Pub Date : 2023-01-01DOI: 10.4236/abb.2023.1410029
Gaoussou K. Keita, Laya Kansaye, Lassina Doumbia, Ibrahim Keita, Mariam Sangare, Tidiani Sinayoko, Boubacar Macalou, Moussa Noussourou Maiga, Nadou Paul Sanogo, Ousmane Koita
Okra is one of the most widespread vegetable crops in the world, particularly in West Africa. However, several factors influence okra crops as biotic and abiotic factors. Among the diseases affecting its culture, okra leaf curl disease is a major threat. This study aims to assess begomoviruses from okra plants with symptoms like leaves curl by molecular approach. A total of thirteen serologically positive samples were tested by PCR assay, and one sample was sequenced among them. The begomovirus was found in six isolates, Bhendi yellow vein mosaic virus (BYVMV) in three isolates, and Okra enation leaf curl virus (OELCuV) in three isolates, respectively. The begomovirus isolate sequences shared 90% identity with the Cotton leaf curl Gezira virus. Mixed infections between these viruses were found. Thus, these results highlight the need to monitor the spread of these disease-causing viruses for okra crops in Mali. In addition, they can also lead to a considerable loss in okra fields in Koulikoro, which is an agricultural region by excellence.
{"title":"Molecular Identification and Characterization of a Begomovirus Associated with Okra Enation Leaf Curl Disease in Mali","authors":"Gaoussou K. Keita, Laya Kansaye, Lassina Doumbia, Ibrahim Keita, Mariam Sangare, Tidiani Sinayoko, Boubacar Macalou, Moussa Noussourou Maiga, Nadou Paul Sanogo, Ousmane Koita","doi":"10.4236/abb.2023.1410029","DOIUrl":"https://doi.org/10.4236/abb.2023.1410029","url":null,"abstract":"Okra is one of the most widespread vegetable crops in the world, particularly in West Africa. However, several factors influence okra crops as biotic and abiotic factors. Among the diseases affecting its culture, okra leaf curl disease is a major threat. This study aims to assess begomoviruses from okra plants with symptoms like leaves curl by molecular approach. A total of thirteen serologically positive samples were tested by PCR assay, and one sample was sequenced among them. The begomovirus was found in six isolates, Bhendi yellow vein mosaic virus (BYVMV) in three isolates, and Okra enation leaf curl virus (OELCuV) in three isolates, respectively. The begomovirus isolate sequences shared 90% identity with the Cotton leaf curl Gezira virus. Mixed infections between these viruses were found. Thus, these results highlight the need to monitor the spread of these disease-causing viruses for okra crops in Mali. In addition, they can also lead to a considerable loss in okra fields in Koulikoro, which is an agricultural region by excellence.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Scoliosis is a serious condition occurring in 1% to 4% of the population. This study was conducted and designed to educate society about scoliosis and measure the knowledge and awareness about it. Methods: This was a cross-sectional study conducted on members of the Saudi Society who have consented to participate in this research between the 8th of January and 5th of February 2023. Results: A total of 427 people agreed to participate in the study. The highest percentage of the participants was female 69.1%. About 41% participants out of 427 were in the age group 18-25 years. Most of the participants were from the Middle Region. (71.9%) of participants were unfamiliar with scoliosis, while (72.1%) had no prior knowledge of the condition. Conclusion: This study indicates insufficient awareness and knowledge about scoliosis in Saudi Arabia. Therefore, further studies are needed to raise awareness about scoliosis and help people to learn more about this condition.
