
Zaheer Hussain, H. Pontes
Research into technological addictions, such as Internet addiction, smartphone addiction and social networking addiction has greatly increased. It is important to understand how technological addictions may be related to different personality types and key individual differences associated to personality. This chapter provides empirical and conceptual insights into how technological addictions may be related to different personality types and key individual differences associated to personality. This chapter focuses on a number of technological addictions and illustrates how research and theory in this area has developed in relation to commonly researched personality traits (e.g., extraversion, introversion, neuroticism, conscientiousness, openness to experience, and narcissism) and key individual differences related to personality (e.g., personality disorders). The complex nature of personality and technological addictions is discussed together with areas for future research.
对网络成瘾、智能手机成瘾和社交网络成瘾等技术成瘾的研究大大增加。了解技术成瘾如何与不同的人格类型以及与人格相关的关键个体差异相关是很重要的。本章提供了关于技术成瘾如何与不同人格类型以及与人格相关的关键个体差异相关的经验和概念见解。本章重点介绍了一些技术成瘾,并说明了这一领域的研究和理论是如何与通常研究的人格特征(如外向、内向、神经质、尽责性、经验开放性和自恋)和与人格相关的关键个体差异(如人格障碍)发展起来的。讨论了人格和技术成瘾的复杂性以及未来研究的领域。
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引用次数: 14
Management of Chronic Mental Illnesses and Substance Use Disorders 慢性精神疾病和物质使用障碍的管理
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-0519-8.CH006
P. Sinha, Amit Garg, P. Khanna, A. Khanna
There is vast literature available about prevalence and pattern of substance use in patients with Chronic mental illness such as Schizophrenia. Many of these studies have also investigated the issues related to the impact of substance use on the course and prognosis of the mental illness and vice versa. The factors affecting the use and its impact on treatment have also been studied to some extent in the Western countries. Estimates of the prevalence of substance abuse in schizophrenia and major affective disorder vary as a function of settings (e.g., community, hospital-in-patient vs. out-patient), demographic characteristics of the sample and assessment methods, with most prevalence rates ranging between15% to 65%. Patients with Chronic Mental illnesses and Substance use disorders are difficult to treat and many models for their management have been proposed. This chapter will deal with some of these issues.
关于精神分裂症等慢性精神疾病患者药物使用的流行程度和模式,已有大量文献。其中许多研究还调查了与药物使用对精神疾病的病程和预后的影响有关的问题,反之亦然。西方国家也对影响使用的因素及其对治疗的影响进行了一定程度的研究。对精神分裂症和重大情感障碍中药物滥用流行率的估计因环境(例如,社区、住院患者与门诊患者)、样本的人口统计学特征和评估方法而异,大多数流行率在15%至65%之间。患有慢性精神疾病和物质使用障碍的患者很难治疗,并且已经提出了许多管理模式。本章将讨论其中的一些问题。
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引用次数: 0
The Diabetes, Depression, and Alcohol Triad 糖尿病、抑郁症和酒精三位一体
Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-7666-2.ch008
M. Strand, Donald Warne
Type 2 diabetes, depression and alcohol abuse exist in many populations as co-morbidities. These conditions contribute to worsened health status and lost productivity. Such diseases also contribute to high medical expenses and other societal costs. Diabetes, depression and alcohol abuse are individually associated with compromised financial status. Treating these combined conditions as a syndrome rather than as isolated disease states may result in improved quality of care, better health outcomes, and reduced costs to society. A conceptual model that could be used to address this triad is the Social Ecological Model in which intrapersonal, interpersonal, institutional and community factors as well as public policy are considered for their impact on outcomes. The triad of diabetes, depression and alcohol abuse may have common etiological factors such as social isolation and poverty, and such a holistic approach to the common determinants underlying all three conditions holds out the most hope to reduce both the prevalence of this unique disease triad and the associated costs to society.
2型糖尿病、抑郁症和酗酒在许多人群中作为合并症存在。这些情况导致健康状况恶化和生产力下降。这类疾病还造成高昂的医疗费用和其他社会成本。糖尿病、抑郁症和酗酒都与财务状况受损有关。将这些综合病症作为一种综合征而不是作为孤立的疾病状态来治疗,可能会提高护理质量,改善健康结果,并降低社会成本。社会生态模型是一个可以用来解决这三个问题的概念模型,其中考虑了个人、人际、制度和社区因素以及公共政策对结果的影响。糖尿病、抑郁症和酗酒这三种疾病可能有共同的病因,如社会孤立和贫穷,而对这三种疾病背后的共同决定因素采取这种整体办法,最有希望减少这一独特疾病的流行率和相关的社会成本。
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引用次数: 1
期刊
Addiction and substance abuse
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