{"title":"Measuring the Level of Knowledge and Awareness about Scoliosis in Saudi Arabia","authors":"Doaa Mohammad Alashgar, Noorah Saleh Al-Sowayan","doi":"10.4236/abb.2023.149028","DOIUrl":"https://doi.org/10.4236/abb.2023.149028","url":null,"abstract":"Background: Scoliosis is a serious condition occurring in 1% to 4% of the population. This study was conducted and designed to educate society about scoliosis and measure the knowledge and awareness about it. Methods: This was a cross-sectional study conducted on members of the Saudi Society who have consented to participate in this research between the 8th of January and 5th of February 2023. Results: A total of 427 people agreed to participate in the study. The highest percentage of the participants was female 69.1%. About 41% participants out of 427 were in the age group 18-25 years. Most of the participants were from the Middle Region. (71.9%) of participants were unfamiliar with scoliosis, while (72.1%) had no prior knowledge of the condition. Conclusion: This study indicates insufficient awareness and knowledge about scoliosis in Saudi Arabia. Therefore, further studies are needed to raise awareness about scoliosis and help people to learn more about this condition.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135599929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noorah Saleh Al-Sowayan, Abrar Mohammed Al-Fadhel, Tahiyat Al Othaim
Introduction: Thalassemia disorder is a genetic disease that causes the blood to have less hemoglobin than normal, the main requirement to control thalassemia’s propagation is to educate the entire society. Methodology: A descriptive survey was taken to evaluate the awareness of thalassemia among Saudi Arabia’s society, with a sample size of 384. Results: The results were written in frequencies, and it shows that most of the participants were unaware and lacking information on thalassemia syndrome. Discussion: The results of this study provide valuable insights into the awareness of thalassemia in Saudi Arabia and highlight the need to raise awareness of this disease. Conclusion: This study is not comprehensive because the survey was not disrupted evenly, but it can give us an overview of the awareness of thalassemia in Saudi Arabia, and it shows that most of the participants were unaware and lacked information on thalassemia.
{"title":"Measuring the Awareness of Thalassemia in Saudi Arabia","authors":"Noorah Saleh Al-Sowayan, Abrar Mohammed Al-Fadhel, Tahiyat Al Othaim","doi":"10.4236/abb.2023.149026","DOIUrl":"https://doi.org/10.4236/abb.2023.149026","url":null,"abstract":"Introduction: Thalassemia disorder is a genetic disease that causes the blood to have less hemoglobin than normal, the main requirement to control thalassemia’s propagation is to educate the entire society. Methodology: A descriptive survey was taken to evaluate the awareness of thalassemia among Saudi Arabia’s society, with a sample size of 384. Results: The results were written in frequencies, and it shows that most of the participants were unaware and lacking information on thalassemia syndrome. Discussion: The results of this study provide valuable insights into the awareness of thalassemia in Saudi Arabia and highlight the need to raise awareness of this disease. Conclusion: This study is not comprehensive because the survey was not disrupted evenly, but it can give us an overview of the awareness of thalassemia in Saudi Arabia, and it shows that most of the participants were unaware and lacked information on thalassemia.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135442419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noorah Saleh Al-Sowayan, Bushra Almeneay, Tahiyat Al Othaim
Recently, people suffer from the inability to maintain weight with an increasing body mass, and this may be due to several reasons, including the type and quantity of food. In current study, the effect of the glycemic index of foods (high-low-medium) on the speed of return of hunger in adult women was discussed. Non-pregnant or lactating women who do not suffer from chronic diseases such as diabetes and pressure, for three days in a row for breakfast, lunch, and dinner, by calculating the number of hours preceding the feeling of hunger, as the results showed that the least hours of hunger were after eating foods with a low glycemic index and then followed by foods with a medium glycemic index, and the number of hours of starvation after eating foods with a high glycemic index was the least, and this leads to an increase in subsequent food intake and an increase in calories during the day. The results indicated: first day that are high in the glycemic index (breakfast). Highest percentage of feeling hungry was 30% after 4 h (lunch). The highest percentage of feeling hungry was 30% after 3 h, (dinner), the highest percentage of not feeling hungry by 50%. The second day with a low glycemic index (breakfast). The highest percentage of feeling hungry after 4 h was 30%, (lunch). The highest percentage of feeling hungry after 4 h was 30%, (dinner). The highest percentage of not feeling hungry was 80%. Third day with a medium glycemic index (breakfast). The highest percentage of feeling hungry was after 3 h and 4 h, with a percentage of 30%, (lunch), the highest percentage of feeling hungry after 4 h, with a percentage of 30%, (dinner), the highest percentage of not feeling hungry by 70%, which increases body mass and weight continuously, and this leads to an increase in vulnerability to chronic diseases. Therefore, it is important to preserve and be careful to eat meals with a low and medium glycemic index in the diets, with the addition of foods with a high glycemic index, without negligence or excess, and we look forward to increasing the research on the effect of the glycemic index of food on the speed of return of hunger while standardizing the quantity and type of food for all volunteers.
{"title":"Effect of Low and High Glycemic Index Meals on Hunger and Satiety","authors":"Noorah Saleh Al-Sowayan, Bushra Almeneay, Tahiyat Al Othaim","doi":"10.4236/abb.2023.149027","DOIUrl":"https://doi.org/10.4236/abb.2023.149027","url":null,"abstract":"Recently, people suffer from the inability to maintain weight with an increasing body mass, and this may be due to several reasons, including the type and quantity of food. In current study, the effect of the glycemic index of foods (high-low-medium) on the speed of return of hunger in adult women was discussed. Non-pregnant or lactating women who do not suffer from chronic diseases such as diabetes and pressure, for three days in a row for breakfast, lunch, and dinner, by calculating the number of hours preceding the feeling of hunger, as the results showed that the least hours of hunger were after eating foods with a low glycemic index and then followed by foods with a medium glycemic index, and the number of hours of starvation after eating foods with a high glycemic index was the least, and this leads to an increase in subsequent food intake and an increase in calories during the day. The results indicated: first day that are high in the glycemic index (breakfast). Highest percentage of feeling hungry was 30% after 4 h (lunch). The highest percentage of feeling hungry was 30% after 3 h, (dinner), the highest percentage of not feeling hungry by 50%. The second day with a low glycemic index (breakfast). The highest percentage of feeling hungry after 4 h was 30%, (lunch). The highest percentage of feeling hungry after 4 h was 30%, (dinner). The highest percentage of not feeling hungry was 80%. Third day with a medium glycemic index (breakfast). The highest percentage of feeling hungry was after 3 h and 4 h, with a percentage of 30%, (lunch), the highest percentage of feeling hungry after 4 h, with a percentage of 30%, (dinner), the highest percentage of not feeling hungry by 70%, which increases body mass and weight continuously, and this leads to an increase in vulnerability to chronic diseases. Therefore, it is important to preserve and be careful to eat meals with a low and medium glycemic index in the diets, with the addition of foods with a high glycemic index, without negligence or excess, and we look forward to increasing the research on the effect of the glycemic index of food on the speed of return of hunger while standardizing the quantity and type of food for all volunteers.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135501656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abb.2023.1410030
Manal Y. Sameeh
Presenting and definition the most important points about nanoparticles for medicinal plants and the most important vital applications of them. The scoping review was performed according to systemic style. The research articles included the selected studies dealing with primary information on nanotechnology and medicinal plants published between 2000 and 2023. The search was at grassroots platforms such as Web of Science and PubMed. Many studies correlated the properties of plants’ nanoparticles such as stability, surface area, and high reactivity, and their small size. It was found that nanoparticles (NPs) have size ranging from some nanometers to 100 nm and their morphology is controlled because of their tiny size, NPs have a big surface area, which makes them suitable for many applications. Green nanotechnology has the potential to become an industry with very high green credentials as it is increasingly commercialized. In general, nanoparticles derived from medicinal plants offer a promising avenue for various bio-applications. Their green synthesis, biocompatibility, and potential therapeutic properties make them an attractive area of research with the potential to impact fields ranging from medicine to agriculture.
介绍并定义了纳米颗粒在药用植物中的重要应用。范围审查是根据系统风格进行的。研究文章包括在2000年至2023年间发表的涉及纳米技术和药用植物基本信息的研究。搜索是在诸如Web of Science和PubMed这样的草根平台上进行的。许多研究将植物纳米颗粒的稳定性、比表面积、高反应性等特性与它们的小尺寸联系起来。研究发现，纳米颗粒的尺寸从几纳米到100纳米不等，由于其微小的尺寸，纳米颗粒的形貌可以控制，具有较大的表面积，这使得纳米颗粒具有广泛的应用前景。随着绿色纳米技术日益商业化，它有可能成为一个具有很高绿色资质的产业。总的来说，从药用植物中提取的纳米颗粒为各种生物应用提供了一条有前途的途径。它们的绿色合成、生物相容性和潜在的治疗特性使它们成为一个有吸引力的研究领域，有可能影响从医学到农业的各个领域。
{"title":"An Overview of Nanoparticles from Medicinal Plants: Synthesis, Characterization and Bio-Applications","authors":"Manal Y. Sameeh","doi":"10.4236/abb.2023.1410030","DOIUrl":"https://doi.org/10.4236/abb.2023.1410030","url":null,"abstract":"Presenting and definition the most important points about nanoparticles for medicinal plants and the most important vital applications of them. The scoping review was performed according to systemic style. The research articles included the selected studies dealing with primary information on nanotechnology and medicinal plants published between 2000 and 2023. The search was at grassroots platforms such as Web of Science and PubMed. Many studies correlated the properties of plants’ nanoparticles such as stability, surface area, and high reactivity, and their small size. It was found that nanoparticles (NPs) have size ranging from some nanometers to 100 nm and their morphology is controlled because of their tiny size, NPs have a big surface area, which makes them suitable for many applications. Green nanotechnology has the potential to become an industry with very high green credentials as it is increasingly commercialized. In general, nanoparticles derived from medicinal plants offer a promising avenue for various bio-applications. Their green synthesis, biocompatibility, and potential therapeutic properties make them an attractive area of research with the potential to impact fields ranging from medicine to agriculture.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135261617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abb.2023.1411031
Silu Jiang, Hao Wang, Fuxia Xie, Li Xia
Objective: To investigate the correlation between lower extremity vascular sclerosis and osteoporosis in elderly men with type 2 diabetes mellitus. Methods: A total of 359 elderly male patients with type II diabetes hospitalized in the First Affiliated Hospital of Chongqing Medical University from January 2018 to June 2023 were retrospectively collected. According to the BMD (Bone Density Value), the patients were categorized into osteoporotic (T ≤ -2.5, n = 248) and non-osteoporotic groups (T > -2.5, n = 111). T test and Chi-square test were used to evaluate the differences in clinical data, biochemical markers and ABI between two groups. Multivariate logistic regression was used to analyze the risk factors of osteoporosis in elderly men with type 2 diabetes mellitus. Results: Compared with the non-osteoporotic group, the differences in diabetes course, systolic blood pressure, ABI, BMI, uric acid, triglyceride, and HDL in the osteoporotic group were statistically significant (P Conclusion: Atherosclerosis of the lower extremities in elderly men with T2DM is closely related to osteoporosis, and can lead to a decrease in bone mass, and an increase in osteoporosis.
目的:探讨老年男性2型糖尿病患者下肢血管硬化与骨质疏松的相关性。方法:回顾性收集2018年1月至2023年6月重庆医科大学第一附属医院住院的老年男性2型糖尿病患者359例。根据骨密度值(BMD)将患者分为骨质疏松组(T≤-2.5,n = 248)和非骨质疏松组(T > -2.5, n = 111)。采用T检验和卡方检验评价两组患者临床资料、生化指标及ABI的差异。采用多因素logistic回归分析老年男性2型糖尿病患者骨质疏松的危险因素。结果:与非骨质疏松组相比，骨质疏松组糖尿病病程、收缩压、ABI、BMI、尿酸、甘油三酯、HDL差异均有统计学意义(P)。结论:老年男性T2DM患者下肢动脉粥样硬化与骨质疏松密切相关，可导致骨量下降，骨质疏松增加。
{"title":"To Explore the Relationship between Lower Extremity Vascular Sclerosis and Osteoporosis in Elderly Men with Type 2 Diabetes Mellitus","authors":"Silu Jiang, Hao Wang, Fuxia Xie, Li Xia","doi":"10.4236/abb.2023.1411031","DOIUrl":"https://doi.org/10.4236/abb.2023.1411031","url":null,"abstract":"Objective: To investigate the correlation between lower extremity vascular sclerosis and osteoporosis in elderly men with type 2 diabetes mellitus. Methods: A total of 359 elderly male patients with type II diabetes hospitalized in the First Affiliated Hospital of Chongqing Medical University from January 2018 to June 2023 were retrospectively collected. According to the BMD (Bone Density Value), the patients were categorized into osteoporotic (T ≤ -2.5, n = 248) and non-osteoporotic groups (T > -2.5, n = 111). T test and Chi-square test were used to evaluate the differences in clinical data, biochemical markers and ABI between two groups. Multivariate logistic regression was used to analyze the risk factors of osteoporosis in elderly men with type 2 diabetes mellitus. Results: Compared with the non-osteoporotic group, the differences in diabetes course, systolic blood pressure, ABI, BMI, uric acid, triglyceride, and HDL in the osteoporotic group were statistically significant (P Conclusion: Atherosclerosis of the lower extremities in elderly men with T2DM is closely related to osteoporosis, and can lead to a decrease in bone mass, and an increase in osteoporosis.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135659487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The conditional mutations in drosophila were obtained by γ-irradiation and selected using the test for dominant lethality. The conditional mutations survive under permissive genetic conditions and, additionally, commence to display novel properties. One of such properties is a recessive lethality. Ten conditional mutations that displayed recessive lethality were mapped with the help of a standard set of deletions. Half mutations contained two and more lethal defects. The fact that a large number of the lethal defects are associated with one mutation suggests that γ-irradiation is the most unlikely cause of the defects. One of the conditional mutations carried four lethal regions and had a Small barrel (Smba) visual phenotype. The Smba phenotype in the Smba/ In(2LR) Cy strain is inherited according to a parental type and disappears in the Smba/In(2LR) Pm strain. Lethality in two of the four lethal regions also disappears in this strain. A separate experiment was conducted to clarify how these regions lost a lethal manifestation after the In(2LR) Cy chromosome in the Smba/In(2LR) Cy strain was replaced with the In(2LR) Pm chromosome. The process of disappearance of the Smba phenotype was also observed in three Smba/In(2LR) Cy substocks. These data suggest that the regions of multiple recessive lethality emerge in a secondary manner under the effect of the earlier formed radiation-induced mutation in ontogene. It is assumed that the recessive lethal regions are the ontogenes with an altered DNA conformation. The conformation in ontogenes is changed in the germline cells during a regular “editing” of the individual development program.
通过γ辐照获得果蝇的条件突变，并采用显性致死试验进行筛选。条件突变在允许的遗传条件下存活，并且开始表现出新的特性。其中一个特性是隐性致死率。在一组标准缺失的帮助下，绘制了10个显示隐性致死率的条件突变。一半的突变包含两个或更多致命缺陷。大量致命缺陷与一种突变有关的事实表明，γ辐照是最不可能导致缺陷的原因。其中一个条件突变携带4个致死区，并具有小桶(Smba)视觉表型。Smba/ in (2LR) Cy株的Smba表型根据亲本型遗传，而Smba/ in (2LR) Pm株的Smba表型消失。在这一毒株中，四个致命区域中的两个的致命性也消失了。另外进行了一项实验，以阐明在Smba/In(2LR) Cy株中的In(2LR) Cy染色体被In(2LR) Pm染色体取代后，这些区域是如何失去致死表现的。在三个Smba/ in (2LR) Cy亚群中也观察到Smba表型消失的过程。这些数据表明，在早期形成的辐射诱发的基因突变的影响下，多重隐性致死区域以次要的方式出现。假定隐性致死区是DNA构象改变的个体基因。在个体发育程序的常规“编辑”过程中，生殖系细胞中的构象发生了变化。
{"title":"Mutation in Ontogene and Emergence of Secondary Chromosome Damages in Drosophila Germline Cells","authors":"Boris F. Chadov, Nina B. Fedorova","doi":"10.4236/abb.2023.149025","DOIUrl":"https://doi.org/10.4236/abb.2023.149025","url":null,"abstract":"The conditional mutations in drosophila were obtained by γ-irradiation and selected using the test for dominant lethality. The conditional mutations survive under permissive genetic conditions and, additionally, commence to display novel properties. One of such properties is a recessive lethality. Ten conditional mutations that displayed recessive lethality were mapped with the help of a standard set of deletions. Half mutations contained two and more lethal defects. The fact that a large number of the lethal defects are associated with one mutation suggests that γ-irradiation is the most unlikely cause of the defects. One of the conditional mutations carried four lethal regions and had a Small barrel (Smba) visual phenotype. The Smba phenotype in the Smba/ In(2LR) Cy strain is inherited according to a parental type and disappears in the Smba/In(2LR) Pm strain. Lethality in two of the four lethal regions also disappears in this strain. A separate experiment was conducted to clarify how these regions lost a lethal manifestation after the In(2LR) Cy chromosome in the Smba/In(2LR) Cy strain was replaced with the In(2LR) Pm chromosome. The process of disappearance of the Smba phenotype was also observed in three Smba/In(2LR) Cy substocks. These data suggest that the regions of multiple recessive lethality emerge in a secondary manner under the effect of the earlier formed radiation-induced mutation in ontogene. It is assumed that the recessive lethal regions are the ontogenes with an altered DNA conformation. The conformation in ontogenes is changed in the germline cells during a regular “editing” of the individual development program.","PeriodicalId":7210,"journal":{"name":"Advances in Bioscience and Biotechnology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135442432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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